公开(公告)号：US12076518B2

公开(公告)日：2024-09-03

申请号：US17522878

申请日：2021-11-09

Applicant: YourBio Health, Inc.

Inventor： Shawn Davis ,  Donald E. Chickering, III ,  Ramin Haghgooie

IPC: A61M37/00 ,  A61B5/15 ,  A61B5/151 ,  A61B5/157

CPC classification number: A61M37/0015 ,  A61B5/150022 ,  A61B5/150221 ,  A61B5/150229 ,  A61B5/150282 ,  A61B5/150427 ,  A61B5/150435 ,  A61B5/150503 ,  A61B5/150511 ,  A61B5/150984 ,  A61B5/15113 ,  A61B5/15144 ,  A61B5/157 ,  A61B5/150526 ,  A61M2037/0023 ,  A61M2037/0046 ,  A61M2037/0053 ,  Y10T29/4998

Abstract: The present invention generally relates to systems and methods for delivering and/or receiving a substance or substances such as blood, from subjects, e.g., from the skin and/or from beneath the skin. In one aspect, the present invention is generally directed to devices and methods for receiving or extracting blood from a subject, e.g., from the skin and/or from beneath the skin, using devices containing a fluid transporter (for example, one or more microneedles), and a storage chamber having an internal pressure less than atmospheric pressure prior to receiving blood. In some cases, the device may be self-contained, and in certain instances, the device can be applied to the skin, and activated to receive blood from the subject. The device, or a portion thereof, may then be processed to determine the blood and/or an analyte within the blood, alone or with an external apparatus. For example, blood may be received from the device, and/or the device may contain sensors or agents able to determine the blood and/or an analyte suspected of being contained in the blood. In another aspect, the present invention is generally directed to arrangements of skin insertion objects such as microneedles and methods of forming and arranging skin insertion objects. Other aspects of the present invention are directed at other devices for receiving blood (or other bodily fluids, e.g., interstitial fluid), kits involving such devices, methods of making such devices, methods of using such devices, and the like.

公开(公告)号：US10034628B2

公开(公告)日：2018-07-31

申请号：US13721604

申请日：2012-12-20

Applicant: Sanofi-Aventis Deutschland GmbH

Inventor： Dominique M. Freeman ,  Don Alden

IPC: A61B5/157 ,  A61B5/15 ,  A61B5/00 ,  A61B5/151

CPC classification number: A61B5/157 ,  A61B5/1411 ,  A61B5/150022 ,  A61B5/150167 ,  A61B5/150175 ,  A61B5/150282 ,  A61B5/150427 ,  A61B5/150511 ,  A61B5/15123 ,  A61B5/15151 ,  A61B5/15161 ,  A61B5/411

Abstract: Reducing the volume or drag on skin or sharpness of the penetrating member entering the wound during the cutting process will reduce the pain associated with lancing, and result in less power desired for retraction of the penetrating member from the skin. A variety of other penetrating member configuration as shown in the application.

公开(公告)号：US09937298B2

公开(公告)日：2018-04-10

申请号：US12335765

申请日：2008-12-16

Applicant: Dominique M. Freeman ,  Don Alden

Inventor： Dominique M. Freeman ,  Don Alden

IPC: A61M5/46 ,  A61B5/15 ,  A61B5/151 ,  G01N33/557 ,  A61M5/158 ,  A61B5/157 ,  A61B5/145 ,  A61B17/3209 ,  A61M5/00 ,  B01L3/00 ,  G01N33/49

CPC classification number: A61M5/46 ,  A61B5/14532 ,  A61B5/150022 ,  A61B5/150061 ,  A61B5/150068 ,  A61B5/150099 ,  A61B5/150152 ,  A61B5/150167 ,  A61B5/150175 ,  A61B5/15019 ,  A61B5/150213 ,  A61B5/150221 ,  A61B5/150358 ,  A61B5/150427 ,  A61B5/150503 ,  A61B5/150572 ,  A61B5/15113 ,  A61B5/15117 ,  A61B5/15123 ,  A61B5/15146 ,  A61B5/15151 ,  A61B5/15153 ,  A61B5/15163 ,  A61B5/15169 ,  A61B5/15171 ,  A61B5/15176 ,  A61B5/15178 ,  A61B5/15184 ,  A61B5/15186 ,  A61B5/157 ,  A61B17/32093 ,  A61M5/158 ,  A61M2005/004 ,  B01L3/5027 ,  B01L3/502715 ,  B01L3/50273 ,  B01L3/502746 ,  B01L2200/10 ,  B01L2300/0663 ,  B01L2300/18 ,  G01N33/4905 ,  G01N33/557 ,  G06F19/00

Abstract: A tissue penetration device includes a magnetic source that produces a controllable magnetic field in a magnetically active region adjacent the magnetic source. A magnetic member is disposed at least partially in the magnetically active region. A permanent magnet is disposed at a proximal end of the magnetically active region for zeroing the position of the magnetic member while the tissue penetration device is inactive.

公开(公告)号：US09802007B2

公开(公告)日：2017-10-31

申请号：US14082434

申请日：2013-11-18

Applicant: Sanofi-Aventis Deutschland GmbH

Inventor： Mark Castle ,  Rodney Kugizaki ,  Robert Englert ,  Thomas Shoup ,  Dominique M. Freeman

IPC: A61B5/00 ,  A61M5/46 ,  A61B5/15 ,  A61B5/157 ,  A61M5/145 ,  A61M5/172 ,  A61M5/20 ,  A61M5/32 ,  A61B5/151

CPC classification number: A61M5/46 ,  A61B5/150022 ,  A61B5/150083 ,  A61B5/150091 ,  A61B5/150099 ,  A61B5/150137 ,  A61B5/150152 ,  A61B5/15016 ,  A61B5/150167 ,  A61B5/150175 ,  A61B5/15019 ,  A61B5/150259 ,  A61B5/150267 ,  A61B5/150282 ,  A61B5/15029 ,  A61B5/150427 ,  A61B5/150572 ,  A61B5/150748 ,  A61B5/150809 ,  A61B5/150816 ,  A61B5/150824 ,  A61B5/150946 ,  A61B5/150954 ,  A61B5/15109 ,  A61B5/15113 ,  A61B5/15123 ,  A61B5/15153 ,  A61B5/15155 ,  A61B5/15163 ,  A61B5/15169 ,  A61B5/15171 ,  A61B5/15176 ,  A61B5/15178 ,  A61B5/15184 ,  A61B5/15186 ,  A61B5/1519 ,  A61B5/15192 ,  A61B5/15194 ,  A61B5/157 ,  A61M5/145 ,  A61M5/172 ,  A61M5/20 ,  A61M5/3287 ,  A61M5/3295 ,  A61M2005/206 ,  A61M2205/33 ,  A61M2205/50

Abstract: A lancet driver is provided wherein the driver exerts a driving force on a lancet during a lancing cycle and is used on a tissue site. The driver comprises of a drive force generator for advancing the lancet along a path into the tissue site, and a manual switch for a user interface input.

公开(公告)号：US20170086724A1

公开(公告)日：2017-03-30

申请号：US15377407

申请日：2016-12-13

Applicant: Sano Intelligence, Inc.

Inventor： Ashwin Pushpala ,  Alan Szmodis ,  Matthew Chapman ,  Weldon Hall ,  Scott Miller ,  Hooman Hafezi

IPC: A61B5/1486 ,  C12Q1/00 ,  A61B5/00 ,  G01N27/327 ,  A61B5/145 ,  A61B5/15

CPC classification number: A61M37/0015 ,  A61B5/14503 ,  A61B5/14514 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/14865 ,  A61B5/1495 ,  A61B5/150022 ,  A61B5/150282 ,  A61B5/150427 ,  A61B5/150969 ,  A61B5/150984 ,  A61B5/4839 ,  A61B5/685 ,  A61B2562/028 ,  A61B2562/12 ,  A61B2562/125 ,  A61M25/00 ,  A61M2037/0023 ,  A61M2037/0046 ,  A61M2037/0053 ,  C12Q1/006 ,  G01N27/3271 ,  Y10T29/49117

Abstract: A microsensor and method of manufacture for a microsensor, comprising an array of filaments, wherein each filament of the array of filaments comprises a substrate and a conductive layer coupled to the substrate and configured to facilitate analyte detection. Each filament of the array of filaments can further comprise an insulating layer configured to isolate regions defined by the conductive layer for analyte detection, a sensing layer coupled to the conductive layer, configured to enable transduction of an ionic concentration to an electronic voltage, and a selective coating coupled to the sensing layer, configured to facilitate detection of specific target analytes/ions. The microsensor facilitates detection of at least one analyte present in a body fluid of a user interfacing with the microsensor.

公开(公告)号：US09526446B2

公开(公告)日：2016-12-27

申请号：US14401947

申请日：2013-05-31

Applicant: SANOFI-AVENTIS DEUTSCHLAND GMBH

Inventor： Frank Richter ,  Ross MacArthur ,  Elizabeth Wolseley-Hext ,  Joseph Cowan ,  Lee Smith ,  David Mills

IPC: A61B5/151 ,  A61B5/15 ,  A61B5/145 ,  A61B5/1477 ,  A61B5/157 ,  A61B5/00 ,  A61B5/1486

CPC classification number: A61B5/15174 ,  A61B5/1411 ,  A61B5/14532 ,  A61B5/1477 ,  A61B5/1486 ,  A61B5/150022 ,  A61B5/150068 ,  A61B5/150175 ,  A61B5/150251 ,  A61B5/150358 ,  A61B5/150427 ,  A61B5/150519 ,  A61B5/150526 ,  A61B5/150755 ,  A61B5/15109 ,  A61B5/15113 ,  A61B5/15115 ,  A61B5/15123 ,  A61B5/15153 ,  A61B5/15155 ,  A61B5/15161 ,  A61B5/157 ,  A61B5/742 ,  A61B5/7475 ,  A61B2562/0295

Abstract: A testing member for eliciting blood samples is provided that can be rotatably mounted inside a cartridge and having a lancet for lancing a body part of a user. The lancet can protrude from an edge of the testing member. The testing member also can have a second blood collection part, and second contact pads, where the second contact pads being electrically connected to the second blood collection part, the second blood collection part and second contact pads together being configured to facilitate an analysis of the quantity of blood in a first blood sample in the second blood collection part. A blood analysis part and first contact pads can be included, where the first contact pads are electrically connected to the blood analysis part, the blood analysis part and first contact pads together being configured to facilitate an analysis of a second blood sample in the blood analysis part.

Abstract translation: 提供了一种用于引导血液样本的测试构件，其可旋转地安装在盒中并具有用于使用户的身体部分穿刺的刺血针。 刺血针可以从测试构件的边缘突出。 测试构件还可以具有第二采血部分和第二接触垫，其中第二接触垫电连接到第二采血部分，第二采血部分和第二接触垫一起配置成有助于分析 第二血液收集部中的第一血液样品中的血液量。 可以包括血液分析部分和第一接触垫，其中第一接触垫电连接到血液分析部分，血液分析部分和第一接触垫一起构造成便于血液分析中第二血液样本的分析 部分。

公开(公告)号：US09351680B2

公开(公告)日：2016-05-31

申请号：US10574373

申请日：2004-10-14

Applicant: Dirk Boecker

Inventor： Dirk Boecker

IPC: A61B5/00 ,  A61B5/157 ,  A61B5/15 ,  A61B5/145

CPC classification number: A61B5/157 ,  A61B5/0002 ,  A61B5/1411 ,  A61B5/14532 ,  A61B5/150022 ,  A61B5/150152 ,  A61B5/150167 ,  A61B5/150175 ,  A61B5/150427 ,  A61B5/150503 ,  A61B5/15087 ,  A61B5/15113 ,  A61B5/15117 ,  A61B5/15123 ,  A61B5/7475 ,  A61B2560/0271 ,  A61B2560/0276 ,  A61B2560/04 ,  A61B2560/0475 ,  G06F19/00

Abstract: An analyte monitoring system is provided. The system may include a housing (200) and a visual display (206) on the housing (200), the visual display (206) having at lease one visual indicator position next to a corresponding marking (208, 210, 212, 214 and 216) on the housing (200). The system may include a processor (60) driving the visual display (206), wherein the processor (60) runs software that is modifiable to provide a variable user interface on the visual display (206). The system may include a wireless communication to allow applets or programs to be down-loaded by the processor (60).

Abstract translation: 提供分析物监测系统。 所述系统可以包括壳体（200）上的壳体（200）和视觉显示器（206），所述视觉显示器（206）具有至少一个视觉指示器位置，紧邻相应的标记（208,210,212,214和 216）。 系统可以包括驱动视觉显示器（206）的处理器（60），其中处理器（60）运行可修改以在视觉显示器（206）上提供可变用户界面的软件。 系统可以包括无线通信以允许小计程序或程序由处理器（60）下载。

公开(公告)号：US20160128615A1

公开(公告)日：2016-05-12

申请号：US14996751

申请日：2016-01-15

Applicant: ABBOTT DIABETES CARE INC.

Inventor： Samuel M. Curry ,  Manuel L. Donnay ,  Tuan Nguyen ,  Louis G. Pace ,  Peter G. Robinson ,  Phillip Yee

IPC: A61B5/15 ,  A61B5/00 ,  A61M5/158 ,  A61B5/151

CPC classification number: A61B5/150022 ,  A61B5/0002 ,  A61B5/01 ,  A61B5/1411 ,  A61B5/14503 ,  A61B5/14532 ,  A61B5/14542 ,  A61B5/14546 ,  A61B5/15016 ,  A61B5/150259 ,  A61B5/150282 ,  A61B5/150396 ,  A61B5/150419 ,  A61B5/150427 ,  A61B5/150511 ,  A61B5/150732 ,  A61B5/15087 ,  A61B5/15107 ,  A61B5/15113 ,  A61B5/15117 ,  A61B5/1513 ,  A61B5/15186 ,  A61B5/1519 ,  A61B5/15194 ,  A61B5/157 ,  A61B5/6865 ,  A61B17/34 ,  A61M5/158 ,  A61M2005/1585

Abstract: An apparatus for insertion of a medical device in the skin of a subject is provided, as well as methods of inserting medical devices.

Abstract translation: 提供了用于将医疗装置插入被检体的皮肤的装置以及插入医疗装置的方法。

公开(公告)号：US09314194B2

公开(公告)日：2016-04-19

申请号：US11622389

申请日：2007-01-11

Applicant: Ajay Deshmukh ,  Dominique Freeman ,  Dirk Boecker ,  Don Alden

Inventor： Ajay Deshmukh ,  Dominique Freeman ,  Dirk Boecker ,  Don Alden

IPC: A61B5/00 ,  B65D81/00 ,  A61B17/32 ,  A61B5/15 ,  A61B5/155 ,  A61B5/151 ,  A61M5/00

CPC classification number: A61B5/1411 ,  A61B5/1427 ,  A61B5/150022 ,  A61B5/150061 ,  A61B5/150068 ,  A61B5/150099 ,  A61B5/150152 ,  A61B5/150167 ,  A61B5/150175 ,  A61B5/150221 ,  A61B5/150358 ,  A61B5/150427 ,  A61B5/150503 ,  A61B5/150572 ,  A61B5/15113 ,  A61B5/15117 ,  A61B5/15123 ,  A61B5/15146 ,  A61B5/15151 ,  A61B5/15153 ,  A61B5/15163 ,  A61B5/15169 ,  A61B5/15171 ,  A61B5/15174 ,  A61B5/15176 ,  A61B5/15178 ,  A61B5/15184 ,  A61B5/15186 ,  A61B5/157 ,  A61M2005/005

Abstract: A body fluid sampling system is provided for use on a tissue site. A drive force generator is coupled to penetrating members. The penetrating members are at least partially housed in a penetrating member housing. The penetrating member housing has openings for the penetrating members. The penetrating members are launched along a launch path by the drive force generator through an opening in the penetrating member housing. Analyte sensors are housed in a analyte sensor housing. Each analyte sensor is associated with a penetrating member. The analyte sensor housing and the penetrating member housing are coupled to provide that each analyte sensor is positioned out of a launch path of a penetrating member. The analyte sensor housing includes desiccant pockets for receiving desiccant plugs.

Abstract translation: 提供体液采样系统用于组织部位。 驱动力发生器联接到穿透构件。 穿透构件至少部分地容纳在穿透构件壳体中。 穿透构件壳体具有用于穿透构件的开口。 穿透构件通过驱动力发生器沿着发射路径通过穿透构件壳体中的开口而发射。 分析物传感器容纳在分析物传感器外壳中。 每个分析物传感器与穿透构件相关联。 分析物传感器壳体和穿透构件壳体被联接以提供每个分析物传感器位于穿透构件的发射路径之外。 分析物传感器外壳包括用于接收干燥剂塞的干燥剂袋。

公开(公告)号：US09265896B2

公开(公告)日：2016-02-23

申请号：US14377235

申请日：2013-02-14

Applicant: SHINMAYWA INDUSTRIES, LTD.

Inventor： Kensuke Uemura ,  G. Alexey Remnev ,  V. Konstantin Shalnov

IPC: B21G1/08 ,  C23C14/24 ,  A61M5/158 ,  A61M5/32 ,  A61B5/15 ,  C23C14/00 ,  C23C14/58 ,  A61B17/06 ,  C23C8/06 ,  B21G1/12

CPC classification number: A61M5/3286 ,  A61B5/150282 ,  A61B5/150396 ,  A61B5/150427 ,  A61B2017/06071 ,  A61M2207/00 ,  B21G1/08 ,  B21G1/12 ,  C23C8/06 ,  C23C14/0042 ,  C23C14/5826 ,  C23F4/00 ,  Y10T29/49885

Abstract: Provided is a method for producing a puncture needle, which causes no significant pain during use such as when pierced. The method for producing the puncture needle includes the step of processing a pipe-like metallic base material having at one end a grinding surface obtained by machine work with plasma generated in an atmosphere filled with a mixed gas mainly including a main gas and a reaction gas.

Abstract translation: 本发明提供一种穿刺针的制造方法，其在使用时不会引起如穿刺时的显着疼痛。 制造穿刺针的方法包括以下步骤：将管状金属基材的一端加工成具有通过机械加工获得的研磨面，所述研磨面在填充有主要气体和反应气体的混合气体的气氛中产生的等离子体 。