SCAFFOLD FOR ISOLATION OF A BIOMOLECULE
    7.
    发明公开

    公开(公告)号:US20240261763A1

    公开(公告)日:2024-08-08

    申请号:US18563133

    申请日:2022-05-24

    摘要: The invention relates to a method of producing an activated substrate comprising: •(a) modifying a substrate, wherein the substrate comprises a base matrix, to form a base matrix comprising a leaving group; •(b) contacting the base matrix formed in step (a) with an aminating agent, to thereby provide an aminated base matrix; and •(c) contacting the aminated base matrix formed in step (b) with a heteroaromatic compound, wherein the heteroaromatic compound is a 5 to 12 membered heteroaromatic ring substituted with at least two halogens and optionally one or more further substituents, to produce an activated substrate. The activated substrate maybe contacted with a molecule comprising a ligand specific for a biomolecule to provide a scaffold for isolation of the biomolecule.

    PROCESS FOR MANUFACTURING LITHIUM SELECTIVE ADSORBENTS

    公开(公告)号:US20240226851A1

    公开(公告)日:2024-07-11

    申请号:US18409721

    申请日:2024-01-10

    摘要: This invention generally relates to a process for manufacturing a lithium selective adsorbent and, more particularly, to a process for manufacturing a lithium selective adsorbent using a recycled and augmented intercalation reaction liquor. An initial quantity of adsorbent precursor is intercalated with lithium using an intercalation reaction liquor to produce an intercalated layered aluminate adsorbent and a post-intercalation reaction liquor. The post-intercalation reaction liquor is decanted, and the intercalated layered aluminate adsorbent is neutralized to produce the lithium selective adsorbent. The decanted intercalation reaction liquor is reconstituted to a pre-intercalation reaction volume of the intercalation reaction liquor, which is recycled to intercalate a subsequent quantity of adsorbent precursor.