公开(公告)号：US20250049559A1

公开(公告)日：2025-02-13

申请号：US18926991

申请日：2024-10-25

Applicant: Musculoskeletal Transplant Foundation

Inventor： Michael Locarno ,  Bryan Choi ,  Manh-Dan Ngo

IPC: A61F2/10 ,  A61K35/36 ,  A61L27/36 ,  A61L27/38 ,  A61L27/60 ,  C12N5/071

Abstract: Allografts for soft tissue repair, including breast reconstruction and other plastic surgery procedures, are disclosed. In an exemplary embodiment, first and second cuts are made into the reticular layer of a skin sample to separate an improved acellular dermal matrix (ACDM) which forms a dermal tissue form useful as a graft. The dermal tissue form consists essentially of reticular dermis and has a first exposed surface formed by reticular dermis, an opposite second exposed surface formed by reticular dermis, and has substantially uniform density and uniform porosity between the first and second exposed surfaces, which allows and promotes rapid and efficient cellular ingrowth and tissue ingrowth substantially equally from either the first or second exposed surfaces upon implantation.

公开(公告)号：US12186453B2

公开(公告)日：2025-01-07

申请号：US15341118

申请日：2016-11-02

Applicant: Massachusetts Institute of Technology ,  The Children's Medical Center Corporation

Inventor： Arturo J. Vegas ,  Joshua C. Doloff ,  Omid Veiseh ,  Robert S. Langer ,  Daniel G. Anderson

IPC: A61L27/38 ,  A61K9/00 ,  A61K35/36 ,  A61K38/02 ,  A61L27/04 ,  A61L27/10 ,  A61L27/16 ,  A61L27/18 ,  A61L27/20 ,  A61L27/34 ,  A61L27/54 ,  A61L27/56 ,  A61L29/14 ,  C08J7/12 ,  A61K35/12 ,  A61K35/39

Abstract: Products, such as devices, prostheses, and materials, whose surfaces have been modified in order to impart beneficial properties to these products are disclosed. The surface-modified products have improved biocompatibility compared to a corresponding product that lacks the modification. Following implantation in a subject, the surface-modified products induce a lower foreign-body response, compared to a corresponding unmodified product.

公开(公告)号：US20240408277A1

公开(公告)日：2024-12-12

申请号：US18641818

申请日：2024-04-22

Applicant: LifeCell Corporation

Inventor： Alexander Ringo

IPC: A61L27/50 ,  A61F2/00 ,  A61K35/36 ,  A61L27/36 ,  A61L27/60

Abstract: The present disclosure relates to tissue matrix products. The products can includes tissue matrices that have holes or perforations located at certain positions to improve certain in vivo functions without substantial loss of strength or other important properties.

公开(公告)号：US12161675B2

公开(公告)日：2024-12-10

申请号：US17252272

申请日：2019-08-02

Applicant: LABORATORY OF CELL APPLIED TECHNOLOGIES, CO

Inventor： Hajime Inoue ,  Chiharu Fujita

IPC: A61K35/36 ,  A61K35/28 ,  A61K47/02 ,  C12N5/00

Abstract: To provide a culture supernatant preparation which has excellent biocompatibility and contains a large quantity of specific genes or proteins. A method for producing the culture supernatant preparation including: a first culturing step of culturing cells to a confluent state using a first medium; a second culturing step of culturing the cells using a second medium that is different from the first medium after the first culturing step; and a culture supernatant preparation obtaining step of obtaining the culture supernatant preparation including the second medium after the second culturing step, the second medium including a calcium ion and a buffering agent.

公开(公告)号：US12133866B2

公开(公告)日：2024-11-05

申请号：US17735146

申请日：2022-05-03

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Yair Reisner ,  Yaki Eidelstein ,  Eran Ophir ,  Assaf Lask ,  Ran Afik ,  Noga Or-Geva ,  Esther Bachar-Lustig

IPC: A61K35/17 ,  A61K35/12 ,  A61K35/22 ,  A61K35/26 ,  A61K35/28 ,  A61K35/34 ,  A61K35/36 ,  A61K35/38 ,  A61K35/39 ,  A61K35/407 ,  A61K35/42 ,  A61K39/00 ,  C12N5/0783

Abstract: A method of generating an isolated population of cells comprising anti-third party cells having a central memory T-lymphocyte (Tcm) phenotype, the cells being tolerance-inducing cells and/or endowed with anti-disease activity, and capable of homing to the lymph nodes following transplantation is disclosed. The method comprising: (a) contacting peripheral blood mononuclear cells (PBMC) with a third party antigen or antigens in the presence of IL-21 so as to allow enrichment of antigen reactive cells; and (b) culturing the cells resulting from step (a) in the presence of IL-21, IL-15 and IL-7 in an antigen free environment so as to allow proliferation of cells comprising the central memory T-lymphocyte (Tcm) phenotype.

公开(公告)号：US20240358766A1

公开(公告)日：2024-10-31

申请号：US18565007

申请日：2022-05-27

Applicant: Stratatech Corporation

Inventor： Allen R. Comer ,  Kenneth R. Gratz

IPC: A61K35/36 ,  A61F2/10 ,  A61L27/24 ,  A61L27/38 ,  A61L27/60 ,  A61P17/02

CPC classification number: A61K35/36 ,  A61F2/105 ,  A61L27/24 ,  A61L27/3813 ,  A61L27/60 ,  A61P17/02 ,  A61L2430/34

Abstract: The present disclosure is directed to allogeneic cultured keratinocyte products.

公开(公告)号：US12090176B2

公开(公告)日：2024-09-17

申请号：US17604040

申请日：2019-04-17

Applicant: NEXUS BIO-DRUG DEVELOPMENT LIMITED

Inventor： Shing Hing Lau

IPC: A61K35/36 ,  A61P7/00

CPC classification number: A61K35/36 ,  A61P7/00

Abstract: Disclosed is therapeutic use of an extract from rabbit skin inflamed by vaccinia virus. Particularly, disclosed is use of an extract from rabbit skin inflamed by vaccinia virus in treating hematopoietic system damage or pancytopenia induced by an anti-cancer therapy. Moreover, disclosed is use of an extract from rabbit skin inflamed by vaccinia virus in treating leukopenia induced by an anti-cancer therapy. Further, the extract from rabbit skin inflamed by vaccinia virus can be Lepalvir.

公开(公告)号：US20240245729A1

公开(公告)日：2024-07-25

申请号：US18565003

申请日：2022-05-27

Applicant: Stratatech Corporation

Inventor： Allen R. Comer ,  Kenneth R. Gratz

IPC: A61K35/36 ,  A61K9/00 ,  A61K35/33 ,  A61K38/39 ,  C12N5/071

CPC classification number: A61K35/36 ,  A61K9/0014 ,  A61K35/33 ,  A61K38/39 ,  C12N5/0698 ,  C12N2500/12 ,  C12N2500/20 ,  C12N2500/32 ,  C12N2500/34 ,  C12N2500/38 ,  C12N2533/54

Abstract: The present disclosure encompasses methods for priming an allogeneic cultured keratinocyte composition for topical use.

公开(公告)号：US12011464B2

公开(公告)日：2024-06-18

申请号：US17276230

申请日：2019-09-19

Applicant: STEMON INC.

Inventor： Yong Seung Lee

IPC: A61K35/36 ,  A61P17/14 ,  C12N5/071 ,  C12N13/00

CPC classification number: A61K35/36 ,  A61P17/14 ,  C12N5/0625 ,  C12N13/00 ,  C12N2529/00

Abstract: A method for producing exosomes comprises steps of: providing ultrasound stimulation directly or indirectly to cells; culturing a mixture of the cells and a medium for a predetermined time; and isolating exosomes from the mixture, wherein providing the stimulation directly to the cells comprises applying ultrasound stimulation to the medium containing the cells, and the providing the stimulation indirectly to the cells comprises applying ultrasound stimulation to the medium not containing the cells and then mixing the medium and the cells. This method for producing exosomes makes it possible to obtain exosomes having a hair regeneration effect not only from stem cells and progenitor cells that are difficult to isolate and multiply, but also from somatic cells that may be easily obtained and maintained, in high yield within a short time by ultrasound treatment that is a simple process.

公开(公告)号：US20240066070A1

公开(公告)日：2024-02-29

申请号：US18272044

申请日：2022-01-11

Applicant: AgeX Therapeutics, Inc.

Inventor： Michael D. West

IPC: A61K35/42 ,  A61K35/36 ,  A61L27/38 ,  A61L27/52 ,  C12N5/071

CPC classification number: A61K35/42 ,  A61K35/36 ,  A61L27/38 ,  A61L27/52 ,  C12N5/0625 ,  C12N2501/602 ,  C12N2501/603 ,  C12N2501/604 ,  C12N2501/605 ,  C12N2501/606 ,  C12N2501/608 ,  C12N2510/00

Abstract: Methods are provided for the ex vivo reprogramming of microbiopsies of tissue such as from the skin, wherein the cells from the tissue are reverted to a state capable of extensive expansion in volume and when transplanted in vivo, of promoting scarless tissue regeneration at the site of administration.