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公开(公告)号：US20230257740A1
公开(公告)日：2023-08-17
申请号：US17721704
申请日：2022-04-15
Applicant: Alnylam Pharmaceuticals, Inc.
Inventor： Dinah Wen-yee Sah , Gregory Hinkle , Rene Alvarez , Stuart Milstein , Qingmin Chen
IPC: C12N15/113 , C12N15/11 , C07F9/6533 , C07H21/04 , A61K9/00 , A61K31/713
CPC classification number: C12N15/113 , A61K9/0019 , A61K31/713 , C07F9/6533 , C07H21/04 , C12N15/111 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/335 , C12N2310/3515 , C12N2320/30 , C12N2320/32
Abstract: The invention relates to a double-stranded ribonucleic acid (dsRNA) targeting a transthyretin (TTR) gene, and methods of using the dsRNA to inhibit expression of TTR.
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公开(公告)号：US20200088746A1
公开(公告)日：2020-03-19
申请号：US16394017
申请日：2019-04-25
Applicant: Alnylam Pharmaceuticals, Inc.
Inventor： James Butler , Renta Hutabarat , Rene Alvarez , Bob Xiong , Lily Y.T. Li
Abstract: The present invention relates to assays and methods for the detection of transthyretin and its isoforms. Specifically, the assays and methods of the present invention embrace liquid chromatography and mass spectrometry. The present invention also relates to unique peptides and peptide variants useful in the assays and methods.
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公开(公告)号：US20190309293A1
公开(公告)日：2019-10-10
申请号：US16276541
申请日：2019-02-14
Applicant: Alnylam Pharmaceuticals, Inc.
Inventor： Dinah Wen-Yee Sah , Gregory Hinkle , Rene Alvarez , Stuart Milstein , Qingmin Chen
IPC: C12N15/113 , C12N15/11 , A61K31/713 , A61K9/00
Abstract: The invention relates to a double-stranded ribonucleic acid (dsRNA) targeting a transthyretin (TTR) gene, and methods of using the dsRNA to inhibit expression of TTR.
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公开(公告)号：US09234196B2
公开(公告)日：2016-01-12
申请号：US14220829
申请日：2014-03-20
Applicant: Alnylam Pharmaceuticals, Inc.
Inventor： Dinah Wen-Yee Sah , Gregory Hinkle , Rene Alvarez , Stuart Milstein , Qingmin Chen
IPC: A61K48/00 , C07H21/02 , C07H21/04 , C12N15/113 , C12N15/11
CPC classification number: C12N15/113 , A61K9/0019 , A61K31/713 , C12N15/111 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/335 , C12N2310/3515 , C12N2320/30 , C12N2320/32 , C12N2310/3521
Abstract: The invention relates to a double-stranded ribonucleic acid (dsRNA) targeting a transthyretin (TTR) gene, and methods of using the dsRNA to inhibit expression of TTR.
Abstract translation: 本发明涉及靶向转甲状腺素蛋白（TTR）基因的双链核糖核酸（dsRNA）以及使用dsRNA抑制TTR表达的方法。
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公开(公告)号：US12227744B2
公开(公告)日：2025-02-18
申请号：US17721704
申请日：2022-04-15
Applicant: Alnylam Pharmaceuticals, Inc.
Inventor： Dinah Wen-Yee Sah , Gregory Hinkle , Rene Alvarez , Stuart Milstein , Qingmin Chen
IPC: C07H21/02 , A61K9/00 , A61K31/713 , C07F9/6533 , C07H21/04 , C12N15/11 , C12N15/113
Abstract: The invention relates to a double-stranded ribonucleic acid (dsRNA) targeting a transthyretin (TTR) gene, and methods of using the dsRNA to inhibit expression of TTR.
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Patent Agency Ranking
公开(公告)号：US20170321213A1
公开(公告)日：2017-11-09
申请号：US15380571
申请日：2016-12-15
Applicant: Alnylam Pharmaceuticals, Inc.
Inventor： Dinah Wen-Yee Sah , Gregory Hinkle , Rene Alvarez , Stuart Milstein , Qingmin Chen
IPC: C12N15/113 , C12N15/11 , A61K9/00 , A61K31/713
CPC classification number: C12N15/113 , A61K9/0019 , A61K31/713 , C12N15/111 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/335 , C12N2310/3515 , C12N2320/30 , C12N2320/32 , C12N2310/3521
Abstract: The invention relates to a double-stranded ribonucleic acid (dsRNA) targeting a transthyretin (TTR) gene, and methods of using the dsRNA to inhibit expression of TTR.
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7.发明申请公开(公告)号：US20160264963A1
公开(公告)日：2016-09-15
申请号：US14965825
申请日：2015-12-10
Applicant: Alnylam Pharmaceuticals, Inc.
Inventor： Dinah Wen-Yee Sah , Gregory Hinkle , Rene Alvarez , Stuart Milstein , Qingmin Chen
IPC: C12N15/113 , A61K9/00 , A61K31/713
CPC classification number: C12N15/113 , A61K9/0019 , A61K31/713 , C12N15/111 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/335 , C12N2310/3515 , C12N2320/30 , C12N2320/32 , C12N2310/3521
Abstract: The invention relates to a double-stranded ribonucleic acid (dsRNA) targeting a transthyretin (TTR) gene, and methods of using the dsRNA to inhibit expression of TTR.
Abstract translation: 本发明涉及靶向转甲状腺素蛋白（TTR）基因的双链核糖核酸（dsRNA）以及使用dsRNA抑制TTR表达的方法。
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公开(公告)号：US10240152B2
公开(公告)日：2019-03-26
申请号：US15380571
申请日：2016-12-15
Applicant: Alnylam Pharmaceuticals, Inc.
Inventor： Dinah Wen-Yee Sah , Gregory Hinkle , Rene Alvarez , Stuart Milstein , Qingmin Chen
IPC: A61K48/00 , C07H21/04 , C12N15/113 , C12N15/11 , A61K9/00 , A61K31/713
Abstract: The invention relates to a double-stranded ribonucleic acid (dsRNA) targeting a transthyretin (TTR) gene, and methods of using the dsRNA to inhibit expression of TTR.
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公开(公告)号：US20170045536A1
公开(公告)日：2017-02-16
申请号：US15338006
申请日：2016-10-28
Applicant: Alnylam Pharmaceuticals, Inc.
Inventor： James Butler , Renta Hutabarat , Rene Alvarez , Bob Xiong , Lily Y.T. Li
CPC classification number: G01N33/78 , C07K14/575 , C12Q1/37 , G01N30/7233 , G01N33/58 , G01N33/6848 , H01J49/00 , H01J49/0081
Abstract: The present invention relates to assays and methods for the detection of transthyretin and its isoforms. Specifically, the assays and methods of the present invention embrace liquid chromatography and mass spectrometry. The present invention also relates to unique peptides and peptide variants useful in the assays and methods.
Abstract translation: 本发明涉及检测转甲状腺素蛋白及其同种型的测定和方法。 具体地说，本发明的测定和方法包括液相色谱和质谱。 本发明还涉及用于测定和方法的独特的肽和肽变体。
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10.发明申请Methods And Compositions For Prevention Or Treatment Of RSV Infection Using Modified Duplex RNA Molecules 审中-公开方法和组合物预防或使用修改的双相RNA分子治疗RSV感染公开(公告)号：US20150337311A1
公开(公告)日：2015-11-26
申请号：US14624384
申请日：2015-02-17
Applicant: Alnylam Pharmaceuticals, Inc.
Inventor： Rachel Meyers , Rene Alvarez , Geoff Cole , Sayda Elbashir
IPC: C12N15/113
CPC classification number: C12N15/1131 , A61K9/0073 , C12N2310/11 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2320/30 , C12N2310/3521 , C12N2310/3533
Abstract: Methods and compositions are provided for the prevention or treatment of RSV infection in a human. The methods include administering one or more doses of a composition comprising an siRNA. The dose can be formulated for topical or parenteral administration. Topical administration includes administration as a nasal spray, or by inhalation of respirable particles or droplets. The siRNA preferably comprises a sense strand and antisense strand with modified nucleotides.
Abstract translation: 提供了用于预防或治疗人体RSV感染的方法和组合物。 所述方法包括施用一种或多种剂量的包含siRNA的组合物。 剂量可以配制用于局部或肠胃外给药。 局部给药包括作为鼻喷雾给药，或通过吸入可吸入颗粒或液滴。 siRNA优选包含具有修饰的核苷酸的有义链和反义链。
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