公开(公告)号：US20220298201A1

公开(公告)日：2022-09-22

申请号：US16969879

申请日：2019-02-20

Applicant: SINGULAR GENOMICS SYSTEMS, INC.

Inventor： Ronald Graham ,  Andrew Spaventa ,  Eli Glezer

IPC: C07H21/04 ,  C12Q1/6869

Abstract: Disclosed herein, inter alia, are compounds, compositions, and methods of use thereof in the sequencing a nucleic acid.

公开(公告)号：US12215124B2

公开(公告)日：2025-02-04

申请号：US16969879

申请日：2019-02-20

Applicant: SINGULAR GENOMICS SYSTEMS, INC.

Inventor： Ronald Graham ,  Andrew Spaventa ,  Eli Glezer

IPC: C07H21/04 ,  C12Q1/6869

Abstract: Disclosed herein, inter alia, are compounds, compositions, and methods of use thereof in the sequencing a nucleic acid.

公开(公告)号：US10954551B2

公开(公告)日：2021-03-23

申请号：US15914835

申请日：2018-03-07

Applicant: Singular Genomics Systems, Inc.

Inventor： Eli Glezer

IPC: C12Q1/68 ,  C12Q1/6818 ,  C12Q1/6874 ,  G01N21/64

Abstract: Methods, systems, and reagents for real-time single molecule sequencing of nucleic acids, particularly long DNA molecules, is described. Preferably, such methods and systems combine FRET (Förster Resonance Energy Transfer)-based proximity sensing of labeled nucleotides in or near a DNA polymerase's active site with FRET-based monitoring of the conformational changes in the polymerase that occur during nucleotide incorporation.

公开(公告)号：US11845923B2

公开(公告)日：2023-12-19

申请号：US17369593

申请日：2021-07-07

Applicant: Singular Genomics Systems, Inc.

Inventor： Souad Naji ,  Carl W. Fuller ,  Eli Glezer ,  Andrew Spaventa

IPC: C12N9/12 ,  C12P19/34

CPC classification number: C12N9/1252 ,  C12P19/34 ,  C12Y207/07007

Abstract: Provided herein are modified Archaeal family B polymerases derived from the Archaeal microorganism Pyrococcus abyssi that exhibit improved incorporation of nucleotide analogues utilized in DNA sequencing.

公开(公告)号：US11591647B2

公开(公告)日：2023-02-28

申请号：US16492076

申请日：2018-03-06

Applicant: SINGULAR GENOMICS SYSTEMS, INC.

Inventor： Eli Glezer ,  Andrew Spaventa ,  David Barker

IPC: C12Q1/6869 ,  C07H21/04 ,  C12Q1/6867

Abstract: The present disclosure provides improved nucleic acid sequencing-by-synthesis (SBS) methods, related kits and reagents, and systems for performing such methods using such kits and reagents.

公开(公告)号：US11136565B2

公开(公告)日：2021-10-05

申请号：US16568089

申请日：2019-09-11

Applicant: Singular Genomics Systems, Inc.

Inventor： Souad Naji ,  Carl W. Fuller ,  Eli Glezer ,  Andrew Spaventa

IPC: C12N9/12 ,  C12P19/34

Abstract: Provided herein are modified Archaeal family B polymerases derived from the Archaeal microorganism Pyrococcus abyssi that exhibit improved incorporation of nucleotide analogues utilized in DNA sequencing.