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    OPHTHALMIC PREPARATION OF TYROSINE KINASE INHIBITOR, AND PREPARATION METHOD THEREFOR AND USE THEREOF
    3.
    发明申请
    OPHTHALMIC PREPARATION OF TYROSINE KINASE INHIBITOR, AND PREPARATION METHOD THEREFOR AND USE THEREOF 有权

    公开(公告)号：US20250064725A1

    公开(公告)日：2025-02-27

    申请号：US18717660

    申请日：2022-11-29

    Applicant: CHENGDU RUIMU BIOPHARMACEUTICALS CO., LTD.

    Inventor： Qing DONG ,  Lubing XUE ,  Xin TANG

    IPC: A61K9/00 ,  A61K31/4439 ,  A61K47/10 ,  A61K47/22 ,  A61K47/26 ,  A61K47/36 ,  A61K47/38 ,  A61K47/44

    Abstract: An ophthalmic preparation of a tyrosine kinase inhibitor suitable for eye drop administration is prepared from the following active ingredients and adjuvants in parts by weight: active ingredient: 0.5-1.5 parts of tyrosine kinase inhibitor, wherein the content of the active ingredient in the ophthalmic preparation is 0.1-1 mg/mL; and pharmaceutically acceptable adjuvants: 200-300 parts of the surfactant, 0.5-7.0 parts of the tackifier, 10-800 parts of the solubilizer, with the balance being solvent. The ophthalmic preparation can effectively deliver the active ingredient to the fundus oculi to treat fundus angiogenesis diseases, with high absorption and utilization rate, small particle size and good stability, which are suitable for preparing sterile preparation by means of microporous filter membrane sterilization method and/or high-temperature sterilization method.

    Methods for preparing complex for enhancing immune response
    7.
    发明授权
    Methods for preparing complex for enhancing immune response 有权

    公开(公告)号：US12226477B2

    公开(公告)日：2025-02-18

    申请号：US17256980

    申请日：2019-06-28

    Applicant: XINFU (BEIJING) MEDICAL TECHNOLOGY CO., LTD.

    Inventor： Haixiang Lin ,  Fang Liu ,  Li Zha

    IPC: A61K39/39 ,  A61K31/787 ,  A61K45/06 ,  A61K47/02 ,  A61K47/26 ,  A61K47/36 ,  A61K39/00

    Abstract: A novel composite, and research on the preparation, application and the like of the composite. The method for preparing the composite comprises: contacting a polyinosinic-polycytidylic acid, at least one cationic stabilizer, and a soluble calcium salt in a liquid reaction system, the cationic stabilizer being a water-soluble non-antibiotic amino compound having a molecular weight of less than or equal to 5 kDa, or a graft copolymer formed by a water-soluble non-antibiotic amino compound and one or more of methoxypolyethylene glycol, polyethylene glycol, polyethylenimine, folic acid, or galactose. The composite has moderate viscosity and molecular weight, is convenient to use in pharmaceutical application, has stable chemical properties, is not easy to be degraded in long-term storage, and is safe to use. The composite, if used alone, can significantly enhance the non-specific immune response of the body and achieve the purpose of preventing and treating diseases, and other drugs, and can achieve better anti-tumor, anti-viral and anti-(super) bacteria efficacy and is easily absorbed by patients, if used in combination with other drugs.

    THERMOSENSITIVE MODIFIED CHITIN SPONGE DRUG-LOADED IMPLANTED SUSTAINED-RELEASE SYSTEM, PREPARATION METHOD THEREFORE, AND USE THEREOF
    9.
    发明申请
    THERMOSENSITIVE MODIFIED CHITIN SPONGE DRUG-LOADED IMPLANTED SUSTAINED-RELEASE SYSTEM, PREPARATION METHOD THEREFORE, AND USE THEREOF 有权

    公开(公告)号：US20250041209A1

    公开(公告)日：2025-02-06

    申请号：US18924547

    申请日：2024-10-23

    Applicant: Xulin JIANG

    Inventor： Xulin JIANG ,  Qianqian QIAO ,  Taotao LI ,  Fan YANG

    IPC: A61K9/00 ,  A61K31/445 ,  A61K45/06 ,  A61K47/36 ,  A61P23/02

    Abstract: The present invention relates to a thermosensitive modified chitin sponge drug-loaded implanted sustained-release system, preparation method therefore, and use thereof. The system comprises the following components: a spongy matrix, the matrix comprising at least one thermosensitive modified chitin polymer, and at least one drug, the drug being a local anesthetic and analgesic drug and/or an anti-inflammatory and antibacterial drug, and the drug being uniformly dispersed in the matrix. All ingredients of the thermosensitive modified chitin sponge drug-loaded implanted sustained-release system have good biodegradability, biocompatibility and bioactivity, and high safety. The system provides drug sustained-release and long-lasting effect, solving the problems that the existing local anesthetic drugs have a short action time. The system may promote wound healing, being easy to store and ship, convenient to use directly, which has great potential in clinical application.

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