公开(公告)号：US20240327766A9

公开(公告)日：2024-10-03

申请号：US18012547

申请日：2021-06-25

Applicant: DLOC BIOSYSTEMS, INC.

Inventor： Waddah Arkan Malaeb

IPC: C12M3/00 ,  C12M1/00 ,  C12M1/12 ,  C12M3/06

CPC classification number: C12M21/08 ,  C12M23/16 ,  C12M23/22 ,  C12M25/02 ,  C12M25/14

Abstract: The present disclosure is directed in one non-limiting embodiment to a biochip for growing ductal tissue including at least one membrane structure, wherein the membrane structure includes at least one porous membrane configured to provide a mimetic cellular environment, at least one chassis, wherein the at least one chassis includes a channel configured to support the at least one membrane structure and at least one microfluidic channel in fluid communication with the channel supporting the at least one membrane structure and at least one cover slip, wherein the at least one chassis is configured such that an internal space is provided within the at least one chassis and capable of creating at least one channel within the at least one chassis, wherein the internal space created between the chassis provides a compartment that is internal relative to the body of the chassis but external relative to the membrane structure.

公开(公告)号：US20240344004A1

公开(公告)日：2024-10-17

申请号：US18751005

申请日：2024-06-21

Applicant: DLOC BIOSYSTEMS, INC.

Inventor： Waddah MALAEB ,  Giulia GRIMALDI ,  Mustafa AMMOURI ,  Farid MALAEB ,  Bahaa Eddine EL ARIDI

IPC: C12M3/00 ,  B01L3/00 ,  C12M1/36 ,  C12M3/06

CPC classification number: C12M21/08 ,  B01L3/502715 ,  C12M23/16 ,  C12M41/48 ,  B01L2200/10 ,  B01L2300/0819 ,  B01L2400/0694

Abstract: A human-on-chip plate. The human-on-chip plate may include, at least one 3D culture biochip, at least one micro-valve, at least one microfluidic channel, at least one inlet or outlet plate port. The outlet ports from one chip may be connected to another chip by routing the valves. Multiple chips may be connected in parallel, in series or in combination and one or more chips in the human-on-chip plate may be bypassed. Each fluid connection may be altered independently and at any time. The at least one valving system connects or separates different compartments of and between the organ-on-chip system. The at least one inlet and one outlet ports to access and block the microchannels. The at least one valving system could allow for sampling, changing the model flow map, and introduce or reduce at least one fluidic chamber.