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    Compositions and methods for therapeutic delivery
    1.
    发明授权
    Compositions and methods for therapeutic delivery 有权

    公开(公告)号：US12234475B2

    公开(公告)日：2025-02-25

    申请号：US18049266

    申请日：2022-10-24

    Applicant: GenVivo, Inc.

    Inventor： Brile Chung ,  Cecilia Roh ,  Robert G. Johnson, Jr.

    IPC: C12N15/86 ,  A61K31/522 ,  A61P35/00 ,  C07H21/04

    Abstract: Described herein are compositions comprising a recombinant retroviral vector for delivering a therapeutic comprising a nucleic acid construct comprising a polynucleotide sequence encoding an interleukin or a subunit thereof. Also described herein are methods of using the composition comprising a recombinant retroviral vector described herein for delivering a therapeutic comprising a nucleic acid construct comprising a polynucleotide sequence encoding an interleukin or a subunit thereof to a subject.

    METHOD FOR PRODUCING POLYNUCLEOTIDES
    5.
    发明申请
    METHOD FOR PRODUCING POLYNUCLEOTIDES 有权

    公开(公告)号：US20250042932A1

    公开(公告)日：2025-02-06

    申请号：US18714078

    申请日：2022-11-29

    Applicant: ATDBio Limited

    Inventor： Tom BROWN ,  Owen COX

    IPC: C07H21/04 ,  C07H1/00 ,  C07H19/073

    Abstract: Provided herein is a method of producing a polynucleotide or an analogue or derivative thereof, comprising providing a support-attached nucleoside, nucleotide, polynucleotide or derivative or analogue thereof, which is a compound of formula (I) as defined herein and attached to a solid support at (II), (ii) increasing the chain length of the support-attached nucleoside, nucleotide, polynucleotide or derivative or analogue thereof by introducing one or more additional nucleoside units, nucleotide units and/or analogues or derivatives thereof; and (iii) cleaving the resulting polynucleotide from the solid support by photo-illuminating the compound of formula (I). Also provided are associated compounds, uses, and polynucleotides obtainable by such methods.

    Methods and compositions for spacial and temporal measurement of catalytic activity
    6.
    发明授权
    Methods and compositions for spacial and temporal measurement of catalytic activity 有权

    公开(公告)号：US12216121B2

    公开(公告)日：2025-02-04

    申请号：US16603722

    申请日：2018-04-12

    Applicant: The University of Chicago

    Inventor： Yamuna Krishnan ,  Krishna Dan ,  Aneesh T. Veetil ,  Kasturi Chakraborty

    IPC: G01N33/573 ,  C07H21/04 ,  G01N21/64

    Abstract: Described herein are nucleic acid molecules and complexes useful for spatiotemporally mapping intra-endosmal thiol disulphide exchange. Aspects of the disclosure relate to a composition comprising a first nucleic acid conjugated to a normalization moiety; and a second nucleic acid conjugated to a catalytic substrate; wherein reaction of the substrate with a catalyst produces a detectable product; and wherein the first and second nucleic acids are complementary or substantially complementary. Further aspects relate to a composition comprising: a first nucleic acid conjugated to a normalization moiety and to a catalytic substrate; and a second nucleic acid; wherein reaction of the substrate with a catalyst produces a detectable product; and wherein the first and second nucleic acids are complementary or substantially complementary.

    Gene knockout of NRF2 for treatment of cancer
    10.
    发明授权
    Gene knockout of NRF2 for treatment of cancer 有权

    公开(公告)号：US12203070B2

    公开(公告)日：2025-01-21

    申请号：US16881919

    申请日：2020-05-22

    Applicant: Christiana Care Gene Editing Institute , Inc.

    Inventor： Eric Kmiec ,  Pawel Bialk

    IPC: C07H21/04 ,  A61K31/7105 ,  C12N9/22 ,  C12N15/113

    Abstract: The disclosure provides a guide RNA (gRNA) comprising a DNA-binding domain and a Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR)-associated endonuclease protein-binding domain, wherein the DNA-binding domain is complementary to a target domain from an NRF2 gene. The disclosure also provides nucleic acid sequence encoding the gRNA. The disclosure further provides a method of treating cancer in a subject comprising administering to the subject a therapeutically effective amount of a pharmaceutical composition comprising a Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR)-associated endonuclease and a guide RNA that is complementary to a target domain from an NRF2 gene in the subject. Methods of treating cancer comprising administering a pharmaceutical composition comprising: a DNA sequence encoding a guide RNA that is complementary to a target domain from an NRF2 gene in the subject; and a nucleic acid sequence encoding a Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR)-associated endonuclease, are also provided.

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