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    3D PRINTER
    8.
    发明申请
    3D PRINTER 审中-公开
    3D打印机

    公开(公告)号：US20160367358A1

    公开(公告)日：2016-12-22

    申请号：US14746631

    申请日：2015-06-22

    申请人： Bao Tran

    发明人： Bao Tran

    IPC分类号： A61F2/10 ,  A61F2/00 ,  A61F2/02 ,  A61F2/28 ,  A61F2/18

    CPC分类号： A61F2/105 ,  A61F2/28 ,  A61F2002/30985 ,  A61F2210/0004 ,  A61F2240/002 ,  A61F2240/004 ,  A61L27/24 ,  A61L27/38 ,  A61L27/3834 ,  A61L27/48 ,  A61L27/54 ,  A61L27/60 ,  A61L2300/414 ,  B33Y10/00 ,  B33Y80/00 ,  C08L89/06

    摘要： A method of reproducing a biological object includes 3D-imaging the object and generating a mold using a 3D printer; obtaining cells from a donor site on the object; preparing a live cell suspension using the cells from the donor site; forming a scaffold in the mold with collagen and seeding the scaffold with live cells, growing the cells in the mold and curing the collagen; and surgically implanting the object into a living subject, where the cells continue to live in the living subject.

    摘要翻译： 一种再生生物体的方法包括3D成像物体并使用3D打印机产生模具; 从物体上的供体位点获得细胞; 使用来自供体位点的细胞制备活细胞悬浮液; 在模具中用胶原形成支架并用活细胞接种支架，使细胞生长在模具中并固化胶原蛋白; 并将对象手术植入活体中，其中细胞继续存活在活体中。

    Multi-layer tissue patches
    9.
    发明授权
    Multi-layer tissue patches 有权

    公开(公告)号：US09480549B2

    公开(公告)日：2016-11-01

    申请号：US13793331

    申请日：2013-03-11

    申请人： AlloSource

    发明人： Adrian C. Samaniego

    IPC分类号： A61F2/02 ,  A61L27/36 ,  A61F2/10 ,  A61K35/50 ,  A61L26/00 ,  A61L27/00

    CPC分类号： A61F2/02 ,  A61F2/105 ,  A61K35/50 ,  A61L26/0061 ,  A61L27/00 ,  A61L27/3604 ,  A61L27/3687

    摘要： Embodiments of the present invention encompass anti-adhesion wound dressings including patches made from amnion tissue obtained from human birth tissue. Exemplary amnion patches can be fabricated by folding a section of amnion over on itself with the epithelial layer on the outside of the folded patch and the fibroblast layer on the inside of the folded patch. Optionally, individual amnion tissue pieces can be sandwiched together to provide a multi-layer patch. Sufficient pressure is applied to the layered amnion to cause adherence between opposing faces of the fibroblast layers. The pressed fibroblast layers provide mechanical strength to hold the amnion patch together with the epithelial layers on the outsides of the amnion patch.

    METHOD OF PRINTING A TISSUE CONSTRUCT WITH EMBEDDED VASCULATURE
    10.
    发明申请
    METHOD OF PRINTING A TISSUE CONSTRUCT WITH EMBEDDED VASCULATURE 审中-公开
    打印组织结构与嵌入式血管的方法

    公开(公告)号：US20160287756A1

    公开(公告)日：2016-10-06

    申请号：US15146613

    申请日：2014-11-04

    申请人： President and Fellows of Harvard College

    发明人： Jennifer A. Lewis ,  David B. Kolesky ,  Mark A. Skylar-Scott ,  Kimberly A. Homan ,  Ryan L. Truby ,  Amelia Sydney Gladman

    IPC分类号： A61L27/50 ,  A61L27/22 ,  A61F2/06 ,  B29C67/00 ,  B33Y10/00 ,  B33Y80/00 ,  A61L27/38 ,  A61L27/36

    CPC分类号： A61L27/507 ,  A61F2/06 ,  A61F2/105 ,  A61F2240/002 ,  A61L27/222 ,  A61L27/225 ,  A61L27/3633 ,  A61L27/3808 ,  A61L27/3813 ,  A61L27/3826 ,  A61L2430/34 ,  B29C64/106 ,  B29C64/40 ,  B33Y10/00 ,  B33Y80/00 ,  C12M33/00

    摘要： A printed tissue construct comprises one or more tissue patterns, where each tissue pattern comprises a plurality of viable cells of one or more predetermined cell types. A network of vascular channels interpenetrates the one or more tissue patterns. An extracellular matrix composition at least partially surrounds the one or more tissue patterns and the network of vascular channels. A method of printing a tissue construct with embedded vasculature comprises depositing one or more cell-laden filaments, each comprising a plurality of viable cells, on a substrate to form one or more tissue patterns. Each of the one or more tissue patterns comprises one or more predetermined cell types. One or more sacrificial filaments, each comprising a fugitive ink, are deposited on the substrate to form a vascular pattern interpenetrating the one or more tissue patterns. The vascular pattern and the one or more tissue patterns are at least partially surrounded with an extracellular matrix composition. The fugitive ink is then removed to create vascular channels in the extracellular matrix composition, thereby forming an interpenetrating vascular network in a tissue construct.

    摘要翻译： 印刷的组织结构包括一个或多个组织图案，其中每个组织图案包括一个或多个预定细胞类型的多个活细胞。 血管通道网络穿过一个或多个组织模式。 细胞外基质组合物至少部分地包围一个或多个组织模式和血管通道的网络。 印刷具有嵌入脉管系统的组织构建体的方法包括在衬底上沉积一个或多个包含多个活细胞的细胞细胞丝，以形成一个或多个组织图案。 一个或多个组织图案中的每一个包括一个或多个预定的细胞类型。 一个或多个牺牲丝，每个包括一种短效油墨，沉积在该基底上以形成一个或多个组织图案互穿的血管图案。 血管图案和一个或多个组织图案至少部分地被细胞外基质组合物包围。 然后除去逸散性油墨以在细胞外基质组合物中产生血管通道，从而在组织构建体中形成互穿血管网络。