公开(公告)号：US11992824B2

公开(公告)日：2024-05-28

申请号：US17353096

申请日：2021-06-21

申请人： Waters Technologies Corporation

发明人： Kevin D. Wyndham ,  Michael F. Morris ,  Darryl W. Brousmiche ,  Jason F. Hill ,  Jacob N. Fairchild

IPC分类号： B01J20/28 ,  B01D15/26 ,  B01D15/30 ,  B01D15/32 ,  B01D15/40 ,  B01D53/02 ,  B01J20/22 ,  B01J20/283 ,  B01J20/288 ,  B01J20/289 ,  B01J20/30 ,  B01J20/32 ,  C07F7/18 ,  B01J20/282 ,  B01J20/284 ,  B01J20/285

CPC分类号： B01J20/283 ,  B01D15/26 ,  B01D15/30 ,  B01D15/305 ,  B01D15/322 ,  B01D15/40 ,  B01D53/025 ,  B01J20/22 ,  B01J20/28004 ,  B01J20/28016 ,  B01J20/28042 ,  B01J20/28057 ,  B01J20/28059 ,  B01J20/28061 ,  B01J20/28064 ,  B01J20/28066 ,  B01J20/28069 ,  B01J20/28071 ,  B01J20/28073 ,  B01J20/28076 ,  B01J20/28078 ,  B01J20/28083 ,  B01J20/28085 ,  B01J20/288 ,  B01J20/289 ,  B01J20/3085 ,  B01J20/3204 ,  B01J20/3206 ,  B01J20/3208 ,  B01J20/3246 ,  B01J20/3285 ,  B01J20/3293 ,  C07F7/1804 ,  B01J20/282 ,  B01J20/284 ,  B01J20/285 ,  B01J20/32 ,  B01J20/3234 ,  B01J2220/54 ,  B01J2220/80

摘要： In one aspect, the present invention provides a chromatographic stationary phase material for various different modes of chromatography represented by Formula 1: [X](W)a(Q)b(T)c (Formula 1). X can be a high purity chromatographic core composition having a surface comprising a silica core material, metal oxide core material, an inorganic-organic hybrid material or a group of block copolymers thereof. W can be absent and/or can include hydrogen and/or can include a hydroxyl on the surface of X. Q can be a functional group that minimizes retention variation over time (drift) under chromatographic conditions utilizing low water concentrations. T can include one or more hydrophilic, polar, ionizable, and/or charged functional groups that chromatographically interact with the analyte. Additionally, b and c can be positive numbers, with the ratio 0.05≤(b/c)≤100, and a≥0.

公开(公告)号：US20190217273A1

公开(公告)日：2019-07-18

申请号：US16359328

申请日：2019-03-20

申请人： Waters Technologies Corporation

发明人： Kevin D. Wyndham ,  Michael F. Morris ,  Darryl W. Brousmiche ,  Jason F. Hill ,  Jacob N. Fairchild

IPC分类号： B01J20/283 ,  C07F7/18 ,  B01J20/28 ,  B01D15/26 ,  B01D15/30 ,  B01D15/32 ,  B01D15/40 ,  B01J20/288 ,  B01J20/32 ,  B01J20/289 ,  B01D53/02 ,  B01J20/22 ,  B01J20/30

CPC分类号： B01J20/283 ,  B01D15/26 ,  B01D15/30 ,  B01D15/305 ,  B01D15/322 ,  B01D15/40 ,  B01D53/025 ,  B01J20/22 ,  B01J20/28004 ,  B01J20/28016 ,  B01J20/28042 ,  B01J20/28057 ,  B01J20/28059 ,  B01J20/28061 ,  B01J20/28064 ,  B01J20/28066 ,  B01J20/28069 ,  B01J20/28071 ,  B01J20/28073 ,  B01J20/28076 ,  B01J20/28078 ,  B01J20/28083 ,  B01J20/28085 ,  B01J20/282 ,  B01J20/284 ,  B01J20/285 ,  B01J20/288 ,  B01J20/289 ,  B01J20/3085 ,  B01J20/32 ,  B01J20/3204 ,  B01J20/3206 ,  B01J20/3208 ,  B01J20/3234 ,  B01J20/3246 ,  B01J20/3285 ,  B01J20/3293 ,  B01J2220/54 ,  B01J2220/80 ,  C07F7/1804

摘要： In one aspect, the present invention provides a chromatographic stationary phase material for various different modes of chromatography represented by Formula 1: [X](W)a(Q)b(T)c (Formula 1). X can be a high purity chromatographic core composition having a surface comprising a silica core material, metal oxide core material, an inorganic-organic hybrid material or a group of block copolymers thereof. W can be absent and/or can include hydrogen and/or can include a hydroxyl on the surface of X. Q can be a functional group that minimizes retention variation over time (drift) under chromatographic conditions utilizing low water concentrations. T can include one or more hydrophilic, polar, ionizable, and/or charged functional groups that chromatographically interact with the analyte. Additionally, b and c can be positive numbers, with the ratio 0.05≤(b/c)≤100, and a≥0.

公开(公告)号：US20190187109A1

公开(公告)日：2019-06-20

申请号：US16223330

申请日：2018-12-18

申请人： Waters Technologies Corporation

发明人： Moon Chul Jung ,  Abhijit Tarafder ,  Wade P. Leveille

IPC分类号： G01N30/14 ,  B01D15/26 ,  B01D15/18

CPC分类号： G01N30/14 ,  B01D15/18 ,  B01D15/26 ,  G01N1/34 ,  G01N30/32 ,  G01N30/34 ,  G01N2030/143 ,  G01N2030/342

摘要： In various aspects provided are purification media and containers for dispensing a purified liquid are provided herein where a high surface area-to-volume chemically interactive purification media positioned at the outlet of a container that purifies the liquid as it is dispensed and/or extracted.

公开(公告)号：US20190048101A1

公开(公告)日：2019-02-14

申请号：US16055771

申请日：2018-08-06

申请人： Kultevat, Inc.

发明人： Anthony Nocera, JR. ,  Daniel R. Swiger

IPC分类号： C08C1/04 ,  C08C1/12 ,  C08C1/14 ,  C07H1/08 ,  B01D11/02 ,  B01D11/04 ,  B01D15/26

CPC分类号： C08C1/04 ,  B01D11/0257 ,  B01D11/0284 ,  B01D11/0288 ,  B01D11/0296 ,  B01D11/0434 ,  B01D11/0488 ,  B01D11/0492 ,  B01D15/26 ,  C07H1/08 ,  C08C1/12 ,  C08C1/14

摘要： Systems and methods for extracting useful by-products and natural rubber from non-Hevea rubber bearing plants are disclosed.

公开(公告)号：US09790573B2

公开(公告)日：2017-10-17

申请号：US15359053

申请日：2016-11-22

申请人： Actinium Pharmaceuticals Inc.

发明人： Josue Manuel Moreno Bermudez ,  Andreas Turler ,  Richard Henkelmann ,  Eva Kabai ,  Ernst Huenges

IPC分类号： A61K51/00 ,  A61M36/14 ,  C22B60/02 ,  C22B7/00 ,  B01D15/20 ,  G21G1/00

CPC分类号： C22B60/0295 ,  A61K51/00 ,  B01D15/206 ,  B01D15/26 ,  C22B7/005 ,  C22B7/007 ,  C22B7/009 ,  G21G1/001 ,  G21G4/08 ,  G21G2001/0089

摘要： The present invention describes a method for purification of 225Ac from irradiated 226Ra-targets provided on a support comprising a leaching treatment of the 225Ra-targets for leaching essentially for the entirety of 223Ac and 226Ra with nitric or hydrochloric acid, followed by a first extraction chromatography for separating 225Ac from 226Ra and other Ra-isotops and a second extraction chromotography for separating 225Ac from 210Po and 210Pb. The finally purified 225Ac can be used to prepare compositions useful for pharmaceutical purposes.

公开(公告)号：US09675959B2

公开(公告)日：2017-06-13

申请号：US13872081

申请日：2013-04-27

申请人： Xinmiao Liang ,  Huihui Wan ,  Xingya Xue

发明人： Xinmiao Liang ,  Huihui Wan ,  Xingya Xue

IPC分类号： B01D15/26 ,  B01J20/28 ,  B01J20/283 ,  B01J20/32 ,  B01J20/288 ,  C01B21/082 ,  B01D15/22 ,  B01J20/282 ,  B01J20/281

CPC分类号： B01J20/288 ,  B01D15/26 ,  B01J20/28057 ,  B01J20/28069 ,  B01J20/28083 ,  B01J20/281 ,  B01J20/282 ,  B01J20/283 ,  B01J20/3204 ,  B01J20/3246 ,  B01J20/3248 ,  C01B21/0823 ,  C01P2002/86 ,  C01P2002/87 ,  C01P2004/61 ,  C01P2004/62 ,  C01P2006/12 ,  C01P2006/14 ,  C01P2006/16 ,  Y10T428/2982

摘要： Novel material for chromatographic separations, processes for its preparation, and separation devices containing the chromatographic material. In particular, the novel materials are porous silicon oxynitride materials, which desirably can be surface modified and have enhanced stability at high pH. The novel porous silicon oxynitride material may offer efficient chromatographic separations, and hold great promise as packing material for chromatographic separations.

公开(公告)号：US20160214920A1

公开(公告)日：2016-07-28

申请号：US15004848

申请日：2016-01-22

申请人： Phytoplant Research S.L.

发明人： Xavier Nadal Roura

IPC分类号： C07C65/19 ,  C07C37/68 ,  B01D15/26 ,  C07C37/84 ,  C07C39/23 ,  C07C51/43 ,  C07C39/19

CPC分类号： C07C37/685 ,  A61K36/185 ,  A61K2236/00 ,  B01D15/26 ,  C07C37/84 ,  C07C39/19 ,  C07C39/23 ,  C07C51/43 ,  C07C65/19

摘要： The present specification discloses methods of purifying one or more cannabinoids from a plant material, purified cannabinoids and pharmaceutical compositions comprising one or more cannabinoids produced by the disclosed method, methods and uses for treating a disease or condition employing such purified cannabinoids and pharmaceutical compositions.

摘要翻译： 本说明书公开了从植物材料纯化一种或多种大麻素的方法，纯化的大麻素和包含一种或多种通过所公开的方法生产的大麻素的药物组合物，用于治疗使用这种纯化大麻素和药物组合物的疾病或病症的方法和用途。

公开(公告)号：US09127043B2

公开(公告)日：2015-09-08

申请号：US13254697

申请日：2010-03-04

申请人： Robert S. Gronke ,  Héctor Zaanoni

发明人： Robert S. Gronke ,  Héctor Zaanoni

IPC分类号： B01D15/26 ,  B01D15/38 ,  C07K1/22

CPC分类号： C07K1/22 ,  B01D15/26 ,  B01D15/3804 ,  B01D15/3828 ,  B01D2015/3838 ,  C07K1/165

摘要： The present invention pertains to improved methods of using dye-ligand affinity chromatography for the isolation of antibodies or proteins comprising an antibody fragment (such as Fc fusion proteins) from a mixture of undesirable contaminants. In particular, the use of an organic polymer such as polyethylene glycol (PEG) in the elution phase of an antibody/dye-ligand chromatography isolation procedure results in improved separation of target antibodies from undesirable contaminants. The methods described herein are particularly useful in separating or removing antibody aggregates, misfolded antibodies, and virus contaminants from target antibodies.

摘要翻译： 本发明涉及使用染料 - 配体亲和层析从不想要的污染物的混合物分离包含抗体片段（例如Fc融合蛋白）的抗体或蛋白质的改进方法。 特别地，在抗体/染料 - 配体色谱分离方法的洗脱阶段中使用有机聚合物如聚乙二醇（PEG）导致靶抗体与不期望的污染物的分离改善。 本文描述的方法特别可用于从靶抗体中分离或去除抗体聚集体，错误折叠的抗体和病毒污染物。

公开(公告)号：US20140353255A1

公开(公告)日：2014-12-04

申请号：US14463525

申请日：2014-08-19

申请人： BRIGHAM YOUNG UNIVERSITY ,  US SYNTHETIC CORPORATION

发明人： David Scott Jensen ,  Andrew E. Dadson

IPC分类号： B01J20/32 ,  B01J20/281 ,  B01D15/26

CPC分类号： B01J20/3293 ,  B01D15/26 ,  B01J13/14 ,  B01J13/22 ,  B01J20/0211 ,  B01J20/0218 ,  B01J20/28004 ,  B01J20/28016 ,  B01J20/28019 ,  B01J20/28057 ,  B01J20/281 ,  B01J20/286 ,  B01J20/3204 ,  B01J20/3223 ,  B01J20/3234 ,  B01J20/3236 ,  B01J20/324 ,  B01J20/3268 ,  B01J20/3272 ,  B01J20/3282 ,  B01J20/3289 ,  B01J20/3295 ,  B01J2220/52 ,  B01J2220/58 ,  B01J2220/82

摘要： In an embodiment, a porous composite particulate material includes a plurality of composite particles. Each composite particle includes an acid-base-resistant core particle at least partially surrounded by one or more layers of acid-base-resistant shell particles. The shell particles are adhered to the core particle by a polymeric layer. The shell particles and/or core particles may be made from an acid-base-resistant material that is stable in harsh chemical conditions. For example, the shell particles may be made from diamond, graphitic carbon, silicon carbide, boron nitride, tungsten carbide, niobium carbide, zirconia, noble metals, combinations of the foregoing, or other acid-base-resistant materials and the core particle may include at least one exterior layer of non-diamond carbon. The porous composite particulate materials disclosed herein and related methods and devices may be used in separation technologies, including, but not limited to, chromatography and solid phase extraction.

摘要翻译： 在一个实施方案中，多孔复合颗粒材料包括多个复合颗粒。 每个复合颗粒包括至少部分地被一层或多层耐酸碱性壳颗粒包围的耐酸碱性芯颗粒。 壳颗粒通过聚合物层粘附到芯颗粒。 壳颗粒和/或芯颗粒可以由在苛刻的化学条件下稳定的耐酸碱材料制成。 例如，壳颗粒可以由金刚石，石墨碳，碳化硅，氮化硼，碳化钨，碳化铌，氧化锆，贵金属，前述的组合或其它耐酸碱材料和芯颗粒制成 包括至少一个非金刚石碳外层。 本文公开的多孔复合颗粒材料和相关方法和装置可以用于分离技术，包括但不限于色谱和固相萃取。

公开(公告)号：US20130323134A1

公开(公告)日：2013-12-05

申请号：US13904813

申请日：2013-05-29

申请人： UOP LLC

发明人： Mark G. Riley ,  Wugeng Liang ,  Deng-Yang Jan ,  Adam Gross

IPC分类号： B01D15/26 ,  B01J8/00

CPC分类号： B01D15/26 ,  B01D15/00 ,  B01J8/00 ,  B01J20/165 ,  B01J20/18 ,  B01J20/2808 ,  C07C7/005 ,  C07C7/13 ,  C07C15/04

摘要： Disclosed is an apparatus for removing water, nitrogen compounds, and unsaturated aliphatic compounds from a hydrocarbon feed stream including a water removal zone, a nitrogen removal zone, and an unsaturated aliphatic compound removal zone. By on aspect, the water removal zone includes a water selective adsorbent, the nitrogen removal zone includes a nitrogen selective adsorbent, and the unsaturated aliphatic compound removal zone includes an unsaturated aliphatic compound removal material.

摘要翻译： 公开了一种从包含除水区，除氮区和不饱和脂肪族化合物除去区的烃进料流中除去水，氮化合物和不饱和脂肪族化合物的装置。 一方面，除水区包括水选择性吸附剂，除氮区包括氮选择性吸附剂，不饱和脂族化合物除去区包括不饱和脂肪族化合物去除物质。