公开(公告)号：US20240358757A1

公开(公告)日：2024-10-31

申请号：US18606648

申请日：2024-03-15

Applicant: Immatics Biotechnologies GmbH

Inventor： Ricarda HANNEN ,  Jens HUKELMANN ,  Florian KOEHLER ,  Daniel Johannes KOWALEWSKI ,  Heiko SCHUSTER ,  Oliver SCHOOR ,  Michael ROEMER ,  Chih-Chiang TSOU ,  Jens FRITSCHE

IPC: A61K35/17 ,  A61K39/00 ,  A61P35/00 ,  C07K14/47 ,  C12N5/0783

CPC classification number: A61K35/17 ,  A61K39/0011 ,  A61P35/00 ,  C07K14/4748 ,  C12N5/0636

Abstract: The invention relates to a peptide comprising an amino acid sequence selected from the group consisting of (i) SEQ ID NO: 1 to SEQ ID NO: 216, and (ii) a variant sequence thereof which maintains capacity to bind to MHC molecule(s) and/or induce T cells cross-reacting with said variant peptide, or a pharmaceutically acceptable salt thereof.

公开(公告)号：US20240358755A1

公开(公告)日：2024-10-31

申请号：US18599888

申请日：2024-03-08

Applicant: Immatics Biotechnologies GmbH

Inventor： Ricarda HANNEN ,  Jens HUKELMANN ,  Florian KOEHLER ,  Daniel Johannes KOWALEWSKI ,  Heiko SCHUSTER ,  Oliver SCHOOR ,  Michael ROEMER ,  Chih-Chiang TSOU ,  Jens FRITSCHE

IPC: A61K35/17 ,  A61K39/00 ,  A61P35/00 ,  C07K14/47 ,  C12N5/0783

CPC classification number: A61K35/17 ,  A61K39/0011 ,  A61P35/00 ,  C07K14/4748 ,  C12N5/0636

Abstract: The invention relates to a peptide comprising an amino acid sequence selected from the group consisting of (i) SEQ ID NO: 1 to SEQ ID NO: 216, and (ii) a variant sequence thereof which maintains capacity to bind to MHC molecule(s) and/or induce T cells cross-reacting with said variant peptide, or a pharmaceutically acceptable salt thereof.

公开(公告)号：US20240350605A1

公开(公告)日：2024-10-24

申请号：US18688336

申请日：2022-08-31

Applicant: Elixirgen Therapeutics, Inc.

Inventor： Minoru S.H. KO

IPC: A61K39/00 ,  A61K9/00 ,  A61K47/36 ,  A61P35/00 ,  C07K14/005 ,  C07K14/47 ,  C12N15/86

CPC classification number: A61K39/001189 ,  A61K9/0021 ,  A61K39/00115 ,  A61K39/001153 ,  A61K39/001186 ,  A61K39/001188 ,  A61K47/36 ,  A61P35/00 ,  C07K14/005 ,  C07K14/4748 ,  C12N15/86 ,  A61K2039/53 ,  A61K2039/54 ,  A61K2039/572 ,  A61K2039/575 ,  A61K2039/70 ,  C07K2319/02 ,  C12N2770/36122 ,  C12N2770/36134 ,  C12N2770/36143 ,  C12N2810/855

Abstract: The present disclosure relates to mRNA, self-replicating RNA, and temperature-sensitive, self-replicating RNA encoding a cancer antigen. The RNA constructs are suitable for cancer immunotherapy in a mammalian subject, such as a human subject.

公开(公告)号：US20240329048A1

公开(公告)日：2024-10-03

申请号：US18443832

申请日：2024-02-16

Applicant: Ramot at Tel-Aviv University Ltd.

Inventor： Adi Barzel ,  Iris Dotan ,  Yuval Raviv

IPC: G01N33/574 ,  C07K14/47 ,  C07K16/30 ,  G01N33/58 ,  G01N33/68

CPC classification number: G01N33/57484 ,  C07K14/4748 ,  C07K16/30 ,  G01N33/58 ,  G01N33/6854

Abstract: High throughput methods for identifying monoclonal antibodies (mAbs) targeted to tumor antigens, using membranal B-cell receptor (BCR) screening of immortalized B-cells are provided. Methods for identification and characterization of tumor-related antigens are also provided as well as therapeutic and diagnostic uses of the newly-identified antibodies and antigens in cancer.

公开(公告)号：US12103984B2

公开(公告)日：2024-10-01

申请号：US17333945

申请日：2021-05-28

Applicant: Immatics Biotechnologies GmbH

Inventor： Andrea Mahr ,  Toni Weinschenk ,  Colette Song ,  Oliver Schoor ,  Jens Fritsche ,  Harpreet Singh

IPC: C07K16/18 ,  A61K35/17 ,  A61K39/00 ,  C07K7/06 ,  C07K7/08 ,  C07K14/47 ,  C07K14/725 ,  C12N15/115 ,  G01N33/68 ,  A61K35/12

CPC classification number: C07K7/08 ,  A61K35/17 ,  A61K39/0011 ,  C07K7/06 ,  C07K14/4748 ,  C07K14/7051 ,  C07K16/18 ,  C12N15/115 ,  G01N33/6893 ,  A61K2035/124 ,  A61K2039/5154 ,  A61K2039/80 ,  A61K2039/804 ,  A61K2039/812 ,  A61K2039/82 ,  A61K2039/828 ,  A61K2039/836 ,  A61K2039/844 ,  A61K2039/852 ,  A61K2039/86 ,  A61K2039/868 ,  A61K2039/876 ,  A61K2039/884 ,  A61K2039/892 ,  C07K2319/00 ,  C12N2310/16 ,  G01N2800/52

Abstract: The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.

公开(公告)号：US12102670B2

公开(公告)日：2024-10-01

申请号：US17576067

申请日：2022-01-14

Applicant: Immatics Biotechnologies GmbH

Inventor： Andrea Mahr ,  Toni Weinschenk ,  Oliver Schoor ,  Jens Fritsche ,  Harpreet Singh ,  Phillip Mueller ,  Julia Leibold ,  Valentina Goldfinger

IPC: A61K38/00 ,  A61K39/00 ,  C07K14/47 ,  C07K14/725 ,  C07K16/30 ,  C12N5/0783 ,  C12N15/115 ,  C12Q1/6886 ,  G01N33/574 ,  G01N33/68

CPC classification number: A61K39/0011 ,  C07K14/47 ,  C07K14/4748 ,  C07K14/7051 ,  C07K16/30 ,  C12N5/0636 ,  C12N15/115 ,  C12Q1/6886 ,  G01N33/5748 ,  G01N33/6848 ,  A61K38/00 ,  A61K2039/5158 ,  A61K2039/572 ,  C07K2319/00 ,  C12N2310/16 ,  C12Q2600/106 ,  C12Q2600/156 ,  C12Q2600/158 ,  C12Q2600/16 ,  G01N33/57407 ,  G01N2570/00 ,  G01N2800/52

Abstract: The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.

公开(公告)号：US20240316199A1

公开(公告)日：2024-09-26

申请号：US18259985

申请日：2021-12-29

Applicant: Alaunos Therapeutics, Inc.

Inventor： Simon OLIVARES ,  Harjet SINGH ,  Laurence James Neil COOPER ,  Lenka Victoria HURTON

IPC: A61K39/00 ,  A61P35/00 ,  C07K14/47 ,  C07K14/54 ,  C07K14/725 ,  C07K16/28

CPC classification number: A61K39/464412 ,  A61K39/4611 ,  A61K39/4632 ,  A61P35/00 ,  C07K14/4748 ,  C07K14/5443 ,  C07K14/7051 ,  C07K16/2803 ,  C07K2317/622 ,  C07K2317/732 ,  C07K2319/92

Abstract: Provided herein are vectors comprising a polycistronic expression casstte comprising a polynucleotide that encodes a CD 19 specific chimeric antigen receptor, a polynucleotide that encodes a cytokine, and a polynucleotide that encodes a marker protein, wherein the polynucleotide that encodes the CD 19-specific chimeric antigen receptor and the polynucleotide that encodes the cytokine coding sequence are separated by a polynucleotide sequence that comprises an F2A element, and wherein the polynucleotide sequence that encodes the cytokine and the polynucleotide sequence that encodes the marker protein are separated by a polynucleotide sequence that comprises a T2A element.

公开(公告)号：US20240307447A1

公开(公告)日：2024-09-19

申请号：US18606754

申请日：2024-03-15

Applicant: Immatics Biotechnologies GmbH

Inventor： Ricarda HANNEN ,  Jens HUKELMANN ,  Florian KOEHLER ,  Daniel Johannes KOWALEWSKI ,  Heiko SCHUSTER ,  Oliver SCHOOR ,  Michael ROEMER ,  Chih-Chiang TSOU ,  Jens FRITSCHE

IPC: A61K35/17 ,  A61K39/00 ,  A61P35/00 ,  C07K14/47 ,  C12N5/0783

CPC classification number: A61K35/17 ,  A61K39/0011 ,  A61P35/00 ,  C07K14/4748 ,  C12N5/0636

Abstract: The invention relates to a peptide comprising an amino acid sequence selected from the group consisting of (i) SEQ ID NO: 1 to SEQ ID NO: 216, and (ii) a variant sequence thereof which maintains capacity to bind to MHC molecule(s) and/or induce T cells cross-reacting with said variant peptide, or a pharmaceutically acceptable salt thereof.

公开(公告)号：US12065477B2

公开(公告)日：2024-08-20

申请号：US17465426

申请日：2021-09-02

Applicant: Immatics Biotechnologies GmbH

Inventor： Heiko Schuster ,  Janet Peper ,  Kevin Roehle ,  Philipp Wagner ,  Hans-Georg Rammensee

IPC: A61K38/00 ,  A61K39/00 ,  A61P35/00 ,  C07K14/47 ,  C07K14/74 ,  C07K16/28 ,  C12Q1/6886 ,  G16B30/00

CPC classification number: C07K14/70539 ,  A61K39/0011 ,  A61P35/00 ,  C07K14/4748 ,  C07K16/2818 ,  C07K16/2833 ,  C12Q1/6886 ,  G16B30/00 ,  A61K39/00 ,  A61K2039/892 ,  C07K2317/34 ,  C12Q2600/156

Abstract: The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.

公开(公告)号：US20240270805A1

公开(公告)日：2024-08-15

申请号：US18588643

申请日：2024-02-27

Applicant: The Wistar Institute of Anatomy and Biology

Inventor： David Weiner ,  Elizabeth Duperret

IPC: C07K14/47 ,  A61K39/00 ,  A61K39/39 ,  A61K45/06 ,  A61P35/00

CPC classification number: C07K14/4748 ,  A61K39/001186 ,  A61K39/39 ,  A61K45/06 ,  A61P35/00 ,  A61K2039/53 ,  A61K2039/55527 ,  A61K2039/55533 ,  A61K2039/572 ,  A61K2039/86 ,  A61K2039/876

Abstract: Disclosed herein are compositions and methods for treating and/or preventing cancer in mammals, and in particular, vaccines that treat and provide protection against tumor growth.