公开(公告)号：US20240336651A1

公开(公告)日：2024-10-10

申请号：US18748165

申请日：2024-06-20

申请人： NATIONAL SUN YAT-SEN UNIVERSITY

发明人： Hong-Wei Yang ,  Nan-Si Li ,  Ying-Pei Hsu ,  Hao-Han Pang

IPC分类号： C07K2/00 ,  A61K38/16 ,  B82Y40/00 ,  C03C17/32 ,  C07K14/005 ,  G01N21/78 ,  G01N27/414 ,  G01N33/543

CPC分类号： C07K2/00 ,  A61K38/162 ,  C03C17/32 ,  C07K14/005 ,  G01N21/78 ,  G01N27/4145 ,  G01N33/54393 ,  B82Y40/00 ,  C03C2217/70 ,  C07K2319/30 ,  C07K2319/735 ,  C07K2319/74 ,  C12N2795/00023

摘要： A method for manufacturing a glass-based biosensor is used to solve the problem of the use of a solution containing a strong acid or a strong base or of an oxygen plasma treatment. The method comprises modifying a silicon-containing substrate by an alcohol solution to form negative charges on at least one coupling surface of the silicon-containing substrate. A least one active layer of polymer having positive charges is formed on the at least one surface of the silicon-containing substrate, respectively. Each of the at least one active layer of polymer has a coupling surface and an active surface opposite to the coupling surface, and the at least one active layer of polymer couples to the silicon-containing substrate via the coupling surface. A plurality of capture biomolecules couples to the active surface.

公开(公告)号：US20240254161A1

公开(公告)日：2024-08-01

申请号：US18583364

申请日：2024-02-21

申请人： Janssen Biotech, Inc.

发明人： Vipul Bhargava ,  Vinod Krishna ,  David J. Pocalyko ,  Pegah Safabakhsh ,  Manuel Alejandro Sepulveda

IPC分类号： C07K2/00 ,  A61K38/00 ,  A61K45/06 ,  C07K1/107 ,  C12N15/86

CPC分类号： C07K2/00 ,  A61K45/06 ,  C07K1/107 ,  C12N15/86 ,  A61K38/00 ,  C12N2710/10041 ,  C12N2710/24041

摘要： The disclosure relates to ovarian cancer neoantigens, polynucleotides encoding them, vectors, host cells, recombinant virus particles, vaccines comprising the neoantigens, proteinaceous molecules binding the ovarian cancer neoantigens, and methods of making and using them.

公开(公告)号：US11931380B2

公开(公告)日：2024-03-19

申请号：US17230791

申请日：2021-04-14

申请人： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA

发明人： Steven M. Albelda ,  Liang-Chuan Wang ,  Gary Koretzky ,  Matthew Riese

IPC分类号： A61K35/17 ,  C07K2/00 ,  C07K16/30 ,  C07K16/40 ,  C12N5/0783 ,  C12N9/16 ,  C12N15/113 ,  A61K38/00 ,  A61K38/45

CPC分类号： A61K35/17 ,  C07K2/00 ,  C07K16/30 ,  C07K16/40 ,  C12N5/0638 ,  C12N9/16 ,  C12N15/1137 ,  A61K38/00 ,  A61K38/45 ,  C12N2310/11 ,  C12N2310/14 ,  C12N2310/531 ,  C12Y207/01107 ,  C12N2310/14 ,  C12N2310/531

摘要： The present invention provides compositions and methods for inhibiting one or more diacylglycerol kinase (DGK) isoform in a cell in order to enhance the cytolytic activity of the cell. In one embodiment, the cells may be used in adoptive T cell transfer. For example, in some embodiments, the cell is modified to express a chimeric antigen receptor (CAR). Inhibition of DGK in T cells used in adoptive T cell transfer increases cytolytic activity of the T cells and thus may be used in the treatment of a variety of conditions, including cancer, infection, and immune disorders.

公开(公告)号：US11833220B2

公开(公告)日：2023-12-05

申请号：US15536428

申请日：2015-12-15

申请人： OXFORD VACMEDIX UK LTD. ,  Shisong Jiang

发明人： Shisong Jiang ,  Xiaobing Xia ,  Hanghai Ding

IPC分类号： A61K39/02 ,  A61K39/12 ,  C07K19/00 ,  C12N5/0783 ,  A61K47/68 ,  A61K39/118 ,  C12N15/70 ,  C12Q1/686 ,  A61K39/39 ,  C07K2/00 ,  C07K16/00

CPC分类号： A61K47/6849 ,  A61K39/02 ,  A61K39/118 ,  A61K39/12 ,  A61K47/6855 ,  C07K19/00 ,  C12N5/0636 ,  C12N15/70 ,  C12Q1/686 ,  A61K39/39 ,  C07K2/00 ,  C07K16/00 ,  C12N2501/505

摘要： Provided are an artificial multi-antigen fusion protein and a preparation method thereof. The fusion protein can effectively stimulate CD8+T and CD4+ T cell immunities, and can be applied to immunodiagnostics or serve as a prophylactic or therapeutic vaccine.

公开(公告)号：US20230340013A1

公开(公告)日：2023-10-26

申请号：US18198205

申请日：2023-05-16

申请人： United Kingdom Research and Innovation

发明人： Jason CHIN ,  Kathrin LANG

IPC分类号： C07K1/00 ,  G01N33/58 ,  C07K2/00 ,  C07C271/22 ,  C07K1/13 ,  C12N9/00

CPC分类号： C07K1/006 ,  G01N33/582 ,  C07K2/00 ,  C07C271/22 ,  C07K1/13 ,  C12N9/93 ,  C12Y601/01026 ,  C07C2602/24

摘要： The invention relates to a polypeptide comprising an amino acid having a bicyclo[6.1.0]non-4-yn-9-ylmethanol (BCN) group, particularly when said BCN group is present as: a residue of a lysine amino acid. The invention also relates to a method of producing a polypeptide comprising a BCN group, said method comprising genetically incorporating an amino acid comprising a BCN group into a polypeptide. The invention also relates to an amino acid comprising bicyclo[6.1.0]non-4-yn-9-ylmethanol (BCN), particularly and amino acid which is bicyclo[6.1.0]non-4-yn-9-ylmethanol (BCN) lysine. In addition the invention relates to a PylRS tRNA synthetase comprising the mutations Y271M, L274G and C313A.

公开(公告)号：US11779548B2

公开(公告)日：2023-10-10

申请号：US16871902

申请日：2020-05-11

申请人： THE SCRIPPS RESEARCH INSTITUTE

发明人： Jie Li ,  Zilei Liu ,  Suhua Li ,  Peng Wu ,  K. Barry Sharpless

IPC分类号： A61K31/05 ,  A61K31/136 ,  C07C305/26 ,  C07K1/113 ,  C07K1/02 ,  A61K51/04 ,  A61K38/31 ,  A61K31/7048 ,  A61K31/70 ,  A61K31/655 ,  A61K31/65 ,  A61K31/56 ,  A61K31/5513 ,  A61K31/53 ,  A61K31/515 ,  A61K31/505 ,  A61K31/485 ,  A61K31/4745 ,  A61K31/473 ,  A61K31/4709 ,  A61K31/47 ,  A61K31/439 ,  A61K31/4353 ,  A61K31/4245 ,  A61K31/4168 ,  A61K31/407 ,  A61K31/4045 ,  A61K31/40 ,  A61K31/397 ,  A61K31/198 ,  A61K31/197 ,  A61K31/14 ,  C07K2/00 ,  C07D295/26 ,  C07D295/185 ,  C07D295/088 ,  C07D277/82 ,  A61K47/54 ,  C40B30/06 ,  C40B30/04 ,  C40B50/08 ,  C12N5/09 ,  C40B40/04

CPC分类号： A61K31/05 ,  A61K31/136 ,  A61K31/14 ,  A61K31/197 ,  A61K31/198 ,  A61K31/397 ,  A61K31/40 ,  A61K31/407 ,  A61K31/4045 ,  A61K31/4168 ,  A61K31/4245 ,  A61K31/439 ,  A61K31/4353 ,  A61K31/47 ,  A61K31/473 ,  A61K31/4709 ,  A61K31/4745 ,  A61K31/485 ,  A61K31/505 ,  A61K31/515 ,  A61K31/53 ,  A61K31/5513 ,  A61K31/56 ,  A61K31/65 ,  A61K31/655 ,  A61K31/70 ,  A61K31/7048 ,  A61K38/31 ,  A61K47/54 ,  A61K51/0497 ,  C07C305/26 ,  C07D277/82 ,  C07D295/088 ,  C07D295/185 ,  C07D295/26 ,  C07K1/02 ,  C07K1/1136 ,  C07K2/00 ,  C40B30/06 ,  C07C2601/14 ,  C07C2603/18 ,  C12N5/0693 ,  C12N2503/02 ,  C40B30/04 ,  C40B40/04 ,  C40B50/08 ,  G01N2500/00

摘要： A high-throughput screening methods for identifying candidate anticancer medicinal agents is described herein. The candidate anticancer medicinal agents are arylfluorosulfate compounds derived from phenolic compounds. The method involves in situ generation of the arylfluorosulfate compounds in multi-well plates by reaction of phenolic compounds in DMSO with a saturated solution of SO2F2 dissolved in a solvent such as acetonitrile, in the presence of an organic base, followed by reaction of generated fluoride ion with trimethylsilanol to form volatile trimethylsilyl fluoride. Solvents, organic base, and silyl compounds are then removed, in vacuo, to afford the arylfluorosulfate compounds suitable for biological screening in cancer cell lines without further purification.

公开(公告)号：US11749377B2

公开(公告)日：2023-09-05

申请号：US15565893

申请日：2016-04-14

申请人： PEACCEL

发明人： Nicolas Fontaine ,  Frédéric Cadet

IPC分类号： G16B30/00 ,  G16B20/00 ,  G16B20/50 ,  C07K2/00 ,  G06F17/14 ,  C12N15/10 ,  C40B40/10

CPC分类号： G16B30/00 ,  C07K2/00 ,  G06F17/14 ,  G16B20/00 ,  G16B20/50 ,  C12N15/1089 ,  C40B40/10

摘要： A method for predicting at least one fitness value of a protein is implemented on a computer and includes the following steps: encoding the amino acid sequence of the protein into a numerical sequence according to a protein database, the numerical sequence comprising a value for each amino acid of the sequence; calculating a protein spectrum according to the numerical sequence; and for each fitness: comparing the calculated protein spectrum with protein spectrum values of a predetermined database, said database containing protein spectrum values for different values of said fitness, predicting a value of said fitness according to the comparison step.

公开(公告)号：US20230220008A1

公开(公告)日：2023-07-13

申请号：US18055255

申请日：2022-11-14

申请人： BicycleTx Limited

发明人： Liuhong CHEN ,  Rachid LANI ,  Kevin MCDONNELL ,  Gemma MUDD ,  Peter U. PARK ,  Punit UPADHYAYA

IPC分类号： C07K7/08 ,  C07K17/02 ,  A61K47/59 ,  C07K14/705 ,  A61K47/66 ,  A61K47/60 ,  C07K2/00 ,  A61K47/64 ,  C07K17/14 ,  C07K7/64 ,  A61P35/00 ,  A61K47/54

CPC分类号： C07K7/08 ,  C07K17/02 ,  A61K47/59 ,  C07K14/70575 ,  A61K47/66 ,  A61K47/60 ,  C07K2/00 ,  A61K47/64 ,  C07K17/14 ,  C07K7/64 ,  A61P35/00 ,  A61K47/54 ,  C07K2319/00

摘要： The present invention relates to multimers of polypeptides which are covalently bound to molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. The invention also describes the multimerization of polypeptides through various chemical linkers and hinges of various lengths and rigidity using different sites of attachments within polypeptides. In particular, the invention describes multimers of peptides which are high affinity binders and activators of CD137. The invention also includes drug conjugates comprising said peptides, conjugated to one or more effector and/or functional groups, to pharmaceutical compositions comprising said peptide ligands and drug conjugates and to the use of said peptide ligands and drug conjugates in preventing, suppressing or treating a disease or disorder mediated by CD137.

公开(公告)号：US11597925B2

公开(公告)日：2023-03-07

申请号：US16438088

申请日：2019-06-11

申请人： Ventana Medical Systems, Inc.

发明人： Aoune Barhoumi ,  Rui Hong

IPC分类号： C07H21/04 ,  C12N15/11 ,  C07K2/00 ,  C07K14/00 ,  C07K16/28 ,  G01N33/53 ,  G01N33/58 ,  G01N33/68

摘要： The disclosure is directed to conjugates, e.g. PNA conjugates, as well as methods of employing the conjugates for detecting one or more targets in a biological sample, e.g. a tissue sample.

公开(公告)号：US11542304B2

公开(公告)日：2023-01-03

申请号：US17080021

申请日：2020-10-26

申请人： BicycleTx Limited

发明人： Liuhong Chen ,  Rachid Lani ,  Kevin Mcdonnell ,  Gemma Mudd ,  Peter U. Park ,  Punit Upadhyaya

IPC分类号： C07K7/08 ,  C07K7/64 ,  C07K2/00 ,  A61K47/64 ,  A61K47/66 ,  A61P35/00 ,  C07K17/02 ,  A61K47/60 ,  C07K17/14 ,  A61K47/59 ,  C07K14/705 ,  A61K47/54

摘要： The present invention relates to multimers of polypeptides which are covalently bound to molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. The invention also describes the multimerization of polypeptides through various chemical linkers and hinges of various lengths and rigidity using different sites of attachments within polypeptides. In particular, the invention describes multimers of peptides which are high affinity binders and activators of CD137. The invention also includes drug conjugates comprising said peptides, conjugated to one or more effector and/or functional groups, to pharmaceutical compositions comprising said peptide ligands and drug conjugates and to the use of said peptide ligands and drug conjugates in preventing, suppressing or treating a disease or disorder mediated by CD137.