公开(公告)号：US11992483B2

公开(公告)日：2024-05-28

申请号：US17369369

申请日：2021-07-07

申请人： Cali Pharmaceuticals, LLC

发明人： Andrew Xian Chen ,  Lijia Chen ,  Damian McLoud

IPC分类号： A61K31/445 ,  A61K9/00 ,  A61K9/107 ,  A61K31/167 ,  A61K31/381 ,  A61K31/47 ,  A61K47/24 ,  A61K47/44 ,  A61P17/02 ,  A61P23/02

CPC分类号： A61K31/445 ,  A61K9/0019 ,  A61K9/107 ,  A61K31/167 ,  A61K31/381 ,  A61K31/47 ,  A61K47/24 ,  A61K47/44 ,  A61P17/02 ,  A61P23/02

摘要： Use of an emulsion for pain relief comprising a local anesthetic, lecithin, oil and an aqueous phase, wherein local anesthetic is non-covalent bound to the emulsion oil droplets and the emulsion is physically and chemically stable and said emulsion provides better safety, extended release pharmacokinetics and a prolonged duration of action of the local anesthetic.

公开(公告)号：US11986556B1

公开(公告)日：2024-05-21

申请号：US18472743

申请日：2023-09-22

申请人： ORCA Products, LLC

发明人： Craig Schmidtke ,  John Graham

IPC分类号： A61K9/00 ,  A61K31/045 ,  A61K31/047 ,  A61K31/085 ,  A61K36/53 ,  A61K36/534 ,  A61K36/9064 ,  A61K47/10 ,  A61K47/26 ,  A61P23/02

CPC分类号： A61K9/006 ,  A61K31/045 ,  A61K31/047 ,  A61K31/085 ,  A61K36/53 ,  A61K36/534 ,  A61K36/9064 ,  A61K47/10 ,  A61K47/26 ,  A61P23/02

摘要： The present disclosure relates to compositions and methods for treating oral pain. The compositions disclosed herein may comprise a dissolvable carrier containing at least one active ingredient. In some embodiments, the active ingredients comprise guaiacol, eugenol, glycerin, menthol oil, peppermint oil, oregano oil, and/or cardamom oil. The methods disclosed herein comprise treating oral pain in a subject using the compositions disclosed herein, wherein such compositions are configured as a paste that can be molded on or about a surface exhibiting oral pain in a subject's oral cavity. Such compositions are resistant to the moist environment of the subject's oral cavity and provide rapid, effective pain relief in the subject.

公开(公告)号：US11969403B2

公开(公告)日：2024-04-30

申请号：US17008913

申请日：2020-09-01

申请人： Sintetica S.A.

发明人： Augusto Mitidieri ,  Elisabetta Donati ,  Clara Bianchi

IPC分类号： A61K31/245 ,  A61K9/00 ,  A61K9/06 ,  A61K47/02 ,  A61K47/12 ,  A61K47/38 ,  A61P23/02

CPC分类号： A61K31/245 ,  A61K9/0048 ,  A61K9/06 ,  A61K47/02 ,  A61K47/12 ,  A61K47/38 ,  A61P23/02

摘要： Topical dosages and formulations of chloroprocaine and pharmaceutically acceptable salts thereof are provided that are efficacious, chemically stable and physiologically balanced for safety and efficacy, particularly during ophthalmic procedures or in response to ophthalmic abrasions or trauma.

公开(公告)号：US11951079B2

公开(公告)日：2024-04-09

申请号：US17065818

申请日：2020-10-08

申请人： Kongkrit Chaiyasate

发明人： Kongkrit Chaiyasate

IPC分类号： A61K31/355 ,  A61K9/70 ,  A61K31/01 ,  A61K31/015 ,  A61K31/045 ,  A61K31/05 ,  A61K36/19 ,  A61K36/45 ,  A61K36/9068 ,  A61K45/06 ,  A61K47/44 ,  A61P23/02

CPC分类号： A61K31/05 ,  A61K9/7023 ,  A61K31/01 ,  A61K31/015 ,  A61K31/045 ,  A61K31/355 ,  A61K36/19 ,  A61K36/45 ,  A61K36/9068 ,  A61K45/06 ,  A61K47/44 ,  A61P23/02

摘要： A topical composition and method of treating chronic pain are provided. The topical composition contains cannabidiol (CBD) and plant extract and is well suited to treat chronic pain while also avoiding the negative side effects caused by commonly used anti-inflammatory and pain-treating compounds. When the topical composition is applied to the skin at the locus of pain and allowed sufficient time to absorb, the pain is reduced or even eliminated. The topical compositions also show therapeutic effect on mucosal tissue and internal tissues of humans or animals.

公开(公告)号：US20240092736A1

公开(公告)日：2024-03-21

申请号：US17773171

申请日：2020-10-29

申请人： Children's Medical Center Corporation

发明人： Daniel S. Kohane ,  Yueqin Zheng

IPC分类号： C07D211/60 ,  A61P23/02 ,  C07C237/08 ,  C07C237/10 ,  C07C237/12

CPC分类号： C07D211/60 ,  A61P23/02 ,  C07C237/08 ,  C07C237/10 ,  C07C237/12

摘要： Provided herein are compounds that are local anesthetics and useful for inducing selective sensory nerve blockade. Also provided are pharmaceutical compositions and kits comprising the compounds, and methods of inducing selective sensory nerve blockade by administering the compounds and/or compositions to a subject.

公开(公告)号：US20230080811A1

公开(公告)日：2023-03-16

申请号：US17792474

申请日：2021-01-14

申请人： SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

发明人： Yong GAN ,  Shiyan GUO ,  Yinyin SUN ,  Quanlei ZHU

IPC分类号： A61K47/24 ,  A61K31/445 ,  A61K47/44 ,  A61K47/12 ,  A61K9/08 ,  A61P23/02

摘要： Provided are a long-acting ropivacaine pharmaceutical composition, a preparation method therefor and use thereof. The pharmaceutical composition comprises: ropivacaine; a pharmaceutical solvent; a pharmaceutical phospholipid; a pharmaceutical oil; and an efficacy enhancer, an optional antioxidant and an optional acid-base regulator. The pharmaceutical composition has a controllable release behavior and a sustained release effect, can significantly reduce the peak plasma concentration of the drug, maintain a stable plasma concentration in the body, prolong the effective treatment time, reduce the effective therapeutic dose, improve the utilization of the drug, and reduce the risk of neurotoxicity. The pharmaceutical composition has a long-acting analgesic effect and can be used for pain treatment.

公开(公告)号：US11596612B1

公开(公告)日：2023-03-07

申请号：US17689827

申请日：2022-03-08

申请人： PTC Innovations, LLC

发明人： Pendleton Wickersham ,  Stephen Bendel ,  Todd Mathis ,  Christian Warren

IPC分类号： A61K31/167 ,  A61K31/4453 ,  A61K31/495 ,  A61P23/02

摘要： The present disclosure provides compounds useful as anesthetics, such as topical anesthetics, of general formula (I): wherein: R1 is H, —OMe, Me, or one or more electron withdrawing groups; R2 and R3 are each independently H or alkyl or, taken together, form a 4- to 8-membered heterocyclic ring with the adjacent nitrogen atom; R4 is H or alkyl; R5 is H or one or more electron donating groups; and n is 1 to 4.

公开(公告)号：US11564902B2

公开(公告)日：2023-01-31

申请号：US16948387

申请日：2020-09-16

申请人： Ventis Pharma

发明人： Jeremy Poulsen ,  Louis Stanfield ,  Lawrence Volz

IPC分类号： A61K31/565 ,  A61K31/16 ,  A61K31/137 ,  A61P23/02 ,  A61K31/245 ,  A61J1/20 ,  A61K31/573 ,  A61K45/06 ,  A61K47/02 ,  B65D81/32 ,  A61K9/08 ,  A61K9/00

摘要： An extended duration anesthetic includes a short duration local anesthetic in a dilute solution and a long duration local anesthetic. The long duration local anesthetic is maintained in a powdered form until the time of administration. Premeasured quantities of the dilute solution and powdered long duration local anesthetic in a kit allow for quick preparation of a solution with desired concentrations of both short duration local anesthetic and long duration local anesthetic at the time of administration.

公开(公告)号：US20220233463A1

公开(公告)日：2022-07-28

申请号：US17611583

申请日：2020-05-14

申请人： BUZZELET DEVELOPMENT AND TECHNOLOGIES LTD.

发明人： NOA RAZ ,  AHARON EYAL

IPC分类号： A61K31/05 ,  A61P29/00 ,  A61K31/352 ,  A61K31/045 ,  A61K31/365 ,  A61K31/125 ,  A61K31/245 ,  A61K31/445 ,  A61P23/02 ,  A61K31/11 ,  A61K31/085

摘要： Provided are methods and compositions for reducing a throat irritation caused by inhaling vapors or particles of at least one material selected from the group consisting of cannabis, cannabinoids, tobaccO, a herb or combinations thereof, the method comprising administering to a subject in need thereof at least one transient receptor potential (TRP) channel modulator prior to or simultaneously with said inhaling said vapors or particles of said at least one material. Further provided are methods and compositions comprising at least one TRP channel agonist, and/or at least one TRP channel partial agonist for treating pain-selective analgesia via TRP channels; methods for treating local pain; methods for treating migraine and symptoms thereof; and methods for treating osteoporosis and symptoms thereof.

公开(公告)号：US20220202736A1

公开(公告)日：2022-06-30

申请号：US17603014

申请日：2020-04-15

申请人： HUZHOU INNOVATION PHARMACEUTICAL CO., LTD.

发明人： Jie ZHANG ,  Peike TANG

IPC分类号： A61K9/70 ,  A61K31/167 ,  A61P23/02 ,  A61K31/196 ,  A61K31/445 ,  A61K8/34 ,  A61Q19/00 ,  A61K8/02

摘要： A medical covering film and system, and a usage method and an application therefor. The medical covering film comprises a barrier film layer (10), an adsorption layer (20), and a reticular adhesive layer (30), one side of the adsorption layer (20) being composited on the barrier film layer (10), and the reticular adhesive layer (30) being composited on the other side of the adsorption layer (20); the area of an adhesive-free region (31) of the reticular adhesive layer (30) occupies 10% or more of the total area of the reticular adhesive layer (30), but not 100%. The present medical covering film can fix a preparation to the affected skin very well, is not easily squeezed off the target skin area by external force, and can maintain the moisture in the preparation very well.