公开(公告)号：US12128098B2

公开(公告)日：2024-10-29

申请号：US17160776

申请日：2021-01-28

申请人： Squarex, LLC

发明人： Hugh McTavish

IPC分类号： A61K39/245 ,  A61K9/00 ,  A61K31/04 ,  A61K31/122 ,  A61K31/215 ,  A61K35/763 ,  A61K39/12 ,  A61K39/165 ,  C07K14/035 ,  G01N33/571 ,  A61K39/00

CPC分类号： A61K39/245 ,  A61K9/0014 ,  A61K9/0021 ,  A61K31/04 ,  A61K31/122 ,  A61K31/215 ,  A61K35/763 ,  A61K39/12 ,  A61K39/165 ,  C07K14/035 ,  G01N33/571 ,  A61K2039/54 ,  A61K2039/545 ,  A61K2039/55511 ,  C12N2710/16611 ,  A61K31/122 ,  A61K2300/00 ,  A61K31/04 ,  A61K2300/00 ,  A61K31/215 ,  A61K2300/00

摘要： A method is presented for treating herpes simplex virus (HSV) infection comprising: (a) locally administering a substance that induces a delayed type hypersensitivity (DTH) response to a patient at a site other than at the site of an HSV lesion to induce a DTH response during one or more outbreaks of the HSV infection. The method reduces the number of HSV outbreaks in persons experiencing outbreaks.

公开(公告)号：US12036256B2

公开(公告)日：2024-07-16

申请号：US17046466

申请日：2019-04-12

申请人： Regeneron Pharmaceuticals, Inc.

发明人： James Brian Rottman

IPC分类号： A61K35/763 ,  A61K39/00 ,  A61K39/12 ,  A61K39/285 ,  A61K39/39 ,  A61P35/00 ,  C07K14/725 ,  C12N7/00

CPC分类号： A61K35/763 ,  A61K39/001102 ,  A61K39/001112 ,  A61P35/00 ,  C07K14/7051 ,  C12N7/00 ,  A61K2039/5156 ,  A61K2039/5158 ,  A61K2039/5256 ,  C07K2319/02 ,  C07K2319/03 ,  C12N2710/16621 ,  C12N2710/16632

摘要： The invention provides improved compositions and methods for the treatment of solid cancers.

公开(公告)号：US11865148B2

公开(公告)日：2024-01-09

申请号：US18060515

申请日：2022-11-30

申请人： Krystal Biotech, Inc.

发明人： Suma Krishnan

IPC分类号： A61K35/763 ,  A61K9/00 ,  A61K38/17 ,  A61K38/39 ,  A61K48/00 ,  C07K14/78 ,  C12N9/02 ,  A61K9/06 ,  A61K47/38

CPC分类号： A61K35/763 ,  A61K9/0014 ,  A61K38/1748 ,  A61K38/39 ,  A61K48/005 ,  C07K14/78 ,  C12N9/0071 ,  C12Y114/11004 ,  A61K9/06 ,  A61K47/38 ,  C12N2710/16643 ,  A61K39/12 ,  A61K2039/53 ,  C12N15/86 ,  C12N7/00 ,  C12N2710/16034 ,  A61K38/39

摘要： Provided herein are methods of delivering transgenes to an eye of a subject comprising the use of pharmaceutical compositions having one or more polynucleotides suitable for enhancing, increasing, augmenting, and/or supplementing the levels of the transgene in the eye. Also provided herein are methods of correcting vision loss in a subject in need thereof comprising the use of the pharmaceutical compositions described herein.

公开(公告)号：US20230372472A1

公开(公告)日：2023-11-23

申请号：US18028139

申请日：2021-09-24

申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE ,  DANA-FARBER CANCER INSTITUTE, INC.

发明人： David M. KNIPE ,  Michael J. WALSH ,  Stephanie K. DOUGAN

IPC分类号： A61K39/245 ,  C12N7/00 ,  A61K35/763 ,  A61K38/20 ,  A61P35/00

CPC分类号： A61K39/245 ,  C12N7/00 ,  A61K35/763 ,  A61K38/208 ,  A61P35/00 ,  C12N2710/16621 ,  C12N2710/16632 ,  C12N2710/16671 ,  A61K2039/572

摘要： Provided herein is a replication-defective oncolytic herpes simplex virus 1 (HSV-1) recombinant virus, comprising within its genome: a coding sequence encoding a fusion protein.

公开(公告)号：US11786569B2

公开(公告)日：2023-10-17

申请号：US16959025

申请日：2019-01-28

申请人： University of Pittsburgh—Of the Commonwealth System of Higher Education

发明人： Greg M. Delgoffe ,  Dayana Rivadeneira ,  Padmavathi Sampath ,  Stephen H. Thorne

IPC分类号： A61K38/00 ,  A61K35/763 ,  A61P35/00 ,  A61K35/768 ,  C07K14/495 ,  C07K14/54 ,  C07K14/545 ,  C07K14/55 ,  C07K14/56 ,  C07K14/57 ,  C07K14/575 ,  C12N7/00 ,  A61K45/06

CPC分类号： A61K35/763 ,  A61K35/768 ,  A61P35/00 ,  C07K14/495 ,  C07K14/545 ,  C07K14/5406 ,  C07K14/5418 ,  C07K14/5425 ,  C07K14/5428 ,  C07K14/5437 ,  C07K14/5443 ,  C07K14/55 ,  C07K14/56 ,  C07K14/57 ,  C07K14/5759 ,  C12N7/00 ,  A61K45/06

摘要： Recombinant oncolytic viruses (OVs) that express one or more metabolic modulator proteins, such as an adipokine (e.g., leptin or chemerin), insulin, and/or IGF-1, and methods of their use to treat cancer, for example in immunotherapy anti-cancer treatments. In some examples, such recombinant OVs and methods increase T cell infiltration into the tumor or tumor microenvironment.

公开(公告)号：US20230241140A1

公开(公告)日：2023-08-03

申请号：US18165770

申请日：2023-02-07

申请人： Oncorus, Inc.

发明人： Mitchell H. FINER ,  Lorena LERNER ,  Christophe QUÉVA ,  Edward KENNEDY

IPC分类号： A61K35/763 ,  C12N7/00 ,  C12N15/86

CPC分类号： A61K35/763 ,  C12N7/00 ,  C12N15/86 ,  C12N2710/16632 ,  C12N2710/16643

摘要： Oncolytic viral vectors that incorporate one or more of the following features: viral replication restriction by insertion of microRNA (miRNA) target sequences into the viral genome; disruption of oncogenic miRNA function; cancer microenvironment remodeling; and cancer cell targeting by incorporation of protease-activated antibodies into the viral particle. Such viral vectors can be used for the treatment and prevention of cancer.

公开(公告)号：US20230203453A1

公开(公告)日：2023-06-29

申请号：US17817245

申请日：2022-08-03

申请人： Replimune Limited

发明人： Robert Coffin

IPC分类号： C12N7/00 ,  A61P35/00 ,  A61K35/763 ,  A61K45/06 ,  C07K14/005 ,  C07K14/535 ,  A61K39/395 ,  C07K16/28

CPC分类号： C12N7/00 ,  A61K35/763 ,  A61K39/3955 ,  A61K39/39558 ,  A61K45/06 ,  A61P35/00 ,  C07K14/005 ,  C07K14/535 ,  C07K16/2818 ,  A61K2039/505 ,  C12N2710/16621 ,  C12N2710/16633 ,  C12N2740/13022

摘要： The present invention relates to an oncolytic virus comprising: (i) a fusogenic protein-encoding gene; and (ii) an immune stimulatory molecule-encoding gene.

公开(公告)号：US10034938B2

公开(公告)日：2018-07-31

申请号：US14424424

申请日：2013-08-30

申请人： AMGEN INC.

发明人： Ari Vanderwalde ,  Mohamed Shabooti

IPC分类号： A61K39/395 ,  A61K35/763 ,  C07K14/535 ,  C07K16/28 ,  A61K39/00 ,  A61K31/00

CPC分类号： A61K39/39558 ,  A61K35/763 ,  A61K39/3955 ,  A61K2039/505 ,  A61K2039/525 ,  C07K14/535 ,  C07K16/2818 ,  C07K2317/21 ,  C07K2317/76 ,  C12N2750/14343 ,  C12N2799/025 ,  A61K31/00

摘要： The invention relates to methods of treating melanoma using a herpes simplex virus in combination with an immune checkpoint inhibitor.

公开(公告)号：US20180169159A1

公开(公告)日：2018-06-21

申请号：US15735502

申请日：2016-06-13

申请人： UNIVERSITY OF MIAMI

发明人： Glen N. Barber

IPC分类号： A61K35/763 ,  A61P35/00 ,  G01N33/574

CPC分类号： A61K35/763 ,  A61P35/00 ,  C12N2710/16633 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/156 ,  C12Q2600/158 ,  G01N33/57492 ,  G01N2333/4706

摘要： The present disclosure provides, in general, a method for selecting a therapy for treating cancer in a human subject and subsequently treating cancer in a subject, which includes isolating a cancer cell from a human subject having cancer, determining the functional activity of STING or cGAS in the cell; and selecting a therapy for the cancer based on the functional activity of the STING or cGAS in the cell. Also provided, if the functional activity of STING and/or cGAS is determined to be defective in the cell, the therapy selected is one that is effective at killing STING-deficient and/or cGAS-deficient cancer cells, e.g., therapy including administering to the subject an oncolytic virus.

公开(公告)号：US20170340731A1

公开(公告)日：2017-11-30

申请号：US15681393

申请日：2017-08-20

申请人： Squarex, LLC

发明人： Hugh McTavish

IPC分类号： A61K39/245 ,  A61K35/763 ,  G01N33/571 ,  C07K14/035 ,  A61K39/00

CPC分类号： A61K39/245 ,  A61K31/04 ,  A61K35/763 ,  A61K39/12 ,  A61K39/165 ,  A61K2039/54 ,  A61K2039/545 ,  A61K2039/55511 ,  C07K14/035 ,  C12N2710/16611 ,  G01N33/571

摘要： A method is presented for treating herpes simplex virus (HSV) infection comprising: (a) locally administering a substance that induces a delayed type hypersensitivity (DTH) response to a patient at a site of an HSV lesion to induce a DTH response at the site of the lesion during one or more outbreaks of the HSV infection.