公开(公告)号：US20200088746A1

公开(公告)日：2020-03-19

申请号：US16394017

申请日：2019-04-25

Applicant: Alnylam Pharmaceuticals, Inc.

Inventor： James Butler ,  Renta Hutabarat ,  Rene Alvarez ,  Bob Xiong ,  Lily Y.T. Li

IPC: G01N33/78 ,  G01N33/68 ,  G01N30/72 ,  C07K14/575 ,  C12Q1/37 ,  G01N33/58

Abstract: The present invention relates to assays and methods for the detection of transthyretin and its isoforms. Specifically, the assays and methods of the present invention embrace liquid chromatography and mass spectrometry. The present invention also relates to unique peptides and peptide variants useful in the assays and methods.

公开(公告)号：US20170045536A1

公开(公告)日：2017-02-16

申请号：US15338006

申请日：2016-10-28

Applicant: Alnylam Pharmaceuticals, Inc.

Inventor： James Butler ,  Renta Hutabarat ,  Rene Alvarez ,  Bob Xiong ,  Lily Y.T. Li

IPC: G01N33/78 ,  G01N30/72

CPC classification number: G01N33/78 ,  C07K14/575 ,  C12Q1/37 ,  G01N30/7233 ,  G01N33/58 ,  G01N33/6848 ,  H01J49/00 ,  H01J49/0081

Abstract: The present invention relates to assays and methods for the detection of transthyretin and its isoforms. Specifically, the assays and methods of the present invention embrace liquid chromatography and mass spectrometry. The present invention also relates to unique peptides and peptide variants useful in the assays and methods.

Abstract translation: 本发明涉及检测转甲状腺素蛋白及其同种型的测定和方法。 具体地说，本发明的测定和方法包括液相色谱和质谱。 本发明还涉及用于测定和方法的独特的肽和肽变体。

公开(公告)号：US20140315231A1

公开(公告)日：2014-10-23

申请号：US14358139

申请日：2012-11-16

Applicant: Alnylam Pharmaceuticals, Inc

Inventor： James Butler ,  Renta Hutabarat ,  Rene Alvarez ,  Bob Xiong ,  Lily Y.T. Li

IPC: G01N33/78 ,  C07K14/575 ,  G01N33/58 ,  C12Q1/37

CPC classification number: G01N33/78 ,  C07K14/575 ,  C12Q1/37 ,  G01N30/7233 ,  G01N33/58 ,  G01N33/6848 ,  H01J49/00 ,  H01J49/0081

Abstract: The present invention relates to assays and methods for the detection of transthyretin and its isoforms. Specifically, the assays and methods of the present invention embrace liquid chromatography and mass spectrometry. The present invention also relates to unique peptides and peptide variants useful in the assays and methods.

Abstract translation: 本发明涉及检测转甲状腺素蛋白及其同种型的测定和方法。 具体地说，本发明的测定和方法包括液相色谱和质谱。 本发明还涉及用于测定和方法的独特的肽和肽变体。