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公开(公告)号：US20240293799A1
公开(公告)日：2024-09-05
申请号：US18644518
申请日：2024-04-24
发明人： Kevin D. Wyndham , Michael F. Morris , Darryl W. Brousmiche , Jason F. Hill , Jacob N. Fairchild
IPC分类号： B01J20/283 , B01D15/26 , B01D15/30 , B01D15/32 , B01D15/40 , B01D53/02 , B01J20/22 , B01J20/28 , B01J20/282 , B01J20/284 , B01J20/285 , B01J20/288 , B01J20/289 , B01J20/30 , B01J20/32 , C07F7/18
CPC分类号： B01J20/283 , B01D15/26 , B01D15/30 , B01D15/305 , B01D15/322 , B01D15/40 , B01D53/025 , B01J20/22 , B01J20/28004 , B01J20/28016 , B01J20/28042 , B01J20/28057 , B01J20/28059 , B01J20/28061 , B01J20/28064 , B01J20/28066 , B01J20/28069 , B01J20/28071 , B01J20/28073 , B01J20/28076 , B01J20/28078 , B01J20/28083 , B01J20/28085 , B01J20/288 , B01J20/289 , B01J20/3085 , B01J20/3204 , B01J20/3206 , B01J20/3208 , B01J20/3246 , B01J20/3285 , B01J20/3293 , C07F7/1804 , B01J20/282 , B01J20/284 , B01J20/285 , B01J20/32 , B01J20/3234 , B01J2220/54 , B01J2220/80
摘要： In one aspect, the present invention provides a chromatographic stationary phase material for various different modes of chromatography represented by Formula 1: [X](W)a(Q)b(T)c (Formula 1). X can be a high purity chromatographic core composition having a surface comprising a silica core material, metal oxide core material, an inorganic-organic hybrid material or a group of block copolymers thereof. W can be absent and/or can include hydrogen and/or can include a hydroxyl on the surface of X. Q can be a functional group that minimizes retention variation over time (drift) under chromatographic conditions utilizing low water concentrations. T can include one or more hydrophilic, polar, ionizable, and/or charged functional groups that chromatographically interact with the analyte. Additionally, b and c can be positive numbers, with the ratio 0.05≤(b/c)≤100, and a≥0.
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公开(公告)号：US11905548B2
公开(公告)日：2024-02-20
申请号：US17881175
申请日：2022-08-04
发明人： Joomi Ahn , Moon Chul Jung , Kevin D. Wyndham
摘要： An immobilized enzymatic reactor can include a wall defining a chamber having an inlet and an outlet; a solid stationary phase covalently linked to an enzyme and disposed within the chamber; and a pressure modulator in a fluid communication with the chamber and adapted to support continuous flow of a liquid sample comprising a polymer analyte through the inlet, over the solid stationary phase, and out of the outlet under a pressure between about 2,500 and 35,000 psi. In one example, the solid stationary phase includes inorganic/organic hybrid particles in an ultra performance liquid chromatography system, the enzyme is a protease, and the polymer analyte is a polypeptide. The immobilized enzymatic reactor can prepare an analyte for applications such as for hydrogen deuterium exchange mass spectrometry.
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公开(公告)号：US11478775B2
公开(公告)日：2022-10-25
申请号：US16101779
申请日：2018-08-13
IPC分类号： B01J20/283 , B01J20/32 , B01J20/285
摘要： The present invention provides novel chromatographic materials, e.g., for chromatographic separations, processes for its preparation and separations devices containing the chromatographic material; separations devices, chromatographic columns and kits comprising the same; and methods for the preparation thereof. The chromatographic materials of the invention are chromatographic materials comprising having a narrow particle size distribution.
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公开(公告)号：US20220034852A1
公开(公告)日：2022-02-03
申请号：US17370589
申请日：2021-07-08
IPC分类号： G01N30/06 , G01N30/72 , C08F230/08 , B01D15/30 , C08L33/14 , C08F220/54 , C08F220/56 , B01J20/28 , B01J20/32 , C08F222/38 , B01J20/286
摘要： The invention relates to poly-amide bonded hydrophilic interaction chromatography (HILIC) stationary phases and novel HILIC methods for use in the characterization of large biological molecules modified with polar groups, known to those skilled in the art as glycans. The invention particularly provides novel, poly-amide bonded materials designed for efficient separation of large biomolecules, e.g. materials having a large percentage of larger pores (i.e. wide pores). Furthermore, the invention advantageously provides novel HILIC methods that can be used in combination with the stationary phase materials described herein to effectively separate protein and peptide glycoforms by eliminating previously unsolved problems, such as on-column aggregation of protein samples, low sensitivity of chromatographic detection of the glycan moieties, and low resolution of peaks due to restricted pore diffusion and long intra/inter-particle diffusion distances.
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公开(公告)号：US20210170304A1
公开(公告)日：2021-06-10
申请号：US17019680
申请日：2020-09-14
发明人： Kevin D. Wyndham , John E. O'Gara
IPC分类号： B01D15/20 , C08J9/36 , B01J20/28 , B01J20/285 , C08J9/26 , C08G83/00 , B01J20/30 , C08J9/16 , C08J9/224 , C08G77/50
摘要： Porous hybrid inorganic/organic materials comprising ordered domains are disclosed. Methods of making the materials and use of the materials for chromatographic applications are also disclosed.
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公开(公告)号：US10744484B2
公开(公告)日：2020-08-18
申请号：US16058069
申请日：2018-08-08
发明人： Darryl W. Brousmiche , Jacob N. Fairchild , Jason F. Hill , Giorgis Isaac , Michael F. Morris , Kevin D. Wyndham
IPC分类号： B01J20/283 , B01D15/26 , B01D15/30 , B01D15/40 , B01J20/22 , B01J20/32 , C07F7/18 , B01J20/288 , B01J20/28 , B01D15/32 , B01D53/02 , B01J20/289 , B01J20/30 , B01J20/285 , B01J20/284 , B01J20/282
摘要： The present disclosure relates to a method of separating a compound of interest, particularly unsaturated compound(s) of interest, from a mixture. The compound is separated using a column having a chromatographic stationary phase material for various different modes of chromatography containing a first substituent and a second substituent. The first substituent minimizes compound retention variation over time under chromatographic conditions. The second substituent chromatographically and selectively retains the compound by incorporating one or more aromatic, polyaromatic, heterocyclic aromatic, or polyheterocyclic aromatic hydrocarbon groups, each group being optionally substituted with an aliphatic group. In some examples, the present disclosure can include a chromatographic system having a chromatographic column having a stationary phase with a chromatographic substrate containing silica, metal oxide, an inorganic-organic hybrid material, a group of block copolymers, or a combination thereof.
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7.发明申请POROUS INORGANIC/ORGANIC HYBRID MATERIALS WITH ORDERED DOMAINS FOR CHROMATOGRAPHIC SEPARATIONS AND PROCESSES FOR THEIR PREPARATION 有权具有用于色谱分离的有序域的多孔无机/有机混合材料及其制备方法公开(公告)号：US20140329919A1
公开(公告)日：2014-11-06
申请号：US14188385
申请日：2014-02-24
发明人： Kevin D. Wyndham , John E. O'Gara
IPC分类号： C08J9/36
CPC分类号： C08J9/36 , B01J20/28095 , B01J20/285 , B01J20/3057 , B01J2220/46 , B29C67/20 , C08G83/001 , Y10T428/249953 , Y10T428/24996 , Y10T428/249967 , Y10T428/249969 , Y10T428/249975 , Y10T428/249981
摘要： Porous hybrid inorganic/organic materials comprising ordered domains are disclosed. Methods of making the materials and use of the materials for chromatographic are also disclosed.
摘要翻译： 公开了包含有序域的多孔杂化无机/有机材料。 还公开了制备材料和用于色谱的材料的使用方法。
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公开(公告)号：US11992824B2
公开(公告)日：2024-05-28
申请号：US17353096
申请日：2021-06-21
发明人： Kevin D. Wyndham , Michael F. Morris , Darryl W. Brousmiche , Jason F. Hill , Jacob N. Fairchild
IPC分类号： B01J20/28 , B01D15/26 , B01D15/30 , B01D15/32 , B01D15/40 , B01D53/02 , B01J20/22 , B01J20/283 , B01J20/288 , B01J20/289 , B01J20/30 , B01J20/32 , C07F7/18 , B01J20/282 , B01J20/284 , B01J20/285
CPC分类号： B01J20/283 , B01D15/26 , B01D15/30 , B01D15/305 , B01D15/322 , B01D15/40 , B01D53/025 , B01J20/22 , B01J20/28004 , B01J20/28016 , B01J20/28042 , B01J20/28057 , B01J20/28059 , B01J20/28061 , B01J20/28064 , B01J20/28066 , B01J20/28069 , B01J20/28071 , B01J20/28073 , B01J20/28076 , B01J20/28078 , B01J20/28083 , B01J20/28085 , B01J20/288 , B01J20/289 , B01J20/3085 , B01J20/3204 , B01J20/3206 , B01J20/3208 , B01J20/3246 , B01J20/3285 , B01J20/3293 , C07F7/1804 , B01J20/282 , B01J20/284 , B01J20/285 , B01J20/32 , B01J20/3234 , B01J2220/54 , B01J2220/80
摘要： In one aspect, the present invention provides a chromatographic stationary phase material for various different modes of chromatography represented by Formula 1: [X](W)a(Q)b(T)c (Formula 1). X can be a high purity chromatographic core composition having a surface comprising a silica core material, metal oxide core material, an inorganic-organic hybrid material or a group of block copolymers thereof. W can be absent and/or can include hydrogen and/or can include a hydroxyl on the surface of X. Q can be a functional group that minimizes retention variation over time (drift) under chromatographic conditions utilizing low water concentrations. T can include one or more hydrophilic, polar, ionizable, and/or charged functional groups that chromatographically interact with the analyte. Additionally, b and c can be positive numbers, with the ratio 0.05≤(b/c)≤100, and a≥0.
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公开(公告)号：US20240082821A1
公开(公告)日：2024-03-14
申请号：US18174217
申请日：2023-02-24
IPC分类号： B01J20/289 , B01J20/10 , B01J20/26 , B01J20/28 , B01J20/32
CPC分类号： B01J20/289 , B01J20/103 , B01J20/261 , B01J20/28071 , B01J20/321 , B01J20/3219 , B01J20/3234 , B01J20/3293 , B01J2220/46
摘要： The present disclosure pertains to non-porous composite particles that are non-porous, polymer-based, organic-inorganic materials. In various embodiments, a non-porous polymer core is surface modified. In various embodiments, a non-porous hybrid organic-inorganic material is disposed on the modified surface of the core. The present disclosure pertains to chromatographic separation devices that comprise such non-porous composite particles.
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公开(公告)号：US11376561B2
公开(公告)日：2022-07-05
申请号：US16591302
申请日：2019-10-02
发明人： Darryl W. Brousmiche , Kevin D. Wyndham , Nicole L. Lawrence , Jacob N. Fairchild , Bonnie A. Alden
摘要： Sorbents, devices, kits and methods useful for sample treatment are disclosed herein. In particular embodiments, described are inorganic/organic hybrid sorbent particles comprising (a) a core region that comprises a silica component and (b) a surface region that comprises an organic copolymer comprising at least one hydrophobic organic monomer and at least one hydrophilic organic monomer.
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