公开(公告)号：US20240026362A1

公开(公告)日：2024-01-25

申请号：US18255690

申请日：2021-12-03

申请人： MICROBIO (SHANGHAI) CO. LTD. ,  ONENESS BIOTECH CO. LTD.

发明人： Yi-Chung CHANG ,  Chi-Fan YANG ,  Yi-Fen CHEN ,  Chia-Chun YANG ,  Yuan-Lin CHOU

IPC分类号： C12N15/113 ,  A61K39/215 ,  A61K39/42 ,  A61K31/675 ,  A61P31/14

CPC分类号： C12N15/1131 ,  A61K39/215 ,  A61K39/42 ,  A61K31/675 ,  A61P31/14 ,  C12N2310/14

摘要： Provided are interfering RNAs (e.g., siRNAs) targeting SARS-CoV (e.g., the POL, Spike, Helicase, or Envelop gene thereof) and therapeutic uses thereof for inhibiting SARS-CoV infection and/or treating diseases associated with the infection (e.g., COVID-19).

公开(公告)号：US11872280B2

公开(公告)日：2024-01-16

申请号：US17829004

申请日：2022-05-31

申请人： CureVac SE ,  GLAXOSMITHKLINE BIOLOGICALS SA

发明人： Nicole Roth ,  Diego Chaves Moreno ,  Hans Wolfgang Große ,  Dominik Vahrenhorst ,  Susanne Rauch

IPC分类号： A61K39/215 ,  A61K9/127 ,  A61K31/713 ,  C12N15/113 ,  A61K9/51 ,  A61P31/14 ,  A61K47/60 ,  A61K47/26 ,  C12N7/00 ,  A61K47/69 ,  A61K39/00

CPC分类号： A61K39/215 ,  A61K9/1272 ,  A61K9/5123 ,  A61K31/713 ,  A61K47/26 ,  A61K47/60 ,  A61K47/6933 ,  A61P31/14 ,  C12N7/00 ,  C12N15/1131 ,  A61K2039/53

摘要： The present invention is directed to a nucleic acid suitable for use in treatment or prophylaxis of an infection with a coronavirus, preferably with a Coronavirus SARS-CoV-2, or a disorder related to such an infection, preferably COVID-19. The present invention is also directed to compositions, polypeptides, and vaccines. The compositions and vaccines preferably comprise at least one of said nucleic acid sequences, preferably nucleic acid sequences in association a lipid nanoparticle (LNP). The invention is also directed to first and second medical uses of the nucleic acid, the composition, the polypeptide, the combination, the vaccine, and the kit, and to methods of treating or preventing a coronavirus infection, preferably a Coronavirus infection.

公开(公告)号：US20230390367A1

公开(公告)日：2023-12-07

申请号：US18249569

申请日：2021-10-19

申请人： Temple University - of the Commonwealth System of Higher Education

发明人： Kamel Khalili ,  Rafal Kaminski ,  Shuren Liao

IPC分类号： A61K38/46 ,  C12N15/113 ,  A61K45/06

CPC分类号： A61K38/465 ,  C12N15/1131 ,  A61K45/06 ,  C12N2310/20

摘要： Compositions include gene editing agents, e.g. CRISPR that employ Cas13a for editing and inactivating sequences in the Coronavirus genome.

公开(公告)号：US20230383296A1

公开(公告)日：2023-11-30

申请号：US18122433

申请日：2023-03-16

申请人： ALIGOS THERAPEUTICS, INC.

发明人： Leonid Beigelman ,  Vivek Kumar Rajwanshi ,  Laxman Eltepu ,  Saul Martinez Montero ,  Jin Hong

IPC分类号： C12N15/113 ,  A61P31/20

CPC分类号： C12N15/1131 ,  A61P31/20 ,  C12N15/1137 ,  C12N15/1136 ,  C12N2310/11 ,  C12N2310/315 ,  C12N2310/314 ,  C12N2310/3231 ,  C12N2310/341 ,  C12N2320/32 ,  C12N2320/51 ,  C12N2320/53 ,  C12N2310/351

摘要： The disclosure includes antisense oligonucleotides (ASOs), including gapmer ASOs, and methods of making and using the same.

公开(公告)号：US20230323354A1

公开(公告)日：2023-10-12

申请号：US18012867

申请日：2021-06-28

申请人： UNIVERSITAT POMPEU FABRA

发明人： Juana María DÍEZ ANTÓN ,  Ivan Javier DOTU RODRÍGUEZ ,  Marc TALLÓ PARRA

IPC分类号： C12N15/113

CPC分类号： C12N15/1131 ,  C12N2310/532

摘要： The present invention relates to an artificial RNA having at least one hybridization region against one or more target disruption structures of one or more RNA fragments, wherein such an artificial RNA suitable for disrupting by hybridization one or more target disruption structures of one or more RNA fragments, thereby modulating the functionality of the one or more RNA fragments.

公开(公告)号：US20230313228A1

公开(公告)日：2023-10-05

申请号：US18021684

申请日：2021-08-20

申请人： Oxford Genetics Limited

发明人： Ryan Cawood

IPC分类号： C12N15/86 ,  C12N15/113

CPC分类号： C12N15/86 ,  C12N15/1131 ,  C12N2710/10351 ,  C12N2710/10343 ,  C12N2310/11 ,  C12N2750/14122

摘要： The present invention relates to a cell for use in producing recombinant adenoviruses (AVs), wherein DNA molecules which are capable of producing antisense RNAs against AAV cap and AAV rep mRNAs are stably integrated into the cell's genome. The invention also relates to processes for the production of such cells and processes for using such cells in the production of recombinant AVs.

公开(公告)号：US20230212566A1

公开(公告)日：2023-07-06

申请号：US17910968

申请日：2021-03-10

申请人： Kiminobu SUGAYA ,  Jonhoi SMITH ,  UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC.

发明人： Kiminobu SUGAYA ,  Jonhoi SMITH

IPC分类号： C12N15/113 ,  A61P35/00 ,  A61K45/06 ,  A61P31/14 ,  A61K9/107

CPC分类号： C12N15/113 ,  A61K9/1075 ,  A61K45/06 ,  A61P31/14 ,  A61P35/00 ,  C12N15/1131 ,  C12N2310/122 ,  C12N2310/531 ,  C12N2320/31 ,  C12N2320/32

摘要： Methods and agents that target nanog or Oct4 expression or activity for treating or preventing cancer are disclosed. Alternative methods involve diagnosing cancer stage or type by identifying presence of cancer cells expressing nanog or Oct4. Also, disclosed are method of treating coronavirus infection that involves administering antiviral knockdown agents, such as oligonucleotide-based inhibitors.

公开(公告)号：US20230203492A1

公开(公告)日：2023-06-29

申请号：US18053308

申请日：2022-11-07

申请人： Oregon State University ,  The U.S.A., as Represented by the Secretary, Department of Health and Human Services

发明人： Hong M. Moulton ,  David Adam Stein ,  Heinrich Ulrich Feldmann ,  Kyle Ture Rosenke

IPC分类号： C12N15/113 ,  A61P31/14 ,  A61P11/00 ,  A61K47/54 ,  A61K47/64 ,  A61K31/7105

CPC分类号： C12N15/1131 ,  A61P31/14 ,  A61P11/00 ,  A61K47/549 ,  A61K47/64 ,  A61K31/7105 ,  C12N2310/11 ,  C12N2310/3513 ,  C12N2310/3125 ,  C12N2310/321 ,  C12N2310/3231 ,  C12N2310/3233

摘要： Disclosed herein are embodiments of a compound useful for treating or preventing betacoronavirus infections such as SARS-Cov-2 infections. Also disclosed is a method for administering the compound to a subject, particularly a human subject, to treat or prevent a betacoronavirus infection in the subject. The compound can comprise an oligomer comprising a nucleic acid base sequence that is antisense to at least a portion of a SARS-CoV-2 genomic RNA, and can comprise a sequence present in the 5′ UTR and first 20 nt of coding sequence of the SARS-CoV-2 genomic RNA. The compound also can contain a peptide sequence. In some embodiments, the compound is a peptide-conjugated phosphorodiamidate morpholino oligomer (PPMO).

公开(公告)号：US20230203137A1

公开(公告)日：2023-06-29

申请号：US18054212

申请日：2022-11-10

申请人： BINGHUAN WENG ,  WOMEN'S HOSPITAL SCHOOL OF MEDICINE ZHEJIANG UNIVERSITY ,  HANGZHOU CHICHUANG BIOTECHNOLOGY CO., LTD.

发明人： Binghuan WENG ,  Hefeng HUANG ,  Hui WANG ,  Lin HE ,  Weiping WANG ,  Zhiyong ZHU ,  Minyue DONG ,  Jiali LIN ,  Wei XU ,  Xufeng YAO

IPC分类号： C07K16/10 ,  C12N15/113 ,  C12N9/48

CPC分类号： C07K16/10 ,  C12N15/1131 ,  C12N9/485 ,  C12Y304/17023 ,  C12N2310/531 ,  C12N2310/14

摘要： The present disclosure provides a preparation method of an artificial antibody. The preparation method includes the following steps: screening a target siRNA from a conserved gene or a microsatellite of a coronavirus, synthesizing a small hairpin RNA (shRNA) that has a loop by complementary sense and antisense strands of the siRNA, synthesizing an ACE2 capable of binding to a receptor-binding domain (RBD), and synthesizing the artificial antibody including an shRNA region and an ACE2 region by ligating the ACE2 to sense and antisense strands of the shRNA separately. The bivalent ACE2 is used for neutralization of the RBD and targeted delivery of the shRNA; the shRNA is ligated to the virus through the ACE2 and enters target cells with virus infection, thereby avoiding a side effect of non-specific delivery of the shRNA to uninfected cells, as well as resisting the variant strain and neutralizing the virus with the ACE2.

公开(公告)号：US11685921B2

公开(公告)日：2023-06-27

申请号：US16724122

申请日：2019-12-20

申请人： Arcturus Therapeutics, Inc.

发明人： Pattraranee Limphong ,  Kiyoshi Tachikawa ,  Christine Esau ,  Padmanabh Chivukula

IPC分类号： C12N15/11 ,  C12N15/113 ,  A61K9/127 ,  A61K47/69

CPC分类号： C12N15/1131 ,  A61K9/1271 ,  A61K47/6911 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/322 ,  C12N2310/323 ,  C12N2310/344 ,  C12N2310/3515 ,  C12N2320/32

摘要： This invention encompasses compounds and compositions useful in methods for medical therapy, in general, for inhibiting Hepatitis B virus in a subject. The compounds have a first strand and a second strand, each of the strands being 19-29 monomers in length, the monomers comprising UNA monomers and nucleic acid monomers, and the compounds are targeted to a sequence of an HBV genome.