公开(公告)号：US20240361227A1

公开(公告)日：2024-10-31

申请号：US18770437

申请日：2024-07-11

申请人： Pratimesh Labs Pvt. Ltd. ,  Council of Scientific and Industrial Research

发明人： Sasikala Subramaniam ,  Prasanta Chowdhury ,  Usama Abbasi Ahmed ,  Prakhar Jain ,  Subham Banerjee

IPC分类号： G01N15/12 ,  B01L3/00 ,  G01N15/10

CPC分类号： G01N15/131 ,  B01L3/502715 ,  B01L2300/0645 ,  B01L2400/0463 ,  G01N2015/1006 ,  G01N2015/135

摘要： Microfluidic impedance based lab on chip is a sensor module to measure the impedance of a single biological cell flowing in channel of micrometer size. In the present invention, the enhancement in the channel cross-section 30 micron [h]×45 micron [w] leads to reduce the pressure drop significantly i.e., around 40 kPa at 100 microliter/min, which demands by cartridge based micro-pump for portable devices at Point of Care (PoC) location. Lab on chip of present invention is capable of withstanding 20 Vpp for several hours without degradation of electrodes and also capable to measure the particle with dimension down to 2 microns. Lab on chip of present invention was also used to count the platelet of the diluted blood samples without any pretreatment and comparable to the clinical lab report.

公开(公告)号：US20240351034A1

公开(公告)日：2024-10-24

申请号：US18542574

申请日：2023-12-15

申请人： BioFluidica, Inc.

发明人： Rolf Muller ,  Mateusz Hupert

IPC分类号： B01L3/00 ,  B01L3/02

CPC分类号： B01L3/502753 ,  B01L3/021 ,  B01L3/502715 ,  B01L2200/027 ,  B01L2200/0647 ,  B01L2200/12 ,  B01L2300/0816 ,  B01L2300/12 ,  B01L2400/0487 ,  B01L2400/086

摘要： The presently disclosed subject matter provides dual-depth thermoplastic microfluidic devices, related kits, microfluidic systems comprising the dual-depth thermoplastic microfluidic device, methods of isolating nucleic acid analytes from a liquid sample, and methods of isolating extracellular vesicles from a liquid sample.

公开(公告)号：US20240351030A1

公开(公告)日：2024-10-24

申请号：US18634178

申请日：2024-04-12

申请人： TDK Corporation

发明人： Rakesh Sethi

IPC分类号： B01L3/00

CPC分类号： B01L3/502715 ,  B01L3/50273 ,  B01L2300/0627 ,  B01L2300/12 ,  B01L2400/0475

摘要： An example microfluidic device includes a first substrate, a second substrate, a set of electrodes, a set of piezoelectric components, a support, a set of piezoelectric actuators coupled to the support, and a polymer component. In the example device, the set of electrodes and the set of piezoelectric components are coupled to a surface of the second substrate. The support is configured to support at least one of the first substrate and the second substrate. The set of piezoelectric actuators is configured to adjust positioning of the support. The polymer is adapted to removably couple the first and second substrates such that a microfluidic channel is formed between the first and second substrates while the first and second substrates are coupled by the polymer.

公开(公告)号：US20240351027A1

公开(公告)日：2024-10-24

申请号：US18434730

申请日：2024-02-06

申请人： Wenzhou University

发明人： Xiaojing Chen ,  Zhonghao Xie ,  Guangzao Huang ,  Yao Zhou ,  Qifan Chen ,  Lechao Zhang

IPC分类号： B01L3/00

CPC分类号： B01L3/502715 ,  B01L2200/025 ,  B01L2200/16 ,  B01L2300/0654 ,  B01L2300/168

摘要： Disclosed is an imaging device for AMI diagnosis includes a first polarizer is arranged in an imaging part and a second polarizer is arranged in a light source part. These two are linear polarizers, and the polarization directions of the first polarizer and the second polarizer are perpendicular to each other. During the imaging process, a near-infrared beam emitted from a near-infrared light source is modulated into a linearly polarized light with a certain angle when passing through the second polarizer. Then, it is irradiated onto a subject and the light is reflected due to the specular reflection effect of the subject turns into a cross-polarized light when passing through the first polarizer. The linearly polarized light perpendicular to the polarization angle of the first polarizer is intercepted, that is, the reflected light is intercepted.

公开(公告)号：US12122996B2

公开(公告)日：2024-10-22

申请号：US16141707

申请日：2018-09-25

申请人： CALIFORNIA INSTITUTE OF TECHNOLOGY

发明人： Rustem F. Ismagilov ,  Eugenia Khorosheva ,  Dmitriy V. Zhukov

IPC分类号： B01L3/00 ,  C12N15/10 ,  C12Q1/6806 ,  C12Q1/6855 ,  G01N33/58 ,  G01N33/68 ,  C40B30/04 ,  C40B40/08 ,  C40B70/00

CPC分类号： C12N15/1065 ,  B01L3/502715 ,  B01L3/502738 ,  C12Q1/6806 ,  C12Q1/6855 ,  G01N33/58 ,  G01N33/68 ,  B01L2200/027 ,  B01L2200/141 ,  B01L2200/16 ,  B01L2300/0816 ,  B01L2300/0861 ,  B01L2300/161 ,  B01L2400/065 ,  C40B30/04 ,  C40B40/08 ,  C40B70/00 ,  C12Q1/6806 ,  C12Q2523/101 ,  C12Q2525/191 ,  C12Q2565/514

摘要： A device for allowing compartmentalized reactions with minimized cross-contamination between the compartments, utilizing a delivery of material by loading wells to pooling wells, such that the pooling wells can be additively provided with reactants while maintaining isolation between the pooling wells. The use of geometric properties is used to facilitate transmission of fluids/droplets without the need for hydrophilic surfaces.

公开(公告)号：US20240344960A1

公开(公告)日：2024-10-17

申请号：US18624379

申请日：2024-04-02

申请人： NanoCellect Biomedical, Inc.

发明人： Sunghwan CHO ,  Jose Manuel MORACHIS ,  Ivan GAGNE ,  Rick SEGIL ,  William Arthur ALAYNICK ,  Zhe MEI ,  Sean PHILLIPS ,  Chien-Chun YANG ,  Dongseob YUN ,  Michael Jerome BENCHIMOL ,  Manna DOUD ,  Nicholas SULLIVAN ,  Constance ARDILA

IPC分类号： G01N15/14 ,  B01L3/00 ,  B07C5/342 ,  G01N15/10 ,  G01N15/149

CPC分类号： G01N15/1425 ,  B01L3/502715 ,  B01L3/502746 ,  B01L3/502761 ,  B07C5/342 ,  G01N15/1484 ,  B01L2200/0652 ,  B01L2300/0819 ,  B01L2400/082 ,  G01N2015/1006 ,  G01N15/149

摘要： A method includes providing a cartridge and the cartridge includes a slot for receiving a microfluidic chip having a set of first channels. The cartridge also includes a set of second channels and each channel of the set of second channels is coupleable to a different channel of the set of first channels during use with the microfluidic chip. The cartridge also includes an indent configured for engagement and alignment of the cartridge during use. The method also includes inserting the cartridge into a device, such that the cartridge engages a first biasing member of the device configured for alignment of the cartridge in a first direction. The first biasing member is configured to bias movement of the cartridge into locking position with a notch of the device.

公开(公告)号：US20240344004A1

公开(公告)日：2024-10-17

申请号：US18751005

申请日：2024-06-21

申请人： DLOC BIOSYSTEMS, INC.

发明人： Waddah MALAEB ,  Giulia GRIMALDI ,  Mustafa AMMOURI ,  Farid MALAEB ,  Bahaa Eddine EL ARIDI

IPC分类号： C12M3/00 ,  B01L3/00 ,  C12M1/36 ,  C12M3/06

CPC分类号： C12M21/08 ,  B01L3/502715 ,  C12M23/16 ,  C12M41/48 ,  B01L2200/10 ,  B01L2300/0819 ,  B01L2400/0694

摘要： A human-on-chip plate. The human-on-chip plate may include, at least one 3D culture biochip, at least one micro-valve, at least one microfluidic channel, at least one inlet or outlet plate port. The outlet ports from one chip may be connected to another chip by routing the valves. Multiple chips may be connected in parallel, in series or in combination and one or more chips in the human-on-chip plate may be bypassed. Each fluid connection may be altered independently and at any time. The at least one valving system connects or separates different compartments of and between the organ-on-chip system. The at least one inlet and one outlet ports to access and block the microchannels. The at least one valving system could allow for sampling, changing the model flow map, and introduce or reduce at least one fluidic chamber.

公开(公告)号：US20240342716A1

公开(公告)日：2024-10-17

申请号：US18293300

申请日：2022-07-29

申请人： OSLER DIAGNOSTICS LIMITED

发明人： Barry LILLIS ,  Jasper MALINSON ,  Jimishkumar PATEL ,  Myles WHITING ,  Richard LUXTON ,  Mark YEOMAN

IPC分类号： B01L3/00

CPC分类号： B01L3/502746 ,  B01L3/502715 ,  B01L3/502738 ,  B01L2200/0621

摘要： Embodiments described herein relate to a liquid handling device, comprising: an inlet conduit configured to receive a liquid sample; a first flow path comprising a sample adequacy control chamber in fluidic communication with the inlet conduit, wherein the sample adequacy control chamber is configured to allow the presence or absence of a volume of liquid within the sample adequacy control chamber to be determined; and a second flow path in fluidic communication with the inlet conduit, wherein the second flow path is configured to provide a higher hydraulic resistance than the first flow path.

公开(公告)号：US20240337614A1

公开(公告)日：2024-10-10

申请号：US18295657

申请日：2023-04-04

申请人： SAUDI ARABIAN OIL COMPANY

发明人： Ghaida Ahmed ALJUHANI ,  Dongkyu CHA ,  Subhash C. AYIRALA ,  Abdulaziz S. AL-QASIM ,  Ali Abdallah AL-YOUSEF

IPC分类号： E21B43/24 ,  B01L3/00 ,  E21B49/08

CPC分类号： G01N27/06 ,  B01L3/502707 ,  B01L3/502715 ,  B01L2300/0861 ,  B01L2300/12 ,  B01L2400/0496

摘要： A method for demonstrating the efficacy of using electrical current in an Electrical Improved Oil Recovery (EIOR) application includes circulating fluid through a microfluidics cell having first and second electrodes, applying a voltage across the first and second electrodes, determining the behavior of the fluid under the effect of the applied voltage, and correlating the determined behavior to a reservoir of interest. The method may include deriving operational parameters from the correlation and operating the reservoir of interest in accordance with the operational parameters, and may include visualization and characterization of enlarging pore throat for enhancing permeability and oil mobilization.

公开(公告)号：US20240335833A1

公开(公告)日：2024-10-10

申请号：US18738051

申请日：2024-06-09

申请人： Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V.

发明人： Sebastian KIBLER ,  Henry LEISTNER ,  Karl NEUMEIER ,  Thomas THALHOFER ,  Kristjan AXELSSON ,  Daniel ANHEUER ,  Martin RICHTER ,  Johannes HÄFNER ,  Claudia DURASIEWICZ ,  Christian WALD ,  Agnes BUSSMANN ,  Lorenz GRÜNERBEL

IPC分类号： B01L3/00 ,  G01N27/22

CPC分类号： B01L3/502715 ,  B01L3/50273 ,  G01N27/22 ,  B01L2200/143

摘要： The inventive concept described herein concerns a microfluidic component, comprising a membrane actuator with a membrane element and an actuator element for deflecting the membrane element. A signal generation device is configured to generate an electric control signal having a time-variant signal curve for controlling the membrane actuator, by which the actuator element actuates the membrane element. A signal processing device is configured to detect, during operation of the microfluidic component, an influence on the temporal signal curve of the control signal, caused by one or more external influencing factors, and, on the basis of this influence on the temporal signal curve, to identify and/or classify at least one causal external influencing factor.