公开(公告)号：US20250064832A1

公开(公告)日：2025-02-27

申请号：US18941896

申请日：2024-11-08

Applicant: The Population Council, Inc. ,  The United States of America, as rep'd by the Secy., Dept. of Health and Human Services

Inventor： Diana L. Blithe ,  Min S. Lee ,  Regine Sitruk-Ware

IPC: A61K31/568 ,  A61K9/00 ,  A61K9/06 ,  A61K31/57 ,  A61K47/10 ,  A61K47/14 ,  A61P15/16

Abstract: The present disclosure relates to a specific combination of a progestin and testosterone in a transdermal composition and usage thereof in a method for ensuring male contraception with more efficacy and less side effects.

公开(公告)号：US20250064796A1

公开(公告)日：2025-02-27

申请号：US18788070

申请日：2024-07-29

Applicant: BioDelivery Sciences International, Inc.

Inventor： Andrew Finn ,  Niraj Vasisht

IPC: A61K31/485 ,  A61K9/00 ,  A61K9/70 ,  A61K31/46 ,  A61K31/4748 ,  A61K47/02 ,  A61K47/10 ,  A61K47/12 ,  A61K47/14 ,  A61K47/22 ,  A61K47/32 ,  A61K47/38

Abstract: The present invention provides abuse deterrent mucoadhesive devices for delivery of buprenorphine. Each device comprises a mucoadhesive layer and a backing layer, and the pH in each layer is selected, such that absorption of buprenorphine is maximized.

公开(公告)号：US20250064793A1

公开(公告)日：2025-02-27

申请号：US18629816

申请日：2024-04-08

Applicant: Madhu Hanharan ,  Joseph Fuisz

Inventor： Madhu Hanharan ,  Joseph Fuisz

IPC: A61K31/465 ,  A61J1/14 ,  A61K9/00 ,  A61K31/00 ,  A61K47/02 ,  A61K47/14 ,  A61K47/18 ,  A61K47/26 ,  A61K47/34 ,  A61K47/38 ,  A61K47/46

Abstract: Embodiments include a film or sheet manufactured by dynamic roll molding. The film or sheet can include an active agent (e.g., nicotine) for oral administration. In aspects, an active agent is applied to the oral mucosa of a subject for local or systemic distribution. Embodiments also include containers and dispensers for orally soluble and edible films or sheets for administering therapeutic agents. The film or sheet can include an active agent (e.g., nicotine) for oral administration. In aspects, an active agent is applied to the oral mucosa of a subject for local or systemic distribution. Embodiments also include containers that dispense orally soluble and edible films or sheets via rotational cassettes which align film or sheet-containing chambers with an open aperture.

公开(公告)号：US20250064731A1

公开(公告)日：2025-02-27

申请号：US18729547

申请日：2023-01-16

Applicant: NOVUMGEN LIMITED

Inventor： Vishal Kumar Barot

IPC: A61K9/08 ,  A61K9/00 ,  A61K31/4168 ,  A61K47/14 ,  A61K47/26

Abstract: The present invention is a liquid pharmaceutical formulation of clonidine hydrochloride. The present invention also a liquid pharmaceutical formulation of clonidine hydrochloride comprising clonidine hydrochloride, preservative, sweetener and a suitable vehicle, wherein the formulation is free of buffer. The present invention also a liquid pharmaceutical formulation of clonidine hydrochloride and process of preparing the same.

公开(公告)号：US20250064726A1

公开(公告)日：2025-02-27

申请号：US18944456

申请日：2024-11-12

Applicant: LIQMEDS WORLDWIDE LIMITED

Inventor： Sandip P. MEHTA ,  Henil Alpeshbhai PATEL ,  Jayanta Kumar MANDAL

IPC: A61K9/00 ,  A61K9/10 ,  A61K31/366 ,  A61K31/40 ,  A61K31/505 ,  A61K47/02 ,  A61K47/10 ,  A61K47/14 ,  A61K47/22 ,  A61K47/24 ,  A61K47/26 ,  A61K47/38 ,  A61K47/40

Abstract: The present invention provides liquid oral dosage form of lipid lowering agent suitable for oral administration to human or animals.

公开(公告)号：US12233143B2

公开(公告)日：2025-02-25

申请号：US17860389

申请日：2022-07-08

Applicant: JLABS Beauty LLC

Inventor： Justine Mullen ,  Anne Schlesselman Buthion

IPC: A61K8/34 ,  A61K8/02 ,  A61K8/06 ,  A61K8/14 ,  A61K8/37 ,  A61K8/49 ,  A61K8/73 ,  A61K8/9789 ,  A61K8/9794 ,  A61K9/00 ,  A61K9/06 ,  A61K9/127 ,  A61K9/70 ,  A61K31/05 ,  A61K36/45 ,  A61K36/738 ,  A61K47/10 ,  A61K47/14 ,  A61K47/22 ,  A61K47/36 ,  A61K47/46 ,  A61P17/10 ,  A61Q19/08

Abstract: The present disclosure provides compositions of rose oil, cannabidiol, and humectants and methods of using said compositions. The present disclosure also products containing the aforementioned products, including a face mask, a serum, a lotion, and an eye cream.

公开(公告)号：US20250049824A1

公开(公告)日：2025-02-13

申请号：US18925887

申请日：2024-10-24

Applicant: SLAYBACK PHARMA LLC

Inventor： Shailendra MANDGE ,  Harish GUNDA ,  Naga Venkata Durga Prasad KETHA ,  Venkateshwar Reddy KEESARA ,  Satheesh Balasubramanian ,  Sumitra Ashokkumar PILLAI

IPC: A61K31/675 ,  A61K9/00 ,  A61K9/08 ,  A61K47/10 ,  A61K47/14

Abstract: The present invention relates to stable liquid oral compositions of cyclophosphamide having extended stability, methods for their administration, processes for their production, and use of these compositions for treatment of diseases treatable by cyclophosphamide. The invention also relates to a kit comprising stable liquid oral compositions of cyclophosphamide.

公开(公告)号：US20250042850A1

公开(公告)日：2025-02-06

申请号：US18262676

申请日：2022-01-24

Applicant: Athos Therapeutics, Inc.

Inventor： Dimitrios Iliopoulos ,  David G. Ho ,  Iordanis Karagiannidis ,  Phithi Nguyen ,  Dimitra Chalkia

IPC: C07D207/333 ,  A61K9/00 ,  A61K9/02 ,  A61K9/20 ,  A61K9/48 ,  A61K31/401 ,  A61K31/4025 ,  A61K31/407 ,  A61K31/4439 ,  A61K31/695 ,  A61K47/02 ,  A61K47/12 ,  A61K47/14 ,  A61K47/26 ,  C07D401/06 ,  C07D403/06 ,  C07D491/107 ,  C07F7/18

Abstract: Disclosed herein are compounds (e.g., pyrrole compounds, carboxy pyrroles, etc.), including pharmaceutical compositions that include one or more of such compounds (e.g., carboxy pyrroles). Also disclosed are methods of making carboxy pyrrole compounds. Also disclosed herein are methods of treating diseases and/or conditions (e.g., inflammation and/or cancer) with the carboxy pyrrole compounds disclosed herein.

公开(公告)号：US20250041219A1

公开(公告)日：2025-02-06

申请号：US18920652

申请日：2024-10-18

Applicant: University of Tennessee Research Foundation

Inventor： Monica M. JABLONSKI ,  Mohamed Moustafa Ibrahim MOUSTAFA

IPC: A61K9/113 ,  A61K9/00 ,  A61K31/198 ,  A61K31/7056 ,  A61K47/14 ,  A61K47/32

Abstract: Microemulsions are disclosed herein that include a discontinuous internal phase comprising an aqueous solution encompassed within an internal emulsifier, a continuous oil phase encompassing the internal phase; and an external emulsifier encompassing the oil phase. Also disclosed are methods for the use of such microemulsions as drug delivery devices, and methods for treating glaucoma and reducing intraocular pressure.

公开(公告)号：US12214071B2

公开(公告)日：2025-02-04

申请号：US18371619

申请日：2023-09-22

Applicant: Alps South Europe

Inventor： Aldo Laghi ,  Nathaniel Vint

IPC: A61K31/235 ,  A61K8/06 ,  A61K8/67 ,  A61K9/00 ,  A61K9/107 ,  A61K31/355 ,  A61K47/10 ,  A61K47/14 ,  A61K47/18 ,  A61K47/44 ,  A61Q19/08

Abstract: Compositions for topical application that effectively deliver antioxidants across the epidermis, dermis, or a combination thereof into cells and/or the bloodstream while concurrently maintaining chemical activity of the antioxidants. In certain aspects, these formulations include emulsions and balms each having a lipophilic carrier and a lipophilic antioxidant solubilized by the lipophilic carrier. Also disclosed herein are methods for making these compositions for topical application.