公开(公告)号：US12168794B2

公开(公告)日：2024-12-17

申请号：US17281063

申请日：2019-10-02

Applicant: OSLER DIAGNOSTICS LIMITED

Inventor： Stanislav Sokolov ,  James Merotra ,  Konstantinos Psarros ,  Samuel Whitby ,  Adriano Dos Santos ,  Flavio Cesar Bedatty Fernandes

IPC: G01N27/327 ,  C12Q1/00 ,  C12Q1/28

Abstract: Disclosed herein is a method for detecting a binding event between an immobilised primary antibody and a target analyte-secondary antibody-enzyme complex using an electrochemical measurement technique.

公开(公告)号：US20240353398A1

公开(公告)日：2024-10-24

申请号：US18682753

申请日：2022-08-11

Applicant: OSLER DIAGNOSTICS LIMITED

Inventor： Konstantinos PSARROS ,  Peter READER ,  Sean Edward GOODWIN ,  Thurein THANT ,  Maryam Noor ALI ,  Madiha Fatima DILPAZIR ,  Olivia JONES ,  Fatiha MEDJAHED

IPC: G01N33/53 ,  G01N33/543 ,  G01N33/68

CPC classification number: G01N33/5306 ,  G01N33/54333 ,  G01N33/6887 ,  G01N2333/4712

Abstract: The present invention relates to compositions suitable for use in immunoassays and method of conducting immunoassays using compositions of the invention. The present invention relates to compositions comprising block co-polymers and/or chaotropic agents which are useful as buffer, diluent and/or washing solutions in immunoassays and immunoassay methods.

公开(公告)号：US20240342716A1

公开(公告)日：2024-10-17

申请号：US18293300

申请日：2022-07-29

Applicant: OSLER DIAGNOSTICS LIMITED

Inventor： Barry LILLIS ,  Jasper MALINSON ,  Jimishkumar PATEL ,  Myles WHITING ,  Richard LUXTON ,  Mark YEOMAN

IPC: B01L3/00

CPC classification number: B01L3/502746 ,  B01L3/502715 ,  B01L3/502738 ,  B01L2200/0621

Abstract: Embodiments described herein relate to a liquid handling device, comprising: an inlet conduit configured to receive a liquid sample; a first flow path comprising a sample adequacy control chamber in fluidic communication with the inlet conduit, wherein the sample adequacy control chamber is configured to allow the presence or absence of a volume of liquid within the sample adequacy control chamber to be determined; and a second flow path in fluidic communication with the inlet conduit, wherein the second flow path is configured to provide a higher hydraulic resistance than the first flow path.

公开(公告)号：US20240019423A1

公开(公告)日：2024-01-18

申请号：US17413368

申请日：2019-12-13

Applicant: OSLER DIAGNOSTICS LIMITED

Inventor： Dene Baldwin ,  Konstantinos Psarros ,  David William Neil Edington

IPC: G01N33/543

CPC classification number: G01N33/54353 ,  G01N33/5438 ,  G01N2470/04 ,  G01N2470/10

Abstract: A microfluidic device is provided for conducting multiplex immunoassays to detect multiple target analytes in a liquid sample using a set of tags and anti-tags. The device comprises an array of different anti-tags immobilised on a surface of a sensor for measuring a signal. Each anti-tag is arranged to immobilise a tagged antibody or tagged antigen thereby in use separating tagged immune complexes from the liquid phase affecting the signal measured. The device comprises a sensor chamber for tagged immune complexes to form in the liquid phase and one or more detection zones each comprising the array of different anti-tags for immobilising tagged immune complexes. In use, liquid comprising the tagged immune complexes flows or is fluidically driven from the sensor chamber to the detection zone(s).

公开(公告)号：US20240377346A1

公开(公告)日：2024-11-14

申请号：US18681757

申请日：2022-08-04

Applicant: OSLER DIAGNOSTICS LIMITED

Inventor： Brian Peter HARROP ,  Sean Edward GOODWIN ,  Flavio Cesar Bedatty FERNANDES ,  Alexander Drew TODD ,  Daniel DE BURCA ,  Stanislav SOKOLOV ,  Michael Alexander O'CONNELL

IPC: G01N27/22 ,  G01N33/49

Abstract: A method of determining haematocrit or haemoglobin concentration of a blood sample comprises calculating, based on a plurality of complex capacitance values of the blood sample, a complex capacitance at a predetermined imaginary component value, each of the plurality of complex capacitance values of the blood sample having a corresponding frequency; and determining the haematocrit or haemoglobin concentration based on the calculated complex capacitance or a real component of the calculated complex capacitance.

公开(公告)号：US12078255B2

公开(公告)日：2024-09-03

申请号：US17916004

申请日：2021-03-30

Applicant: Osler Diagnostics Limited

Inventor： Barry Lillis ,  Steven Green ,  Damian Holland

IPC: F16K11/16 ,  B01L3/00 ,  F16K31/524 ,  F16K99/00

CPC classification number: F16K11/165 ,  B01L3/502715 ,  B01L3/502738 ,  F16K31/52491 ,  F16K99/0026 ,  F16K99/0028 ,  F16K99/0042 ,  B01L2200/025 ,  B01L2300/0887 ,  B01L2400/0655

Abstract: The present disclosure relates to an actuator, an actuator assembly, a method of operating an actuator, a computer program and a system. In one aspect, an actuator may comprise a plurality of independently operable actuation elements and an operator having an operator surface. Each actuation element may have an actuation surface. The operator may be driveable to move the operator surface along a path to selectively engage with the respective actuation surface of each actuation element to actuate the actuation element.

公开(公告)号：US20240189824A1

公开(公告)日：2024-06-13

申请号：US18553189

申请日：2022-04-01

Applicant: Osler Diagnostics Limited

Inventor： Stuart MAY ,  Mark YEOMAN ,  Mark HYLAND ,  Richard LUXTON ,  Barry LILLIS

IPC: B01L3/00

CPC classification number: B01L3/523 ,  B01L2200/0684 ,  B01L2200/0689 ,  B01L2200/16 ,  B01L2300/044 ,  B01L2300/047 ,  B01L2300/0672 ,  B01L2300/0851 ,  B01L2400/0481 ,  B01L2400/0487

Abstract: Embodiments described herein relate to a liquid handling apparatus, comprising: a capsule configured to store a liquid reagent; a liquid handling device, comprising: a first conduit in fluidic communication with a first port; and a second conduit in fluidic communication with a second port; and a capsule interface mechanism configured to create: a first opening in the capsule in fluidic communication with the first port; and a second opening in the capsule in fluidic communication with the second port; wherein creating the first opening and the second opening allows the liquid reagent to be removed from the capsule.

公开(公告)号：USD1030796S1

公开(公告)日：2024-06-11

申请号：US29825342

申请日：2022-01-31

Applicant: Osler Diagnostics Limited

Designer： Barry David Lillis ,  David George Robinson ,  Michael Kew ,  Jan Konig ,  Janina Hippelein

Abstract: The file of this patent contains at least one drawing/photograph executed in color. Copies of this patent with color drawing(s)/photograph(s) will be provided by the Office upon request and payment of the necessary fee.
FIG. 1 is a front view of a display screen with graphical user interface for analyzer showing the claimed design in accordance with one embodiment.
FIG. 2 is a front view of a display screen with graphical user interface for analyzer showing the claimed design in accordance with another embodiment; and,
FIG. 3 is a front view of a display screen with graphical user interface for analyzer showing the claimed design in accordance with another embodiment.
The broken line showing of a device and a display screen with graphical user interface is included for the purpose of showing portions of the article which form no part of the claimed design.

公开(公告)号：US20240181459A1

公开(公告)日：2024-06-06

申请号：US18553188

申请日：2022-04-01

Applicant: Osler Diagnostics Limited

Inventor： Mark HYLAND ,  Nuno REIS ,  Mark YEOMAN ,  Richard LUXTON ,  Barry LILLIS ,  Stuart MAY

IPC: B01L3/00

CPC classification number: B01L3/52 ,  B01L2200/026 ,  B01L2200/16

Abstract: Embodiments described herein relate to a liquid storage cavity, comprising: a base; one or more walls extending from the base, wherein the liquid storage cavity has a volume defined by the base and the one or more walls; and a periphery at which the one or more walls are joined to the base, wherein at least a portion of the periphery includes a peripheral recess defined by the base and at least one of the one or more walls, wherein the peripheral recess is configured to house a volume of liquid.

公开(公告)号：US20230147534A1

公开(公告)日：2023-05-11

申请号：US17916004

申请日：2021-03-30

Applicant: Osler Diagnostics Limited

Inventor： Barry Lillis ,  Steven Green ,  Damian Holland

IPC: F16K11/16 ,  B01L3/00 ,  F16K31/524 ,  F16K99/00

CPC classification number: F16K11/165 ,  B01L3/502715 ,  B01L3/502738 ,  F16K31/52491 ,  F16K99/0026 ,  F16K99/0028 ,  F16K99/0042 ,  B01L2200/025 ,  B01L2300/0887 ,  B01L2400/0655

Abstract: The present disclosure relates to an actuator, an actuator assembly, a method of operating an actuator, a computer program and a system. In one aspect, an actuator may comprise a plurality of independently operable actuation elements and an operator having an operator surface. Each actuation element may have an actuation surface. The operator may be driveable to move the operator surface along a path to selectively engage with the respective actuation surface of each actuation element to actuate the actuation element.