公开(公告)号：US20230257740A1

公开(公告)日：2023-08-17

申请号：US17721704

申请日：2022-04-15

Applicant: Alnylam Pharmaceuticals, Inc.

Inventor： Dinah Wen-yee Sah ,  Gregory Hinkle ,  Rene Alvarez ,  Stuart Milstein ,  Qingmin Chen

IPC: C12N15/113 ,  C12N15/11 ,  C07F9/6533 ,  C07H21/04 ,  A61K9/00 ,  A61K31/713

CPC classification number: C12N15/113 ,  A61K9/0019 ,  A61K31/713 ,  C07F9/6533 ,  C07H21/04 ,  C12N15/111 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/335 ,  C12N2310/3515 ,  C12N2320/30 ,  C12N2320/32

Abstract: The invention relates to a double-stranded ribonucleic acid (dsRNA) targeting a transthyretin (TTR) gene, and methods of using the dsRNA to inhibit expression of TTR.

公开(公告)号：US10240152B2

公开(公告)日：2019-03-26

申请号：US15380571

申请日：2016-12-15

Applicant: Alnylam Pharmaceuticals, Inc.

Inventor： Dinah Wen-Yee Sah ,  Gregory Hinkle ,  Rene Alvarez ,  Stuart Milstein ,  Qingmin Chen

IPC: A61K48/00 ,  C07H21/04 ,  C12N15/113 ,  C12N15/11 ,  A61K9/00 ,  A61K31/713

Abstract: The invention relates to a double-stranded ribonucleic acid (dsRNA) targeting a transthyretin (TTR) gene, and methods of using the dsRNA to inhibit expression of TTR.

公开(公告)号：US20140051747A1

公开(公告)日：2014-02-20

申请号：US14060545

申请日：2013-10-22

Applicant: ALNYLAM PHARMACEUTICALS, INC.

Inventor： Dinah Wen-Yee Sah ,  Qingmin Chen

IPC: C12N15/113

CPC classification number: C12N15/1131 ,  C12N2310/14

Abstract: This invention relates to double-stranded ribonucleic acid (dsRNA), and its use in mediating RNA interference to inhibit the expression of an RNA from the West Nile virus (WNV), and the use of the dsRNA to treat pathological processes mediated by WNV infection, such as viral encephalitis.

Abstract translation: 本发明涉及双链核糖核酸（dsRNA）及其在介导RNA干扰抑制西尼罗河病毒（WNV）RNA表达的用途，以及使用dsRNA治疗由WNV感染介导的病理过程 ，如病毒性脑炎。

公开(公告)号：US20190309293A1

公开(公告)日：2019-10-10

申请号：US16276541

申请日：2019-02-14

Applicant: Alnylam Pharmaceuticals, Inc.

Inventor： Dinah Wen-Yee Sah ,  Gregory Hinkle ,  Rene Alvarez ,  Stuart Milstein ,  Qingmin Chen

IPC: C12N15/113 ,  C12N15/11 ,  A61K31/713 ,  A61K9/00

Abstract: The invention relates to a double-stranded ribonucleic acid (dsRNA) targeting a transthyretin (TTR) gene, and methods of using the dsRNA to inhibit expression of TTR.

公开(公告)号：US09234196B2

公开(公告)日：2016-01-12

申请号：US14220829

申请日：2014-03-20

Applicant: Alnylam Pharmaceuticals, Inc.

Inventor： Dinah Wen-Yee Sah ,  Gregory Hinkle ,  Rene Alvarez ,  Stuart Milstein ,  Qingmin Chen

IPC: A61K48/00 ,  C07H21/02 ,  C07H21/04 ,  C12N15/113 ,  C12N15/11

CPC classification number: C12N15/113 ,  A61K9/0019 ,  A61K31/713 ,  C12N15/111 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/335 ,  C12N2310/3515 ,  C12N2320/30 ,  C12N2320/32 ,  C12N2310/3521

Abstract: The invention relates to a double-stranded ribonucleic acid (dsRNA) targeting a transthyretin (TTR) gene, and methods of using the dsRNA to inhibit expression of TTR.

Abstract translation: 本发明涉及靶向转甲状腺素蛋白（TTR）基因的双链核糖核酸（dsRNA）以及使用dsRNA抑制TTR表达的方法。

公开(公告)号：US12227744B2

公开(公告)日：2025-02-18

申请号：US17721704

申请日：2022-04-15

Applicant: Alnylam Pharmaceuticals, Inc.

Inventor： Dinah Wen-Yee Sah ,  Gregory Hinkle ,  Rene Alvarez ,  Stuart Milstein ,  Qingmin Chen

IPC: C07H21/02 ,  A61K9/00 ,  A61K31/713 ,  C07F9/6533 ,  C07H21/04 ,  C12N15/11 ,  C12N15/113

Abstract: The invention relates to a double-stranded ribonucleic acid (dsRNA) targeting a transthyretin (TTR) gene, and methods of using the dsRNA to inhibit expression of TTR.

公开(公告)号：US20170321213A1

公开(公告)日：2017-11-09

申请号：US15380571

申请日：2016-12-15

Applicant: Alnylam Pharmaceuticals, Inc.

Inventor： Dinah Wen-Yee Sah ,  Gregory Hinkle ,  Rene Alvarez ,  Stuart Milstein ,  Qingmin Chen

IPC: C12N15/113 ,  C12N15/11 ,  A61K9/00 ,  A61K31/713

CPC classification number: C12N15/113 ,  A61K9/0019 ,  A61K31/713 ,  C12N15/111 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/335 ,  C12N2310/3515 ,  C12N2320/30 ,  C12N2320/32 ,  C12N2310/3521

Abstract: The invention relates to a double-stranded ribonucleic acid (dsRNA) targeting a transthyretin (TTR) gene, and methods of using the dsRNA to inhibit expression of TTR.

公开(公告)号：US20160264963A1

公开(公告)日：2016-09-15

申请号：US14965825

申请日：2015-12-10

Applicant: Alnylam Pharmaceuticals, Inc.

Inventor： Dinah Wen-Yee Sah ,  Gregory Hinkle ,  Rene Alvarez ,  Stuart Milstein ,  Qingmin Chen

IPC: C12N15/113 ,  A61K9/00 ,  A61K31/713

CPC classification number: C12N15/113 ,  A61K9/0019 ,  A61K31/713 ,  C12N15/111 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/335 ,  C12N2310/3515 ,  C12N2320/30 ,  C12N2320/32 ,  C12N2310/3521

Abstract: The invention relates to a double-stranded ribonucleic acid (dsRNA) targeting a transthyretin (TTR) gene, and methods of using the dsRNA to inhibit expression of TTR.

Abstract translation: 本发明涉及靶向转甲状腺素蛋白（TTR）基因的双链核糖核酸（dsRNA）以及使用dsRNA抑制TTR表达的方法。

公开(公告)号：US09200282B2

公开(公告)日：2015-12-01

申请号：US14060545

申请日：2013-10-22

Applicant: Alnylam Pharmaceuticals, Inc.

Inventor： Dinah Wen-Yee Sah ,  Qingmin Chen

IPC: C07H21/04 ,  C12N15/113

CPC classification number: C12N15/1131 ,  C12N2310/14

Abstract: This invention relates to double-stranded ribonucleic acid (dsRNA), and its use in mediating RNA interference to inhibit the expression of an RNA from the West Nile virus (WNV), and the use of the dsRNA to treat pathological processes mediated by WNV infection, such as viral encephalitis.

Abstract translation: 本发明涉及双链核糖核酸（dsRNA）及其在介导RNA干扰抑制西尼罗河病毒（WNV）RNA表达的用途，以及使用dsRNA治疗由WNV感染介导的病理过程 ，如病毒性脑炎。

公开(公告)号：US20200283766A1

公开(公告)日：2020-09-10

申请号：US16751026

申请日：2020-01-23

Applicant: Alnylam Pharmaceuticals, Inc.

Inventor： Dinah Wen-Yee Sah ,  Gregory Hinkle ,  Rene Alvarez ,  Stuart Milstein ,  Qingmin Chen

IPC: C12N15/113 ,  C12N15/11 ,  C07F9/6533 ,  C07H21/04 ,  A61K9/00 ,  A61K31/713

Abstract: The invention relates to a double-stranded ribonucleic acid (dsRNA) targeting a transthyretin (TTR) gene, and methods of using the dsRNA to inhibit expression of TTR.