公开(公告)号：US12115282B2

公开(公告)日：2024-10-15

申请号：US18063600

申请日：2022-12-08

申请人： Research Institute at Nationwide Children's

发明人： Christopher Breuer ,  Robert Strouse ,  Yong Ung-Lee ,  Cameron Best ,  Narutoshi Hibino

IPC分类号： A61L27/38 ,  A61L27/18 ,  A61L27/20 ,  A61L27/24 ,  A61L27/50 ,  A61L27/54 ,  A61L27/58 ,  B33Y10/00 ,  B33Y80/00 ,  D01D5/00

CPC分类号： A61L27/3834 ,  A61L27/18 ,  A61L27/20 ,  A61L27/24 ,  A61L27/507 ,  A61L27/54 ,  A61L27/58 ,  B33Y10/00 ,  B33Y80/00 ,  D01D5/0076 ,  A61L2300/41 ,  A61L2300/414 ,  A61L2300/416 ,  A61L27/18 ,  C08L67/04 ,  A61L27/18 ,  C08L77/00 ,  A61L27/18 ,  C08L85/02

摘要： It has been established that optimizing cell seeding onto tissue engineering vascular grafts (TEVG) is associated with reduced inflammatory responses and reduced post-operative stenosis of TEVG. Cell seeding increased TEVG patency in a dose dependent manner, and TEVG patency improved when more cells were seeded, however duration of incubation time showed minimal effect on TEVG patency. Methods of engineering patient specific TEVG including optimal numbers of cells to maintain graft patency and reduce post-operative stenosis are provided. Closed, single-use customizable systems for seeding TEVG are also provided. Preferably the systems are custom-designed based on morphology of the patient specific graft, to enhance the efficacy of cell seeding.

公开(公告)号：US20240301114A1

公开(公告)日：2024-09-12

申请号：US18664001

申请日：2024-05-14

申请人： MITSUBISHI CHEMICAL CORPORATION

发明人： Haruhiko KUSAKA ,  Kazuki WAKABAYASHI ,  Masanori YAMAMOTO ,  Kazunao KUSANO ,  Hiroto ITO ,  Takashi KOMAYA ,  Teruhiko OHARA ,  Kentaro UCHINO ,  Haruo IIDUKA

IPC分类号： C08F290/06 ,  A61L27/18 ,  A61L27/50 ,  A61L29/06 ,  A61L29/14 ,  A61L31/06 ,  A61L31/14 ,  B32B27/40 ,  C07D493/04 ,  C08F20/36 ,  C08G18/44 ,  C08G18/66 ,  C08G18/67 ,  C08G18/75 ,  C08G64/02 ,  C08G64/16 ,  C08G64/30 ,  C08L75/04 ,  C09D175/04 ,  C09D175/14 ,  C09D175/16 ,  C09J175/04 ,  C09J175/14

CPC分类号： C08F290/067 ,  A61L27/18 ,  A61L27/50 ,  A61L27/507 ,  A61L29/06 ,  A61L29/14 ,  A61L31/06 ,  A61L31/14 ,  B32B27/40 ,  C07D493/04 ,  C08F20/36 ,  C08G18/44 ,  C08G18/664 ,  C08G18/672 ,  C08G18/755 ,  C08G64/02 ,  C08G64/0208 ,  C08G64/1608 ,  C08G64/302 ,  C08G64/305 ,  C08L75/04 ,  C09D175/04 ,  C09D175/14 ,  C09D175/16 ,  C09J175/04 ,  C09J175/14 ,  A61L2430/20

摘要： The present invention provides a novel polycarbonate diol and a polyurethane using the polycarbonate diol as raw materials. The novel polycarbonate diol produces polycarbonate diol-based polyurethane which has a high degree of hardness, superior abrasion resistance, and superior hydrophilicity, and is usable for an application such as a paint, a coating agent, a synthetic leather, an artificial leather, and a highly-functional elastomers, or the like. The present invention also provides an active-energy radiation curable polymer composition giving a cured film having a superior contamination resistance and high degree of hardness. The present invention is obtained, for example, by reacting specific two types of diols with diester carbonate in the presence of a transesterification catalyst being a compound using a metal of Group 1 or 2 on the periodic table. The present invention provides a polycarbonate diol wherein the metal content of the transesterification catalyst is 100 weight ppm or less, a polyurethane obtainable by using this polycarbonate diol and an active-energy radiation curable polymer composition containing the urethane(meth)acrylate oligomer which is obtained from the polycarbonate diol.

公开(公告)号：US12048781B2

公开(公告)日：2024-07-30

申请号：US16612677

申请日：2018-05-16

申请人： T.C ISTANBUL MEDIPOL ÜNIVERSITESI ,  T.C. MARMARA UNIVERSITESI

发明人： Oguzhan Gunduz ,  Ahmet Zeki Sengil ,  Faik Nuzhet Oktar ,  Nazmi Ekren ,  Selami Cakmak ,  Ahmet Talat Inan ,  Mehmet Onur Aydogdu ,  Esra Altun

IPC分类号： A61L27/50 ,  A61F2/06 ,  A61L27/20 ,  A61L27/24 ,  A61L27/26 ,  D01D1/02 ,  D01D5/00 ,  D01F2/24 ,  A61L27/18

CPC分类号： A61L27/507 ,  A61F2/06 ,  A61L27/20 ,  A61L27/24 ,  A61L27/26 ,  D01D1/02 ,  D01D5/003 ,  D01F2/24 ,  A61L27/18 ,  D10B2509/00

摘要： A three-dimensional biomimetic artificial blood vessel that is biodegradable and biocompatible, is inspired by the morphological structure and physiological role of blood vessels having small diameter in the human circulatory system. A method of production by electro spinning is also disclosed.

公开(公告)号：US11998655B2

公开(公告)日：2024-06-04

申请号：US17056391

申请日：2019-05-17

申请人： Cambridge Enterprise Limited

发明人： Ruth Elizabeth Cameron ,  Serena Michelle Best ,  David James Barrett ,  Matthew Linley

IPC分类号： A61L24/10 ,  A61L24/00 ,  A61L27/24 ,  A61L27/50 ,  A61L27/54

CPC分类号： A61L24/102 ,  A61L24/0015 ,  A61L27/24 ,  A61L27/507 ,  A61L27/54 ,  A61L2420/08

摘要： This invention relates to collagen biomaterials and methods for manufacturing collagen biomaterials. Method disclosed herein include steps of providing a suspension of insoluble collagen fibres, providing a layer deposition interface and applying an electric field across the suspension to cause electrophoretic deposition of the insoluble collagen fibres at the layer deposition interface. Biomaterials disclosed herein include a layer comprising an array of fibres of collagen, and a layered composite material comprising at least first and second fibrous layers each comprising an array of fibres of collagen, and a shape adapting layer sandwiched between the first and second fibrous layers. Biomaterials as described herein may be useful in a range of tissue engineering and other applications.

公开(公告)号：US11998439B2

公开(公告)日：2024-06-04

申请号：US16793355

申请日：2020-02-18

申请人： University of Pittsburgh—Of the Commonwealth System of Higher Education

发明人： Robert Andrew Allen ,  Chelsea Elizabeth Stowell ,  Yadong Wang

IPC分类号： A61F2/07 ,  A61F2/06 ,  A61L27/14 ,  A61L27/18 ,  A61L27/22 ,  A61L27/50 ,  A61L27/54 ,  A61L27/58 ,  D01D5/00 ,  D01F11/04 ,  A61L27/24

CPC分类号： A61F2/07 ,  A61F2/06 ,  A61L27/14 ,  A61L27/18 ,  A61L27/222 ,  A61L27/507 ,  A61L27/54 ,  A61L27/58 ,  D01D5/0076 ,  D01D5/0084 ,  D01F11/04 ,  A61L27/225 ,  A61L27/24 ,  D01D5/0007 ,  A61L27/18 ,  C08L67/04

摘要： A method of fabricating a vascular graft that includes preparing a biodegradable polyester electrospun tubular core; applying an adhesive composition comprising poly(lactide) copolymer to an outer surface of the biodegradable polyester electrospun tubular core; and surrounding the adhesive-applied biodegradable polyester electrospun tubular core with a polyester sheath.

公开(公告)号：US11975121B2

公开(公告)日：2024-05-07

申请号：US17083267

申请日：2020-10-28

申请人： PETVIVO HOLDINGS, INC.

发明人： David B. Masters ,  Eric P. Berg

IPC分类号： A61K31/726 ,  A61K8/64 ,  A61K8/65 ,  A61K31/70 ,  A61K31/715 ,  A61K31/727 ,  A61K31/728 ,  A61K35/545 ,  A61K38/39 ,  A61K45/06 ,  A61L27/20 ,  A61L27/22 ,  A61L27/24 ,  A61L27/34 ,  A61L27/48 ,  A61L27/50 ,  A61L31/10 ,  A61L33/12 ,  A61Q19/08 ,  A61K38/00 ,  A61M25/00

CPC分类号： A61L27/24 ,  A61K8/64 ,  A61K8/65 ,  A61K31/70 ,  A61K31/715 ,  A61K31/726 ,  A61K31/727 ,  A61K31/728 ,  A61K35/545 ,  A61K38/39 ,  A61K45/06 ,  A61L27/20 ,  A61L27/22 ,  A61L27/227 ,  A61L27/34 ,  A61L27/48 ,  A61L27/507 ,  A61L31/10 ,  A61L33/12 ,  A61Q19/08 ,  A61K38/00 ,  A61K2800/91 ,  A61M25/0045 ,  A61L27/34 ,  C08L89/00 ,  A61L27/48 ,  C08L89/00 ,  A61L31/10 ,  C08L89/00 ,  A61L27/20 ,  C08L5/00

摘要： The present invention relates to protein biocoacervates and biomaterials and the methods of making and using protein biocoacervates and biomaterials. More specifically the present invention relates to protein biocoacervates and biomaterials that may be utilized for various medical applications including, but not limited to, drug delivery devices for the controlled release of pharmacologically active agents, coated medical devices (e.g. stents, valves . . . ), vessels, tubular grafts, vascular grafts, wound healing devices including protein suture biomaterials and biomeshes, dental plugs and implants, skin/bone/tissue grafts, tissue fillers, protein biomaterial adhesion prevention barriers, cell scaffolding and other biocompatible biocoacervate or biomaterial devices.

公开(公告)号：US11963869B2

公开(公告)日：2024-04-23

申请号：US17456075

申请日：2021-11-22

申请人： Edwards Lifesciences Corporation

发明人： Louis A. Campbell ,  Donald E. Bobo, Jr. ,  Gregory A. Wright ,  Tak G. Cheung

IPC分类号： A61F2/24 ,  A61F2/00 ,  A61F2/06 ,  A61L27/22 ,  A61L27/24 ,  A61L27/36 ,  A61L27/50

CPC分类号： A61F2/2418 ,  A61F2/0095 ,  A61F2/06 ,  A61F2/2409 ,  A61F2/2412 ,  A61F2/2415 ,  A61F2/2427 ,  A61L27/222 ,  A61L27/24 ,  A61L27/3625 ,  A61L27/3687 ,  A61L27/507 ,  A61F2210/0004 ,  A61F2220/0075 ,  A61F2310/00371 ,  A61F2310/00383 ,  A61L2430/20 ,  A61L2430/40

摘要： A valved conduit including a bioprosthetic valve, such as a heart valve, and a tubular conduit sealed with a bioresorbable material. The bioprosthetic heart valve includes prosthetic tissue that has been treated such that the tissue may be stored dry for extended periods without degradation of functionality of the valve. The bioprosthetic heart valve may have separate bovine pericardial leaflets or a whole porcine valve. The sealed conduit includes a tubular matrix impregnated with a bioresorbable medium such as gelatin or collagen. The valved conduit is stored dry in packaging in which a desiccant pouch is supplied having a capacity for absorbing moisture within the packaging limited to avoid drying the bioprosthetic tissue out beyond a point where its ability to function in the bioprosthetic heart valve is compromised. The heart valve may be sewn within the sealed conduit or coupled thereto with a snap-fit connection.

公开(公告)号：US20240091415A1

公开(公告)日：2024-03-21

申请号：US18367047

申请日：2023-09-12

申请人： FRAUNHOFER-GESELLSCHAFT ZUR FÖRDERUNG DER ANGEWANDTEN FORSCHUNG e. V.

发明人： Christian Schmelzer ,  Andrea Friedmann ,  Tobias Hedtke

IPC分类号： A61L27/52 ,  A61L27/22 ,  A61L27/50 ,  B29C64/118 ,  B29C64/30 ,  B33Y10/00 ,  B33Y40/20 ,  B33Y70/00 ,  B33Y80/00 ,  C07K14/78

CPC分类号： A61L27/52 ,  A61L27/227 ,  A61L27/507 ,  B29C64/118 ,  B29C64/30 ,  B33Y10/00 ,  B33Y40/20 ,  B33Y70/00 ,  B33Y80/00 ,  C07K14/78 ,  B29K2105/0061

摘要： A process for producing a biocompatible three-dimensional article, the process comprising the steps of providing in an elastin derivative provision step a water-soluble elastin derivative, producing in a hydrogel production step a hydrogel for 3D bioprinting comprising said water-soluble elastin derivative, and 3D bioprinting in a bioprinting step the biocompatible three-dimensional article by extrusion of said hydrogel.

公开(公告)号：US11931951B2

公开(公告)日：2024-03-19

申请号：US17951568

申请日：2022-09-23

申请人： New Jersey Institute of Technology

发明人： Murat Guvendiren ,  Shen Ji

IPC分类号： B29C64/106 ,  A61L27/50 ,  A61L27/52 ,  B29C64/40 ,  B33Y10/00 ,  B33Y70/00 ,  B33Y80/00

CPC分类号： B29C64/106 ,  A61L27/507 ,  A61L27/52 ,  B29C64/40 ,  B33Y10/00 ,  B33Y70/00 ,  B33Y80/00

摘要： A method is disclosed for 3D printing of soft polymeric material such as a hydrogel or elastomer for scaffolds or devices with embedded channels with tunable shape and size such as a channel inner diameter). The method utilizes extrusion based printing of polymer solutions usually referred as direct ink writing (DIW) or BioPlotting, and requires sequential printing of a photocurable polymer solution, herein, referred as the matrix material, and a sacrificial polymer solution that may dissolve in an aqueous media.

公开(公告)号：US11931479B2

公开(公告)日：2024-03-19

申请号：US17064082

申请日：2020-10-06

申请人： GUNZE LIMITED

发明人： Goki Matsumura ,  Hideki Sato ,  Mieko Ishikawa

IPC分类号： A61L27/50 ,  A61L27/18 ,  A61L27/56 ,  A61L27/58 ,  D02G3/04 ,  D02G3/38 ,  D02G3/44

CPC分类号： A61L27/507 ,  A61L27/18 ,  A61L27/56 ,  A61L27/58 ,  D02G3/045 ,  D02G3/38 ,  D02G3/448

摘要： The present invention provides an artificial blood vessel that can achieve a balance between cell penetration efficiency and crush resistance and can regenerate a blood vessel at very high efficiency. Provided is an artificial blood vessel having a tubular shape, including: a foam containing a bioabsorbable material; a reinforcement A containing a bioabsorbable material; and a reinforcement B including threads containing a bioabsorbable material, the foam being reinforced with the reinforcements A and B, wherein the reinforcement A is a non-woven fabric, a film, or a weft-knitted, warp-knitted, or woven fabric made of knitted or woven fibers, the reinforcement B includes monofilament threads each having a cross-sectional diameter of 0.1 mm or more and 1 mm or less, the reinforcement B includes a winding portion having a helical shape, a ring shape, or an X shape and a warp thread portion stretched in a direction parallel to a longitudinal direction of the artificial blood vessel, and the artificial blood vessel is a composite including the reinforcement A and reinforcement B inside the foam.