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公开(公告)号：US20240341849A1
公开(公告)日：2024-10-17
申请号：US18750990
申请日：2024-06-21
Applicant: NANOSPECTRA BIOSCIENCES, INC.
Inventor： Glenn Patrick Goodrich , Jon Schwartz , Andrew Mark Murphy
IPC: A61B18/28 , A61B17/34 , A61B18/00 , A61B18/04 , A61B18/20 , A61B18/22 , A61B18/24 , A61K9/00 , A61K9/51 , A61K41/00 , A61M25/06 , A61N5/06 , A61N5/067
CPC classification number: A61B18/28 , A61B17/3415 , A61B18/22 , A61B18/24 , A61K9/0009 , A61K9/0019 , A61K9/5115 , A61K41/0028 , A61K41/0052 , A61M25/0662 , A61N5/0603 , A61N5/062 , A61B2018/00011 , A61B2018/00023 , A61B2018/00547 , A61B2018/00577 , A61B2018/00589 , A61B18/04 , A61B2018/2005 , A61B2018/2205 , A61B2018/2261 , A61N5/0625 , A61N2005/063 , A61N2005/0659 , A61N5/067
Abstract: Various methods, systems, and devices for treating tissue ablation are disclosed. Some embodiments disclosed herein pertain to methods of treating tumors, systems used for irradiating tissue and tumors with electromagnetic radiation, components and devices of that system, and kits for providing systems used for irradiating tissue and tumors with electromagnetic radiation. In some embodiments, the system provides sub-ablative infrared radiation that is absorbed by nanoparticles. In some embodiments, the nanoparticles absorb the radiation converting it into heat energy. In some embodiments, though the infrared radiation itself may be sub-ablative, the heat energy generated by the nanoparticles is sufficient to cause thermal coagulation, hyperthermia, and/or tissue ablation.
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公开(公告)号：US20240181060A1
公开(公告)日：2024-06-06
申请号：US18529658
申请日：2023-12-05
Applicant: NABORS ENERGY TRANSITION SOLUTIONS LLC
Inventor： Evan JOHNSON , Anthony G. PETRELLO , Paul YOLLIN , Dylan COOK
CPC classification number: A61K41/0028 , A61K47/52
Abstract: The present disclosure relates to a cancer treatment delivery method that may include preparing a cancer treatment delivery component that may include a carbon-based nanomaterial composition and a cancer treatment composition attached to the carbon-based nanomaterial composition, delivering the cancer treatment delivery component to a treatment location, and applying a radio frequency to the cancer treatment delivery component at the treatment location. The radio frequency may be configured to heat the cancer treatment delivery component and cause the cancer treatment composition to detach from the carbon-based nanomaterial composition for delivery at the treatment location.
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3.发明公开
公开(公告)号：US20240165234A1
公开(公告)日：2024-05-23
申请号：US18509901
申请日：2023-11-15
Applicant: NANOBACTERIE
Inventor： Edouard ALPHANDÉRY
CPC classification number: A61K41/0028 , A61K9/5015 , A61K9/5036 , A61K9/5115 , A61K9/5192 , A61K41/0052 , B82Y5/00
Abstract: A composition including at least one nanoparticle or at least one chain of at least two nanoparticles, wherein each nanoparticle in the chain preferentially includes an iron oxide mineral core preferentially surrounded by a coating, wherein the composition further includes a cryo-protectant or protectant compound, wherein the volume occupied by the cryo-protectant or protectant compound in the composition is preferentially larger than the volume occupied by at least one chain in the composition, preferentially by a factor of at least 1, 2, 5, 10 or 103, wherein the percentage in mass of cryo-protectant or protectant compound in the composition is preferentially between 0.5 and 50%, wherein the composition is preferentially isotonic.
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公开(公告)号：US11969398B2
公开(公告)日：2024-04-30
申请号：US17324738
申请日：2021-05-19
Applicant: Pathak Holdings LLC
Inventor： Chandrashekhar P. Pathak
IPC: A61K31/155 , A61K9/00 , A61K9/06 , A61K9/16 , A61K9/50 , A61K31/337 , A61K31/37 , A61K31/496 , A61K31/573 , A61K31/7036 , A61K31/727 , A61K41/00 , A61K47/02 , A61K47/32 , A61K47/34 , A61L27/22 , A61L27/38 , A61L27/50 , A61M5/32 , A61M37/00 , A61L27/54 , A61M5/30
CPC classification number: A61K31/155 , A61K9/0014 , A61K9/0021 , A61K9/0024 , A61K9/0048 , A61K9/0051 , A61K9/06 , A61K9/1641 , A61K9/1647 , A61K9/1658 , A61K9/5031 , A61K9/5052 , A61K31/337 , A61K31/37 , A61K31/496 , A61K31/573 , A61K31/7036 , A61K31/727 , A61K41/0028 , A61K47/02 , A61K47/32 , A61K47/34 , A61L27/225 , A61L27/3804 , A61L27/50 , A61M5/3298 , A61M37/0015 , A61M37/0076 , A61L27/54 , A61L2300/442 , A61L2400/06 , A61M5/3015 , A61M2037/0023 , A61M2037/003 , A61M2037/0046 , A61M2037/0053 , A61M2205/36 , A61M2205/3606 , A61M2205/3633 , A61M2205/3653 , A61M2207/00 , C12Y304/21068 , C12Y304/24069
Abstract: This invention discloses methods and composition to form biodegradable polymer implant arrays in the live tissue. Artificial cavities are created in the live tissue by using laser ablation, oscillating needle, microneedle array and other methods. The cavities are then filled with biodegradable polymer solution. The solvent in the polymer solution is dissipated in the tissue to form a biodegradable polymer implant in artificial cavities. The cavities and implants formed are arranged to form of an array of implants. The biodegradable polymer in the cavity can also be loaded with drug to form biodegradable drug delivery array in the live tissue.
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公开(公告)号：US20240050660A1
公开(公告)日：2024-02-15
申请号：US18382290
申请日：2023-10-20
Applicant: Gholam A. Peyman
Inventor： Gholam A. Peyman
CPC classification number: A61M5/282 , C12N9/22 , A61K48/005 , A61K41/0028 , A61K47/6849 , A61K47/6929 , C12N2310/20
Abstract: A method of using a plungerless aspiration and/or injection device is disclosed herein. The method includes providing a plungerless aspiration and/or injection device; administering to a patient in need thereof, using the plungerless aspiration and/or injection device, a plurality of nanoparticles coated with a biocompatible molecule for cell uptake, the nanoparticles conjugated with at least one gene, an antibody that targets the nanoparticles to a target cell, and a deoxyribonucleic acid (DNA) editing complex forming a complex of coated nanoparticle-gene-DNA editing complex; delivering the coated nanoparticle-gene-DNA editing complex to the target cell using the nanoparticle of the complex as a carrier of the complex to the target cell without using a viral vector and without using a plasmid vector; and stimulating the coated nanoparticle-gene-DNA editing complex with one or more energy sources under conditions sufficient to introduce the at least one gene into the target cell.
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公开(公告)号：US20230285561A1
公开(公告)日：2023-09-14
申请号：US18187878
申请日：2023-03-22
Inventor： Robert H. GRUBBS , Marshall L. STOLLER , Hoyong CHUNG , Alissa M. FITZGERALD , Thomas W. KENNY , Renee M. THOMAS
CPC classification number: A61K9/1075 , A61K41/0028 , A61K47/24 , A61K9/08 , A61K2121/00
Abstract: This invention related to manufactured microbubbles, as well as methods of using manufactured microbubbles, for example, in medicinal applications. The invention pertains to the physical structure and materials of the microbubbles, as well as to methods for manufacturing microbubbles, methods for targeting microbubbles for specific medicinal applications, and methods for delivering microbubbles in medical treatment.
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公开(公告)号：US11737971B2
公开(公告)日：2023-08-29
申请号：US16808984
申请日：2020-03-04
Inventor： Flordeliza Villanueva , Andrew Carson , Charles F McTiernan , Jianjun Wang
IPC: A61K9/00 , A61K41/00 , A61K48/00 , A61N7/00 , B65D25/00 , C12N15/11 , C12N15/87 , C12N15/88 , A61K9/127 , C12N15/113
CPC classification number: A61K9/0002 , A61K9/0009 , A61K41/0028 , A61K48/0075 , A61K48/0083 , A61N7/00 , B65D25/00 , C12N15/111 , C12N15/87 , C12N15/88 , A61K9/127 , A61K9/1272 , A61N2007/0039 , C12N15/1138 , C12N2310/14 , C12N2320/32
Abstract: The invention pertains to a lipid-based microbubble stably binding a plurality of nucleic acids, and a method of delivering the microbubble and nucleic acids to a specific target site using ultrasound. The delivered nucleic acids create transgenic cells (i.e., for example, a transgenic tumor cell), wherein the transgenic cell expresses the proteins encoded by the delivered nucleic acids. This technology provides a significant improvement for microbubble-drug delivery platforms as known microbubble do not efficiently bind nucleic acids. The improvements described herein include but are not limited to identifying proper lipid proportionality ratios and/or cationic surfactant layers that provide an optimum mechanical index compatible with ultrasonics. Microbubble perfusion and/or nucleic acid delivery may be performed by a combination of imaging and ultrasound/microbubble targeted delivery to simultaneously perform low power two-dimensional imaging and high power microbubble destruction. Such systems are useful in therapeutics and/or diagnostics. For example, the data disclosed herein shows proof of principle in conjunction with the delivery of therapeutic siRNA molecules to slow tumor growth.
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公开(公告)号：US20230263891A1
公开(公告)日：2023-08-24
申请号：US18016251
申请日：2021-07-15
Applicant: Salk Institute for Biological Studies
Inventor： Sreekanth CHALASANI , Yusuf TUFAIL , Jose Mendoza LOPEZ , Marc Duque RAMIREZ , Uri MAGARAM , Corinne LEE-KUBLI , Eric Warren EDSINGER
CPC classification number: A61K41/0028 , A61K38/177 , A61K48/0083 , A61P25/00 , C12N15/86 , C12N2750/14143
Abstract: Described herein are compositions featuring TRPA1 polypeptides and polynucleotides, methods for expressing such polypeptides and polynucleotides in a cell type of interest, and methods for inducing the activation of the TRPA1 polypeptide in neurons and other cell types using ultrasound.
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公开(公告)号：US20230211020A1
公开(公告)日：2023-07-06
申请号：US17928065
申请日：2021-05-27
Applicant: ACT Therapeutics Ltd
Inventor： Svein KVÅLE , Andrew John HEALEY , Per Christian SONTUM , Spiros KOTOPOULIS
CPC classification number: A61K49/223 , A61K9/0009 , A61K41/0028 , A61K9/1075 , A61P31/04
Abstract: The present invention relates to ultrasound mediated delivery of antimicrobial agents to sites of infection, and particularly for treatment of infections. Thus, the invention provides a cluster composition and a pharmaceutical composition, for use in delivery and preparation for administration of antimicrobial agents and treatment of infections.
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公开(公告)号：US20230172852A1
公开(公告)日：2023-06-08
申请号：US18062416
申请日：2022-12-06
Applicant: ImmunityBio, Inc.
Inventor： Philip T. Liu , Clifford Anders Olson , Wade Nichols Richardson , Wendy Higashide
CPC classification number: A61K9/06 , A61K38/063 , A61K41/0028 , A61K47/36 , C12N15/87 , C12N15/1055
Abstract: Disclosed herein are mannan nanogels as a novel vaccine delivery platform as well as a novel method of making a self-assembling mannan nanogel for in vivo delivery of therapeutic agents.
