公开(公告)号：US20240361343A1

公开(公告)日：2024-10-31

申请号：US18771037

申请日：2024-07-12

申请人： THE BRIGHAM AND WOMEN'S HOSPITAL, INC. ,  BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY ,  BETH ISRAEL DEACONESS MEDICAL CENTER

发明人： Utkan Demirci ,  Ionita Ghiran ,  Savas Tasoglu ,  Ronald W. Davis ,  Lars Steinmetz ,  Naside Gozde Durmus ,  Huseyin Cumhur Tekin

IPC分类号： G01N33/80 ,  B01L3/00 ,  B03C1/32 ,  C12N13/00 ,  C12Q1/18 ,  G01N15/00 ,  G01N15/06 ,  G01N15/10 ,  G01N15/1031 ,  G01N27/76 ,  G01N33/487 ,  G01N33/49 ,  G01N33/574

CPC分类号： G01N33/80 ,  B01L3/502715 ,  B01L3/502761 ,  B03C1/32 ,  C12N13/00 ,  C12Q1/18 ,  G01N15/0656 ,  G01N15/1031 ,  G01N27/76 ,  G01N33/487 ,  G01N33/491 ,  G01N33/574 ,  B01L2200/0647 ,  B01L2300/0654 ,  B01L2300/0838 ,  B01L2300/168 ,  B03C2201/18 ,  B03C2201/26 ,  G01N2015/0053 ,  G01N2015/1006 ,  G01N2500/10 ,  G01N2800/042 ,  G01N2800/26 ,  G01N2800/52 ,  G01N2800/7042

摘要： Magnetic cell levitation and cell monitoring systems and methods are disclosed. A method for separating a heterogeneous population of cells is performed by placing a microcapillary channel containing the heterogeneous population of cells in a magnetically-responsive medium in the disclosed levitation system and separating the cells by balancing magnetic and corrected gravitational forces on the individual cells. A levitation system is also disclosed, having a microscope on which the microcapillary channel is placed and a set of two magnets between which the microcapillary channel is placed. Additionally, a method for monitoring cellular processes in real-time using the levitation system is disclosed.

公开(公告)号：US12131802B2

公开(公告)日：2024-10-29

申请号：US15443102

申请日：2017-02-27

申请人： OPKO Diagnostics, LLC ,  Oy Arctic Partners Ab

发明人： Andrew J. Vickers ,  Peter T. Scardino ,  Hans Lilja ,  Vincent Linder ,  David Steinmiller

IPC分类号： G16B20/00 ,  B01L3/00 ,  C12Q1/6886 ,  G01N33/543 ,  G01N33/574 ,  G01N33/68 ,  G16B40/00 ,  G16H10/40 ,  G16H50/20 ,  G16H50/30

CPC分类号： G16B20/00 ,  B01L3/502 ,  B01L3/502715 ,  B01L3/502761 ,  C12Q1/6886 ,  G01N33/54366 ,  G01N33/57434 ,  G01N33/6893 ,  G16B40/00 ,  G16H10/40 ,  G16H50/20 ,  G16H50/30 ,  B01L2300/0654 ,  B01L2300/0816 ,  B01L2300/087 ,  B01L2400/0487 ,  C12Q2600/112 ,  C12Q2600/158 ,  C12Q2600/16 ,  G01N2333/96455

摘要： Methods and apparatuses for predicting risk of prostate cancer and/or prostate gland volume are provided. More particularly, this disclosure relates to methods and apparatuses for providing the models and employing the models for predicting risk of prostate cancer and/or predicting prostate gland volume. The methods and apparatuses for predicting risk of prostate cancer and/or prostate gland volume are provided using, at least in part, information from a panel of kallikrein markers.

公开(公告)号：US12130235B2

公开(公告)日：2024-10-29

申请号：US17205473

申请日：2021-03-18

申请人： Johnson & Johnson Consumer Inc.

发明人： Curt Binner ,  Justin Mellinger ,  Alexandru Paunescu

IPC分类号： G01N21/31 ,  A61F13/42 ,  A61F13/49 ,  B01L3/00 ,  C12Q1/26 ,  C12Q1/28 ,  C12Q1/54 ,  G01N21/78 ,  G01N33/493 ,  G01N33/52 ,  G01N21/77

CPC分类号： G01N21/78 ,  A61F13/42 ,  A61F13/49 ,  B01L3/502707 ,  B01L3/502761 ,  B01L3/502776 ,  C12Q1/26 ,  C12Q1/28 ,  C12Q1/54 ,  G01N21/31 ,  G01N33/493 ,  G01N33/52 ,  B01L2200/10 ,  G01N2021/7756 ,  G01N2021/7766 ,  G01N2201/062

摘要： A system and kit for measuring analyte concentration in a bodily fluid include a durable component, at least one indicator component including an indicator zone, and at least one moisture sensor. The kit has multiple individually packaged indicator components. Methods of measuring analyte concentration in bodily fluids include the steps of collecting and transporting bodily fluid to at least one colorimetric analyte sensing element and detecting the presence of bodily fluid in contact with the at least one colorimetric analyte sensing element, collecting optical data relating to the at least one colorimetric analyte sensing element with at least one spectrophotometer after a predetermined time period after detecting the presence of bodily fluid, communicating the optical data to a computing system having at least one processor and data storage, and analyzing the optical data to determine at least one analyte concentration in the bodily fluid.

公开(公告)号：US12130229B2

公开(公告)日：2024-10-29

申请号：US17696036

申请日：2022-03-16

申请人： Stichting IMEC Nederland

发明人： Joris Van Nieuwstadt ,  Jan Willem De Wit

IPC分类号： G01N21/33 ,  B01L3/00 ,  G01N1/14

CPC分类号： G01N21/33 ,  B01L3/502715 ,  G01N1/14 ,  B01L2300/0654 ,  B01L2400/0487 ,  G01N2201/062

摘要： A device for light-based analysis of a substance in a liquid sample comprises: an analysis cell for holding the liquid sample during analysis; a plunger configured for movement along walls of the analysis cell for allowing entry of the liquid sample into the analysis cell and pushing the liquid sample out of the analysis cell, wherein a first analysis measurement is allowed to be performed while a second portion of the plunger is arranged between a light source and a light detector; wherein the plunger is movable to a completely retracted position in the analysis cell for allowing a second analysis measurement to be performed such that light being detected by the light detector is passed through the liquid sample filling a space between opposite walls of the analysis cell.

公开(公告)号：US12128414B2

公开(公告)日：2024-10-29

申请号：US17929369

申请日：2022-09-02

申请人： Mesa Biotech, Inc.

发明人： Mark Nowakowski ,  Michael Wang ,  Robert B Cary ,  Hong Cai ,  Conrad Lindberg ,  Martin Bouliane ,  Donald J Thomas

IPC分类号： B01L7/00 ,  B01L3/00 ,  C12Q1/04 ,  C12Q1/6816 ,  C12Q1/6844

CPC分类号： B01L7/52 ,  B01L3/502723 ,  B01L3/50273 ,  B01L3/502738 ,  B01L3/502746 ,  B01L3/502761 ,  B01L3/502769 ,  C12Q1/04 ,  C12Q1/6816 ,  C12Q1/6844 ,  B01L3/502715 ,  B01L2200/0621 ,  B01L2200/0689 ,  B01L2200/147 ,  B01L2200/16 ,  B01L2300/048 ,  B01L2300/0822 ,  B01L2300/0883 ,  B01L2300/123 ,  B01L2300/1827 ,  B01L2400/0406 ,  B01L2400/0445 ,  B01L2400/0457 ,  B01L2400/0638 ,  B01L2400/0677 ,  B01L2400/0694 ,  C12Q2531/113 ,  C12Q2560/00 ,  C12Q1/6816 ,  C12Q2565/629

摘要： An automated method for performing an assay of the present disclosure can be performed in a microfluidic device that is a lateral flow device having numerous features to ensure correct operation of the device under gravity, such as vent pockets for enabling the flow of sample fluid from one chamber to the next when the vent pocket is unsealed. Each chamber can have a reagent recess proximal to an inlet end of the chamber. A reagent pellet formed in a reagent recess can be effectively mixed with a sample as the sample flows into the chamber. A flexible circuit with patterned metallic electrical components disposed on a heat stable material can be in direct contact with fluid in the chambers and has resistive heating elements aligned with, for example, a chamber for performing an amplification reaction. A lateral flow detection chamber can include a capillary pool proximal to a sample receiving end of a lateral flow strip, providing effective mixing and dispersion of a sample with detection particles, as well as enhancing, uniformity of particle migration on the detection strip. The microfluidic device can be configured to be hermetically sealed, thereby preventing contamination of a testing environment.

公开(公告)号：US12128413B2

公开(公告)日：2024-10-29

申请号：US17877231

申请日：2022-07-29

申请人： Zhejiang Orient Gene Biotech Co.,Ltd

发明人： Jianqiu Fang ,  Jun Ling ,  Xiulong Ge ,  Fangzhou Xu

IPC分类号： B01L3/00

CPC分类号： B01L3/508 ,  B01L2300/041

摘要： A test device includes a housing and a carrier detachable from the housing. The housing includes a socket, and the carrier contains a testing element, and the carrier along with the testing element therein is capable of being inserted into the housing through the socket. The housing includes a blocking structure and a locking structure. The blocking structure and the locking structure are integrated to form a locking component. When the carrier is inserted into the housing, and a position of the carrier is locked by the locking structure, the carrier is abutted against the blocking structure. The carrier keeps stable after being inserted into the housing; and the carrier is located in the same position for each insertion.

公开(公告)号：US12128412B2

公开(公告)日：2024-10-29

申请号：US17593167

申请日：2020-03-09

申请人： QUANTUMDX GROUP LIMITED

发明人： James Bennett ,  Neil Litten ,  Richard Smith ,  Julian Brandon-Jones

IPC分类号： B01L3/00 ,  A61B10/00

CPC分类号： B01L3/5029 ,  A61B10/0096 ,  B01L2300/042 ,  B01L2300/0672 ,  B01L2300/0832 ,  B01L2400/0683

摘要： A specimen container has a vessel having a reservoir and a specimen collection region. The specimen container also has a sleeve located within the vessel and moveable in the direction of the reservoir. Movement of the sleeve in the direction of the reservoir results in the specimen collection region and reservoir being brought into fluid communication with each other.

公开(公告)号：US12128408B2

公开(公告)日：2024-10-29

申请号：US16532798

申请日：2019-08-06

申请人： Bio-Rad Laboratories, Inc.

发明人： Robert Dean Lovchik ,  Iago Pereiro Pereiro ,  Govind Kaigala ,  Anna Fomitcheva Khartchenko

IPC分类号： B01L3/00 ,  B01D21/28 ,  B03C1/28 ,  B03C1/30 ,  B03C5/00 ,  G01N27/447

CPC分类号： B01L3/502761 ,  B01D21/283 ,  B03C1/288 ,  B03C1/30 ,  B03C5/005 ,  G01N27/44791 ,  B01L2200/0647 ,  B01L2300/0877 ,  B01L2300/12 ,  B01L2300/123 ,  B01L2400/0424 ,  B01L2400/043 ,  B03C2201/18 ,  B03C2201/20

摘要： A microfluidic device may be provided. The microfluidic device comprises a processing surface having an aperture. The microfluidic device comprises a liquid ejection channel. The liquid ejection channel guides to the aperture. The microfluidic device comprises a first liquid injection channel guiding to the liquid ejection channel. The first liquid injection channel has a first end and a second end and is arranged to provide a fluid flow from the first end to the second end. At least a portion of the first liquid injection channel is closer to the processing surface than (both) the first and second ends to sediment particles.

公开(公告)号：US12128402B2

公开(公告)日：2024-10-29

申请号：US17686105

申请日：2022-03-03

申请人： HandyLab, Inc.

发明人： Kalyan Handique

IPC分类号： B01L7/00 ,  B01L3/00 ,  F16K99/00

CPC分类号： B01L3/502715 ,  B01L3/5025 ,  B01L3/5027 ,  B01L3/502723 ,  B01L3/502738 ,  B01L7/52 ,  F16K99/0001 ,  B01L2200/027 ,  B01L2200/0684 ,  B01L2200/10 ,  B01L2200/12 ,  B01L2200/14 ,  B01L2300/021 ,  B01L2300/0636 ,  B01L2300/0681 ,  B01L2300/0809 ,  B01L2300/0816 ,  B01L2300/0861 ,  B01L2300/0887 ,  B01L2300/165 ,  B01L2300/1805 ,  B01L2300/1822 ,  B01L2300/1827 ,  B01L2300/1844 ,  B01L2300/1894 ,  B01L2400/0677

摘要： The technology described herein generally relates to microfluidic cartridges configured to amplify and detect polynucleotides extracted from multiple biological samples in parallel. The technology includes a microfluidic substrate, comprising: a plurality of sample lanes, wherein each of the plurality of sample lanes comprises a microfluidic network having, in fluid communication with one another: an inlet; a first valve and a second valve; a first channel leading from the inlet, via the first valve, to a reaction chamber; and a second channel leading from the reaction chamber, via the second valve, to a vent.

公开(公告)号：US12128401B2

公开(公告)日：2024-10-29

申请号：US17947207

申请日：2022-09-19

申请人： UNIST(ULSAN NATIONAL INSTITUTE OF SCIENCE AND TECHNOLOGY)

发明人： Taesung Kim ,  Juyeol Bae

IPC分类号： B29C33/38 ,  B01L3/00 ,  B29C33/52 ,  B81C1/00 ,  B29K83/00

CPC分类号： B01L3/502707 ,  B29C33/3842 ,  B29C33/52 ,  B81C1/00119 ,  B01L2300/0874 ,  B29K2083/00 ,  B81C2201/0108

摘要： Provided is a microfluidic film including a first microfluidic film including a first base film, a first microchannel, which is formed on the first base film and through which a fluid flows, and a first through passage, which is configured to pass through the first base film, and a second microfluidic film including a second base film being stacked on the first base film and a second through passage, which is configured to pass through the second base film and communicates with the first through passage.