公开(公告)号：US20240350786A1

公开(公告)日：2024-10-24

申请号：US18757648

申请日：2024-06-28

Applicant: ProCell Therapies, LLC

Inventor： Mitchell Edward Schwartz ,  Daniel Troyen-Schwartz ,  Steven D. Troyen

IPC: A61M37/00

CPC classification number: A61M37/0015 ,  A61M2037/0023 ,  A61M2037/0061

Abstract: A micro-channeling system, the system includes a micro-channeling device, a needle tip connector and a variety of micro-needling assemblies. The micro-channeling device is designed to provide reciprocal motion, in and out of skin, for the micro-needling assemblies when applied to skin. A quick connector is provided for easy interchange of the micro-needling assemblies. Benefits of the system include ergonomic holding, versatility of needle arrays and reduced vibration.

公开(公告)号：US12115333B2

公开(公告)日：2024-10-15

申请号：US17244324

申请日：2021-04-29

Applicant: MuPharma Pty Ltd

Inventor： Harry Unger ,  Mark Unger ,  Sean Michael Langelier

IPC: A61M37/00 ,  A61K39/00 ,  A61K39/12 ,  A61K39/21 ,  A61K41/00 ,  A61N1/30 ,  A61N7/00 ,  C12N7/00

CPC classification number: A61M37/0092 ,  A61K39/12 ,  A61K39/21 ,  A61K41/0047 ,  A61M37/0015 ,  A61N1/30 ,  A61N7/00 ,  C12N7/00 ,  A61K2039/5256 ,  A61K2039/54 ,  A61M2037/0007 ,  A61M2037/0023 ,  A61M2205/3344 ,  A61M2205/3375 ,  C12N2710/24021 ,  C12N2710/24043 ,  C12N2710/24143 ,  C12N2740/16034 ,  C12N2740/16071

Abstract: There is disclosed systems and methods for non-invasive delivery of an agent to biological tissues. Delivery of the agent to the tissues can be by one or more modalities. In some embodiments the systems and methods use agent carrier body including a tissue contacting surface for non-invasively engaging tissues under treatment. The tissue contacting surface can be at least partly defined by a plurality of protrusions that are in fluid communication with one or more reservoirs forming part of the agent carrier body. The protrusions may extend outward from an inside of a void and terminate at said tissue contacting surface.

公开(公告)号：US20240325546A1

公开(公告)日：2024-10-03

申请号：US18593212

申请日：2024-03-01

Applicant: UNIVERSITY OF MASSACHUSETTS ,  MCGILL UNIVERSITY

Inventor： Hassan H. Fakih ,  Hanadi Sleiman ,  Anastasia Khvorova ,  Qi Tang ,  John E. Harris ,  Julia Alterman ,  Mohammad Zain Ul Abideen ,  Raymond Furgal

IPC: A61K47/54 ,  A61M37/00 ,  C12N15/113

CPC classification number: A61K47/549 ,  A61K47/542 ,  A61M37/0015 ,  C12N15/113 ,  A61M2037/0023 ,  A61M2037/0046 ,  A61M2037/0061 ,  C12N2310/14 ,  C12N2310/351

Abstract: This disclosure provides compositions, systems, and methods for the topical delivery of therapeutic oligonucleotides with microneedle particles.

公开(公告)号：US12070567B2

公开(公告)日：2024-08-27

申请号：US17712755

申请日：2022-04-04

Applicant: Georgia Tech Research Corporation

Inventor： Andrew Tadros ,  Mark R. Prausnitz

IPC: A61M37/00 ,  A61K8/02 ,  A61K9/00 ,  A61K31/352 ,  A61Q19/00

CPC classification number: A61M37/0015 ,  A61K8/0204 ,  A61K8/0245 ,  A61K9/0021 ,  A61K31/352 ,  A61Q19/00 ,  A61K2800/87 ,  A61K2800/91 ,  A61M2037/0023 ,  A61M2037/0046 ,  A61M2037/0053 ,  A61M2037/0061

Abstract: Provided herein are microneedle particles, compositions that include microneedle particles, methods of treating skin, and methods of delivering a substance of interest. The microneedle particles may include one or more microneedles, and the microneedle particles may be configured to prevent the entire microneedle particle from penetrating the biological tissue. The microneedle particles may be dispersed in a liquid medium to form a composition. A biological tissue may be contacted with the microneedle particles to pre-treat the biological tissue, and a substance of interest may be applied to the pre-treated biological tissue.

公开(公告)号：US12064520B2

公开(公告)日：2024-08-20

申请号：US17694852

申请日：2022-03-15

Applicant: Massachusetts Institute of Technology ,  The Brigham and Women's Hospital, Inc.

Inventor： Carlo Giovanni Traverso ,  Alex G. Abramson ,  Ester Caffarel Salvador ,  Niclas Roxhed ,  Minsoo Khang ,  Taylor Bensel ,  Robert S. Langer

IPC: A61K9/48 ,  A61B5/145 ,  A61B10/02 ,  A61B10/06 ,  A61J3/07 ,  A61K9/00 ,  A61K38/28 ,  A61M5/142 ,  A61M5/145 ,  A61M5/158 ,  A61M5/20 ,  A61M5/32 ,  A61M31/00 ,  A61M37/00 ,  A61N1/05 ,  A61N1/32 ,  A61N1/36

CPC classification number: A61K9/4808 ,  A61B5/14503 ,  A61B5/14539 ,  A61B10/02 ,  A61J3/07 ,  A61K9/0002 ,  A61K9/0012 ,  A61K9/0021 ,  A61K9/0065 ,  A61K9/0092 ,  A61K9/4866 ,  A61K38/28 ,  A61M5/14276 ,  A61M5/1454 ,  A61M5/158 ,  A61M5/2033 ,  A61M5/329 ,  A61M5/3295 ,  A61M31/002 ,  A61M37/0015 ,  A61M37/0069 ,  A61N1/325 ,  A61N1/36007 ,  A61B2010/0208 ,  A61B10/0233 ,  A61B10/06 ,  A61M2005/14284 ,  A61M2005/1581 ,  A61M2005/1585 ,  A61M2037/0023 ,  A61M2037/0053 ,  A61M2205/0238 ,  A61M2205/21 ,  A61M2210/1053 ,  A61M2210/106 ,  A61N1/0509

Abstract: Components with relatively high loading of active pharmaceutical ingredients (e.g., drugs), are generally provided. In some embodiments, the component (e.g., a tissue interfacing component) comprises a solid therapeutic agent (e.g., a solid API) and a supporting material (e.g., a binder such as a polymer) such that the solid therapeutic agent is present in the component in an amount of greater than or equal to 10 wt % versus the total weight of the tissue interfacing component. Such tissue-interfacing components may be useful for delivery of API doses e.g., to a subject. Advantageously, in some embodiments, the reduction of volume required to deliver the required API dose as compared to a liquid formulation permits the creation of solid needle delivery systems for a wide variety of drugs in a variety of places/tissues (e.g., tongue, GI mucosal tissue, skin) and/or reduces and/or eliminates the application of an external force in order to inject a drug solution through the small opening in the needle. In some cases, a physiologically relevant dose may be present in a single tissue interfacing component (e.g., having a relatively high API loading).

公开(公告)号：US20240269447A1

公开(公告)日：2024-08-15

申请号：US18197935

申请日：2023-05-16

Applicant: ProCell Therapies, LLC

Inventor： Mitchell Edward Schwartz ,  Daniel Troyen-Schwartz

IPC: A61M37/00

CPC classification number: A61M37/0015 ,  A61M2037/0023 ,  A61M2037/0061

Abstract: A micro-needling system, the system includes a micro-channeling device, a needle tip connector and a variety of micro-needling assemblies. The micro-channeling device is designed to provide reciprocal motion, in and out of skin, for the micro-needling assemblies when applied to skin. A quick connector is provided for easy interchange of the micro-needling assemblies. Benefits of the system include ergonomic holding, versatility of needle arrays and reduced vibration.

公开(公告)号：US20240260990A1

公开(公告)日：2024-08-08

申请号：US18453197

申请日：2023-08-21

Applicant: SRGI HOLDINGS, LLC

Inventor： Edward KNOWLTON

IPC: A61B17/322 ,  A61B10/02 ,  A61B17/00 ,  A61B17/30 ,  A61B17/32 ,  A61B17/3205 ,  A61B17/3209 ,  A61B17/3211 ,  A61B17/34 ,  A61B17/54 ,  A61B18/00 ,  A61B90/00 ,  A61F2/04 ,  A61F2/10 ,  A61F13/00 ,  A61L27/02 ,  A61L27/20 ,  A61L27/36 ,  A61L27/48 ,  A61L27/52 ,  A61L27/54 ,  A61M5/178 ,  A61M5/46 ,  A61M19/00 ,  A61M35/00 ,  A61M37/00

CPC classification number: A61B17/322 ,  A61B17/32 ,  A61B17/320068 ,  A61B17/32053 ,  A61B17/32093 ,  A61B17/3211 ,  A61B17/3468 ,  A61B17/54 ,  A61B90/02 ,  A61F2/042 ,  A61F2/105 ,  A61F13/00 ,  A61L27/025 ,  A61L27/20 ,  A61L27/362 ,  A61L27/3691 ,  A61L27/48 ,  A61L27/52 ,  A61L27/54 ,  A61M5/178 ,  A61M5/46 ,  A61M35/003 ,  A61B10/0233 ,  A61B2017/00752 ,  A61B2017/00761 ,  A61B2017/00792 ,  A61B2017/00884 ,  A61B2017/00951 ,  A61B2017/00969 ,  A61B2017/306 ,  A61B2017/320052 ,  A61B2017/320064 ,  A61B2017/32007 ,  A61B2017/3225 ,  A61B2018/00601 ,  A61B2018/00994 ,  A61B2217/005 ,  A61F2002/044 ,  A61F2002/047 ,  A61F2013/00157 ,  A61F2013/0028 ,  A61L2300/414 ,  A61L2400/06 ,  A61M19/00 ,  A61M2037/0023

Abstract: Systems, instruments, methods, and compositions are described involving removing a portion of the epidermis within a donor site on a subject, and harvesting dermal plugs within the donor site. An injectable filler is formed by mincing the dermal plugs. The injectable filler is configured for injecting into a recipient site on the subject.

公开(公告)号：US20240238569A1

公开(公告)日：2024-07-18

申请号：US18239752

申请日：2023-08-29

Applicant: One Drop Biosensor Technologies, LLC

Inventor： Ashwin Pushpala ,  Alan Szmodis ,  Matthew Chapman ,  Weldon Hall ,  Scott Miller ,  Hooman Hafezi

IPC: A61M37/00 ,  A61B5/00 ,  A61B5/145 ,  A61B5/1486 ,  A61B5/1495 ,  A61B5/15 ,  A61M25/00 ,  C12Q1/00 ,  G01N27/327

CPC classification number: A61M37/0015 ,  A61B5/14503 ,  A61B5/14514 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/14865 ,  A61B5/1495 ,  A61B5/150022 ,  A61B5/150282 ,  A61B5/150427 ,  A61B5/150969 ,  A61B5/150984 ,  A61B5/4839 ,  A61B5/685 ,  C12Q1/006 ,  G01N27/3271 ,  A61B2562/028 ,  A61B2562/12 ,  A61B2562/125 ,  A61M25/00 ,  A61M2037/0023 ,  A61M2037/0046 ,  A61M2037/0053 ,  Y10T29/49117

Abstract: A microsensor and method of manufacture for a microsensor, comprising an array of filaments, wherein each filament of the array of filaments comprises a substrate and a conductive layer coupled to the substrate and configured to facilitate analyte detection. Each filament of the array of filaments can further comprise an insulating layer configured to isolate regions defined by the conductive layer for analyte detection, a sensing layer coupled to the conductive layer, configured to enable transduction of an ionic concentration to an electronic voltage, and a selective coating coupled to the sensing layer, configured to facilitate detection of specific target analytes/ions. The microsensor facilitates detection of at least one analyte present in a body fluid of a user interfacing with the microsensor.

公开(公告)号：US20240207590A1

公开(公告)日：2024-06-27

申请号：US18543180

申请日：2023-12-18

Applicant: POSTECH Research and Business Development Foundation ,  SNTEL Co., LTD

Inventor： Geunbae LIM ,  Jungho LEE

IPC: A61M37/00

CPC classification number: A61M37/0015 ,  A61M2037/0023 ,  A61M2037/0053

Abstract: A microneedle patch according to one embodiment of the present disclosure includes: a base including an invasive part and a non-invasive part; and a microneedle located in the invasive part of the base, wherein at least a portion of the microneedle is loaded with drug, and no microneedle is located in the non-invasive part.

公开(公告)号：US12017031B2

公开(公告)日：2024-06-25

申请号：US17504718

申请日：2021-10-19

Applicant: SORRENTO THERAPEUTICS, INC.

Inventor： Russell Frederick Ross

IPC: A61M37/00 ,  A61B17/20 ,  A61K9/00 ,  A61K9/70 ,  A61K38/17 ,  A61K38/19 ,  B29C59/00 ,  B29C59/02 ,  B29L31/00

CPC classification number: A61M37/0015 ,  A61B17/205 ,  A61K9/0021 ,  A61K9/7023 ,  A61K38/1793 ,  A61K38/191 ,  B29C59/002 ,  B29C59/026 ,  A61M2037/0023 ,  A61M2037/003 ,  A61M2037/0038 ,  A61M2037/0053 ,  A61M2037/0061 ,  B29C2059/023 ,  B29K2995/0056 ,  B29L2031/7544 ,  B29L2031/756 ,  Y10T156/10 ,  Y10T156/1039 ,  Y10T156/1057

Abstract: A medical device for delivering a drug compound through a stratum corneum includes a support having an aperture, an array of microneedles extending outwardly from the support, a plurality of nanostructures associated with each microneedle, and a reservoir wherein the drug compound is retained. At least one microneedle contains a shaft extending from the support. The shaft includes a tip configured to penetrate the stratum corneum. The shaft defines a channel extending from the support to the tip. The channel is in at least partial alignment with the aperture. At least some of the microneedles of the array of microneedles each have a cross-sectional dimension of from about 1 micrometer to about 1 millimeter. At least some of the nanostructures have a cross-sectional dimension less than about 500 nanometers and greater than about 5 nanometers and an aspect ratio of from about 0.2 to about 5.