公开(公告)号：US20240325683A1

公开(公告)日：2024-10-03

申请号：US18286418

申请日：2022-04-12

Applicant: RAIN Scientific, Inc.

Inventor： TIM KOEHLER ,  PAUL FRANKHOUSER

IPC: A61M25/00 ,  A61N1/04 ,  A61N1/30 ,  A61N1/32 ,  C22C5/08

CPC classification number: A61M25/0017 ,  A61N1/0436 ,  A61N1/044 ,  A61N1/306 ,  A61N1/325 ,  C22C5/08 ,  A61M2025/0019 ,  A61M2205/0205 ,  A61M2205/04

Abstract: The present invention is directed to devices and methods that efficiently and safely kill pathogens in blood functions by the generation of metal ions in situ. Such metal ions include silver ions, copper ions, and gold ions; however, additional metals can be employed for generation of ions in situ, including platinum, iridium, and zinc. The activity of the devices and methods of the present invention is extremely broad, and can kill pathogenic bacteria, viruses, and fungi. The activity of the devices and methods of the present invention does not depend on specific interactions between the device and the surface of the pathogen being killed. Additionally, the activity of the devices and methods is not subject to the development of resistance by the pathogen, such as can occur subsequent to the administration of conventional antibacterial, antifungal, or antiviral agents.

公开(公告)号：US12011587B2

公开(公告)日：2024-06-18

申请号：US17190630

申请日：2021-03-03

Applicant: TUSKER MEDICAL, INC.

Inventor： Mahyar Z. Kermani ,  Bernard H. Andreas ,  Rohit Girotra ,  Mansour A. Saleki ,  Nikhil D. Bhat

IPC: A61N1/30 ,  A61F11/00 ,  A61F11/20 ,  A61N1/04 ,  A61N1/32 ,  A61N1/05

CPC classification number: A61N1/30 ,  A61F11/00 ,  A61F11/202 ,  A61N1/0428 ,  A61N1/0472 ,  A61N1/303 ,  A61N1/325 ,  A61N1/0526 ,  A61N1/306

Abstract: Various systems and methods provide iontophoretic delivery of anesthesia at a patient's tympanic membrane. At least one example is a method including: performing iontophoresis within a first ear canal by driving, by a control unit, a DC signal to an electrode of a first iontophoresis device positioned within the first ear canal, the electrode at least partially submerged within an iontophoresis fluid within the first ear canal; measuring, by the control unit, a mixed capacitance associated with the electrode by driving a first AC signal having a first frequency to the electrode; and determining, based on a change in the mixed capacitance, that an air bubble is present in the iontophoresis fluid.

公开(公告)号：US20240181251A1

公开(公告)日：2024-06-06

申请号：US18285273

申请日：2022-02-18

Applicant: Sevil TUNC ,  AVB BIYOTEKNOLOJI ANONIM SIRKETTI ,  AVB BIYOTEKNOLOJI ANONIM SIRKETI ,  BEZMIALEM VAKIF UNIVERSITESI

Inventor： Serkan TUNC ,  Sevil TUNC ,  Rabia ATMACA ,  Burak Tutkucan ODUNCU ,  Ismail MERAL ,  Savas USTUNOVA

IPC: A61N1/20 ,  A61N1/04 ,  A61N1/32

CPC classification number: A61N1/205 ,  A61N1/0408 ,  A61N1/325 ,  A61N1/326 ,  A61N1/328

Abstract: A method of creating an antioxidant, antiapoptotic, antiaging, anti-inflammatory, antibacterial, antitoxic, energy metabolism regulating effect and balancing blood pH by creating chemical and biological reactions in human and animal body is provided. The method includes a circuit configuration that is created by serial connection of the human and animal body with resistance function to an electric circuit on which there is direct current and serially connected frequency generator to create chemical and biological reactions in the human and animal body, connecting the positively charged (anode) wire from the lung and/or abdominal area and/or legs and/or arms and connecting the negatively charged (cathode) wire to create a 180° angle on the back and/or legs and/or arms on the exact opposite of the point of connection of the positively charged wire in the body.

公开(公告)号：US20240156513A1

公开(公告)日：2024-05-16

申请号：US18324225

申请日：2023-05-26

Applicant: ImmunSYS, Inc.

Inventor： Gary M. Onik

IPC: A61B18/14 ,  A61B5/00 ,  A61B5/145 ,  A61M5/00 ,  A61N1/32

CPC classification number: A61B18/14 ,  A61B5/14532 ,  A61B5/14539 ,  A61B5/14546 ,  A61B5/4839 ,  A61B5/4848 ,  A61B18/1477 ,  A61M5/00 ,  A61N1/325 ,  A61N1/327 ,  A61B2018/00577

Abstract: A method of non-thermally ablating undesirable tissue in the body by application of pulsed, bipolar, instant charge reversal electrical fields of sufficient energy to cause complete and immediate cell membrane rupture and destruction. Energy is delivered through radio frequency pulses of particular frequencies, wave characteristics, pulse widths and pulse numbers, such that enhanced physical stresses are placed on the cell membrane to cause its immediate and complete destruction thereby spilling the entire cell content and membrane constituents into, the extracellular space without denaturing proteins so as to enable an immuno-logical response to destroy and remove the target tissue and similarly marked tissue elsewhere in the subject.

公开(公告)号：US11786707B2

公开(公告)日：2023-10-17

申请号：US16811699

申请日：2020-03-06

Applicant: Udayan Patel

Inventor： Udayan Patel

IPC: A61M25/10 ,  A61N1/32 ,  A61F2/958

CPC classification number: A61M25/1002 ,  A61F2/958 ,  A61M25/104 ,  A61M25/1011 ,  A61N1/325 ,  A61N1/327 ,  A61M2025/105 ,  A61M2025/1015 ,  A61M2025/1079 ,  A61M2210/12

Abstract: A medical device that delivers therapeutic agent to the tissue within the bodily passageway while simultaneously permitting flow of bodily fluids past the location of treatment. The medical device includes an inflatable balloon and optionally one or more balloon wall openings that are configured to allow fluid in the interior of the inflatable balloon to flow through the inflatable balloon when the inflatable balloon is pressurized by the fluid in the interior of the inflatable balloon. During the inflation of the inflatable balloon at the treatment site, the flow of blood through the blood vessel is maintained across the treatment site by use of one or more bypass passageways in the medical device.

公开(公告)号：US11717678B2

公开(公告)日：2023-08-08

申请号：US16949888

申请日：2020-11-19

Applicant: Colgate-Palmolive Company

Inventor： Scott Demarest ,  Mark Dobrovolny

IPC: A61N1/30 ,  A61B5/145 ,  A61B5/00 ,  H02N2/18 ,  H02J7/32 ,  A61N1/32 ,  A61N1/05 ,  A61C19/06 ,  H10N30/30 ,  H10N30/80 ,  H10N30/853 ,  H10N30/857 ,  A61B10/00 ,  A61N1/378 ,  A61N1/04

CPC classification number: A61N1/306 ,  A61B5/14507 ,  A61B5/14539 ,  A61B5/4205 ,  A61B5/4839 ,  A61B5/682 ,  A61C19/063 ,  A61N1/0548 ,  A61N1/325 ,  H02J7/32 ,  H02N2/18 ,  H10N30/30 ,  H10N30/802 ,  H10N30/853 ,  H10N30/857 ,  A61B2010/0083 ,  A61B2562/029 ,  A61N1/0428 ,  A61N1/3785

Abstract: An oral care device for placement in the oral cavity. The oral care device may include a support component, a piezoelectric component, and/or a therapeutic element. The support component is configured for placement between one or more maxillary teeth and one or more mandibular teeth. The piezoelectric element is configured to generate an electrical current from relative movement of the maxillary teeth and the mandibular teeth. The therapeutic element is configured to release a therapeutic composition into the oral cavity at least in part in response to receiving the electrical signal. The device may include the piezoelectric component, the therapeutic element, or both.

公开(公告)号：US20180326201A1

公开(公告)日：2018-11-15

申请号：US15777151

申请日：2016-11-18

Applicant: Vomaris Innovations, Inc.

Inventor： Michael Nagel ,  Wendell King

IPC: A61N1/04 ,  A61F9/00 ,  A61N1/32 ,  A61N1/30

CPC classification number: A61N1/0444 ,  A45D2200/1045 ,  A45D2200/202 ,  A61F9/0017 ,  A61F13/00051 ,  A61N1/0428 ,  A61N1/044 ,  A61N1/0456 ,  A61N1/0476 ,  A61N1/0492 ,  A61N1/303 ,  A61N1/325

Abstract: An apparatus includes multiple first reservoirs and multiple second reservoirs joined with a substrate. Selected ones of the multiple first reservoirs include a reducing agent, and first reservoir surfaces of selected ones of the multiple first reservoirs are proximate to a first substrate surface. Selected ones of the multiple second reservoirs include an oxidizing agent, and second reservoir surfaces of selected ones of the multiple second reservoirs are proximate to the first substrate surface.

公开(公告)号：US10052465B2

公开(公告)日：2018-08-21

申请号：US15615344

申请日：2017-06-06

Applicant: The Foundry, LLC

Inventor： Mark E. Deem ,  Hanson Gifford

IPC: A61K9/22 ,  A61N1/30 ,  A61M31/00 ,  A61M29/02 ,  A61K38/48 ,  A61M25/10 ,  A61M35/00 ,  A61N1/05 ,  A61N1/32 ,  A61K9/00 ,  A61M29/00 ,  A61B18/14 ,  A61B17/00 ,  A61M25/00 ,  A61N7/00 ,  A61N7/02 ,  A61B18/18

CPC classification number: A61M31/00 ,  A61B17/12104 ,  A61B17/12136 ,  A61B17/12159 ,  A61B17/24 ,  A61B17/3478 ,  A61B18/1492 ,  A61B18/18 ,  A61B18/1815 ,  A61B2017/003 ,  A61B2018/0022 ,  A61B2018/00327 ,  A61K9/0043 ,  A61K38/4886 ,  A61K38/4893 ,  A61M29/02 ,  A61M37/0092 ,  A61M2025/1013 ,  A61M2025/105 ,  A61M2210/0618 ,  A61N1/0546 ,  A61N1/325 ,  A61N1/327 ,  A61N5/02 ,  A61N5/045 ,  A61N7/00 ,  A61N7/02 ,  A61N7/022 ,  A61N2007/0043 ,  C12Y304/24069

Abstract: Methods and systems for delivering toxin and toxin fragments to a patient's nasal cavity provide for both release of the toxin and delivery of energy which selectively porates target cells to enhance uptake of the toxin. The use of energy-mediated delivery is particularly advantageous with light chain fragment toxins which lack cell binding capacity.

公开(公告)号：US20180220906A1

公开(公告)日：2018-08-09

申请号：US15949331

申请日：2018-04-10

Applicant: Valencell, Inc.

Inventor： Steven Francis LeBoeuf ,  Jesse Berkley Tucker ,  Michael Edward Aumer

IPC: A61B5/0205 ,  G01N21/59 ,  G01N21/47 ,  G01D11/00 ,  A61N1/32 ,  A61M37/00 ,  A61B7/04 ,  A61B7/00 ,  A61B5/00 ,  A61B5/22 ,  A61B5/1477 ,  A61B5/1455 ,  A61B5/145 ,  A61B5/12 ,  A61B5/11 ,  A61B5/103 ,  A61B5/0496 ,  A61B5/0476 ,  A61B5/04 ,  A61B5/03 ,  A61B5/029 ,  A61B5/026 ,  A61B5/024 ,  A61B5/021 ,  A61B5/01 ,  A61B5/087 ,  A61B5/08 ,  A61B5/053

CPC classification number: A61B5/02055 ,  A61B5/0002 ,  A61B5/0013 ,  A61B5/0015 ,  A61B5/0022 ,  A61B5/0059 ,  A61B5/0071 ,  A61B5/0084 ,  A61B5/01 ,  A61B5/0205 ,  A61B5/021 ,  A61B5/024 ,  A61B5/02427 ,  A61B5/02438 ,  A61B5/026 ,  A61B5/029 ,  A61B5/031 ,  A61B5/04 ,  A61B5/04001 ,  A61B5/0476 ,  A61B5/0496 ,  A61B5/0533 ,  A61B5/0816 ,  A61B5/087 ,  A61B5/1032 ,  A61B5/11 ,  A61B5/1112 ,  A61B5/1118 ,  A61B5/112 ,  A61B5/1126 ,  A61B5/12 ,  A61B5/14539 ,  A61B5/14542 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/14551 ,  A61B5/14552 ,  A61B5/14556 ,  A61B5/1477 ,  A61B5/222 ,  A61B5/224 ,  A61B5/4064 ,  A61B5/411 ,  A61B5/415 ,  A61B5/418 ,  A61B5/4205 ,  A61B5/4227 ,  A61B5/4266 ,  A61B5/4542 ,  A61B5/4806 ,  A61B5/4812 ,  A61B5/4839 ,  A61B5/4845 ,  A61B5/4848 ,  A61B5/486 ,  A61B5/4866 ,  A61B5/4872 ,  A61B5/4875 ,  A61B5/6803 ,  A61B5/6815 ,  A61B5/6816 ,  A61B5/6817 ,  A61B5/6887 ,  A61B5/7203 ,  A61B5/721 ,  A61B5/7405 ,  A61B5/742 ,  A61B7/00 ,  A61B7/04 ,  A61B2560/0242 ,  A61M37/00 ,  A61M2037/0007 ,  A61N1/325 ,  G01D11/00 ,  G01N21/47 ,  G01N21/59 ,  G01N2201/021 ,  G01N2201/0612 ,  G01N2201/062

Abstract: Wearable apparatus for monitoring various physiological and environmental factors are provided. Real-time, noninvasive health and environmental monitors include a plurality of compact sensors integrated within small, low-profile devices, such as earpiece modules. Physiological and environmental data is collected and wirelessly transmitted into a wireless network, where the data is stored and/or processed.

公开(公告)号：US20180193623A1

公开(公告)日：2018-07-12

申请号：US15039946

申请日：2015-02-03

Applicant: AMGEN INC.

Inventor： Stephanie Toy

IPC: A61M37/00

CPC classification number: A61M37/0015 ,  A61M37/00 ,  A61M2037/0007 ,  A61M2037/0023 ,  A61M2037/0046 ,  A61M2037/0061 ,  A61N1/0412 ,  A61N1/0428 ,  A61N1/325

Abstract: A drug delivery device (100) includes a base (102) having a first region (104) with a drug delivery assembly (106) associated therewith. The drug delivery device also includes an antenna (112) disposed in the first region to radiate an electromagnetic field, the base defining a plane (114) and the antenna disposed in the plane of the base, and an electromagnetic field generator (116) selectively coupled to the antenna.