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1.发明公开公开(公告)号：US20240361227A1
公开(公告)日：2024-10-31
申请号：US18770437
申请日：2024-07-11
Inventor： Sasikala Subramaniam , Prasanta Chowdhury , Usama Abbasi Ahmed , Prakhar Jain , Subham Banerjee
CPC classification number: G01N15/131 , B01L3/502715 , B01L2300/0645 , B01L2400/0463 , G01N2015/1006 , G01N2015/135
Abstract: Microfluidic impedance based lab on chip is a sensor module to measure the impedance of a single biological cell flowing in channel of micrometer size. In the present invention, the enhancement in the channel cross-section 30 micron [h]×45 micron [w] leads to reduce the pressure drop significantly i.e., around 40 kPa at 100 microliter/min, which demands by cartridge based micro-pump for portable devices at Point of Care (PoC) location. Lab on chip of present invention is capable of withstanding 20 Vpp for several hours without degradation of electrodes and also capable to measure the particle with dimension down to 2 microns. Lab on chip of present invention was also used to count the platelet of the diluted blood samples without any pretreatment and comparable to the clinical lab report.
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2.发明公开公开(公告)号：US20240142761A1
公开(公告)日：2024-05-02
申请号：US18497032
申请日：2023-10-30
Inventor： Moritz Kreysing , Anatol Fritsch , Matthaeus Mittasch
CPC classification number: G02B21/36 , B01L3/50273 , G02B21/0032 , G02B21/02 , G02B21/08 , G02B21/28 , G02B21/30 , B01L2400/0463 , G01N21/6458
Abstract: The present invention relates to an apparatus for simultaneous imaging and execution of contact-free directed hydrodynamic flow in a specimen with at least one light source, in particular a laser, adapted to dynamically heat the interior and/or a surface of the specimen, a microscope with an objective adapted to image at least a part of the specimen and to guide, in particular focus, a light beam of the light source, in particular a laser beam, into and/or onto the specimen to heat at least one specified location of the specimen, means for manipulating the specified location, and a sample chamber for the specimen that is accessible for imaging radiation and the light beam to allow simultaneous imaging and manipulation of the sample via the objective. Furthermore the present invention is directed to a method for simultaneous imaging and executing contact-free directed hydrodynamic flow in a specimen wherein, at least one light source, in particular a laser, dynamically heats the interior and/or a surface of the specimen via a light beam, in particular via a laser beam, the beam of the at least one light source is directed to the specimen through an objective of a microscope, the light beam is variably guided, in particular focused, to specified locations of the specimen inducing a hydrodynamic flow in the specimen, and imaging the specimen via the same objective as used for introduction of the light beam.
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公开(公告)号：US11660594B2
公开(公告)日：2023-05-30
申请号：US17444937
申请日：2021-08-12
Applicant: HERAEUS ELECTRO-NITE INTERNATIONAL N.V.
Inventor： Jan Doets , Guy Neyens , Dries Beyens , Jean-Paul Verhoeven , Arne Potargent
CPC classification number: B01L3/502 , B22D2/00 , G01N1/125 , B01L2300/0832 , B01L2400/0463 , B22C9/02 , B22D23/04
Abstract: The present invention relates to a sampler for taking samples from a molten metal bath, particularly a molten iron, the sampler comprising:
a carrier tube having an immersion end; and
a sample chamber assembly arranged on the immersion end of the carrier tube, the sample chamber assembly comprising a cover plate and a housing, wherein the housing comprises:
an immersion end having a first opening for an inflow conduit and an opposing end having a second opening for a gas coupler,
a first face extending between the immersion end and the opposing end, the first face having a first depression proximate the immersion end and a second depression, the first depression being an analysis zone and the second depression being a ventilation zone, a portion of the analysis zone overlying a distribution zone which is in direct flow communication with the first opening and configured to receive the molten steel from the inflow conduit,
wherein the first depression having a cross sectional circle segment profile along a central longitudinal axis that is concavely or triangularly shaped,
wherein the cover plate and the housing are configured to be assembled together to form a sample cavity including the distribution zone, the analysis zone and the ventilation zone, such that an analysis surface of a solidified steel sample formed within the sample cavity lies in a first plane, and
wherein the first and second openings are spaced apart from the first plane.
The invention also relates to a sampler for taking samples from a molten metal bath, particularly a molten iron, the sampler comprising:
a carrier tube having an immersion end;
a sample chamber assembly arranged on the immersion end of the carrier tube, the sample chamber assembly comprising a cover plate and a housing, wherein the cover plate comprising a sealing member configured to provide a substantially gas tight seal between the cover plate and the housing, wherein the sealing member consist of an essentially non-contaminating material for the samples in the sample chamber.-
4.发明申请公开(公告)号：US20180243742A1
公开(公告)日：2018-08-30
申请号：US15753907
申请日：2016-08-13
Applicant: National Health Research Institutes
Inventor： Chia-Hsien HSU
CPC classification number: B01L3/502761 , B01L3/502715 , B01L2200/0668 , B01L2300/0816 , B01L2300/0864 , B01L2300/0883 , B01L2300/12 , B01L2300/16 , B01L2400/0463 , B01L2400/0487 , C12M23/16 , C12M47/04
Abstract: A hydrodynamic shuttling chip device comprising an array of single-cell trapping units is disclosed. Each unit comprises: (a) an incoming channel with a capture site; (b) a large chamber located posterior to the capture site, having a receiving structure spaced apart from the capture site at a distance of g; (c) a trapping channel located between the capture site and the receiving, site; (d) a chamber channel located posterior to and in fluidic connection with the large chamber; and (e) a by-pass channel, located lateral to the incoming channel, large chamber and chamber channel and having a first end and a second end opposite to the first end, the first end branching out from the incoming channel immediately prior to the capture site and the second end joining the chamber channel. A method of capturing single cells of more than one type is also disclosed.
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公开(公告)号：US09789485B2
公开(公告)日：2017-10-17
申请号：US14429280
申请日：2013-09-20
Inventor： Jongyoon Han , Chao Yu Peter Chen , Chong Jin Ong , Guofeng Guan , Ali Asgar Bhagat , Lidan Wu
CPC classification number: B01L3/502753 , B01D21/00 , B01D21/0087 , B01D21/265 , B01F5/0606 , B01L3/50273 , B01L2200/0652 , B01L2300/0816 , B01L2300/0864 , B01L2300/0883 , B01L2400/0463 , B01L2400/0478 , B01L2400/0487 , B01L2400/084 , B03B5/62 , C12M47/04
Abstract: A micro-fluidic device includes at least one inlet and a curvilinear microchannel having a trapezoidal cross section defined by a radially inner side, a radially outer side, a bottom side, and a top side, the cross section having a) the radially inner side and the radially outer side unequal in height, or b) the radially inner side equal in height to the radially outer side, and wherein the top side has at least two continuous straight sections, each unequal in width to the bottom side.
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Patent Agency Ranking
公开(公告)号：US09645055B2
公开(公告)日：2017-05-09
申请号：US14264658
申请日：2014-04-29
Applicant: Heraeus Electro-Nite International N.V.
Inventor： Guido Cappa , Gerrit Broekmans
CPC classification number: G01N1/125 , B01L3/502 , B01L2200/0684 , B01L2300/0681 , B01L2300/0832 , B01L2400/0463 , G01N1/1409 , G01N33/206 , Y10S73/09
Abstract: A sampler has a sample chamber for a sample forming from a molten material, at least one lower cooling body, at least one upper cooling body, at least one inner cooling body, and at least one filling part. The sample chamber is surrounded jointly at least by the lower cooling body and the inner cooling body, such that at least the sample chamber can be cooled by at least the lower and inner cooling bodies. The filling part merges into the sample chamber by a filling opening. Between a region of the outer surface of the inner cooling body and a region of the outer surface of the upper cooling body opposite the outer surface of the inner cooling body, the sampler has at least one gap for conducting at least one gas. The volume of the respective cooling bodies is larger than the volume of the gap.
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公开(公告)号：US09110045B2
公开(公告)日：2015-08-18
申请号：US14387035
申请日：2013-03-19
Applicant: Envic-Sense AB
Inventor： Peter Gårdhagen , Eva-Lena Gårdhagen
CPC classification number: G01N35/08 , B01L3/50273 , B01L3/502746 , B01L2300/0636 , B01L2300/0816 , B01L2300/0877 , B01L2400/0463 , B01L2400/0487 , B01L2400/086 , G01N35/1095
Abstract: The present invention relates to a device for controlling the flow of a fluid in a compartment (4) with an inlet opening (5) and an outlet opening (6). The device comprises an inlet channel (8) connected to the inlet opening for transportation of fluid to the compartment, an outlet channel (9) connected to the outlet opening for transportation of fluid from the compartment and a pump (17) arranged to pump the fluid. The compartment is provided with a third opening (12). The device comprises a distribution chamber (15) connected to the inlet channel and a third channel (14) connected between the distribution chamber and the third opening for transportation of fluid between the distribution chamber and the compartment. The pump is arranged to vary the fluid flow velocity in the distribution chamber between a lower and a higher flow velocity, and the third channel is arranged so that its transport direction depends upon the flow velocity in the distribution chamber such that the fluid in the third channel is transported in a direction from the distribution chamber to the compartment at said lower flow velocity in the distribution chamber, which leads to a slow flow in the compartment, and in the opposite direction at said higher flow velocity in the distribution chamber due an injector effect, which leads to a substantial increase in the flow velocity in the inlet channel and thus in the compartment.
Abstract translation: 本发明涉及一种用于控制具有入口（5）和出口（6）的隔室（4）中的流体流动的装置。 该装置包括连接到入口的入口通道（8），用于将流体输送到隔间;连接到出口的出口通道（9），用于输送来自隔间的流体;以及泵（17） 流体。 隔室设置有第三开口（12）。 该装置包括连接到入口通道的分配室（15）和连接在分配室和第三开口之间的第三通道（14），用于在分配室和室之间输送流体。 泵被布置成改变分配室中的流体流速在较低和较高流速之间，并且第三通道被布置成使得其输送方向取决于分配室中的流速，使得第三 通道在分配室中以所述较低流速从分配室向隔室输送，这导致隔室中的缓慢流动，并且由于喷射器在分配室中的所述较高流速处于相反方向 效果，这导致入口通道中以及因此在隔室中的流速的显着增加。
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公开(公告)号：US20120077283A1
公开(公告)日：2012-03-29
申请号：US13242665
申请日：2011-09-23
Applicant: Guillaume Durin , James A. Laugharn, JR.
Inventor： Guillaume Durin , James A. Laugharn, JR.
CPC classification number: B01L3/50215 , B01L3/5021 , B01L3/50255 , B01L2200/0631 , B01L2200/0663 , B01L2200/141 , B01L2300/042 , B01L2300/0681 , B01L2300/0838 , B01L2300/0841 , B01L2300/0854 , B01L2400/0409 , B01L2400/0463 , B01L2400/086 , C12N15/10 , C12Q1/6806 , G01N1/28 , Y10T436/25
Abstract: Systems and methods include processing devices used to fragment nucleic acids to average nucleic acid sizes ranging from between about 5 kbp and about 20 kbp. A processing device may include an inlet portion and a channel upstream from a shearing region arranged so that a relatively constant pressure is established and maintained (e.g., a pressure that changes by less than about 40%) at an entrance of the shearing region during a majority of sample flow through the shearing region. In some embodiments, after forcing the sample through the shearing region once, the processing device may be taken out of the centrifuge, inverted and placed back into the centrifuge so that the sample is forced through the shearing region again.
Abstract translation: 系统和方法包括用于分解核酸以平均约5kbp至约20kbp的核酸大小的加工装置。 处理装置可以包括入口部分和从剪切区域上游的通道，其布置成使得在剪切区域的入口处建立和维持相对恒定的压力（例如，变化小于约40％的压力） 大部分样品流过剪切区域。 在一些实施方案中，在将样品强制通过剪切区域一次之后，处理装置可以从离心机中取出，倒置并放回到离心机中，使得样品再次被迫穿过剪切区域。
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公开(公告)号：US07273705B2
公开(公告)日：2007-09-25
申请号：US10704707
申请日：2003-11-12
Applicant: Yung-Chiang Chung
Inventor： Yung-Chiang Chung
CPC classification number: B01L3/502784 , B01L7/52 , B01L2200/0673 , B01L2400/0463 , C12Q1/6806 , G01N1/34 , C12Q2565/629 , C12Q2527/107
Abstract: An RNA separation method includes injecting a reaction solution into a reaction region which contains a covalent linking of specific RNA probe for hybridizing with the reaction solution; adjusting a moderate hybridization temperature in the reaction region; moving the remainder of the reaction solution to a transition region by using a pneumatic actuator; adding a buffer solution to the reaction region, and heating the reaction region to a moderate denature temperature by a heating apparatus; moving a waste solution which is product produced from the reaction region after denature to a waste region by using the pneumatic actuator; and moving the remainder solution back to the reaction region by the pneumatic actuator.
Abstract translation: RNA分离方法包括将反应溶液注入含有与反应溶液杂交的特异性RNA探针的共价连接的反应区域; 调节反应区域中的中等杂交温度; 通过使用气动致动器将反应溶液的剩余部分移动到过渡区域; 向反应区域加入缓冲溶液，并通过加热装置将反应区域加热至适度的变性温度; 通过使用气动执行机构，将从变性后的反应区域产生的产品的废液移动到废弃区域; 并通过气动致动器将剩余溶液移回反应区域。
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公开(公告)号：US06192939B1
公开(公告)日：2001-02-27
申请号：US09345451
申请日：1999-07-01
Applicant: Nan-Kuang Yao , Yue-Min Wan , Chi-chen Chen , Lung-Yu Hung , Shin-Hwan Wang , Si-Wei Chang
Inventor： Nan-Kuang Yao , Yue-Min Wan , Chi-chen Chen , Lung-Yu Hung , Shin-Hwan Wang , Si-Wei Chang
IPC: F15D114
CPC classification number: F15C1/16 , B01L3/50273 , B01L3/502738 , B01L2400/0463 , B01L2400/0487 , Y10S366/03 , Y10T436/2575
Abstract: A pneumatic apparatus and method for driving a microflow is disclosed. The microflow driving apparatus of this invention comprises an external pneumatic driving device that generates an array of airflows; an air gallery to accept airflows of said pneumatic driving device and to generate a suction force and an exclusion force; and a fluid channel connected with said air gallery to allow a fluid to flow inside it. In the air gallery, a trapezoid block is provided to generate an air circle from at least one of said airflows. An open gap is provided in the fluid channel at the connection of the air gallery and the fluid channel. When different combinations of airflows are introduced into the air gallery, a suction force or an exclusion force is generated to drive the reaction fluid inside the fluid channel to proceed, retreat or pause. A method using the apparatus for driving a microflow is also disclosed.
Abstract translation: 公开了一种用于驱动微流的气动装置和方法。 本发明的微流驱动装置包括产生气流阵列的外部气动驱动装置; 用于接收所述气动驱动装置的气流并产生吸力和排除力的空气库; 以及与所述空气流道连接以允许流体在其内部流动的流体通道。 在空气库中，提供梯形块以从至少一个所述气流产生空气圈。 在空气槽和流体通道的连接处，在流体通道中设置有开放的间隙。 当气流的不同组合被引入空气槽中时，产生吸力或排斥力以驱动流体通道内的反应流体进行，退避或暂停。 还公开了使用该微流驱动装置的方法。
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