公开(公告)号：US11364307B2

公开(公告)日：2022-06-21

申请号：US16798198

申请日：2020-02-21

Applicant: GenVivo, Inc.

Inventor： John P. Levy ,  Rebecca A Reed ,  Joseph McNulty ,  Robert G. Johnson, Jr.

IPC: A61K48/00 ,  C12N9/12 ,  A61K31/713 ,  A61K31/522 ,  C07K14/005 ,  C12N15/86

Abstract: Nucleic acid sequences encoding improved Herpes Simplex Virus Thymidine Kinases are provided, including their use in diagnostic and therapeutic applications. The thymidine kinases may be mutated using conservative mutations, non-conservative mutations, or both. Also provided are gene therapeutic systems, including viral and retroviral particles.

公开(公告)号：US11253611B2

公开(公告)日：2022-02-22

申请号：US16510731

申请日：2019-07-12

Applicant: GenVivo, Inc.

Inventor： John P. Levy ,  Rebecca A. Reed ,  Joseph McNulty ,  Robert G. Johnson, Jr.

IPC: A61K48/00 ,  C12N9/12 ,  A61K31/713 ,  A61K31/522 ,  C07K14/005 ,  C12N15/86

Abstract: Nucleic acid sequences encoding improved Herpes Simplex Virus Thymidine Kinases are provided, including their use in diagnostic and therapeutic applications. The thymidine kinases may be mutated using conservative mutations, non-conservative mutations, or both. Also provided are gene therapeutic systems, including viral and retroviral particles.

公开(公告)号：US10350302B2

公开(公告)日：2019-07-16

申请号：US15994999

申请日：2018-05-31

Applicant: GenVivo, Inc.

Inventor： John P. Levy ,  Rebecca A. Reed ,  Joseph McNulty ,  Robert G. Johnson, Jr.

IPC: A61K48/00 ,  C12N9/12 ,  A61K31/713 ,  A61K31/522 ,  C07K14/005

Abstract: Nucleic acid sequences encoding improved Herpes Simplex Virus Thymidine Kinases are provided, including their use in diagnostic and therapeutic applications. The thymidine kinases may be mutated using conservative mutations, non-conservative mutations, or both. Also provided are gene therapeutic systems, including viral and retroviral particles.

公开(公告)号：US12234475B2

公开(公告)日：2025-02-25

申请号：US18049266

申请日：2022-10-24

Applicant: GenVivo, Inc.

Inventor： Brile Chung ,  Cecilia Roh ,  Robert G. Johnson, Jr.

IPC: C12N15/86 ,  A61K31/522 ,  A61P35/00 ,  C07H21/04

Abstract: Described herein are compositions comprising a recombinant retroviral vector for delivering a therapeutic comprising a nucleic acid construct comprising a polynucleotide sequence encoding an interleukin or a subunit thereof. Also described herein are methods of using the composition comprising a recombinant retroviral vector described herein for delivering a therapeutic comprising a nucleic acid construct comprising a polynucleotide sequence encoding an interleukin or a subunit thereof to a subject.