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公开(公告)号：US20240358825A1
公开(公告)日：2024-10-31
申请号：US18406869
申请日：2024-01-08
申请人： Zoetis Services LLC
发明人： Paul Joseph Dominowski , Ramasamy Mannar Mannan , Richard Lee Krebs , James Richard Thompson , Tedd Alan Childers , Mary Kathryn Olsen , Robert John Yancey, Jr. , Risini Dhammika Weeratna , Shucheng Zhang , Cedo Martin Bagi
IPC分类号： A61K39/39 , A61K39/00 , A61K39/002 , A61K39/012 , A61K39/02 , A61K39/108 , A61K39/12 , A61K39/145 , A61K39/15 , A61K39/21 , A61K39/215 , A61P37/02
CPC分类号： A61K39/39 , A61K39/0011 , A61K39/002 , A61K39/012 , A61K39/0208 , A61K39/0241 , A61K39/0258 , A61K39/12 , A61K39/145 , A61K39/15 , A61K39/21 , A61K39/215 , A61P37/02 , A61K2039/521 , A61K2039/5252 , A61K2039/5254 , A61K2039/54 , A61K2039/55 , A61K2039/552 , A61K2039/55505 , A61K2039/55511 , A61K2039/55555 , A61K2039/55561 , A61K2039/55566 , A61K2039/55572 , A61K2039/55577 , C12N2720/12334 , C12N2720/12351 , C12N2740/13034 , C12N2740/13051 , C12N2760/16134 , C12N2760/16151 , C12N2770/20034 , C12N2770/20051 , C12N2770/24334 , C12N2770/24351 , Y02A50/30
摘要： This invention relates to adjuvant formulations comprising various combinations of triterpenoids, sterols, immunomodulators, polymers, and Th2 stimulators; methods for making the adjuvant compositions; and the use of the adjuvant formulations in immunogenic and vaccine compositions with different antigens. This invention further relates to the use of the formulations in the treatment of animals.
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2.发明申请公开(公告)号：US20180305710A1
公开(公告)日：2018-10-25
申请号：US15315233
申请日：2016-05-12
发明人： Dong Jun AN , Seong In LIM , Jae Young SONG , Hye Young JEOUNG , Eun Ju SOHN , In Hwan HWANG , Nam Jo PARK , Yong Jik LEE , Nam Hyung KIM , Sung Min GU
IPC分类号： C12N15/82 , A23K20/147 , G01N33/569 , A61K39/145 , C07K14/11
CPC分类号： C12N15/8258 , A23K20/142 , A23K20/147 , A23K20/174 , A23K50/30 , A61K39/12 , A61K39/145 , A61K2039/517 , C07K14/005 , C07K14/11 , C12N15/8205 , C12N15/8257 , C12N2770/24322 , C12N2770/24334 , C12N2770/24351 , G01N33/56983 , G01N2333/183
摘要： A recombinant vector for transforming a plant, a plant transformed with the recombinant vector, a plant-made classical swine fever virus antigen pmE2 protein expressed in the plant and uses thereof is provided. By using a recombinant vector having a polynucleotide encoding a GP55 protein of CSFV according to the present invention; and a polynucleotide encoding a cellulose-binding domain protein; and a plant transformed with the recombinant vector, a plant-made classical swine fever virus antigen pmE2 protein may be produced with high efficiency, and has higher safety and stability than those achieved by other production methods. Also, since the plant-derived classical swine fever virus antigen protein pmE2 has a cellulose-binding domain (CBD) protein, it may be usefully used as an effective marker to determine a virus exposure pathway and an antibody producing pathway.
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公开(公告)号：US20170304434A1
公开(公告)日：2017-10-26
申请号：US15494920
申请日：2017-04-26
申请人： Zoetis Services LLC
发明人： Paul Joseph Dominowski , Ramasamy Mannar Mannan , Richard Lee Krebs , James Richard Thompson , Tedd Alan Childers , Mary Kathryn Olsen , Robert John Yancey, Jr. , Risini Dhammika Weeratna , Shucheng Zhang , Cedo Martin Bagi
IPC分类号： A61K39/39 , A61K39/012 , A61K39/02 , A61K39/108 , A61K39/00 , A61K39/145 , A61K39/15 , A61K39/21 , A61K39/215 , A61K39/12 , A61K39/002
CPC分类号： A61K39/39 , A61K39/0011 , A61K39/002 , A61K39/012 , A61K39/0208 , A61K39/0241 , A61K39/0258 , A61K39/12 , A61K39/145 , A61K39/15 , A61K39/21 , A61K39/215 , A61K2039/521 , A61K2039/5252 , A61K2039/5254 , A61K2039/54 , A61K2039/55 , A61K2039/552 , A61K2039/55505 , A61K2039/55511 , A61K2039/55555 , A61K2039/55561 , A61K2039/55566 , A61K2039/55572 , A61K2039/55577 , C12N2720/12334 , C12N2720/12351 , C12N2740/13034 , C12N2740/13051 , C12N2760/16134 , C12N2760/16151 , C12N2770/20034 , C12N2770/20051 , C12N2770/24334 , C12N2770/24351 , Y02A50/474
摘要： This invention relates to adjuvant formulations comprising various combinations of triterpenoids, sterols, immunomodulators, polymers, and Th2 stimulators; methods for making the adjuvant compositions; and the use of the adjuvant formulations in immunogenic and vaccine compositions with different antigens. This invention further relates to the use of the formulations in the treatment of animals.
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公开(公告)号：US09662385B2
公开(公告)日：2017-05-30
申请号：US14013299
申请日：2013-08-29
申请人： Zoetis Services LLC
发明人： Paul Joseph Dominowski , Ramasamy Mannar Mannan , Richard Lee Krebs , James Richard Thompson , Tedd Alan Childers , Mary Kathryn Olsen , Robert John Yancey, Jr. , Risini Dhammika Weeratna , Shucheng Zhang , Cedo Martin Bagi
IPC分类号： A61K45/00 , A61K39/39 , A61K39/00 , A61K39/012 , A61K39/02 , A61K39/108 , A61K39/12 , A61K39/145 , A61K39/15 , A61K39/21 , A61K39/215 , A61K39/002
CPC分类号： A61K39/39 , A61K39/0011 , A61K39/002 , A61K39/012 , A61K39/0208 , A61K39/0241 , A61K39/0258 , A61K39/12 , A61K39/145 , A61K39/15 , A61K39/21 , A61K39/215 , A61K2039/521 , A61K2039/5252 , A61K2039/5254 , A61K2039/54 , A61K2039/55 , A61K2039/552 , A61K2039/55505 , A61K2039/55511 , A61K2039/55555 , A61K2039/55561 , A61K2039/55566 , A61K2039/55572 , A61K2039/55577 , C12N2720/12334 , C12N2720/12351 , C12N2740/13034 , C12N2740/13051 , C12N2760/16134 , C12N2760/16151 , C12N2770/20034 , C12N2770/20051 , C12N2770/24334 , C12N2770/24351 , Y02A50/474
摘要： This invention relates to adjuvant formulations comprising various combinations of triterpenoids, sterols, immunomodulators, polymers, and Th2 stimulators; methods for making the adjuvant compositions; and the use of the adjuvant formulations in immunogenic and vaccine compositions with different antigens. This invention further relates to the use of the formulations in the treatment of animals.
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5.发明申请APTAMERS SCREENING METHOD BASED ON GRAPHENE WITHOUT TARGET IMMOBILIZATION AND THE APTAMERS OBTAINED FROM THE METHOD 审中-公开基于没有目标固定的石墨的APTAMERS筛选方法和从该方法获得的APTAMERS公开(公告)号：US20160202262A1
公开(公告)日：2016-07-14
申请号：US15066118
申请日：2016-03-10
发明人： Man Bock Gu , Jee Woong Park , Tatavarty Rameshwar
IPC分类号： G01N33/574 , G01N33/53 , B01D15/38 , C12N9/10
CPC分类号： G01N33/57488 , B01D15/3823 , C12N7/00 , C12N9/1048 , C12N15/1048 , C12N15/115 , C12N2310/16 , C12N2310/351 , C12N2320/13 , C12N2330/30 , C12N2770/24351 , C12Q1/6811 , C12Y204/02012 , G01N33/5308 , G01N33/56983 , G01N33/57407 , G01N33/6893 , G01N2333/183 , G01N2333/91142 , C12Q2525/205 , C12Q2541/101
摘要： Provided is aptamers screening method based on graphene without target immobilization and the aptamers obtained from the method, and more particularly, a new GO-SELEX method without target immobilization in which a single-stranded nucleic acid pool may react with a non-bound target material or a counter-target material, after which a single-stranded nucleic acid which has not been bound to the target or counter-target may be separated by using the graphene. Also, the specific aptamer obtained through the above-described method may be used for diagnosing target related diseases.
摘要翻译： 提供了基于没有靶固定的石墨烯的适体筛选方法和从该方法获得的适体，更具体地说，没有目标固定的新的GO-SELEX方法，其中单链核酸库可以与未结合的靶材料反应 或反靶物质，之后可以通过使用石墨烯分离未结合靶或对靶的单链核酸。 此外，通过上述方法获得的特异性适体可用于诊断目标相关疾病。
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公开(公告)号：US08580280B2
公开(公告)日：2013-11-12
申请号：US12490767
申请日：2009-06-24
申请人： Paul J. Dominowski , Ramasamy M. Mannan , Richard L. Krebs , James R. Thompson , Tedd A. Childers , Mary K. Olsen , Robert J. Yancey, Jr. , Risini Weeratna , Shucheng Zhang , Cedo M. Bagi
发明人： Paul J. Dominowski , Ramasamy M. Mannan , Richard L. Krebs , James R. Thompson , Tedd A. Childers , Mary K. Olsen , Robert J. Yancey, Jr. , Risini Weeratna , Shucheng Zhang , Cedo M. Bagi
CPC分类号： A61K39/39 , A61K39/0011 , A61K39/002 , A61K39/012 , A61K39/0208 , A61K39/0241 , A61K39/0258 , A61K39/12 , A61K39/145 , A61K39/15 , A61K39/21 , A61K39/215 , A61K2039/521 , A61K2039/5252 , A61K2039/5254 , A61K2039/54 , A61K2039/55 , A61K2039/552 , A61K2039/55505 , A61K2039/55511 , A61K2039/55555 , A61K2039/55561 , A61K2039/55566 , A61K2039/55572 , A61K2039/55577 , C12N2720/12334 , C12N2720/12351 , C12N2740/13034 , C12N2740/13051 , C12N2760/16134 , C12N2760/16151 , C12N2770/20034 , C12N2770/20051 , C12N2770/24334 , C12N2770/24351 , Y02A50/474
摘要： This invention relates to adjuvant formulations comprising various combinations of triterpenoids, sterols, immunomodulators, polymers, and Th2 stimulators; methods for making the adjuvant compositions; and the use of the adjuvant formulations in immunogenic and vaccine compositions with different antigens. This invention further relates to the use of the formulations in the treatment of animals.
摘要翻译： 本发明涉及包含三萜类，甾醇，免疫调节剂，聚合物和Th2刺激剂的各种组合的佐剂制剂; 制备佐剂组合物的方法; 以及在具有不同抗原的免疫原性和疫苗组合物中使用佐剂制剂。 本发明还涉及该制剂在动物治疗中的用途。
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公开(公告)号：US2720484A
公开(公告)日：1955-10-11
申请号：US14458150
申请日：1950-02-16
申请人： ALLIED LAB INC
IPC分类号： C12N7/02
CPC分类号： C12N7/00 , C12N2770/24351
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公开(公告)号：US20160202259A1
公开(公告)日：2016-07-14
申请号：US15066514
申请日：2016-03-10
发明人： Man Bock Gu , Jee Woong Park , Tatavarty Rameshwar
IPC分类号： G01N33/569 , C12N15/115 , C12N7/00
CPC分类号： G01N33/57488 , B01D15/3823 , C12N7/00 , C12N9/1048 , C12N15/1048 , C12N15/115 , C12N2310/16 , C12N2310/351 , C12N2320/13 , C12N2330/30 , C12N2770/24351 , C12Q1/6811 , C12Y204/02012 , G01N33/5308 , G01N33/56983 , G01N33/57407 , G01N33/6893 , G01N2333/183 , G01N2333/91142 , C12Q2525/205 , C12Q2541/101
摘要： Provided is aptamers screening method based on graphene without target immobilization and the aptamers obtained from the method, and more particularly, a new GO-SELEX method without target immobilization in which a single-stranded nucleic acid pool may react with a non-bound target material or a counter-target material, after which a single-stranded nucleic acid which has not been bound to the target or counter-target may be separated by using the graphene. Also, the specific aptamer obtained through the above-described method may be used for diagnosing target related diseases.
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9.发明授权Aptamers screening method based on graphene without target immobilization and the aptamers obtained from the method 有权基于没有靶固定的石墨烯的适体筛选方法和从该方法获得的适体公开(公告)号：US09322024B2
公开(公告)日：2016-04-26
申请号：US14342241
申请日：2012-08-30
申请人： Man Bock Gu , Jee Woong Park , Tatavarty Rameshwar
发明人： Man Bock Gu , Jee Woong Park , Tatavarty Rameshwar
IPC分类号： C07H21/04 , C12N15/115 , C12N15/10 , C12Q1/68 , G01N33/569 , G01N33/574 , G01N33/68
CPC分类号： G01N33/57488 , B01D15/3823 , C12N7/00 , C12N9/1048 , C12N15/1048 , C12N15/115 , C12N2310/16 , C12N2310/351 , C12N2320/13 , C12N2330/30 , C12N2770/24351 , C12Q1/6811 , C12Y204/02012 , G01N33/5308 , G01N33/56983 , G01N33/57407 , G01N33/6893 , G01N2333/183 , G01N2333/91142 , C12Q2525/205 , C12Q2541/101
摘要： Provided is aptamers screening method based on graphene without target immobilization and the aptamers obtained from the method, and more particularly, a new GO-SELEX method without target immobilization in which a single-stranded nucleic acid pool may react with a non-bound target material or a counter-target material, after which a single-stranded nucleic acid which has not been bound to the target or counter-target may be separated by using the graphene. Also, the specific aptamer obtained through the above-described method may be used for diagnosing target related diseases.
摘要翻译： 提供了基于没有靶固定的石墨烯的适体筛选方法和从该方法获得的适体，更具体地说，没有目标固定的新的GO-SELEX方法，其中单链核酸库可以与未结合的靶材料反应 或反靶物质，之后可以通过使用石墨烯分离未结合靶或对靶的单链核酸。 此外，通过上述方法获得的特异性适体可用于诊断目标相关疾病。
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公开(公告)号：US20140056940A1
公开(公告)日：2014-02-27
申请号：US14013299
申请日：2013-08-29
申请人： ZOETIS LLC
发明人： Paul Joseph Dominowski , Ramasamy Mannar Mannan , Richard Lee Krebs , James Richard Thompson , Tedd Alan Childers , Mary Kathryn Olsen , Robert John Yancey, JR. , Risini Dhammika Weeratna , Shucheng Zhang , Cedo Martin Bagi
IPC分类号： A61K39/39 , A61K39/002 , A61K39/108 , A61K39/145 , A61K39/21 , A61K39/00 , A61K39/15 , A61K39/12 , A61K39/02
CPC分类号： A61K39/39 , A61K39/0011 , A61K39/002 , A61K39/012 , A61K39/0208 , A61K39/0241 , A61K39/0258 , A61K39/12 , A61K39/145 , A61K39/15 , A61K39/21 , A61K39/215 , A61K2039/521 , A61K2039/5252 , A61K2039/5254 , A61K2039/54 , A61K2039/55 , A61K2039/552 , A61K2039/55505 , A61K2039/55511 , A61K2039/55555 , A61K2039/55561 , A61K2039/55566 , A61K2039/55572 , A61K2039/55577 , C12N2720/12334 , C12N2720/12351 , C12N2740/13034 , C12N2740/13051 , C12N2760/16134 , C12N2760/16151 , C12N2770/20034 , C12N2770/20051 , C12N2770/24334 , C12N2770/24351 , Y02A50/474
摘要： This invention relates to adjuvant formulations comprising various combinations of triterpenoids, sterols, immunomodulators, polymers, and Th2 stimulators; methods for making the adjuvant compositions; and the use of the adjuvant formulations in immunogenic and vaccine compositions with different antigens. This invention further relates to the use of the formulations in the treatment of animals.
摘要翻译： 本发明涉及包含三萜类，甾醇，免疫调节剂，聚合物和Th2刺激剂的各种组合的佐剂制剂; 制备佐剂组合物的方法; 以及在具有不同抗原的免疫原性和疫苗组合物中使用佐剂制剂。 本发明还涉及该制剂在动物治疗中的用途。
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