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公开(公告)号：US11992824B2
公开(公告)日：2024-05-28
申请号：US17353096
申请日：2021-06-21
发明人： Kevin D. Wyndham , Michael F. Morris , Darryl W. Brousmiche , Jason F. Hill , Jacob N. Fairchild
IPC分类号： B01J20/28 , B01D15/26 , B01D15/30 , B01D15/32 , B01D15/40 , B01D53/02 , B01J20/22 , B01J20/283 , B01J20/288 , B01J20/289 , B01J20/30 , B01J20/32 , C07F7/18 , B01J20/282 , B01J20/284 , B01J20/285
CPC分类号： B01J20/283 , B01D15/26 , B01D15/30 , B01D15/305 , B01D15/322 , B01D15/40 , B01D53/025 , B01J20/22 , B01J20/28004 , B01J20/28016 , B01J20/28042 , B01J20/28057 , B01J20/28059 , B01J20/28061 , B01J20/28064 , B01J20/28066 , B01J20/28069 , B01J20/28071 , B01J20/28073 , B01J20/28076 , B01J20/28078 , B01J20/28083 , B01J20/28085 , B01J20/288 , B01J20/289 , B01J20/3085 , B01J20/3204 , B01J20/3206 , B01J20/3208 , B01J20/3246 , B01J20/3285 , B01J20/3293 , C07F7/1804 , B01J20/282 , B01J20/284 , B01J20/285 , B01J20/32 , B01J20/3234 , B01J2220/54 , B01J2220/80
摘要： In one aspect, the present invention provides a chromatographic stationary phase material for various different modes of chromatography represented by Formula 1: [X](W)a(Q)b(T)c (Formula 1). X can be a high purity chromatographic core composition having a surface comprising a silica core material, metal oxide core material, an inorganic-organic hybrid material or a group of block copolymers thereof. W can be absent and/or can include hydrogen and/or can include a hydroxyl on the surface of X. Q can be a functional group that minimizes retention variation over time (drift) under chromatographic conditions utilizing low water concentrations. T can include one or more hydrophilic, polar, ionizable, and/or charged functional groups that chromatographically interact with the analyte. Additionally, b and c can be positive numbers, with the ratio 0.05≤(b/c)≤100, and a≥0.
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公开(公告)号：US11857948B2
公开(公告)日：2024-01-02
申请号：US16759548
申请日：2018-11-02
IPC分类号： B01J20/281
CPC分类号： B01J20/281 , B01J2220/42 , B01J2220/54
摘要： A packing material for chromatography, the packing material comprising coated particles, wherein the coated particles comprise non-porous particles and a portion of the surface area of the non-porous particles is coated with a coating composition comprising graphene and/or graphene oxide.
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公开(公告)号：US20230405551A1
公开(公告)日：2023-12-21
申请号：US18198349
申请日：2023-05-17
发明人： Jayesh Dharia , Michael Ostrander
IPC分类号： B01J20/26 , B01J20/28 , B01J20/289 , B01J20/32 , B01D15/38
CPC分类号： B01J20/265 , B01J20/28052 , B01J20/28035 , B01J20/28038 , B01J20/289 , B01J2220/54 , B01J20/3278 , B01J20/3297 , B01J20/321 , B01D15/3828 , B01J20/3219
摘要： A method for producing a chromatography medium by:
a) exposing a nanoweb sheet having mean flow pore size from 0.1 to 5 μm and a porosity from 40 to 90 volume % to a gaseous phase comprising a vinyl monomer to produce a functionalized nanoweb sheet;
b) layering a plurality of functionalized nanoweb sheets to form a functionalized nanoweb stack;
c) cutting the functionalized nanoweb stack with a die to form die-cut functionalized nanoweb stacks having regular shapes; and
d) exposing the die-cut functionalized nanoweb stacks in an aqueous medium to a ligand such as a protein which is capable of forming covalent bonds.-
公开(公告)号：US20230372893A1
公开(公告)日：2023-11-23
申请号：US18247231
申请日：2021-09-24
申请人： National Institute of Advanced Industrial Science and Technology , Futamura Kagaku Kabushiki Kaisha
发明人： Nobuyoshi YAMASHITA , Sachi TANIYASU , Tsutomu KOUSAKA , Makoto YOKOI , Chiharu HORI , Kodai SHIMAMURA , Takuya ASANO
IPC分类号： B01J20/20 , C01B32/306 , B01J20/28 , B01J20/282
CPC分类号： B01J20/20 , C01B32/306 , B01J20/28064 , B01J20/28066 , B01J20/28092 , B01J20/282 , B01J2220/54 , B01J2220/58 , C01P2006/12 , C01P2006/14
摘要： An activated carbon for adsorbing neutral per- and polyfluoroalkyl compounds used in quantitative analysis of neutral per- and polyfluoroalkyl compounds in a water sample includes an activated carbon having a BET specific surface area of 900 m2/g or more for desorbably adsorbing neutral per- and polyfluoroalkyl compounds distributed in a gas phase from the water sample by aerating or bubbling, with an inert gas as a carrier gas, the water sample sealed in a vessel and temperature-controlled to a temperature at which the neutral per- and polyfluoroalkyl compounds can be distributed in a gas phase.
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5.发明公开公开(公告)号：US20230338924A1
公开(公告)日：2023-10-26
申请号：US17729153
申请日：2022-04-26
发明人： Tsung-Han TU , Chia-Wei LIN , Shih-Yu WANG , Hui CHEN , Min-Shyan SHEU , Shih-Horng YANG
IPC分类号： B01J20/26 , B01J20/28 , B01J20/285 , B01J20/30 , B01D15/20 , B01J20/288
CPC分类号： B01J20/285 , B01D15/206 , B01J20/267 , B01J20/28004 , B01J20/28016 , B01J20/28052 , B01J20/28085 , B01J20/28095 , B01J20/288 , B01J20/3021 , B01J20/3085 , B01J2220/54
摘要： The invention relates to a stationary phase medium for adsorption chromatography, which is in form of porous particles suitable for being packed into a chromatographic column. The porous particles are made of cross-linked polymeric material and formed with interconnected macropores to constitute a porous network, through which a mobile phase fluid may flow in a convective manner. The porous particles are substantially free of diffusive pores and, thus, the mass transfer through the porous network is governed by convection alone. The porous particles are fabricated to have irregular granular configurations with rough outer surfaces, so that the convective flow between the porous particles will not be impeded during chromatography process.
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公开(公告)号：US11740163B2
公开(公告)日：2023-08-29
申请号：US16160925
申请日：2018-10-15
申请人： DIONEX CORPORATION
发明人： Xiaodong Liu , Christopher A. Pohl
IPC分类号： B01J20/286 , B01J20/287 , B01J20/289 , B01J20/32 , G01N1/40 , C07F7/21
CPC分类号： G01N1/405 , B01J20/286 , B01J20/287 , B01J20/289 , B01J20/3219 , B01J20/3246 , B01J20/3257 , C07F7/21 , B01J2220/54
摘要： A method of separating analytes in a liquid sample includes flowing the liquid sample through a chromatography column configured for use in liquid chromatography. The chromatography column contains a composition that includes a solid support having an exterior surface, a ligand, and a linker. The ligand includes a polyhedral oligomeric silsesquioxane moiety. The linker is covalently bound to both the polyhedral oligomeric silsesquioxane moiety and the exterior surface of the solid support.
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公开(公告)号：US11692982B2
公开(公告)日：2023-07-04
申请号：US16870027
申请日：2020-05-08
发明人： Robert Furstenberg , Christopher Breshike , Todd H. Stievater , Dmitry Kozak , R. Andrew McGill
CPC分类号： G01N30/6095 , B01J20/28052 , B01J20/32 , B01J2220/54 , G01N2030/025
摘要： Presented herein is a new concept of uniformly spin coating a flat surface with a stationary phase and creating a gas chromatography column by pressing a grooved lid, with micro-stamped ridges, down onto the coated substrate. The lids are molded out of commercially available rigid materials including epoxies so that when pressed onto a flat surface it will create an air tight seal. The epoxy material is rendered inert by a thin layer of gold.
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公开(公告)号：US11680081B2
公开(公告)日：2023-06-20
申请号：US16955119
申请日：2018-12-13
发明人： Gustav Rodrigo , Mats Ander , Ronnie Palmgren , Tomas Bjorkman
IPC分类号： C07K1/22 , B01D15/38 , B01J20/24 , B01J20/28 , B01J20/288 , B01J20/30 , B01J20/32 , C07K16/00
CPC分类号： C07K1/22 , B01D15/3809 , B01J20/24 , B01J20/288 , B01J20/28016 , B01J20/3071 , B01J20/3212 , B01J20/3217 , B01J20/3274 , B01J20/3295 , C07K16/00 , B01J2220/54
摘要： Methods that include providing and reacting a solid support and an alkali-stable ligand derived from an immunoglobulin-binding bacterial protein to form a separation matrix having covalently coupled alkali-stable ligands; and washing with a wash solution comprising at least 10 mM of an alkali metal hydroxide.
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公开(公告)号：US20190217273A1
公开(公告)日：2019-07-18
申请号：US16359328
申请日：2019-03-20
发明人： Kevin D. Wyndham , Michael F. Morris , Darryl W. Brousmiche , Jason F. Hill , Jacob N. Fairchild
IPC分类号： B01J20/283 , C07F7/18 , B01J20/28 , B01D15/26 , B01D15/30 , B01D15/32 , B01D15/40 , B01J20/288 , B01J20/32 , B01J20/289 , B01D53/02 , B01J20/22 , B01J20/30
CPC分类号： B01J20/283 , B01D15/26 , B01D15/30 , B01D15/305 , B01D15/322 , B01D15/40 , B01D53/025 , B01J20/22 , B01J20/28004 , B01J20/28016 , B01J20/28042 , B01J20/28057 , B01J20/28059 , B01J20/28061 , B01J20/28064 , B01J20/28066 , B01J20/28069 , B01J20/28071 , B01J20/28073 , B01J20/28076 , B01J20/28078 , B01J20/28083 , B01J20/28085 , B01J20/282 , B01J20/284 , B01J20/285 , B01J20/288 , B01J20/289 , B01J20/3085 , B01J20/32 , B01J20/3204 , B01J20/3206 , B01J20/3208 , B01J20/3234 , B01J20/3246 , B01J20/3285 , B01J20/3293 , B01J2220/54 , B01J2220/80 , C07F7/1804
摘要： In one aspect, the present invention provides a chromatographic stationary phase material for various different modes of chromatography represented by Formula 1: [X](W)a(Q)b(T)c (Formula 1). X can be a high purity chromatographic core composition having a surface comprising a silica core material, metal oxide core material, an inorganic-organic hybrid material or a group of block copolymers thereof. W can be absent and/or can include hydrogen and/or can include a hydroxyl on the surface of X. Q can be a functional group that minimizes retention variation over time (drift) under chromatographic conditions utilizing low water concentrations. T can include one or more hydrophilic, polar, ionizable, and/or charged functional groups that chromatographically interact with the analyte. Additionally, b and c can be positive numbers, with the ratio 0.05≤(b/c)≤100, and a≥0.
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10.发明申请公开(公告)号：US20190060869A1
公开(公告)日：2019-02-28
申请号：US16189894
申请日：2018-11-13
发明人： Martin Hall , Sture Larsson , Andreas Muranyi , Gustav Rodrigo , Jinyu Zou , Per-Mikael Aberg
IPC分类号： B01J20/24 , B01D15/38 , C07K16/00 , B01J20/32 , C07K17/10 , B01J20/28 , B01J20/285 , B01J20/289 , C07K14/31 , C07K1/22 , B01J20/286 , C07K17/00
CPC分类号： B01J20/24 , B01D15/3809 , B01J20/28019 , B01J20/285 , B01J20/286 , B01J20/289 , B01J20/3212 , B01J20/3219 , B01J20/3274 , B01J20/3293 , B01J2220/52 , B01J2220/54 , C07K1/22 , C07K14/31 , C07K16/00 , C07K17/00 , C07K17/10 , C07K2317/55
摘要： The present invention relates to a chromatography ligand, which comprises Domain C from Staphylococcus protein A (SpA), or a functional fragment or variant thereof. The chromatography ligand presents an advantageous capability of withstanding harsh cleaning in place (CIP) conditions, and is capable of binding Fab fragments of antibodies. The ligand may be provided with a terminal coupling group, such as arginine or cysteine, to facilitate its coupling to an insoluble carrier such as beads or a membrane. The invention also relates process of using the ligand in isolation of antibodies, and to a purification protocol which may include washing steps and/or regeneration with alkali.
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