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公开(公告)号：US20230390759A1
公开(公告)日：2023-12-07
申请号：US18236310
申请日：2023-08-21
发明人： Ian Kleinemolen , Armando Tovar , Jeffrey Hawkins , Florence Ying Lee , Peter R. Delmenico , Dena Marrinucci , Sean Ford , Rachel Krupa
IPC分类号： B01L3/00
CPC分类号： B01L3/502 , B01L2300/0816 , B01L2300/0887
摘要： An assay device includes a first flow channel of a first size and a second flow channel of a second size disposed within a planar substrate, the second size being larger than the first size. The first flow channel is configured to receive a liquid sample and allow a first flow of the liquid sample within the first flow channel whereby a first analyte of the liquid sample is distributed within the first flow channel as a first monolayer. The second flow channel is configured to receive the liquid sample and allow a second flow of the liquid sample within the second flow channel whereby a second analyte of the liquid sample is distributed within the second flow channel as a second monolayer. The first analyte has higher population density within the liquid sample compared to the second analyte.
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公开(公告)号：USD960386S1
公开(公告)日：2022-08-09
申请号：US29735086
申请日：2020-05-18
设计人： Jeff Hawkins , Dena Marrinucci , Ian Kleinemolen , Alan Quinn , Tyson Grant
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公开(公告)号：US20190086324A1
公开(公告)日：2019-03-21
申请号：US16082878
申请日：2017-03-23
摘要： Provided herein are systems, devices and methods for performing multianalyte detection in a biological sample, such as a human blood sample. Multiwell plates useful for performing multianalyte detection are also provided. The systems, devices and methods provided herein relate to the field of direct-to-consumer diagnostics (DTC diagnostics) and are useful, e.g., for facilitating consumer access to consumer healthcare and consumer wellness information. Other uses of the systems, devices and methods provided herein relate to the fields of medical research and drug discovery.
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公开(公告)号：US20240264072A1
公开(公告)日：2024-08-08
申请号：US18614181
申请日：2024-03-22
IPC分类号： G01N21/03 , B01L3/00 , G01N21/07 , G01N21/76 , G01N33/02 , G01N33/15 , G01N33/18 , G01N33/49 , G01N33/493
CPC分类号： G01N21/0303 , B01L3/502 , B01L3/502715 , G01N21/07 , G01N21/76 , G01N33/02 , G01N33/15 , G01N33/1893 , G01N33/4915 , G01N33/493 , B01L3/50273 , B01L3/5085 , B01L2300/0663 , B01L2300/0858 , B01L2300/0861 , B01L2300/087 , B01L2400/0409 , G01N2021/0325
摘要： A device includes a lower reservoir surface, an upper reservoir surface, and a reservoir sidewall extending between the upper and lower reservoir surfaces which together define a reservoir. The reservoir is configured to be completely filled by a liquid such that the liquid forms a column contacting the upper reservoir surface, the lower reservoir surface, and the reservoir sidewall, with a meniscus of the liquid being outside of the reservoir. At least one of the upper reservoir surface and the lower reservoir surface is configured to transmit light.
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公开(公告)号：US20230228674A1
公开(公告)日：2023-07-20
申请号：US17968674
申请日：2022-10-18
CPC分类号： G01N21/253 , G01N21/6452 , B01L3/5085 , B01L3/545 , G01N33/5304 , G01N2021/1738
摘要： Provided herein are systems, devices and methods for performing multianalyte detection in a biological sample, such as a human blood sample. Multiwell plates useful for performing multianalyte detection are also provided. The systems, devices and methods provided herein relate to the field of direct-to-consumer diagnostics (DTC diagnostics) and are useful, e.g., for facilitating consumer access to consumer healthcare and consumer wellness information. Other uses of the systems, devices and methods provided herein relate to the fields of medical research and drug discovery.
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公开(公告)号：USD959019S1
公开(公告)日：2022-07-26
申请号：US29735096
申请日：2020-05-18
设计人： Jeff Hawkins , Dena Marrinucci , Ian Kleinemolen , Alan Quinn , Tyson Grant
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公开(公告)号：US20200064254A1
公开(公告)日：2020-02-27
申请号：US16516001
申请日：2019-07-18
IPC分类号： G01N21/03 , G01N33/49 , G01N21/76 , G01N33/493 , G01N33/02 , G01N33/18 , G01N33/15 , B01L3/00
摘要： A device includes a lower reservoir surface, an upper reservoir surface, and a reservoir sidewall extending between the upper and lower reservoir surfaces which together define a reservoir. The reservoir is configured to be completely filled by a liquid such that the liquid forms a column contacting the upper reservoir surface, the lower reservoir surface, and the reservoir sidewall, with a meniscus of the liquid being outside of the reservoir. At least one of the upper reservoir surface and the lower reservoir surface is configured to transmit light.
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公开(公告)号：US20240139732A1
公开(公告)日：2024-05-02
申请号：US18539226
申请日：2023-12-13
发明人： Jeff Hawkins , Ian Kleinemolen , Florence Lee , Matthew Tyson Grant , Dena MARRINUCCI , Xiaodong ZHAO
IPC分类号： B01L3/00
CPC分类号： B01L3/502707 , B01L2300/0645 , B01L2300/0887
摘要： A method of manufacturing a laminate microfluidic device is described herein. Also described is the microfluidic device manufactured via the method of the disclosure, as well as use of the device to perform an assay. The laminate device includes a substrate layer, an adhesive layer having a cured adhesive with one or more channels or recesses formed therein, and a top layer.
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公开(公告)号：US20240025147A1
公开(公告)日：2024-01-25
申请号：US18025376
申请日：2021-09-22
发明人： Eumene Lee , Tyson Grant , Steven Quintero
CPC分类号： B32B7/12 , B32B27/365 , B32B27/325 , B32B37/12 , B32B37/26 , B32B2250/24 , B32B2307/308
摘要： Methods of bonding plastics are described herein. The method includes providing a substrate having a melting temperature in a first range, providing a bonding film having a melting temperature in the first range, providing an adhesive layer, providing an optical film having a melting temperature in a second range, laminating the bonding film, the adhesive layer, and optical film together, and bonding the laminate to the substrate. Another method includes providing the substrate and the optical film, coating the substrate with a thermal matching layer having a melting temperature in the second range, or coating the optical film with a thermal matching layer having a melting temperature in the first range, and bonding the thermal matching layer to the substrate or the optical film that is uncoated with the thermal matching layer. A difference between melting temperatures of the substrate and the optical film is about 50 to 250° F.
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公开(公告)号：US20230279326A1
公开(公告)日：2023-09-07
申请号：US17925791
申请日：2021-05-18
摘要： The present disclosure provides a capture assembly optionally for use in an automated sample analyzer. The sample analyzer includes an optical assembly for scanning a sample well of a planar substrate, e.g., a multiwell plate that is loaded onto and secured to the capture assembly to perform an assay, e.g., detection of an analyte in the sample. The capture assembly automatically aligns the planar substrate about a rotational axis of a drive shaft and secures the substrate to the drive shaft to prevent unwanted movement or slippage of the substrate during starting, stopping and rotation of the substrate at varying rotational velocities thereby ensuring the sample well is reliably detected by the optical assembly.
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