公开(公告)号：US11643667B2

公开(公告)日：2023-05-09

申请号：US16115140

申请日：2018-08-28

Applicant: CELLINO BIOTECH, INC.

Inventor： Matthias Wagner ,  Marinna Madrid

IPC: C12N15/87 ,  C12M1/42 ,  A61B18/20 ,  A61K9/00 ,  A61B18/26 ,  A61B17/00 ,  A61B18/00 ,  B82Y5/00 ,  H01S3/00

CPC classification number: C12N15/87 ,  A61B18/20 ,  A61B18/26 ,  A61K9/0009 ,  A61K9/0019 ,  C12M35/02 ,  A61B2017/00765 ,  A61B2018/00577 ,  A61B2018/263 ,  B82Y5/00 ,  H01S3/00

Abstract: An intracellular delivery system and method are provided. The intracellular delivery system comprises a laser-activated surface and cells positioned at a distance from the laser-activated surface. A laser provided a laser pulse that is used to porate membranes of the cells to deliver or extract cargo from the cells into a liquid surrounding the cells. The method of intracellular delivery comprises positioning a laser-activated surface at a distance from cells and applying a laser pulse from the laser to the surface to porate membranes of the cells to deliver or extract cargo from the cells into a liquid surrounding the cells.

公开(公告)号：US09814906B2

公开(公告)日：2017-11-14

申请号：US14693369

申请日：2015-04-22

Applicant: L'OREAL

Inventor： David H. McDaniel

IPC: A61N5/06 ,  A61B18/20 ,  A61K41/00 ,  A61N5/067 ,  A61B17/00 ,  A61B17/22 ,  A61B18/00 ,  A61B18/18

CPC classification number: A61N5/0616 ,  A61B18/203 ,  A61B2017/00765 ,  A61B2017/22085 ,  A61B2018/00452 ,  A61B2018/00476 ,  A61B2018/1807 ,  A61K41/0057 ,  A61K41/0071 ,  A61N5/0617 ,  A61N5/062 ,  A61N2005/0651 ,  A61N2005/0652 ,  A61N2005/0659 ,  A61N2005/067

Abstract: Disclosed is a system and method for treatment of skin disorders. More particularly, the disclosed invention is directed toward the use of multiple light sources for treating skin with or without the use of a topical compositions or photomodulation enhancing agents. Dual light emitting diodes may, for example, be used at relatively low power (less than about 10 J/cm2) to photomodulate skin or living tissue to reduce wrinkles, fine lines, acne, acne bacteria, and other skin disorders.

公开(公告)号：US09700502B2

公开(公告)日：2017-07-11

申请号：US12904822

申请日：2010-10-14

Applicant: George Cotsarelis ,  Mayumi Ito

Inventor： George Cotsarelis ,  Mayumi Ito

IPC: A61Q7/00 ,  A61K8/49 ,  A61K9/00 ,  A61B8/00 ,  A61K8/65 ,  A61Q5/00 ,  A61Q5/10 ,  A61K31/506 ,  A61K31/517 ,  A61K31/65 ,  A61K35/36 ,  A61K38/18 ,  A61M37/00 ,  A61B17/00 ,  A61B18/00

CPC classification number: A61K8/4953 ,  A61B2017/00765 ,  A61B2018/00452 ,  A61K8/65 ,  A61K9/0014 ,  A61K31/506 ,  A61K31/517 ,  A61K31/65 ,  A61K35/36 ,  A61K38/1825 ,  A61K2800/74 ,  A61K2800/805 ,  A61M37/00 ,  A61M2037/0007 ,  A61Q5/00 ,  A61Q5/10 ,  A61Q7/00

Abstract: The present invention provides methods of treating baldness in a subject and generating new hair follicles, comprising epidermal disruption and administration of a compound that promotes a differentiation of an uncommitted epidermal cell into a hair follicle cell. The present invention also provides methods for hair removal and inducing hair pigmentation.

公开(公告)号：US09579380B2

公开(公告)日：2017-02-28

申请号：US11081448

申请日：2005-03-16

Applicant: Jonathan A. Eppstein

Inventor： Jonathan A. Eppstein

IPC: A61N1/30 ,  A61K41/00 ,  A61B1/313 ,  A61B5/145 ,  A61B18/04 ,  A61M37/00 ,  A61N1/32 ,  A61B5/15 ,  A61B5/151 ,  A61B18/10 ,  A61B18/20 ,  A61B17/00 ,  A61B18/00 ,  A61N1/04 ,  A61N7/00

CPC classification number: A61K41/0047 ,  A61B1/313 ,  A61B5/14514 ,  A61B5/150022 ,  A61B5/150076 ,  A61B5/150083 ,  A61B5/150091 ,  A61B5/150099 ,  A61B5/150129 ,  A61B5/150175 ,  A61B5/15136 ,  A61B18/04 ,  A61B18/10 ,  A61B18/203 ,  A61B2017/00026 ,  A61B2017/00172 ,  A61B2017/00765 ,  A61B2018/00452 ,  A61B2018/00577 ,  A61B2018/00642 ,  A61B2018/00791 ,  A61M37/0092 ,  A61M2037/0007 ,  A61N1/0412 ,  A61N1/0428 ,  A61N1/0476 ,  A61N1/325 ,  A61N1/327 ,  A61N2007/0034

Abstract: A method of enhancing the permeability of a biological membrane, including the skin or mucosa of an animal or the outer layer of a plant to a permeant is described utilizing microporation of selected depth and optionally one or more of sonic, electromagnetic, mechanical and thermal energy and a chemical enhancer. Microporation is accomplished to form a micropore of selected depth in the biological membrane and the porated site is contacted with the permeant. Additional permeation enhancement measures may be applied to the site to enhance both the flux rate of the permeant into the organism through the micropores as well as into targeted tissues within the organism.

Abstract translation: 使用选定深度和任选的一种或多种声波，电磁，机械和热能的微孔来描述增强生物膜（包括动物的皮肤或粘膜或植物外层）渗透性的渗透性的方法 和化学增强剂。 完成微孔以在生物膜中形成选定深度的微孔，并且该位置与渗透物接触。 可以将另外的渗透增强措施应用于该部位，以增强通过微孔以及生物体内靶向组织的渗透物通向微生物的通量。

公开(公告)号：US09511210B2

公开(公告)日：2016-12-06

申请号：US11750967

申请日：2007-05-18

Applicant: Mark E. Deem ,  Hanson Gifford ,  Steven Kim ,  Alexey Salamini

Inventor： Mark E. Deem ,  Hanson Gifford ,  Steven Kim ,  Alexey Salamini

IPC: A61M31/00 ,  A61K38/48 ,  A61M25/10 ,  A61M35/00 ,  A61N1/05 ,  A61N1/32 ,  A61M29/00 ,  A61M29/02 ,  A61K9/00 ,  A61B18/14 ,  A61B18/18 ,  A61B17/00 ,  A61M25/00 ,  A61N7/00 ,  A61N7/02

CPC classification number: A61M31/00 ,  A61B18/1492 ,  A61B18/18 ,  A61B2017/00765 ,  A61K9/0043 ,  A61K38/4886 ,  A61K38/4893 ,  A61M25/007 ,  A61M25/0084 ,  A61M25/10 ,  A61M29/00 ,  A61M29/02 ,  A61M35/00 ,  A61M2025/0008 ,  A61M2025/0057 ,  A61M2025/0096 ,  A61M2025/105 ,  A61M2210/0618 ,  A61N1/05 ,  A61N1/0546 ,  A61N1/0568 ,  A61N1/327 ,  A61N7/00 ,  A61N7/022 ,  C12Y304/24069 ,  Y02A50/471

Abstract: Apparatus for delivering toxin and toxin fragments to a patient's nasal cavity provide for both release of the toxin and delivery of energy which selectively porates target cells to enhance uptake of the toxin. The use of energy-mediated delivery is particularly advantageous with light chain fragment toxins which lack cell binding capacity.

Abstract translation: 将毒素和毒素片段输送到患者鼻腔的装置提供毒素的释放和能量的释放，所述能量选择性地对靶细胞进行培养以增强毒素的摄取。 使用能量介导的递送对于缺乏细胞结合能力的轻链片段毒素是特别有利的。

公开(公告)号：US09220926B2

公开(公告)日：2015-12-29

申请号：US13327611

申请日：2011-12-15

Applicant: George Cotsarelis ,  Mayumi Ito

Inventor： George Cotsarelis ,  Mayumi Ito

IPC: A61Q7/00 ,  A61Q5/10 ,  A61K8/65 ,  A61Q5/00 ,  A61B17/00 ,  A61B18/00

CPC classification number: A61K8/4953 ,  A61B2017/00765 ,  A61B2018/00452 ,  A61K8/65 ,  A61K9/0014 ,  A61K31/506 ,  A61K31/517 ,  A61K31/65 ,  A61K35/36 ,  A61K38/1825 ,  A61K2800/74 ,  A61K2800/805 ,  A61M37/00 ,  A61M2037/0007 ,  A61Q5/00 ,  A61Q5/10 ,  A61Q7/00

Abstract: The present invention provides methods of treating baldness in a subject and generating new hair follicles, comprising epidermal disruption and administration of a compound that promotes a differentiation of an uncommitted epidermal cell into a hair follicle cell. The present invention also provides methods for hair removal and inducing hair pigmentation.

Abstract translation: 本发明提供了治疗受试者的秃发并产生新的毛囊的方法，包括表皮破坏和施用促进将未表达的表皮细胞分化为毛囊细胞的化合物。 本发明还提供了脱毛和诱导毛发色素沉着的方法。

公开(公告)号：US08651112B2

公开(公告)日：2014-02-18

申请号：US12753207

申请日：2010-04-02

Applicant: David McDaniel

Inventor： David McDaniel

IPC: A61B19/00 ,  A61N5/06

CPC classification number: A61N5/0617 ,  A61B18/203 ,  A61B2017/00765 ,  A61B2017/22085 ,  A61B2018/00452 ,  A61B2018/00476 ,  A61B2018/1807 ,  A61N5/062 ,  A61N2005/0652

Abstract: A system for producing preferential damage to hair exiting mammalian skin. A agent having an average diameter for enabling the agent to penetrate the hair duct is selected. The agent is designed to attach to, or become physically incorporated into, the hair shaft, the hair follicle, the hair bulb or the hair duct. The agent has an electromagnetic radiation absorption characteristic which enables the agent to absorb a first wavelength of electromagnetic radiation from a skin-penetrating electromagnetic radiation source, such as a laser. The agent is applied to the skin so that the agent penetrates the skin and attaches to or becomes physically incorporated into the hair shaft, the hair follicle, the hair bulb or the hair duct. The agent is exposed to the first wavelength of electromagnetic radiation and absorbs the first wavelength of electromagnetic radiation.

Abstract translation: 用于对离开哺乳动物皮肤的毛发产生优先损伤的系统。 选择具有使试剂穿过发道的平均直径的试剂。 该药剂被设计成附着到头发，头发毛囊，毛发或头发管道上，或者将它们物理地并入到头发，毛发，头发灯泡或发道中。 该试剂具有电磁辐射吸收特性，其使得试剂能够从诸如激光的皮肤穿透电磁辐射源吸收第一波长的电磁辐射。 将药剂施用于皮肤，使得药剂渗透皮肤并附着或变成物理地并入毛发，毛囊，毛发或毛发管道中。 该试剂暴露于第一波长的电磁辐射并吸收第一波长的电磁辐射。

公开(公告)号：US20130345661A1

公开(公告)日：2013-12-26

申请号：US13533719

申请日：2012-06-26

Applicant: Franklin J. Chang

Inventor： Franklin J. Chang

IPC: A61M37/00 ,  A61N1/30

CPC classification number: A61B17/3207 ,  A61B17/545 ,  A61B2017/00765 ,  A61B2018/00452 ,  A61B2217/005 ,  A61B2218/001 ,  A61M37/00 ,  A61M37/0092 ,  A61M2037/0007 ,  A61N1/325 ,  A61N1/327 ,  A61N1/328

Abstract: A device and methods for increasing the permeability of the skin's surface to fluid and/or drug delivery is described. The device comprises an abrasive media to remove the outer layer of the stratum corneum, while at the same time applying an electric current that stimulates the skin under the stratum corneum, and delivers fluids from a supply reservoir. The device may also have a vacuum function which evacuates fluid and skin debris from the surface of the skin and delivers the evacuated fluid and skin debris to a waste (or collection) container.

公开(公告)号：US08491521B2

公开(公告)日：2013-07-23

申请号：US12218760

申请日：2008-07-17

Applicant: Michael T. Peterson ,  Alan Van Houten

Inventor： Michael T. Peterson ,  Alan Van Houten

IPC: A61B17/20

CPC classification number: A61B17/20 ,  A61B2017/00765

Abstract: An applicator for use with an ultrasound transducer assembly is disclosed. In an embodiment, an applicator includes a nozzle body having an interior and an exterior surface; a nozzle liner having an interior and an exterior surface and being engageable with the nozzle body such that a plurality of channels are defined at least in part by the exterior surface of the nozzle liner and the interior surface of the nozzle body, each of the plurality of channels having an inlet and an outlet; a passageway defined by a space between the nozzle body and the nozzle liner, in fluid communication with the inlets of each of the plurality of channels; and an opening sized and shaped for introducing fluid to the passageway to provide fluid flow from the outlet of each of the plurality of channels essentially simultaneously. Kits and methods are also disclosed.

Abstract translation: 公开了一种与超声换能器组件一起使用的敷贴器。 在一个实施例中，施加器包括具有内部和外部表面的喷嘴主体; 喷嘴衬套，其具有内部和外部表面并且可与喷嘴体接合，使得多个通道至少部分地由喷嘴衬套的外表面和喷嘴体的内表面限定，每个通道 具有入口和出口的通道; 由所述喷嘴主体和所述喷嘴衬套之间的空间限定的与所述多个通道中的每一个的入口流体连通的通道; 以及开口的尺寸和形状，用于将流体引入通道以基本​​上同时地从多个通道中的每一个的出口提供流体流动。 还披露了套件和方法。

公开(公告)号：US20130150730A1

公开(公告)日：2013-06-13

申请号：US13758584

申请日：2013-02-04

Applicant: Palomar Medical Technologies, Inc.

Inventor： Gregory B. ALTSHULER ,  Joseph P. CARUSO ,  Henry H. ZENZIE ,  James G. BURKE ,  Andrei V. EROFEEV

IPC: A61B5/00

CPC classification number: A61B5/0077 ,  A45D26/0061 ,  A45D44/005 ,  A61B18/203 ,  A61B2017/00026 ,  A61B2017/00747 ,  A61B2017/00765 ,  A61B2017/00769 ,  A61B2018/00011 ,  A61B2018/00029 ,  A61B2018/00452 ,  A61B2018/00476 ,  A61B2018/00904 ,  A61B2090/065 ,  A61N1/328

Abstract: Photocosmetic device for use in medical or non-medical environments (e.g., a home, barbershop, or spa), which can be used for a variety of tissue treatments. Radiation is delivered to the tissue via optical systems designed to pattern the radiation and project the radiation to a particular depth. The device has a variety of cooling systems including phase change cooling solids and liquids to cool treated skin and the radiation sources. Contact sensors and motion sensor may be used to enhance treatment. The device may be modular to facilitate manufacture and replacement of parts.

Abstract translation: 用于医疗或非医疗环境（例如，家庭，理发店或温泉）的光学设备，其可用于各种组织处理。 辐射通过设计成对辐射进行图案化并将辐射投射到特定深度的光学系统传送到组织。 该装置具有各种冷却系统，包括相变冷却固体和液体以冷却经处理的皮肤和辐射源。 接触传感器和运动传感器可用于增强治疗。 该装置可以是模块化的，以便于部件的制造和更换。