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    DELIVERY DEVICES FOR NASOPHARYNGEAL MUCOSA TARGETS
    2.
    发明申请
    DELIVERY DEVICES FOR NASOPHARYNGEAL MUCOSA TARGETS 有权
    用于NASOPHARYNGEM MUCOSA目标的递送设备

    公开(公告)号：US20140243793A1

    公开(公告)日：2014-08-28

    申请号：US14151588

    申请日：2014-01-09

    申请人： The Foundry, LLC

    发明人： John Morriss ,  Hanson Gifford

    IPC分类号： A61M31/00 ,  A61K38/48

    CPC分类号： A61M31/007 ,  A61K38/4893 ,  A61M5/329 ,  A61M11/001 ,  A61M11/007 ,  A61M11/06 ,  A61M15/08 ,  A61M15/085 ,  A61M16/0438 ,  A61M16/0456 ,  A61M16/0461 ,  A61M16/0481 ,  A61M31/002 ,  A61M2210/0618 ,  A61M2210/0681

    摘要： A system for delivering a therapeutic agent to nasopharyngeal mucosa tissue has a shaft, a porous pad of compliant material coupled to the shaft near the distal end, and a drug reservoir. The porous pad is configured to expand from a contracted configuration to an expanded configuration. The expanded configuration is adapted to engage and conform to the mucosa tissue in a nasal cavity, and the contracted configuration has a size suitable for introduction into the nasal cavity. The drug reservoir holds a therapeutic agent and is at least partially covered by the porous pad. The drug reservoir is configured to release a fixed volume of the therapeutic agent into the porous pad within a period of less than about 120 minutes, and has a wall with a plurality of channels fluidly coupled with the porous pad.[

    摘要翻译： 用于将治疗剂递送到鼻咽粘膜组织的系统具有轴，连接到靠近远端的轴的顺应性材料的多孔垫和药物储存器。 多孔垫被构造成从收缩构型扩展到扩展构型。 膨胀构型适于与鼻腔中的粘膜组织相配合并且收缩构型具有适于引入鼻腔的尺寸。 药物储存器保持治疗剂并且至少部分被多孔垫覆盖。 药物储存器构造成在小于约120分钟的时间段内将固定体积的治疗剂释放到多孔垫中，并且具有与多孔垫片流体耦合的多个通道的壁。 [

    METHODS AND APPARATUS FOR DELIVERING A THERAPEUTIC AGENT TO NASOPHARYNGEAL MUCOSA TARGETS
    10.
    发明申请
    METHODS AND APPARATUS FOR DELIVERING A THERAPEUTIC AGENT TO NASOPHARYNGEAL MUCOSA TARGETS 有权
    将治疗药物递送至鼻咽癌MUCOSA目标的方法和装置

    公开(公告)号：US20140242064A1

    公开(公告)日：2014-08-28

    申请号：US14151767

    申请日：2014-01-09

    申请人： The Foundry, LLC

    发明人： John Morriss ,  Cary Reich ,  Hanson Gifford

    IPC分类号： A61M31/00 ,  A61K9/00 ,  A61K9/12

    CPC分类号： A61K38/4893 ,  A61K9/0043 ,  A61K9/122 ,  A61M31/00 ,  C12Y304/24069

    摘要： A system for delivering a therapeutic agent to a nasopharyngeal mucosa target comprises a foam generating mechanism, a gas, a therapeutic agent in liquid form that inhibits mucus production, and a delivery device. Actuation of the foam generating mechanism entraps gaseous bubbles from the gas in the liquid thereby forming a foam. The therapeutic agent is dispersed in the foam which has an expanded configuration adapted to fill a nasopharyngeal space and deliver the therapeutic agent to the mucosa targets. The delivery device is for delivering the foam to the nasopharyngeal space. The foam may also have a collapsed configuration for removal from the nasopharyngeal space or for concentration of the therapeutic agent onto the mucosa.

    摘要翻译： 用于将治疗剂递送到鼻咽粘膜靶的系统包括泡沫产生机构，气体，液体形式的抑制粘液生成的治疗剂和递送装置。 泡沫发生机构的致动从液体中的气体中捕获气泡，从而形成泡沫。 将治疗剂分散在具有适于填充鼻咽空间并将治疗剂递送至粘膜靶的膨胀构型的泡沫中。 输送装置用于将泡沫输送到鼻咽空间。 泡沫体还可以具有用于从鼻咽部空间去除或将治疗剂浓缩到粘膜上的收缩构型。