公开(公告)号：US20190083446A1

公开(公告)日：2019-03-21

申请号：US16131174

申请日：2018-09-14

申请人： Sintetica S.A.

发明人： Augusto Mitidieri ,  Elisabetta Donati ,  Clara Bianchi

IPC分类号： A61K31/245 ,  A61K47/38 ,  A61K47/02 ,  A61K47/12 ,  A61K9/00 ,  A61P23/02

摘要： Topical dosages and formulations of chloroprocaine and pharmaceutically acceptable salts thereof are provided that are efficacious, chemically stable and physiologically balanced for safety and efficacy, particularly during ophthalmic procedures or in response to ophthalmic abrasions or trauma.

公开(公告)号：US11969403B2

公开(公告)日：2024-04-30

申请号：US17008913

申请日：2020-09-01

申请人： Sintetica S.A.

发明人： Augusto Mitidieri ,  Elisabetta Donati ,  Clara Bianchi

IPC分类号： A61K31/245 ,  A61K9/00 ,  A61K9/06 ,  A61K47/02 ,  A61K47/12 ,  A61K47/38 ,  A61P23/02

CPC分类号： A61K31/245 ,  A61K9/0048 ,  A61K9/06 ,  A61K47/02 ,  A61K47/12 ,  A61K47/38 ,  A61P23/02

摘要： Topical dosages and formulations of chloroprocaine and pharmaceutically acceptable salts thereof are provided that are efficacious, chemically stable and physiologically balanced for safety and efficacy, particularly during ophthalmic procedures or in response to ophthalmic abrasions or trauma.

公开(公告)号：US11590105B2

公开(公告)日：2023-02-28

申请号：US16991112

申请日：2020-08-12

申请人： Sintetica S.A.

发明人： Augusto Mitidieri ,  Elisabetta Donati ,  Clara Bianchi ,  Barbara Piccagli

IPC分类号： A61K31/4015 ,  A61K9/00 ,  A61K45/06 ,  A61M25/00

摘要： Methods of treatment, pharmaceutically acceptable solutions, and implantable devices are provided for the intrathecal treatment of AED-resistant seizures using levetiracetam.

公开(公告)号：US20220257537A1

公开(公告)日：2022-08-18

申请号：US17670620

申请日：2022-02-14

申请人： Sintetica S.A.

发明人： Nicola Caronzolo ,  Elisabetta Donati ,  Clara Bianchi

IPC分类号： A61K31/137 ,  A61M5/14 ,  A61K47/54

摘要： Ready to use large volume containers of dilute solutions of phenylephrine having excellent shelf stability.

公开(公告)号：US10792271B2

公开(公告)日：2020-10-06

申请号：US16131174

申请日：2018-09-14

申请人： Sintetica S.A.

发明人： Augusto Mitidieri ,  Elisabetta Donati ,  Clara Bianchi

IPC分类号： A61K31/245 ,  A61K9/06 ,  A61P23/02 ,  A61K9/00 ,  A61K47/02 ,  A61K47/12 ,  A61K47/38

摘要： Topical dosages and formulations of chloroprocaine and pharmaceutically acceptable salts thereof are provided that are efficacious, chemically stable and physiologically balanced for safety and efficacy, particularly during ophthalmic procedures or in response to ophthalmic abrasions or trauma.

公开(公告)号：US20230398070A1

公开(公告)日：2023-12-14

申请号：US18032188

申请日：2021-09-29

申请人： SINTETICA S.A.

发明人： Nicola Caronzolo ,  Elisabetta Donati ,  Clara Bianchi

IPC分类号： A61K9/08 ,  A61K31/137 ,  A61K9/00 ,  A61K47/02

CPC分类号： A61K9/08 ,  A61K31/137 ,  A61K9/0019 ,  A61K47/02

摘要： The invention concerns a process for producing a stable, injectable solution containing noradrenaline, comprising the following steps: (a) dissolving noradrenaline and optionally one or more excipients in deoxygenated or degassed water, in order to produce a solution containing noradrenaline; (b) distributing the noradrenaline solution in an inert gas current into a container; (c) sterilizing the solution containing, before step (b) and/or after step (d); (d) hermetically sealing the container; (e) wherein the oxygen concentration in the solution containing noradrenaline is less than 300 ppbw immediately after sealing the container; and (f) wherein the oxygen concentration in the headspace immediately after sealing the container is at most 1.0 percent v/v. It also concerns a drug product obtainable in particular by the above process, and the use of a gas atmosphere comprising an oxygen concentration of less than 1.0 percent v/v, as a headspace in a container comprising a solution containing noradrenaline. Finally, it concerns a process for reducing the number of subvisible particles in a solution containing noradrenaline.

公开(公告)号：US20230270717A1

公开(公告)日：2023-08-31

申请号：US18100039

申请日：2023-01-23

申请人： Sintetica S.A.

发明人： Augusto Mitidieri ,  Elisabetta Donati ,  Clara Bianchi ,  Barbara Piccagli

IPC分类号： A61K31/4015 ,  A61K9/00 ,  A61M25/00

CPC分类号： A61K31/4015 ,  A61K9/0085 ,  A61M25/0067 ,  A61K9/0019 ,  A61K45/06

摘要： Methods of treatment, pharmaceutically acceptable solutions, and implantable devices are provided for the intrathecal treatment of AED-resistant seizures using levetiracetam.

公开(公告)号：US20230110216A1

公开(公告)日：2023-04-13

申请号：US17911429

申请日：2021-03-17

申请人： SINTETICA S.A.

发明人： Augusto Mitidieri ,  Elisabeta Donati ,  Clara Bianchi

IPC分类号： A61K31/245 ,  A61K9/06 ,  A61K47/38 ,  A61K9/00

摘要： Sterile ophthalmic gels of chloroprocaine having improved functionality, pharmacokinetics, and stability, particularly in terms of clarity, and to methods of making and using same.

公开(公告)号：US20230091583A1

公开(公告)日：2023-03-23

申请号：US17991861

申请日：2022-11-22

申请人： SINTETICA S.A.

发明人： Nicola Caronzolo ,  Elizabetta Donati ,  Clara Bianchi

IPC分类号： A61J1/14 ,  A61J1/10 ,  A61K31/137 ,  A61K47/02

摘要： Provided are ready to use drip bags of dilute noradrenaline having improved stability in terms of subvisible particle formation.

公开(公告)号：US20240216323A1

公开(公告)日：2024-07-04

申请号：US18406539

申请日：2024-01-08

申请人： Sintetica S.A.

发明人： Augusto Mitidieri ,  Elisabetta Donati ,  Clara Bianchi

IPC分类号： A61K31/245 ,  A61K9/00 ,  A61K9/06 ,  A61K47/02 ,  A61K47/12 ,  A61K47/38 ,  A61P23/02

CPC分类号： A61K31/245 ,  A61K9/0048 ,  A61K9/06 ,  A61K47/02 ,  A61K47/12 ,  A61K47/38 ,  A61P23/02

摘要： Topical dosages and formulations of chloroprocaine and pharmaceutically acceptable salts thereof are provided that are efficacious, chemically stable and physiologically balanced for safety and efficacy, particularly during ophthalmic procedures or in response to ophthalmic abrasions or trauma.