公开(公告)号：US20240327248A1

公开(公告)日：2024-10-03

申请号：US18744458

申请日：2024-06-14

申请人： Marquette University

发明人： Brooke Mayer ,  Kaushik Venkiteshwaran

IPC分类号： C02F1/28 ,  B01J20/34 ,  C02F101/10 ,  C02F103/34 ,  C12Q1/00 ,  G01N30/00 ,  G01N30/06 ,  G01N30/88

CPC分类号： C02F1/286 ,  B01J20/3475 ,  C12Q1/00 ,  G01N30/00 ,  G01N30/06 ,  C02F2101/105 ,  C02F2103/34 ,  C02F2303/16 ,  G01N30/88

摘要： The present invention provides systems and methods for concentrating and recovering phosphate from samples. The method comprises using immobilized PBP for binding phosphate and a desorption solution having a pH of 11 or greater to recover phosphate from a sample when the phosphate is found at very low detection levels. Further systems and method for removing arsenate for water sources is also provided.

公开(公告)号：US20240302317A1

公开(公告)日：2024-09-12

申请号：US18261325

申请日：2022-01-13

申请人： VIREX HEALTH, INC.

发明人： Mark William Grinstaff ,  Scott Edward Schaus ,  Jane P. Bearinger ,  Augustus Lang ,  Ziad Al-Shamsie ,  Dylann Ceriani

IPC分类号： G01N27/327 ,  C12Q1/00 ,  G01N33/569 ,  G01N33/68 ,  G01N33/74

CPC分类号： G01N27/3275 ,  C12Q1/005 ,  G01N27/3271 ,  G01N33/56983 ,  G01N33/6869 ,  G01N33/74 ,  G01N2333/165 ,  G01N2333/5412 ,  G01N2333/5756 ,  G01N2469/10

摘要： The strip systems, methods, devices and associated kits disclosed herein are used to determine the presence and/or level a target analyte(s) in sample (e.g., a biological sample such as saliva or nasal swab) wherein the target analyte(s) may be a microorganism (e.g., a whole virus) or molecule (e.g., a viral antigen) associated with a healthy state, disease or injury or otherwise altered physiological condition. In certain embodiments, the systems, methods, devices and kits provide one or more improved properties relative to the lateral flow protein and other assays known in the art for the detection, including but not limited to, assay time, ease of use, risk of infection, accuracy, specificity, selectivity, limit of detection of the assay, quantitative detection and the effect of common interferents to the sensor output, cost, simplicity or a combination thereof. In certain embodiments, the systems, assays, methods and kids are multiplexed, i.e., permit detection or monitoring of more than one target analyte (e.g., two different viruses or a virus and a bacterium).

公开(公告)号：US20240247297A1

公开(公告)日：2024-07-25

申请号：US18597704

申请日：2024-03-06

申请人： Abbott Diabetes Care Inc.

发明人： Tianmei OUYANG ,  Benjamin J. FELDMAN

IPC分类号： C12Q1/00 ,  A61B5/1486 ,  C12N11/082 ,  C12Q1/26 ,  G01N27/27 ,  G01N27/327 ,  G01N33/573 ,  G01N33/66

CPC分类号： C12Q1/001 ,  A61B5/14865 ,  C12N11/082 ,  C12Q1/004 ,  C12Q1/005 ,  C12Q1/006 ,  C12Q1/26 ,  G01N27/3275 ,  G01N33/5735 ,  G01N33/66 ,  C12Y106/05002 ,  G01N27/27

摘要： NADP-dependent oxidoreductase compositions, and electrodes, sensors and systems that include the same. Analyte sensors include an electrode having a sensing layer disposed thereon, the sensing layer comprising a polymer and an enzyme composition distributed therein. The enzyme composition includes nicotinamide adenine dinucleotide phosphate (NAD(P)+) or derivative thereof; an NAD(P)+-dependent dehydrogenase; an NAD(P)H oxidoreductase; and an electron transfer agent comprising a transition metal complex.

公开(公告)号：US20240238569A1

公开(公告)日：2024-07-18

申请号：US18239752

申请日：2023-08-29

申请人： One Drop Biosensor Technologies, LLC

发明人： Ashwin Pushpala ,  Alan Szmodis ,  Matthew Chapman ,  Weldon Hall ,  Scott Miller ,  Hooman Hafezi

IPC分类号： A61M37/00 ,  A61B5/00 ,  A61B5/145 ,  A61B5/1486 ,  A61B5/1495 ,  A61B5/15 ,  A61M25/00 ,  C12Q1/00 ,  G01N27/327

CPC分类号： A61M37/0015 ,  A61B5/14503 ,  A61B5/14514 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/14865 ,  A61B5/1495 ,  A61B5/150022 ,  A61B5/150282 ,  A61B5/150427 ,  A61B5/150969 ,  A61B5/150984 ,  A61B5/4839 ,  A61B5/685 ,  C12Q1/006 ,  G01N27/3271 ,  A61B2562/028 ,  A61B2562/12 ,  A61B2562/125 ,  A61M25/00 ,  A61M2037/0023 ,  A61M2037/0046 ,  A61M2037/0053 ,  Y10T29/49117

摘要： A microsensor and method of manufacture for a microsensor, comprising an array of filaments, wherein each filament of the array of filaments comprises a substrate and a conductive layer coupled to the substrate and configured to facilitate analyte detection. Each filament of the array of filaments can further comprise an insulating layer configured to isolate regions defined by the conductive layer for analyte detection, a sensing layer coupled to the conductive layer, configured to enable transduction of an ionic concentration to an electronic voltage, and a selective coating coupled to the sensing layer, configured to facilitate detection of specific target analytes/ions. The microsensor facilitates detection of at least one analyte present in a body fluid of a user interfacing with the microsensor.

公开(公告)号：US20240230578A1

公开(公告)日：2024-07-11

申请号：US18609422

申请日：2024-03-19

申请人： Radiometer Medical ApS

发明人： Thomas KJAER

IPC分类号： G01N27/327 ,  C12Q1/00 ,  G01N33/70

CPC分类号： G01N27/3274 ,  C12Q1/005 ,  G01N33/70 ,  G01N2333/90683 ,  G01N2333/986

摘要： A method of calibrating a device for measuring the concentration of creatinine using one or more calibration solutions, the method comprising: receiving concentrations at an initial time of creatine, Cr, and/or creatinine, Crn, of the one or more calibration solutions; receiving outputs of the measuring device at the end time; calculating the concentration of Cr and/or Crn in the calibration solutions at an end time using a temperature model, wherein the temperature model indicates changes in temperature of the calibration solutions from the initial time to the end time; and determining a relationship between the outputs of the measuring device and the calculated concentrations of Cr and/or Crn.

公开(公告)号：US20240226633A9

公开(公告)日：2024-07-11

申请号：US18538086

申请日：2023-12-13

申请人： Panasonic Intellectual Property Management Co., Ltd.

发明人： Fumiya WAYAMA ,  Noriyuki HATSUGAI ,  Yasuaki OKUMURA

IPC分类号： A62D3/115 ,  A62D3/02 ,  A62D3/37 ,  C12Q1/00

CPC分类号： A62D3/115 ,  A62D3/02 ,  A62D3/37 ,  C12Q1/001 ,  A62D2101/26

摘要： An immobilized enzyme electrode includes: an electrode; a redox enzyme that oxidizes or reduces a target molecule; and an electron carrier that performs electron transport between the electrode and the redox enzyme. The electron carrier is immobilized on the electrode via a first linker that is in a form of a chain, and the redox enzyme is immobilized on the electrode via a second linker that is longer than the first linker, the second linker being in a form of a chain.

公开(公告)号：US12029554B2

公开(公告)日：2024-07-09

申请号：US17822505

申请日：2022-08-26

申请人： Abbott Diabetes Care Inc.

发明人： Udo Hoss ,  Phu Le ,  Yi Wang ,  Frank David Fujimoto ,  Suyue Qian ,  Lam Tran

IPC分类号： A61B5/145 ,  A61B5/1473 ,  C12Q1/00

CPC分类号： A61B5/14532 ,  A61B5/1473 ,  C12Q1/001 ,  C12Q1/006

摘要： Embodiments of the present disclosure relate to analyte determining methods and devices (e.g., electrochemical analyte monitoring systems) that have a sensing surface that includes two or more sensing elements disposed laterally to each other, where the sensing surface is on a working electrode of in vivo and/or in vitro analyte sensors, e.g., continuous and/or automatic in vivo monitoring using analyte sensors and/or test strips. Also provided are systems and methods of using the, for example electrochemical, analyte sensors in analyte monitoring.

公开(公告)号：US20240218415A1

公开(公告)日：2024-07-04

申请号：US17907111

申请日：2021-03-25

申请人： Universal Sequencing Technology Corporation

发明人： Peiming Zhang ,  Sanjay B. Hari ,  Kisup Chung ,  Ming Lei

IPC分类号： C12Q1/00

CPC分类号： C12Q1/001

摘要： This invention is related to a nanogap device for the electronic sensing of biomolecules.

公开(公告)号：US20240200117A1

公开(公告)日：2024-06-20

申请号：US18555853

申请日：2021-04-29

申请人： BIOSENSE INC.

发明人： Paul LAMBERT ,  David Shimomoto SANCHEZ ,  Luis Angel Bojorquez VAZQUEZ

IPC分类号： C12Q1/00

CPC分类号： C12Q1/005 ,  C12Q1/006

摘要： A biosensor for monitoring one or more metabolites within a base fluid includes at least one working electrode having an inert conductive layer, a catalyst layer deposited over the inert conductive layer comprising a nanocomposite through which hydrogen peroxide may be adsorbed, an enzyme layer deposited over the catalyst layer comprising one or more enzymes selected to perform a redox reaction towards one or more metabolites, and a binder membrane providing supporting structure to the inert conductive layer, the catalyst layer, and the enzyme layer, the binder membrane selectively allowing molecules having a weight or size below a threshold from passing therethrough. The biosensor also includes an electrical interface in electrical communication with the inert conductive layer and configured to receive an electrical signal indicative of metabolites from the working electrode resulting from a biochemical reaction at or generated by one or more of the layers.

公开(公告)号：US12013396B2

公开(公告)日：2024-06-18

申请号：US16941933

申请日：2020-07-29

申请人： TEXAS TECH UNIVERSITY SYSTEM

发明人： Dimitri Pappas

IPC分类号： G01N33/569 ,  B01L3/00 ,  G01N33/543 ,  C12Q1/00 ,  G01N33/00

CPC分类号： G01N33/56972 ,  B01L3/50273 ,  G01N33/54366 ,  G01N33/569 ,  C12Q1/00 ,  G01N33/00

摘要： Disclosed is a system and method for a microdevice to separate blood cells based on differences in antigen expression. Specifically, cells of the same phenotype are separated based on whether or not they are activated during infection or resting. The device of the present disclosure takes a small sample of blood and provides differential cell counts that can be used to test for infection and inflammatory response. The device can be used to identify sepsis and other infections rapidly. By measuring differences in activated white cell counts such as neutrophils, the device of the present disclosure measures physiological response to infection in hospitalized patients recovering from burns, surgeries, etc.