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    Anodized Metal Oxide Substrates Supporting Solid Support Feature Arrays for Patterned Flowcells
    2.
    发明申请
    Anodized Metal Oxide Substrates Supporting Solid Support Feature Arrays for Patterned Flowcells 有权

    公开(公告)号：US20250066849A1

    公开(公告)日：2025-02-27

    申请号：US18760831

    申请日：2024-07-01

    Applicant: Illumina, Inc.

    Inventor： Timothy Beerling

    IPC: C12Q1/6874 ,  B01L3/00 ,  C12Q1/6804

    Abstract: A flow cell assembly is provided that includes a support layer of low-background material, a film of anodized metal oxide (AMO) material adhered to the support layer, and a substrate formed, in part, by one or more patterns imparted in the AMO material. A flow cell assembly herein may include a support layer of low-background material, a film of AMO material adhered to the support layer, and a substrate surface comprising one or more patterns imparted in the AMO material. Each pattern may comprise an array of nanowell features surrounded by interstitial regions of featureless AMO film.

    FLUIDIC TRANSISTORS AND USES THEREOF
    4.
    发明申请
    FLUIDIC TRANSISTORS AND USES THEREOF 有权

    公开(公告)号：US20250065324A1

    公开(公告)日：2025-02-27

    申请号：US18287948

    申请日：2022-04-22

    Applicant: The General Hospital Corporation

    Inventor： Kaustav Aras Gopinathan ,  Mehmet Toner

    IPC: B01L3/00

    Abstract: A fluidic transistor comprising: a flow region configured to transport a first fluid; a gate region configured to contain a second fluid; and a deformable region disposed between the flow and gate regions, wherein the deformable region is configured to induce flow-limitation as the first fluid is transported within the flow region.

    Microfluidic chip and microfluidic device for physicochemically treating single cell, and method for physicochemically treating single cell by using microfluidic chip and microfluidic device
    6.
    发明授权
    Microfluidic chip and microfluidic device for physicochemically treating single cell, and method for physicochemically treating single cell by using microfluidic chip and microfluidic device 有权

    公开(公告)号：US12233417B2

    公开(公告)日：2025-02-25

    申请号：US16973555

    申请日：2018-07-16

    Applicant: SHENZHEN VITAVITRO BIOTECH CO., LTD.

    Inventor： Xiaozhen Lin ,  Jie Wu ,  Yanjing Fang

    IPC: B01L3/00 ,  C12M1/00 ,  C12M1/42

    Abstract: Provided is a microfluidic chip for physicochemically treating a single cell whose diameter is 50-400 micrometers. The body of the microfluidic chip comprises a fluidic layer, a pneumatic layer, and an elastic film sandwiched between the fluidic layer and the pneumatic layer; the fluidic layer comprises a switch-back single cell treating and retrieving channel, a first reagent inflow channel, a second reagent inflow channel, a reagent mixing channel, a third reagent inflow channel, a backwash channel, and a negative pressure and waste liquid sharing channel; the pneumatic layer comprises a pneumatic micro-valve group for controlling the opening and closing of each channel in the fluidic layer; the first reagent inflow channel and the second reagent inflow channel are separately connected with the inlet of the reagent mixing channel; the reagent mixing channel, the third reagent inflow channel, the backwash channel, and the negative pressure and waste liquid sharing channel are separately connected with the switch-back single cell treating and retrieving channel; and the third reagent inflow channel and the backwash channel are separately independent channels or share one channel. Also provided is a microfluidic device comprising the microfluidic chip and a method for physicochemically treating a single cell by using the microfluidic chip and the microfluidic device.

    GLASS CONTAINER COATED INTERNALLY WITH A METAL-ORGANIC FRAMEWORK
    9.
    发明申请
    GLASS CONTAINER COATED INTERNALLY WITH A METAL-ORGANIC FRAMEWORK 有权

    公开(公告)号：US20250059083A1

    公开(公告)日：2025-02-20

    申请号：US18723378

    申请日：2022-11-29

    Applicant: UNIVERSIDAD DE LA LAGUNA

    Inventor： Jorge Pasán García ,  Ivan Taima Mancera ,  Adrián Gutierrez Serpa ,  Patricia Napolitano Tabares ,  Verónica Pino Estévez ,  David Diaz Diaz ,  Juan Ayala Diaz

    IPC: C03C17/28 ,  B01L3/00

    Abstract: The present invention relates to a device consisting of a glass container, the inner walls of which have been modified after successive activation, silanisation and amidation reactions to house a porous crystalline coating. Said coating, which has the atomic sequence —Si—O—R-M-MOF, is covalently bonded to the inner wall of the container in an inverted radial manner, where R may be A) —Si—(CH2)3—NH—CH(═O)—(C6H4)—COO—; B) —Si—(CH2)n—NH—CH(═O)—(CH2)2—(C2HN3)—(CH2)n—(C6H4)—COO—; C) —Si—(CH2)n—O—CH2—CH(—OH)—CH2—NH—(CH2)n—(C6H4)—COO—; D) —Si—(CH2)n—S—(CH2)2—(CH2)n—(C6H4)—COO—, and M is a metal dependent on the type of MOF. The container can be used for the extraction and pre-concentration of analytes present in samples of different natures, from environmental to biological. The invention also relates to the use thereof for dosing medicines or for colouring or flavouring beverages.

    A MICROFLUIDIC SYSTEM
    10.
    发明申请
    A MICROFLUIDIC SYSTEM 有权

    公开(公告)号：US20250058319A1

    公开(公告)日：2025-02-20

    申请号：US18725408

    申请日：2022-12-29

    Applicant: miDiagnostics NV

    Inventor： David MIKAELIAN

    IPC: B01L3/00 ,  B01F33/30 ,  B01F35/71

    Abstract: The present inventive concept relates to a microfluidic system (10) for diluting a sample liquid of a predetermined sample volume. The system (10) comprises: a first sample channel (100) ending in a first valve (110), wherein the first sample channel (100) is arranged to contain the sample liquid of the predetermined volume; a buffer reservoir (120) arranged for receiving a buffer liquid; a timing channel (102) connecting the buffer reservoir (120) and the first valve (110), wherein the timing channel (102) is arranged to draw, by capillary action, buffer liquid from the buffer reservoir (120) to an output (1102) of the first valve (110) and to open the first valve (110), whereby sample liquid present in the first sample channel (100) is allowed to flow through the output (1102) of the first valve (110) together with buffer liquid from the timing channel (102); a buffer channel (104) connecting the buffer reservoir (120) and a second valve (112), wherein the buffer channel (104) is arranged to draw, by capillary action, buffer liquid from the buffer

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