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公开(公告)号：US20250001009A1
公开(公告)日：2025-01-02
申请号：US18712223
申请日：2022-11-21
Applicant: University of Pittsburgh - Of the Commonwealth System of Higher Education , Regents of the University of Michigan , Kyushu University, National University Corporation
Inventor： Alejandro Soto-Gutierrez , Kazuki Takeishi , Kazutoyo Morita , Nils Haep , Rodrigo Machado Florentino , Abhinav Achreja , Deepak Nagrath , Olamide Animasahun , Tomoharu Yoshizumi
IPC: A61K48/00 , A61K31/122 , A61K31/164 , A61K31/355 , A61K31/7105 , A61K33/04 , A61K38/06 , A61K38/44 , A61P1/16 , C12N15/86
Abstract: Methods are disclosed herein for promoting survival of a donor liver in a recipient subject, wherein the donor liver is homozygous for rs738409:G mutation in the patatin-like phospholipase domain-containing protein 3 (PNPLA3) gene. The method can include administering to the subject glutathione (GSH) and/or a nucleic acid molecule encoding a component of the ferroptosis pathway (such as GPX4).
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公开(公告)号：US20240415876A1
公开(公告)日：2024-12-19
申请号：US18792849
申请日：2024-08-02
Applicant: Braintree Laboratories, Inc.
Inventor： Edmund V. Dennett , Mark Cleveland , Russell W. Pelham , Matthew Walker
Abstract: Disclosed herein are methods of administering compositions comprising a mixture of salts that induce purgation of the colon and are useful to cleanse the colon. Furthermore, the disclosed methods prevent degradation of PEG and allow for cleansing of the colon without the use of adjunct laxatives, including stimulant laxatives such as bisacodyl. The disclosed methods are superior to the prior art in that they allow for higher tolerability, improved safety, lower volumes, and improved patient compliance.
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公开(公告)号：US20240390414A1
公开(公告)日：2024-11-28
申请号：US18208186
申请日：2023-06-09
Applicant: Thiogenics LLC
Inventor： Christian Bogner , Alex Zaharakis
Abstract: Disclosed is a method for treating oxidative stress or inflammation which comprises administering to a subject suffering from oxidative stress or inflammation a therapeutically effective amount of sodium thiosulfate.
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公开(公告)号：US12150957B2
公开(公告)日：2024-11-26
申请号：US18672876
申请日：2024-05-23
Applicant: American Regent, Inc.
Inventor： Gopal Anyarambhatla , Richard Lawrence , Jasmina Marinkovic
IPC: A61K33/30 , A61K9/00 , A61K31/7004 , A61K33/00 , A61K33/04 , A61K33/06 , A61K33/22 , A61K33/24 , A61K33/32 , A61K33/34 , A61K47/10 , A61K47/20 , A61P3/02
Abstract: Injectable compositions that can be added to parenteral nutrition are provided. In particular, a stable injectable composition is provided which includes water, and at least one of about 800 μg to about 4,000 μg of zinc, about 40 μg to about 400 μg of copper, from about 4 μg to about 90 μg of selenium, or from about 1 μg to about 80 μg of manganese per 1 mL of the injectable composition. Methods of preparing and using of the stable injectable composition are also provided.
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公开(公告)号：US12150956B2
公开(公告)日：2024-11-26
申请号：US18653608
申请日：2024-05-02
Applicant: American Regent, Inc.
Inventor： Gopal Anyarambhatla , Richard Lawrence , Jasmina Marinkovic
IPC: A61K33/30 , A61K9/00 , A61K31/7004 , A61K33/00 , A61K33/04 , A61K33/06 , A61K33/22 , A61K33/24 , A61K33/32 , A61K33/34 , A61K47/10 , A61K47/20 , A61P3/02
Abstract: Injectable compositions that can be added to parenteral nutrition are provided. In particular, a stable injectable composition is provided which includes water, and at least one of about 800 μg to about 4,000 μg of zinc, about 40 μg to about 400 μg of copper, from about 4 μg to about 90 μg of selenium, or from about 1 μg to about 80 μg of manganese per 1 mL of the injectable composition. Methods of preparing and using of the stable injectable composition are also provided.
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Patent Agency Ranking
公开(公告)号：US20240350637A1
公开(公告)日：2024-10-24
申请号：US18503027
申请日：2023-11-06
Applicant: Fennec Pharmaceuticals Inc.
Inventor： Thomas Claiborne Lovelace , Joseph Alexander Moore, III , Christopher McKinnon Lee , Daniel Logan Kirschner
CPC classification number: A61K47/20 , A61K9/0019 , A61K9/08 , A61K33/04 , A61K33/243 , A61K47/02 , A61K47/18 , A61K47/183
Abstract: Described herein is anhydrous sodium thiosulfate, methods for synthesizing anhydrous sodium thiosulfate, pharmaceutical compositions thereof, and methods of treating ototoxicity. Anhydrous sodium thiosulfate is synthesized from sodium sulfite, sulfur, and cetylpyridinium chloride. The anhydrous sodium thiosulfate is formulated into a pharmaceutical composition comprising a buffer and solvent. These compositions are useful for eliminating or reducing ototoxicity in pediatric patients receiving platinum-based chemotherapeutics.
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公开(公告)号：US20240350517A1
公开(公告)日：2024-10-24
申请号：US18759278
申请日：2024-06-28
Applicant: Azura Ophthalmics Ltd.
Inventor： Yair ALSTER , Omer RAFAELI , Kirsten Angela MACFARLANE , Cary REICH , Shimon AMSELEM , Doron FRIEDMAN
IPC: A61K31/60 , A61K8/22 , A61K8/23 , A61K9/00 , A61K9/06 , A61K31/122 , A61K31/17 , A61K31/19 , A61K31/327 , A61K31/4015 , A61K31/555 , A61K33/04 , A61K35/04
CPC classification number: A61K31/60 , A61K8/22 , A61K8/23 , A61K9/0048 , A61K9/06 , A61K31/122 , A61K31/17 , A61K31/19 , A61K31/327 , A61K31/4015 , A61K31/555 , A61K33/04 , A61K35/04 , A61K9/0014
Abstract: Described herein are compositions and methods for the treatment of meibomian gland dysfunction. Said compositions and methods comprise keratolytic agents, such as salicylic acid, selenium disulfide, or the like. Topical administration of said compositions to the eyelid margin or surrounding areas provides therapeutic benefit to patients suffering from meibomian gland dysfunction.
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公开(公告)号：US20240342233A1
公开(公告)日：2024-10-17
申请号：US18749877
申请日：2024-06-21
Applicant: Laura Mann Kevehazi
Inventor： Laura Mann Kevehazi
IPC: A61K36/42 , A61K31/01 , A61K31/4375 , A61K33/04 , A61K36/074 , A61K36/185 , A61P13/08
CPC classification number: A61K36/42 , A61K31/01 , A61K31/4375 , A61K33/04 , A61K36/074 , A61K36/185 , A61P13/08
Abstract: A composition for protecting the prostate tissue and inhibiting prostate cancer development has Pumpkin seed extract; Nettle root extract; Berberine; Embilica officinalis (Amla berry); Ganoderma Lucidum (Reishi mushroom); Lycopene; and Selenium.
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9.发明公开公开(公告)号：US20240315998A1
公开(公告)日：2024-09-26
申请号：US18677822
申请日：2024-05-29
Applicant: FILTRICINE, INC.
Inventor： Xiyan Li , Xin Wang , Xiaolu Yang
IPC: A61K31/198 , A61K31/07 , A61K31/14 , A61K31/355 , A61K31/375 , A61K31/4188 , A61K31/455 , A61K31/51 , A61K31/519 , A61K31/525 , A61K31/593 , A61K31/675 , A61K31/7004 , A61K31/714 , A61K33/04 , A61K33/16 , A61K33/18 , A61K33/24 , A61K33/26 , A61K33/30 , A61K33/32 , A61K33/34
CPC classification number: A61K31/198 , A61K31/07 , A61K31/14 , A61K31/355 , A61K31/375 , A61K31/4188 , A61K31/455 , A61K31/51 , A61K31/519 , A61K31/525 , A61K31/593 , A61K31/675 , A61K31/7004 , A61K31/714 , A61K33/04 , A61K33/16 , A61K33/18 , A61K33/24 , A61K33/26 , A61K33/30 , A61K33/32 , A61K33/34
Abstract: The present disclosure provides compositions and methods for treating cancer with nutritionally modified diets and/or dialysis treatment, such as through amino acid depletion of one or more nonessential amino acids. In some aspects, the present disclosure provides compositions and methods for treating obesity with such modified diets and/or dialysis treatment. Furthermore, in some aspects, the present disclosure provides compositions and methods for treating renal disease with such modified diets and/or dialysis treatment.
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公开(公告)号：US20240299445A1
公开(公告)日：2024-09-12
申请号：US18665222
申请日：2024-05-15
Applicant: Azura Ophthalmics Ltd.
Inventor： Doron FRIEDMAN , Yair ALSTER , Omer RAFAELI , Shimon AMSELEM , Zakhar NUDELMAN
Abstract: Described herein are compositions and methods for the treatment of meibomian gland dysfunction. Said methods are performed by administering said composition comprising a selenium disulfide and an anhydrous semi-solid base. The stable anhydrous composition are substantially free of selenium disulfide agglomerates.
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