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公开(公告)号：US20240347222A1
公开(公告)日：2024-10-17
申请号：US18644443
申请日：2024-04-24
申请人： TerraPower, LLC
CPC分类号： G21G1/02 , B01D11/0203 , B01D11/0403 , B01D15/40 , G21C19/42 , G21G1/08 , B01D2215/027 , G21G2001/0036 , G21G2001/0094 , Y02P20/54
摘要： Targetry coupled separation refers to enhancing the production of a predetermined radiation product through the selection of a target (including selection of the target material and the material's physical structure) and separation chemistry in order to optimize the recovery of the predetermined radiation product. This disclosure describes systems and methods for creating (through irradiation) and removing one or more desired radioisotopes from a target and further describes systems and methods that allow the same target to undergo multiple irradiations and separation operations without damage to the target. In contrast with the prior art that requires complete dissolution or destruction of a target before recovery of any irradiation products, the repeated reuse of the same physical target allowed by targetry coupled separation represents a significant increase in efficiency and decrease in cost over the prior art.
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公开(公告)号：US12117426B2
公开(公告)日：2024-10-15
申请号：US17272973
申请日：2019-08-30
发明人： Keiko Matsumoto , Yuta Shimanaka , Nozomu Kono , Hiroyuki Arai
摘要： Provided is a method for separating PIPs by which isomers of PIPs can be separated without deacylating the PIPs. The method includes at least a separation step of injecting a sample containing a plurality of PIPs into an analysis flow path of a supercritical fluid chromatograph having a separation column filled with a separation medium containing β-cyclodextrin and separating the plurality of PIPs by supercritical fluid chromatography.
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公开(公告)号：US20240293799A1
公开(公告)日：2024-09-05
申请号：US18644518
申请日：2024-04-24
发明人： Kevin D. Wyndham , Michael F. Morris , Darryl W. Brousmiche , Jason F. Hill , Jacob N. Fairchild
IPC分类号： B01J20/283 , B01D15/26 , B01D15/30 , B01D15/32 , B01D15/40 , B01D53/02 , B01J20/22 , B01J20/28 , B01J20/282 , B01J20/284 , B01J20/285 , B01J20/288 , B01J20/289 , B01J20/30 , B01J20/32 , C07F7/18
CPC分类号： B01J20/283 , B01D15/26 , B01D15/30 , B01D15/305 , B01D15/322 , B01D15/40 , B01D53/025 , B01J20/22 , B01J20/28004 , B01J20/28016 , B01J20/28042 , B01J20/28057 , B01J20/28059 , B01J20/28061 , B01J20/28064 , B01J20/28066 , B01J20/28069 , B01J20/28071 , B01J20/28073 , B01J20/28076 , B01J20/28078 , B01J20/28083 , B01J20/28085 , B01J20/288 , B01J20/289 , B01J20/3085 , B01J20/3204 , B01J20/3206 , B01J20/3208 , B01J20/3246 , B01J20/3285 , B01J20/3293 , C07F7/1804 , B01J20/282 , B01J20/284 , B01J20/285 , B01J20/32 , B01J20/3234 , B01J2220/54 , B01J2220/80
摘要： In one aspect, the present invention provides a chromatographic stationary phase material for various different modes of chromatography represented by Formula 1: [X](W)a(Q)b(T)c (Formula 1). X can be a high purity chromatographic core composition having a surface comprising a silica core material, metal oxide core material, an inorganic-organic hybrid material or a group of block copolymers thereof. W can be absent and/or can include hydrogen and/or can include a hydroxyl on the surface of X. Q can be a functional group that minimizes retention variation over time (drift) under chromatographic conditions utilizing low water concentrations. T can include one or more hydrophilic, polar, ionizable, and/or charged functional groups that chromatographically interact with the analyte. Additionally, b and c can be positive numbers, with the ratio 0.05≤(b/c)≤100, and a≥0.
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公开(公告)号：US20240280550A1
公开(公告)日：2024-08-22
申请号：US18437259
申请日：2024-02-09
申请人： SHIMADZU CORPORATION
发明人： Yusuke Masuda , Hidetoshi Terada
CPC分类号： G01N30/88 , B01D15/40 , G01N2030/027 , G01N2030/884
摘要： A method for analyzing a sample containing a carboxylic acid anhydride includes, in a stated order, a first step of causing the sample to pass through a column together with a first mobile phase to detect a carboxylic acid anhydride eluted from the column in supercritical fluid chromatography, and a second step of causing a second mobile phase to pass through the column by switching the mobile phase from the first mobile phase to the second mobile phase after a lapse of a retention time of the carboxylic acid anhydride to detect at least one of a carboxylic acid ester and a carboxylic acid eluted from the column. The first mobile phase is a mixture of carbon dioxide and an organic solvent having no hydroxyl group, and the second mobile phase is a mixture of carbon dioxide, an acid, and an organic solvent having a hydroxyl group.
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公开(公告)号：US12036566B2
公开(公告)日：2024-07-16
申请号：US18485807
申请日：2023-10-12
摘要： A gas-liquid separator system that can effectively and efficiently separate liquid from a streaming mixture having a liquid portion and a gas portion. The gas-liquid separator may be used in supercritical fluid chromatography application where an analyte is separated from a carrier gas, such as carbon dioxide. A streaming mixture is dispensed into a separation chamber formed by a spindle shaft configured inside of a shroud cavity. The shroud cavity has a plurality of concave channels along the inner surface and extend down to an outlet end. The concave channels create pressure variations that promote the liquid portion to condense onto the inner surface of the shroud and flow down to the exhaust port. A spherical collection portion is configured on the outlet of the shroud and the condensed liquid flows thereover and down along a cone portion and off the cone tip.
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公开(公告)号：US20230416176A1
公开(公告)日：2023-12-28
申请号：US18253164
申请日：2021-10-21
发明人： Ray Marriott
CPC分类号： C07C37/004 , C07C39/23 , C07C37/82 , B01D11/0288 , B01D15/40
摘要： The present invention discloses a method for extracting cannabidiol from dried, milled and decarboxylated hemp by submitting to a subcritical liquid carbon dioxide extraction followed by a mild liquid carbon dioxide separation.
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公开(公告)号：US11680735B2
公开(公告)日：2023-06-20
申请号：US17313189
申请日：2021-05-06
发明人： Kenneth Joseph James , Brian Jeffrey Waibel , Kenneth Richard Krewson , Kim Ferrara , Curtis Ebersold
IPC分类号： F25B7/00 , F25B9/00 , F25B9/10 , F25B25/00 , F25B49/02 , G01N30/20 , G01N30/30 , G01N30/54 , B01D15/16 , B01D15/40 , B04C5/081 , B04C5/085 , B04C9/00 , C07C45/79 , C07C51/47 , C07C67/56 , C07C231/24 , C09K5/04
CPC分类号： F25B25/005 , B01D15/165 , B01D15/40 , B04C5/081 , B04C5/085 , B04C9/00 , C07C45/79 , C07C51/47 , C07C67/56 , C07C231/24 , C09K5/041 , F25B7/00 , F25B9/002 , F25B9/008 , F25B9/10 , F25B49/02 , G01N30/30 , G01N30/54 , B04C2009/004 , C09K2205/106 , C09K2205/13 , C09K2205/132 , F25B2600/2513 , F25B2700/21171 , G01N30/20 , Y02P20/54
摘要： Provided is a chiller and system that may be utilized in a supercritical fluid chromatography method, wherein a non-polar solvent may replace a portion or all of a polar solvent for the purpose of separating or extracting desired sample molecules from a combined sample/solvent stream. The system may reduce the amount of polar solvent necessary for chromatographic separation and/or extraction of desired samples. The system may incorporate a supercritical fluid chiller, a supercritical fluid pressure-equalizing vessel and a supercritical fluid cyclonic separator. The supercritical fluid chiller allows for efficient and consistent pumping of liquid-phase gases employing off-the-shelf HPLC pumps. The pressure equalizing vessel allows the use of off-the-shelf HPLC column cartridges. The system may further incorporate the use of one or more disposable cartridges containing silica gel or other suitable medium. The system may also utilize an open loop cooling circuit using fluids with a positive Joule-Thompson coefficient.
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8.发明申请公开(公告)号：US20180252683A1
公开(公告)日：2018-09-06
申请号：US15909258
申请日：2018-03-01
CPC分类号： G01N30/32 , B01D15/163 , B01D15/40 , G01N30/724 , G01N2030/326
摘要： The present disclosure relates to methodologies, systems and devices for controlling pressure of a mobile phase in a CO2-based chromatography system. A pump is used to pump a mobile phase containing CO2 and is located upstream of a chromatography column. A primary pressure control element is located downstream of the chromatography column and controls the pressure of the mobile phase within the column. A secondary pressure control element is located downstream of the primary pressure control element and maintains the pressure of the mobile phase above a threshold value between an outlet of the primary pressure control element and the point of detection within a detector. The detector is located downstream of both the primary pressure control element and the secondary pressure control element.
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9.发明申请公开(公告)号：US20180196019A1
公开(公告)日：2018-07-12
申请号：US15850146
申请日：2017-12-21
CPC分类号： G01N30/26 , G01N30/20 , G01N30/34 , G01N30/462 , G01N30/463 , G01N30/465 , G01N30/60 , B01D15/40
摘要： A method of performing a chromatographic separation includes modulating a portion of a flowstream to a trap column to retain at least one analyte from the flowstream on the trap column. A flow of a modifier is provided through the trap column to generate an elution comprising the at least one analyte. A flow of a compressible fluid-based chromatography (CFC) mobile phase or CFC solvent is merged with the elution from the trap column to generate a diluted elution. Carbon dioxide may be used as the CFC solvent or as a component of the CFC mobile phase. The diluted elution is provided to a CFC column where at least one analyte is focused at a head of the CFC column. Examples of a flowstream that may be used include an eluent from a chromatography column or a fluid flow from an extraction system.
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公开(公告)号：US20180111060A1
公开(公告)日：2018-04-26
申请号：US15791622
申请日：2017-10-24
CPC分类号： B01D15/40 , B01D15/10 , B01D15/161 , B01D15/163 , B01D19/0005 , B01D19/0021 , B01D19/0042 , B01D19/0057 , B01D19/0063 , B01D2257/504 , G01N30/84
摘要： Examples of gas liquid separators include a chamber, a fluid mixture inlet, a gas outlet and a liquid outlet. The fluid mixture inlet and the gas and liquid outlets are in fluid communication with the chamber. A fluid mixture received at the fluid mixture inlet diffuses inside the chamber and is separated into a liquid and a gas. The separated liquid is gravity-fed to the liquid outlet. The gas liquid separators have reduced dispersion and increased liquid recovery in comparison to conventional gas liquid separators used for chromatographic separations. The reduced dispersion yields an improvement in the shape of chromatographic peaks.
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