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公开(公告)号：US20240352398A1
公开(公告)日：2024-10-24
申请号：US18642596
申请日：2024-04-22
申请人： Ecovative Design LLC
CPC分类号： C12M41/48 , C12M29/06 , C12M35/02 , C12M41/12 , C12M41/34 , C12M41/40 , C12N1/14 , C12R2001/645
摘要： A method of growing an extra-particle aerial mycelium employs electrostatically charged mist to control mist deposition uniformity in a growth environment, and on a growth matrix (or growing extra-particle aerial mycelium on a growth matrix) comprising nutritive substrate and a fungus in a growth environment with a predetermined environment of humidity, temperature, carbon dioxide, and oxygen. Control of mist deposition by electrostatically charging mist allows for control of the morphology and uniformity of the extra-particle aerial mycelium produced, independent of airflow uniformity, growth environment size, and structural obstacles that may be present within a growth environment. Control of mist deposition by electrostatically charging mist also offers the potential for targeted mist application where it might be needed most for fungal organism growth.
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2.发明公开公开(公告)号：US20240309306A1
公开(公告)日：2024-09-19
申请号：US18673916
申请日：2024-05-24
发明人： Martin LEUTHOLD , Stefan WEISSHAAR
摘要： A modular processing system (100) for biopharmaceutical processes includes (i) at least one first and at least one second processing unit (30, 32), which can be fluidically connected to each other; and (ii) at least one adapter plate (200), through which at least one fluid flow (14), flowing from the first processing unit (30) to the second processing unit (32), can flow. The adapter plate deflects the fluid flow between the first processing unit and the second processing unit at least partially; and/or controls the fluid flow, preferably, the pressure thereof, in an open loop or closed loop manner. A method for the modular construction of a processing system (100) for biopharmaceutical processes is also disclosed.
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公开(公告)号：US12077737B2
公开(公告)日：2024-09-03
申请号：US17041841
申请日：2019-03-27
申请人： FCC AQUALIA S.A.
发明人： Victor Monsalvo Garcia , Daniel Puyol Santos , Juan Antonio Melero Hernandez , Fernando Martinez Castillejo , Raul Molina Gil , Zouhayr Arbib , Frank Rogalla
IPC分类号： C05F17/40 , C02F1/30 , C02F3/28 , C05F7/00 , C05F17/30 , C05F17/986 , C12M1/00 , C12M1/107 , C12M1/34
CPC分类号： C12M21/02 , C02F1/30 , C02F3/2866 , C05F7/005 , C05F17/30 , C05F17/40 , C05F17/986 , C12M21/04 , C12M23/18 , C12M23/22 , C12M23/36 , C12M23/38 , C12M31/00 , C12M41/32 , C12M41/36 , C12M41/40 , C12M43/06 , C12M45/06 , C12M47/00 , C02F2203/006 , C02F2301/046
摘要： The present invention is related to an anaerobic photobioreactor and a method for active biomass cultivation, wastewater treatment, nutrients recovery, energy production and high-value products synthesis. Phototrophic bacteria are cultured in the anaerobic photobioreactor lighted with solar or artificial irradiation where certain light wavelengths are selectively discarded with a light selector installed on the top of the photobioreactor. In this light-based process wastewater treatment and resources recovery, like nutrients and high-value bioproducts (fertilizers, polymers and proteins) present in wastewater are performed simultaneously. Cultured biomass is treated by anaerobic digestion for biofuel production, including optative hydrolytic pre-treatment, and/or valuable bioproducts can be obtained in a downstream process.
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公开(公告)号：US12070746B2
公开(公告)日：2024-08-27
申请号：US15958142
申请日：2018-04-20
发明人： Dan Gazit , Gadi Pelled , Zulma Gazit , Dmitriy Sheyn , Christopher David Hinojosa , Norman Wen , Geraldine Hamilton
IPC分类号： C12N5/077 , A61K49/00 , A61K51/02 , A61L27/38 , B01L3/00 , C12N5/00 , C12N5/071 , C12N5/074 , C12N5/0775 , G01N33/50 , G01T1/164 , G01T1/29 , C07K14/78 , C12M1/34
CPC分类号： B01L3/5027 , A61K49/0019 , A61K49/005 , A61K51/02 , A61L27/3895 , B01L3/5085 , C12N5/0062 , C12N5/0075 , C12N5/0654 , C12N5/0655 , C12N5/0662 , C12N5/0663 , C12N5/0668 , C12N5/0696 , C12N5/0697 , G01N33/5038 , G01T1/1644 , G01T1/2985 , A61M2205/3334 , C07K14/78 , C12M41/40
摘要： Microfluidic “organ-on-a-chip” devices have been developed with the aim to replicate human tissues in vitro. However, there is no option to quantitatively monitor biological processes that take place within the chip, over time. Destructive methods in order to analyze, tissue formation, gene expression, protein secretion etc. require the harvest of the “tissue” at a certain time point. Described herein are methods and compositions for non-destructive molecular imaging methods and systems in order to quantitatively monitor specific biological processes, over time, within the chip, without the need to harvest.
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公开(公告)号：US20240254427A1
公开(公告)日：2024-08-01
申请号：US18443395
申请日：2024-02-16
发明人： Christopher C. Langenfeld , David D.B Cannan , Dirk A. Van Der Merwe , Dean Kamen , Jason A. Demers , Frederick Morgan , Timothy D. Moreau , Brian D. Tracey , Matthew Ware , Richard J. Lanigan , Michael A. Baker , David Blumberg, JR. , Richard E. Andrews , Derek G. Kane , Dane C. Fawkes , Thomas J. Bollenbach , Michael C. Tilley , Stuart A. Jacobson , John F. Mannisto
IPC分类号： C12M1/36 , A01N1/02 , A61L27/38 , B33Y10/00 , B33Y30/00 , B33Y70/00 , C12M1/00 , C12M1/12 , C12M1/26 , C12M1/34 , C12M3/00 , C12N5/00
CPC分类号： C12M41/48 , A01N1/0247 , A61L27/3895 , B33Y10/00 , B33Y30/00 , B33Y70/00 , C12M21/08 , C12M23/22 , C12M23/38 , C12M25/02 , C12M27/18 , C12M29/00 , C12M33/00 , C12M37/02 , C12M41/12 , C12M41/40 , C12M41/46 , C12N5/0018 , C12N5/0062 , C12N2533/00 , C12N2533/50 , C12N2533/90
摘要： A system and method for growing and maintaining biological material including producing a protein associated with the tissue, selecting cells associated with the tissue, expanding the cells, creating at least one tissue bio-ink including the expanded cells, printing the at least one tissue bio-ink in at least one tissue growth medium mixture, growing the tissue from the printed at least one tissue bio-ink, and maintaining viability of the tissue.
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6.发明公开公开(公告)号：US20240254398A1
公开(公告)日：2024-08-01
申请号：US18560290
申请日：2022-05-17
申请人： Kiverdi, Inc.
发明人： John Reed , David Stout , Elisabeth Perea , Jin-Ping Lim , Jil Geller , Dan Robertson , Robert Wilson , Ripudaman Malhotra
CPC分类号： C10G2/50 , C12M27/02 , C12M41/26 , C12M41/34 , C12M41/40 , C12N1/20 , C12P1/04 , C12R2001/01
摘要： Bioreactors and methods for growing a chemoautotrophic culture of a microorganism, such as a hydrogen-oxidizing or carbon monoxide-oxidizing microorganism, are provided. The bioreactors and methods provide for enhanced growth and productivity of microorganisms that use gaseous sources of carbon and energy and provide an environment for carbon fixing to produce organic molecules of interest and/or biomass. The present bioreactors and methods achieve enhanced growth with respect to cell density, culture duration and/or growth rate, while maintaining safe operating conditions.
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公开(公告)号：US11999934B2
公开(公告)日：2024-06-04
申请号：US18378921
申请日：2023-10-11
申请人： Xilis, Inc.
发明人： Bradley Scott Thomas , Timothy A. Miller , Daniel Nelson , Raheel Samuel , George Robinson , Tyler Welder
摘要： A microfluidic apparatus includes a microfluidic chip for MicroOrganoSpheres (MOS) generation. A first channel is defined in a surface of the microfluidic chip and includes: a droplet generation portion including an inlet portion, a junction between the inlet portion and an emulsifying fluid channel, and a chamber downstream of the junction. A cross-sectional area of the chamber is larger than that of the inlet portion. The first channel includes a polymerization portion downstream of the droplet generation portion, the polymerization portion having a serpentine configuration. The apparatus includes a cartridge for MOS demulsification, including: a collection container; a substrate disposed on the collection container, and a membrane disposed between the collection container and the surface of the substrate. A second channel is defined in the surface of the substrate that faces the collection container and is fluidically connected to an output of the polymerization portion of the first channel.
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8.发明授权公开(公告)号：US11959060B1
公开(公告)日：2024-04-16
申请号：US16875897
申请日：2020-05-15
申请人： Humacyte, Inc.
发明人： Heather L. Prichard , Dustin Cashman , Joshua McCall , Laura E. Niklason , Benjamin Orbon , Justin T. Strader
摘要： Embodiments of the present disclosure are directed to systems, apparatuses, devices and methods for tissue cultivating. Such systems may comprise a plurality of bioreactors, each bioreactor comprising a bag having a mandrel tube arranged therein, and a fluid management system for managing fluid flow among the plurality of bioreactors. The fluid management system can include at least one intra-luminal pump, configured to flow intra-luminal fluid in a first direction in the bioreactors, at least one media pump, configured to flow biomedia fluid in the bioreactors in a second direction opposite to the first direction, and a plurality of valves and/or clamps to effect at least one of filling, flowing, cessation of flow, and draining of at least one of the intra-luminal fluid and biomedia fluid tubes among the bioreactors.
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公开(公告)号：US11952566B2
公开(公告)日：2024-04-09
申请号：US17052942
申请日：2019-01-04
摘要： The invention relates to an apparatus 10 for storing and/or processing at least one medium 11, in particular a bioprocessing device, comprising at least one disposable container 1, which is designed to accommodate at least some of the at least one medium 11, and at least one overpressure protection means 5, which is fluid-connected to the at least one disposable container 1. The at least one overpressure protection means is designed, when triggered, to conduct at least some of the at least one medium 11 into an apparatus region 3a′ in front of the overpressure protection means 5 in relation to a flow direction F, in particular into the at least one disposable container 1 and/or into at least one further, second container 1a.
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公开(公告)号：US11920114B2
公开(公告)日：2024-03-05
申请号：US17176873
申请日：2021-02-16
申请人： EMULATE, Inc.
发明人： Daniel Levner , Josiah Daniel Sliz , Christopher David Hinojosa , Joshua Gomes , Jose Fernandez-Alcon
IPC分类号： C12M3/06 , A01N1/02 , B01L3/00 , B01L9/00 , C12M1/00 , C12M1/34 , C12M1/36 , C12M1/42 , C12M3/00 , C12N5/071
CPC分类号： C12M23/16 , A01N1/021 , A01N1/0247 , B01L3/502707 , B01L3/502715 , B01L3/50273 , B01L3/502738 , B01L9/527 , C12M21/08 , C12M23/38 , C12M23/40 , C12M23/42 , C12M29/10 , C12M35/04 , C12M41/40 , C12M41/48 , C12N5/0602 , B01L2200/025 , B01L2200/027 , B01L2200/12 , B01L2300/0681 , B01L2300/0887 , B01L2300/123 , B01L2300/14 , B01L2300/161 , B01L2300/165 , B01L2400/0481 , B01L2400/0487 , B01L2400/06 , C12N2521/00
摘要： A culture module is contemplated that allows the perfusion and optionally mechanical actuation of one or more microfluidic devices, such as organ-on-a-chip microfluidic devices comprising cells that mimic at least one function of an organ in the body. A method for pressure control is contemplated to allow the control of flow rate (while perfusing cells) despite limitations of common pressure regulators. The method for pressure control allows for perfusion of a microfluidic device, such as an organ on a chip microfluidic device comprising cells that mimic cells in an organ in the body, that is detachably linked with said assembly, so that fluid enters ports of the microfluidic device from a fluid reservoir, optionally without tubing, at a controllable flow rate.
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