公开(公告)号：US20240316199A1

公开(公告)日：2024-09-26

申请号：US18259985

申请日：2021-12-29

Applicant: Alaunos Therapeutics, Inc.

Inventor： Simon OLIVARES ,  Harjet SINGH ,  Laurence James Neil COOPER ,  Lenka Victoria HURTON

IPC: A61K39/00 ,  A61P35/00 ,  C07K14/47 ,  C07K14/54 ,  C07K14/725 ,  C07K16/28

CPC classification number: A61K39/464412 ,  A61K39/4611 ,  A61K39/4632 ,  A61P35/00 ,  C07K14/4748 ,  C07K14/5443 ,  C07K14/7051 ,  C07K16/2803 ,  C07K2317/622 ,  C07K2317/732 ,  C07K2319/92

Abstract: Provided herein are vectors comprising a polycistronic expression casstte comprising a polynucleotide that encodes a CD 19 specific chimeric antigen receptor, a polynucleotide that encodes a cytokine, and a polynucleotide that encodes a marker protein, wherein the polynucleotide that encodes the CD 19-specific chimeric antigen receptor and the polynucleotide that encodes the cytokine coding sequence are separated by a polynucleotide sequence that comprises an F2A element, and wherein the polynucleotide sequence that encodes the cytokine and the polynucleotide sequence that encodes the marker protein are separated by a polynucleotide sequence that comprises a T2A element.