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公开(公告)号：US12128155B2
公开(公告)日：2024-10-29
申请号：US17602237
申请日：2020-04-08
IPC分类号： A61L27/24 , A61L27/38 , A61L27/52 , A61L27/56 , B29C39/10 , B29C39/26 , B29K105/00 , B29L31/00
CPC分类号： A61L27/24 , A61L27/38 , A61L27/52 , A61L27/56 , B29C39/10 , B29C39/26 , B29K2089/00 , B29K2105/0061 , B29L2031/753
摘要： The present invention provides tissue equivalent scaffold structures and methods of production thereof. Such methods include providing a casting chamber comprising an elongate mould portion, axially disposing a lumen template within the elongate mould portion, and at least partly filling the casting chamber with a gel casting material comprising a matrix of fibrils or fibres and an interstitial fluid phase, such that a portion of the lumen template extends above the casting material. The fluid phase of the gel is allow to flow axially out of the elongate mould portion, in a restricted manner, thereby resulting in axial densification of the gel casting material to form a tissue equivalent tubular scaffold. Tissue equivalent scaffold structures according to the present invention are able to support cell populations both within the walls and on the surface of the construct. They have enhanced mechanical strength due to increased collagen density, and are customisable in terms of luminal diameter and wall thickness. They may find application in tubular tissue engineering.
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公开(公告)号：US12076770B2
公开(公告)日：2024-09-03
申请号：US17271816
申请日：2019-08-29
CPC分类号： B21D19/043 , B21D5/01 , B21D5/06 , B21D5/08 , B21D22/16 , B21D31/005
摘要： The present invention relates to methods of working sheet metal, and sheet metal working apparatus for performing such methods. Such methods include steps of providing a sheet metal workpiece having first and second surfaces opposed to each other and at least one edge, bending the workpiece to form at least a first sidewall portion defined between the edge and a basal region, the first sidewall portion thereby defining a curved fold region in the sheet metal workpiece adjacent the first sidewall portion. Following this, first anvil tool and a first forming tool are provided for contact with and constraint of the first and second surfaces of the sheet metal workpiece respectively. The forming tool and/or the anvil tool are then progressively slid along the curved fold region to cause shear material transfer in the curved fold region to further deform the curved fold region. Such methods can allow for formation of components of similar shape as made at present by deep drawing methods, but with less wastage of the starting material.
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公开(公告)号：US20240263238A1
公开(公告)日：2024-08-08
申请号：US18578982
申请日：2022-07-14
IPC分类号： C12Q1/6883 , C07K16/00 , C12N15/113
CPC分类号： C12Q1/6883 , C07K16/00 , C12N15/113 , C07K2317/622 , C12N2310/11 , C12Q2600/158
摘要： The present application features methods of treating schizophrenia and bipolar disorder by targeting dysregulated novel open reading frames (nORF) in which increased or reduced expression of the dysregulated nORF is associated with the schizophrenia or bipolar disorder.
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公开(公告)号：US20240252457A1
公开(公告)日：2024-08-01
申请号：US18568243
申请日：2022-06-08
IPC分类号： A61K31/194 , A61K9/00 , A61K45/06 , A61P9/10
CPC分类号： A61K31/194 , A61K9/0019 , A61K45/06 , A61P9/10
摘要： The present invention relates to compositions for use in treating or preventing ischaemia reperfusion injury. In particular, the present invention relates to a composition comprising a salt of formula (I): for use in treating or preventing ischaemia reperfusion injury in a subject; wherein said composition has a pH of from about 4.0 to about 7.0. and wherein X, Y, n, m, Z, A and B are as defined herein.
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公开(公告)号：US20240200098A1
公开(公告)日：2024-06-20
申请号：US18543249
申请日：2023-12-18
IPC分类号： C12N15/86 , A61K35/545 , C12N5/0735 , C12N5/074 , C12N5/077 , C12N5/079 , C12N9/22 , C12N15/11 , G01N33/50
CPC分类号： C12N15/86 , A61K35/545 , C12N5/0606 , C12N5/0607 , C12N5/0622 , C12N5/0658 , C12N9/22 , C12N15/11 , G01N33/5005 , C12N2310/20 , C12N2501/999 , C12N2506/02 , C12N2506/03 , C12N2750/14143 , C12N2800/80 , C12N2830/003 , G01N2800/00
摘要： The present invention relates to a stable method for introducing at least one inducible cassette into a cell, and permitting controllable transcription from within that inducible cassette. The method may be used for any cell type, from any eukaryotic organism, but has a particular application in the introduction of inducible cassettes into pluripotent stem cells, such as animal or human pluripotent stem cells (hPSCs). The inducible cassette is controllably inserted in such a way to ensure that the genetic material it contains is not silenced or subject to negative influences from the insertion site, and transcription of the genetic material is controlled.
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公开(公告)号：US20240175798A1
公开(公告)日：2024-05-30
申请号：US18285010
申请日：2022-03-29
发明人： Steven F. LEE , Kevin O'HOLLERAN , Alex COLLINS
IPC分类号： G01N15/1434 , G01N15/149 , G02B21/00
CPC分类号： G01N15/1434 , G01N15/149 , G02B21/0032 , G02B21/006 , G01N2015/1445
摘要： A microscopic imaging method comprising: illuminating a three-dimensional object with a light sheet generated by an illumination optical system and capturing light-field information of the illuminated object with an imaging optical system.
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公开(公告)号：US20240137129A1
公开(公告)日：2024-04-25
申请号：US18261999
申请日：2022-01-25
IPC分类号： H04B10/58
CPC分类号： H04B10/58
摘要： Techniques for driving a directly modulated laser whilst correcting non-linearities an optical output waveform, based on generating a modulating current waveform that approximates an ideal modulating current that produces a linear optical output waveform. The techniques enable useful, practical approximations to the ideal modulating current to be determined.
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公开(公告)号：US20240132554A1
公开(公告)日：2024-04-25
申请号：US18274839
申请日：2022-01-27
IPC分类号： C07K14/445 , C12N15/113
CPC分类号： C07K14/445 , C12N15/113 , C07K2317/622 , C12N2310/14 , C12N2740/15043 , C12N2750/14143
摘要： The present application features methods of diagnosing treating malaria by targeting novel open reading frames in Plasmodium falciparum. The novel open reading frames (nORFs) associated with malaria are expressed in a mosquito and in a human
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公开(公告)号：US20240122991A1
公开(公告)日：2024-04-18
申请号：US18546746
申请日：2022-02-17
发明人： Fotios Sampaziotis , Ludovic Vallier , Kourosh Saeb-Parsy , Andrew Butler , Christopher Watson , Teik Choon See
IPC分类号： A61K35/407 , A61K35/413 , A61P1/16
CPC分类号： A61K35/407 , A61K35/413 , A61P1/16
摘要： This invention relates to in vitro and in vivo methods for engrafting liver cells, such as cholangiocytes, into a liver comprising administering the liver cells to the biliary tree of the liver. The liver cells may be in the form of aggregates and may be administered in the direction of decreasing biliary duct diameter. This may be useful for example for the treatment of an individual with a diseased or damaged liver.
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公开(公告)号：US20240093180A1
公开(公告)日：2024-03-21
申请号：US17999619
申请日：2021-05-27
IPC分类号： C12N15/10
CPC分类号： C12N15/1065
摘要： The invention relates to a method of preparing a nucleic acid library from a sample comprising high molecular weight DNA (HMW DNA), preferably genomic DNA, comprising the steps (i) contacting said DNA with a first restriction enzyme and a second restriction enzyme; (ii) contacting said DNA with a pair of oligonucleotide adapters according to any of claims 1 to 12; (iii) contacting said DNA with at least one DNA ligase; and (iv) incubating to allow digestion of the DNA by said first restriction enzyme and second restriction enzyme, annealing of said oligonucleotide adapters to the digested DNA, and ligation of the annealed oligonucleotide adapters to the digested DNA by said at least one DNA ligase. The invention also relates to oligonucleotide adapters, a kit, and uses of same.
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