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1.发明公开公开(公告)号：US20240165269A1
公开(公告)日：2024-05-23
申请号：US18487740
申请日：2023-10-16
CPC分类号： A61K48/0066 , A61K38/1709 , A61K48/0033 , A61P25/28 , C12N15/86 , C12N2740/15043 , C12N2750/14143 , C12N2830/003 , C12N2830/008
摘要： The present disclosure relates to methods for inducing rejuvenation in a population of glial progenitor cells and methods for treating a subject having a glial cell-related disorder. Methods include administering, to the population of adult glial progenitor cells, an effective amount of an expression vector comprising a nucleotide sequence encoding B-cell lymphoma/leukemia 11A (BCL11A) and a regulatory element operably linked to the nucleotide sequence.
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公开(公告)号：US20240035037A1
公开(公告)日：2024-02-01
申请号：US18217863
申请日：2023-07-03
IPC分类号： C12N15/52 , C12N15/65 , C12N15/113 , C12N15/85 , C12N15/67
CPC分类号： C12N15/52 , C12N15/65 , C12N15/113 , C12N15/85 , C12N15/67 , C12N2710/22031 , C12N2015/8518 , C12N2840/203 , C12N2830/60 , C12N2830/003 , C12N2830/001 , C12N2800/107 , C12N2800/90
摘要： Recombinant expression vectors are disclosed that include a control sequence for recombinant expression of proteins of interest; the control sequence combines a mCMV enhancer sequence with a rat EF-1alpha intron sequence or a human cytomegalovirus (huCMV) intron A sequence. Some of the vectors are useful for inducible expression. Some of the vectors contain a 5′ PiggyBac ITR and a 3′ PiggyBac ITR to promote genomic integration into a host cell chromosome. A method of selecting a stable production cell line for manufacturing a protein of interest is also disclosed. Also disclosed are mammalian host cells comprising the inventive recombinant expression vectors and methods of producing a protein of interest, in vitro, involving the mammalian host cell.
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公开(公告)号：US09738907B2
公开(公告)日：2017-08-22
申请号：US10841603
申请日：2004-05-07
申请人： Philippa Radcliffe , James E. Miskin , Fraser J. Wilkes , Kyriacos A. Mitrophanous , Susan M. Kingsman
发明人： Philippa Radcliffe , James E. Miskin , Fraser J. Wilkes , Kyriacos A. Mitrophanous , Susan M. Kingsman
IPC分类号： C12N15/867 , C12N15/11 , C12N7/00 , A61K48/00 , C12N15/86
CPC分类号： C12N15/86 , A61K48/00 , C12N2740/15043 , C12N2830/003 , C12N2830/008 , C12N2830/50 , C12N2830/85 , C12N2840/20 , C12N2840/203 , C12N2840/44
摘要： Provided is a multicistronic retroviral vector genome having a first nucleic acid sequence upstream of at least one internal regulatory element, such that the level of genomic RNA available for packaging in the absence of rev, or a functional equivalent thereof, is increased.
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公开(公告)号：US09714414B2
公开(公告)日：2017-07-25
申请号：US14473250
申请日：2014-08-29
发明人： Rudolf Jaenisch , Yaqub Hanna , Marius Wernig , Christopher J. Lengner , Alexander Meissner , Oliver Tobias Brambrink , G. Grant Welstead , Ruth Foreman
IPC分类号： C12N5/074 , C07K14/47 , A01K67/027 , C12N15/85 , C12N15/877 , G01N33/50
CPC分类号： C12N5/0696 , A01K67/0273 , A01K67/0275 , A01K2217/05 , A01K2227/105 , C07K14/4702 , C12N15/8509 , C12N15/8775 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/605 , C12N2501/606 , C12N2506/11 , C12N2506/13 , C12N2800/30 , C12N2830/003 , C12N2830/006 , G01N33/5023 , G01N2333/91011
摘要： The disclosure relates to a method of reprogramming one or more somatic cells, e.g., partially differentiated or fully/terminally differentiated somatic cells, to a less differentiated state, e.g., a pluripotent or multipotent state. In further embodiments the invention also relates to reprogrammed somatic cells produced by methods of the invention, to uses of said cells, and to methods for identifying agents useful for reprogramming somatic cells.
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公开(公告)号：US20170159072A9
公开(公告)日：2017-06-08
申请号：US14966078
申请日：2015-12-11
发明人： Jefferey Arbeit , David Curiel
CPC分类号： C12N15/86 , A61K38/00 , A61K48/00 , A61K48/0058 , C07K14/71 , C07K14/715 , C07K14/7158 , C07K2319/32 , C07K2319/735 , C12N7/00 , C12N9/78 , C12N2710/10321 , C12N2710/10332 , C12N2710/10343 , C12N2710/10345 , C12N2830/002 , C12N2830/003 , C12N2830/008 , C12Y305/04001 , Y02A50/475
摘要： Disclosed are adenovirus vectors comprising a ROBO4 enhancer/promoter operatively linked to a transgene. Also disclosed are adenovirus vectors comprising a chimeric AD5-T4 phage fibritin shaft, a trimerization domain displaying a myeloid cell-binding peptide (MBP), and a ROBO4 enhancer promoter operatively linked to a transgene. Also disclosed are methods of expressing a transgene in an endothelial cell in vivo, comprising administering to a mammal an adenovirus comprising a ROBO4 enhancer/promoter operatively linked to a transgene. Also disclosed are uses of the adenoviral vectors, including mobilization of granulocytes, monocytes and lymphocytes from bone marrow, mobilization of cancer cells in vivo, selective targeting of endothelial cells, and cancer treatment methods.
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公开(公告)号：US20170028058A1
公开(公告)日：2017-02-02
申请号：US15201783
申请日：2016-07-05
发明人： Feng Yao
IPC分类号： A61K39/245 , C12N7/00
CPC分类号： A61K39/245 , A61K35/763 , A61K39/12 , A61K2039/5254 , A61K2039/5256 , A61K2039/545 , A61K2039/57 , C12N7/00 , C12N15/869 , C12N15/8695 , C12N2710/16011 , C12N2710/16021 , C12N2710/16034 , C12N2710/16062 , C12N2710/16071 , C12N2710/16611 , C12N2710/16621 , C12N2710/16622 , C12N2710/16634 , C12N2710/16661 , C12N2710/16662 , C12N2830/003 , C12N2830/006 , G01N33/56994
摘要： The present invention is directed to Herpes simplex-2 viruses that may be used in vaccines to immunize patients against genital herpes.
摘要翻译： 本发明涉及可用于免疫患者的生殖器疱疹疫苗的单纯疱疹病毒2型病毒。
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7.发明申请STEM CELL DELIVERED ONCOLYTIC HERPES SIMPLEX VIRUS AND METHODS FOR TREATING BRAIN TUMORS 审中-公开STEM CELL传播肿瘤性肝炎简单病毒和治疗脑肿瘤的方法公开(公告)号：US20160303174A1
公开(公告)日：2016-10-20
申请号：US15102962
申请日：2014-12-11
发明人： Khalid SHAH
IPC分类号： A61K35/763 , A61K38/17 , C07K14/705 , A61K9/00 , C12N7/00 , A61K35/28
CPC分类号： A61K35/763 , A61K9/0019 , A61K35/28 , A61K35/30 , A61K35/35 , A61K35/51 , A61K35/545 , A61K38/177 , C07K14/705 , C07K14/70575 , C12N7/00 , C12N2710/16132 , C12N2710/16632 , C12N2710/16671 , C12N2830/003
摘要： Disclosed herein is an isolated stem cell or population thereof that comprises oncolytic herpes simplex virus (oHSV). Examples of possible stem cells include mesenchymal stem cells (MSC), neuronal stem cells and induced pluripotent stem cells. Various forms of the oHSV are disclosed. Also disclosed are methods of treating brain cancer in a subject by administering the stem cells containing oHSV to the subject to deliver the oHSV to brain cancer cells in the subject. The method is for the treatment of primary brain cancer and secondary metastatic brain cancer.
摘要翻译： 本文公开了包含溶瘤性单纯疱疹病毒（oHSV）的分离的干细胞或其群体。 可能的干细胞的实例包括间充质干细胞（MSC），神经元干细胞和诱导多能干细胞。 公开了各种形式的oHSV。 还公开了通过向受试者施用含有oHSV的干细胞以将oHSV输送到受试者的脑癌细胞中来治疗受试者的脑癌的方法。 该方法用于治疗原发性脑癌和继发性转移性脑癌。
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公开(公告)号：US20160145643A1
公开(公告)日：2016-05-26
申请号：US14966078
申请日：2015-12-11
发明人： Jefferey Arbeit , David Curiel
CPC分类号： C12N15/86 , A61K38/00 , A61K48/00 , A61K48/0058 , C07K14/71 , C07K14/715 , C07K14/7158 , C07K2319/32 , C07K2319/735 , C12N7/00 , C12N9/78 , C12N2710/10321 , C12N2710/10332 , C12N2710/10343 , C12N2710/10345 , C12N2830/002 , C12N2830/003 , C12N2830/008 , C12Y305/04001 , Y02A50/475
摘要： Disclosed are adenovirus vectors comprising a ROBO4 enhancer/promoter operatively linked to a transgene. Also disclosed are adenovirus vectors comprising a chimeric AD5-T4 phage fibritin shaft, a trimerization domain displaying a myeloid cell-binding peptide (MBP), and a ROBO4 enhancer promoter operatively linked to a transgene. Also disclosed are methods of expressing a transgene in an endothelial cell in vivo, comprising administering to a mammal an adenovirus comprising a ROBO4 enhancer/promoter operatively linked to a transgene. Also disclosed are uses of the adenoviral vectors, including mobilization of granulocytes, monocytes and lymphocytes from bone marrow, mobilization of cancer cells in vivo, selective targeting of endothelial cells, and cancer treatment methods.
摘要翻译： 公开了包含可操作地连接到转基因的ROBO4增强子/启动子的腺病毒载体。 还公开了包含嵌合AD5-T4噬菌体纤维蛋白轴，显示骨髓细胞结合肽（MBP）的三聚体结构域和可操作地连接到转基因的ROBO4增强子启动子的腺病毒载体。 还公开了在体内在内皮细胞中表达转基因的方法，包括向哺乳动物施用包含可操作地连接到转基因的ROBO4增强子/启动子的腺病毒。 还公开了腺病毒载体的使用，包括从骨髓中移动粒细胞，单核细胞和淋巴细胞，体内移动癌细胞，选择性靶向内皮细胞和癌症治疗方法。
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公开(公告)号：US20160143951A1
公开(公告)日：2016-05-26
申请号：US14776672
申请日：2014-03-14
发明人： Jeanne B. Lawrence , Jun Jiang , Lisa L. Hall
CPC分类号： A61K35/28 , A01K67/0271 , A01K67/0275 , A01K2207/12 , A01K2217/072 , A01K2217/15 , A01K2217/203 , A01K2227/105 , A01K2267/0318 , A01K2267/0356 , A61K48/005 , A61K48/0075 , A61K2035/124 , C12N9/12 , C12N15/111 , C12N15/1137 , C12N15/85 , C12N15/8509 , C12N15/907 , C12N2310/111 , C12N2310/113 , C12N2310/14 , C12N2330/51 , C12N2800/40 , C12N2810/10 , C12N2830/003 , C12N2830/32 , C12N2999/005 , C12Y207/12001
摘要： Methods and compositions for reducing expression of genes on Chromosome 21 (“Chr 21”) by targeting an XIST transgene to the Dual specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A) gene or a Regulator of calcineurin 1 (RCAN1) gene, and cells and transgenic animals comprising an XIST transgene inserted into a DYRK1A or RCAN1 allele, e.g., cells and animals trisomic for human Chr 21 and mouse Chr 16.
摘要翻译： 通过将XIST转基因靶向双重特异性酪氨酸磷酸化调节激酶1A（DYRK1A）基因或钙调神经磷酸酶1（RCAN1）基因的调节剂）和细胞，减少染色体21（“Chr 21”）上基因表达的方法和组合物 以及包含插入到DYRK1A或RCAN1等位基因中的XIST转基因的转基因动物，例如用于人Chr 21和小鼠Chr 16的三体细胞和动物。
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公开(公告)号：US20160115456A1
公开(公告)日：2016-04-28
申请号：US14923321
申请日：2015-10-26
IPC分类号： C12N5/074
CPC分类号： C12N5/0696 , A01K67/0273 , A01K67/0275 , A01K2217/05 , A01K2227/105 , C07K14/4702 , C12N15/85 , C12N15/8509 , C12N15/8775 , C12N2501/602 , C12N2501/603 , C12N2501/605 , C12N2506/1307 , C12N2510/00 , C12N2830/003 , C12N2830/006
摘要： The invention provides methods for reprogramming somatic cells to generate multipotent or pluripotent cells. Such methods are useful for a variety of purposes, including treating or preventing a medical condition in an individual. The invention further provides methods for identifying an agent that reprograms somatic cells to a less differentiated state.
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