公开(公告)号：US20240360215A1

公开(公告)日：2024-10-31

申请号：US18645760

申请日：2024-04-25

Applicant: The Regents of the University of California

Inventor： James L. Rubenstein

IPC: C07K16/28 ,  A61K9/00 ,  A61K31/454 ,  A61K31/519 ,  A61K39/00 ,  A61P35/00

CPC classification number: C07K16/2803 ,  A61K9/0019 ,  A61K31/454 ,  A61K31/519 ,  A61P35/00 ,  A61K2039/505 ,  A61K2039/54 ,  A61K2039/545 ,  C07K2317/24

Abstract: The disclosure provides a method of treating CNS lymphomas using a combination therapy comprising an anti-CD19 antibody and an immunomodulatory imide drug.

公开(公告)号：US20240360211A1

公开(公告)日：2024-10-31

申请号：US18436088

申请日：2024-02-08

Applicant: Singapore Health Services PTE LTD. ,  National University of Singapore

Inventor： Stuart Alexander Cook ,  Sebastian Schaefer

IPC: C07K16/24 ,  A61K39/00 ,  C07K14/54 ,  C07K14/715 ,  C07K16/28 ,  C12N15/113

CPC classification number: C07K16/244 ,  C07K14/5428 ,  C07K14/7155 ,  C07K16/2866 ,  C12N15/1136 ,  C12N15/1138 ,  A61K2039/505 ,  A61K2039/54 ,  C07K2317/20 ,  C07K2317/21 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2319/00 ,  C07K2319/32 ,  C07K2319/43 ,  C12N2310/14

Abstract: Aspects of the disclosure relate to the treatment, prevention or alleviation of conditions such as fibrosis in a subject. In some embodiments, the treatment, prevention or alleviation of fibrosis in a subject through the administration of an agent capable of inhibiting the action of Interleukin 11 (IL-11) is disclosed.

公开(公告)号：US20240358825A1

公开(公告)日：2024-10-31

申请号：US18406869

申请日：2024-01-08

Applicant: Zoetis Services LLC

Inventor： Paul Joseph Dominowski ,  Ramasamy Mannar Mannan ,  Richard Lee Krebs ,  James Richard Thompson ,  Tedd Alan Childers ,  Mary Kathryn Olsen ,  Robert John Yancey, Jr. ,  Risini Dhammika Weeratna ,  Shucheng Zhang ,  Cedo Martin Bagi

IPC: A61K39/39 ,  A61K39/00 ,  A61K39/002 ,  A61K39/012 ,  A61K39/02 ,  A61K39/108 ,  A61K39/12 ,  A61K39/145 ,  A61K39/15 ,  A61K39/21 ,  A61K39/215 ,  A61P37/02

CPC classification number: A61K39/39 ,  A61K39/0011 ,  A61K39/002 ,  A61K39/012 ,  A61K39/0208 ,  A61K39/0241 ,  A61K39/0258 ,  A61K39/12 ,  A61K39/145 ,  A61K39/15 ,  A61K39/21 ,  A61K39/215 ,  A61P37/02 ,  A61K2039/521 ,  A61K2039/5252 ,  A61K2039/5254 ,  A61K2039/54 ,  A61K2039/55 ,  A61K2039/552 ,  A61K2039/55505 ,  A61K2039/55511 ,  A61K2039/55555 ,  A61K2039/55561 ,  A61K2039/55566 ,  A61K2039/55572 ,  A61K2039/55577 ,  C12N2720/12334 ,  C12N2720/12351 ,  C12N2740/13034 ,  C12N2740/13051 ,  C12N2760/16134 ,  C12N2760/16151 ,  C12N2770/20034 ,  C12N2770/20051 ,  C12N2770/24334 ,  C12N2770/24351 ,  Y02A50/30

Abstract: This invention relates to adjuvant formulations comprising various combinations of triterpenoids, sterols, immunomodulators, polymers, and Th2 stimulators; methods for making the adjuvant compositions; and the use of the adjuvant formulations in immunogenic and vaccine compositions with different antigens. This invention further relates to the use of the formulations in the treatment of animals.

公开(公告)号：US20240352133A1

公开(公告)日：2024-10-24

申请号：US18749821

申请日：2024-06-21

Applicant: Viridian Therapeutics, Inc.

Inventor： Vahe BEDIAN ,  Yang ZHAO

IPC: C07K16/28 ,  A61K33/04 ,  A61K39/00 ,  A61K39/395 ,  A61K45/06 ,  A61P27/02 ,  C07K16/24

CPC classification number: C07K16/2863 ,  A61K33/04 ,  A61K39/3955 ,  A61K45/06 ,  A61P27/02 ,  C07K16/241 ,  C07K16/248 ,  C07K16/2887 ,  A61K2039/54 ,  A61K2039/545 ,  C07K2317/24 ,  C07K2317/622

Abstract: Antibodies and compositions against IGF-1R and uses thereof are provided herein.

公开(公告)号：US20240350605A1

公开(公告)日：2024-10-24

申请号：US18688336

申请日：2022-08-31

Applicant: Elixirgen Therapeutics, Inc.

Inventor： Minoru S.H. KO

IPC: A61K39/00 ,  A61K9/00 ,  A61K47/36 ,  A61P35/00 ,  C07K14/005 ,  C07K14/47 ,  C12N15/86

CPC classification number: A61K39/001189 ,  A61K9/0021 ,  A61K39/00115 ,  A61K39/001153 ,  A61K39/001186 ,  A61K39/001188 ,  A61K47/36 ,  A61P35/00 ,  C07K14/005 ,  C07K14/4748 ,  C12N15/86 ,  A61K2039/53 ,  A61K2039/54 ,  A61K2039/572 ,  A61K2039/575 ,  A61K2039/70 ,  C07K2319/02 ,  C12N2770/36122 ,  C12N2770/36134 ,  C12N2770/36143 ,  C12N2810/855

Abstract: The present disclosure relates to mRNA, self-replicating RNA, and temperature-sensitive, self-replicating RNA encoding a cancer antigen. The RNA constructs are suitable for cancer immunotherapy in a mammalian subject, such as a human subject.

公开(公告)号：US20240343812A1

公开(公告)日：2024-10-17

申请号：US18391233

申请日：2023-12-20

Applicant: Viridian Therapeutics, Inc.

Inventor： Denis O'Shaughnessy ,  Barrett Katz

IPC: C07K16/28 ,  A61K39/00 ,  A61P5/14 ,  A61P27/02 ,  A61P37/00

CPC classification number: C07K16/2863 ,  A61P5/14 ,  A61P27/02 ,  A61P37/00 ,  A61K2039/505 ,  A61K2039/54 ,  A61K2039/545 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/77 ,  C07K2317/92

Abstract: Antibodies and compositions against IGF-1R and uses thereof are provided herein.

公开(公告)号：US12109259B2

公开(公告)日：2024-10-08

申请号：US16326833

申请日：2017-09-01

Applicant: GLAXOSMITHKLINE BIOLOGICALS, S.A.

Inventor： Mariagrazia Pizza ,  Steven B. Black

IPC: A61K39/095 ,  A61K39/116 ,  A61K39/39 ,  A61K47/64 ,  C07K14/22 ,  C07K16/12 ,  A61K39/00

CPC classification number: A61K39/095 ,  A61K39/116 ,  A61K39/39 ,  A61K47/646 ,  C07K14/22 ,  C07K16/1217 ,  A61K2039/54 ,  A61K2039/55 ,  A61K2039/55505 ,  A61K2039/58 ,  C07K2317/33

Abstract: A method for immunizing a subject in need thereof against Neisseria gonorrhoeae by administering an immunogenic composition comprising meningococcal outer membrane vesicles (OMVs).

公开(公告)号：US20240325530A1

公开(公告)日：2024-10-03

申请号：US18587617

申请日：2024-02-26

Applicant: Versanis Bio, Inc.

Inventor： Lloyd Berl KLICKSTEIN ,  Matthias MACHACEK

IPC: A61K39/395 ,  A61K38/26 ,  A61K39/00 ,  A61P3/04

CPC classification number: A61K39/3955 ,  A61K38/26 ,  A61P3/04 ,  A61K2039/54 ,  A61K2039/545

Abstract: The disclosure relates to the combined use of an ActRII pathway agent, e.g., an ActRII receptor antibody, and a GLP-1 agonist for the treatment of metabolic disorders, including obesity. As provided herein, the combination treatment reduces fat mass and maintains or increases lean mass.

公开(公告)号：US12103963B2

公开(公告)日：2024-10-01

申请号：US18351189

申请日：2023-07-12

Applicant: University of Massachusetts

Inventor： Mark S. Klempner ,  Yang Wang ,  Lisa Cavacini ,  Alla Amcheslavsky

IPC: C07K16/12 ,  A61P31/04 ,  G01N33/46 ,  G01N33/569 ,  A61K39/00

CPC classification number: C07K16/1232 ,  A61P31/04 ,  G01N33/56916 ,  A61K2039/505 ,  A61K2039/54 ,  A61K2039/545 ,  C07K2317/14 ,  C07K2317/24 ,  C07K2317/522 ,  C07K2317/53 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/569 ,  C07K2317/76 ,  C07K2317/92 ,  G01N2333/245 ,  G01N2469/10

Abstract: The invention provides anti-ETEC adhesin protein antibodies and methods of using the same.

公开(公告)号：US20240317878A1

公开(公告)日：2024-09-26

申请号：US18597624

申请日：2024-03-06

Applicant: Novartis AG

Inventor： Erik Wallström ,  Marina Savelieva Praz ,  Algirdas Jonas Kakarieka Weisskopf ,  Joseph Michael Kahn

IPC: C07K16/28 ,  A61K9/00 ,  A61K39/00 ,  A61P25/28 ,  A61P37/06

CPC classification number: C07K16/2887 ,  A61K9/0019 ,  A61P25/28 ,  A61P37/06 ,  A61K2039/505 ,  A61K2039/54 ,  A61K2039/545 ,  C07K2317/21

Abstract: The disclosure is directed to treatment regimens for treating Multiple Sclerosis (MS). These methods utilize administration of ofatumumab. an anti-CD20 monoclonal antibody. to the patient during a loading dose regimen and a maintenance regimen