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公开(公告)号：US12012373B2
公开(公告)日：2024-06-18
申请号：US17626519
申请日：2020-07-10
IPC分类号： C07C311/29 , C07C69/16 , C07C309/42 , C07C311/51 , C07C317/22 , C07D205/06 , C07D205/12 , C07D207/404 , C07D211/54 , C07D213/71 , C07D233/84 , C07D235/16 , C07D239/38 , C07D249/08 , C07D249/10 , C07D263/32 , C07D277/30 , C07D295/26 , C07D305/08 , C07D307/64 , C07D487/10
CPC分类号： C07C311/29 , C07C69/16 , C07C309/42 , C07C311/51 , C07C317/22 , C07D205/06 , C07D205/12 , C07D207/404 , C07D211/54 , C07D213/71 , C07D233/84 , C07D235/16 , C07D239/38 , C07D249/08 , C07D249/10 , C07D263/32 , C07D277/30 , C07D295/26 , C07D305/08 , C07D307/64 , C07D487/10
摘要： This disclosure relates to cannabinoid derivatives having the structure of formula (I), pharmaceutical compositions comprising them, and methods of using the cannabinoid derivatives in treating or preventing a diseases associated with a cannabinoid receptor in subject in need thereof, wherein the cannabinoid receptor is one or more of CB1, CB2, 5HT1A, 5HT2A, GPR18, GPR55, GPR119, TRPV1, TRPV2, PPARγ or a μ-opioid receptor.
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公开(公告)号：US20230312499A1
公开(公告)日：2023-10-05
申请号：US18053582
申请日：2022-11-08
发明人： Justin S. CISAR , Cheryl A. GRICE , Todd K. JONES , Micah J. NIPHAKIS , Jae Won CHANG , Kenneth M. LUM , Benjamin F. CRAVATT
IPC分类号： C07D295/205 , C07C271/12 , C07D317/46 , C07D317/58 , C07D231/12 , C07D231/16 , C07D231/56 , C07D241/04 , C07D471/04 , C07D471/10 , C07D261/08 , C07D487/04 , C07D263/32 , C07D205/04 , C07D491/107 , C07D207/14 , C07D271/06 , C07D307/79 , C07D405/14 , C07D215/42 , C07D213/40 , A61P25/22 , C07D295/26 , C07D213/55 , C07D401/04 , C07D407/06 , C07D413/06 , C07C271/10 , C07D207/09 , C07D213/38 , C07D215/46 , C07D401/10 , C07D403/10 , C07D413/10
CPC分类号： C07D295/205 , C07C271/12 , C07D317/46 , C07D317/58 , C07D231/12 , C07D231/16 , C07D231/56 , C07D241/04 , C07D471/04 , C07D471/10 , C07D261/08 , C07D487/04 , C07D263/32 , C07D205/04 , C07D491/107 , C07D207/14 , C07D271/06 , C07D307/79 , C07D405/14 , C07D215/42 , C07D213/40 , A61P25/22 , C07D295/26 , C07D213/55 , C07D401/04 , C07D407/06 , C07D413/06 , C07C271/10 , C07D207/09 , C07D213/38 , C07D215/46 , C07D401/10 , C07D403/10 , C07D413/10
摘要： This disclosure provides compounds and compositions which may be modulators of MAGL and/or ABHD6 and their use as medicinal agents, processes for their preparation, and pharmaceutical compositions that include disclosed compounds as at least one active agent. The disclosure also provides for method of treating a patient in need thereof, where the patient is suffering from post-traumatic stress disorder comprising administering a disclosed compound or composition.
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公开(公告)号：US20230242548A1
公开(公告)日：2023-08-03
申请号：US18058655
申请日：2022-11-23
发明人： Jonathan Ostrem , Ulf Peters , Kevan M. Shokat
IPC分类号： C07D495/04 , A61K38/17 , C07D231/40 , C07D401/04 , C07D401/06 , C07D401/12 , C07D405/12 , C07D409/04 , C07D413/12 , C07D417/12 , C07D471/10 , C07D487/10 , C07D207/14 , C07D211/62 , C07D295/185 , C07D295/26 , C07D211/58 , C07D487/04 , C12N9/14 , C07C235/20 , C07C317/08 , C12Q1/6886
CPC分类号： C07D495/04 , A61K38/1709 , C07C235/20 , C07C317/08 , C07D207/14 , C07D211/58 , C07D211/62 , C07D231/40 , C07D295/26 , C07D295/185 , C07D401/04 , C07D401/06 , C07D401/12 , C07D405/12 , C07D409/04 , C07D413/12 , C07D417/12 , C07D471/10 , C07D487/04 , C07D487/10 , C12N9/14 , C12Q1/6886 , C12Q2600/156 , C12Q2600/158 , C12Y306/05002 , G01N2500/04
摘要： K-Ras is the most frequently mutated oncogene in human cancer. Disclosed herein are compositions and methods for modulating K-Ras and treating cancer.
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公开(公告)号：US20230242496A1
公开(公告)日：2023-08-03
申请号：US18001516
申请日：2021-06-15
发明人： Jian JIN , Marta FILIZOLA , Aneel AGGARWAL , Samir PAREKH , Abhijeet KAPOOR , Shashidhar S. JATIANI , H. Umit KANISKAN , Jianping HU , Yudao SHEN , Fanye MENG , Lihuai QIN , Yulin HAN , Xufen YU , Chengwei ZHANG , Prashasti KUMAR , Rinku JAIN , Clement LEE
IPC分类号： C07D279/16 , C07D265/36 , C07C321/28 , C07D249/18 , C07D215/48 , C07D239/74 , C07D231/56 , C07D277/64 , C07D235/06 , C07D335/06 , C07D209/34 , C07D263/58 , C07D285/14 , C07D217/02 , C07D417/12 , C07D239/42 , C07D233/64 , C07D403/04 , C07D215/38 , C07D239/72 , C07C311/46 , C07D295/135 , C07D239/48 , C07D235/16 , C07D215/227 , C07D295/26 , C07D239/54 , C07D405/12
CPC分类号： C07D279/16 , C07D265/36 , C07C321/28 , C07D249/18 , C07D215/48 , C07D239/74 , C07D231/56 , C07D277/64 , C07D235/06 , C07D335/06 , C07D209/34 , C07D263/58 , C07D285/14 , C07D217/02 , C07D417/12 , C07D239/42 , C07D233/64 , C07D403/04 , C07D215/38 , C07D239/72 , C07C311/46 , C07D295/135 , C07D239/48 , C07D235/16 , C07D215/227 , C07D295/26 , C07D239/54 , C07D405/12
摘要： Disclosed are compounds that are chemical inhibitors of SOX11. The compounds disclosed are useful in treatment of various cancers.
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公开(公告)号：US20230041593A1
公开(公告)日：2023-02-09
申请号：US17949184
申请日：2022-09-20
申请人： Versitech Limited
发明人： Yi Tsun Richard KAO , Peng GAO , Xuechen LI , Ming LIU
IPC分类号： A61K31/40 , C07D295/26 , C07D317/60 , A61P31/04 , A61K31/357 , A61K31/167 , A61K31/18 , A61K31/404 , A61K31/4402 , A61K31/4406 , A61K31/444 , A61K31/4453 , A61K31/454 , A61K31/47 , A61K31/496
摘要： Provided herein are compounds, derivatives thereof, composition comprising one or more of said compounds and derivatives prevention and/or treatment of microbial infections and/or related diseases or conditions. The present compounds and/or derivatives thereof can be represented by Formula (I): In one embodiment, said microbial infections are bacterial infections. More specifically, said bacterial infections are staphylococcal infections.
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公开(公告)号：US20220184008A1
公开(公告)日：2022-06-16
申请号：US17594070
申请日：2020-04-02
申请人： FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA , FONDAZIONE TELETHON , ALMA MATER STUDIORUM - UNIVERSITA' DI BOLOGNA , UNIVERSITA' DEGLI STUDIO DI GENOVA
发明人： Laura Cancedda , Marco De Vivo , Andrea Contestabile , Marco Borgogno , Annalisa Savardi , Jose Antonio Ortega Martinez
IPC分类号： A61K31/18 , A61K45/06 , A61P25/00 , A61P25/28 , C07C311/39 , C07D307/52 , C07C311/43 , C07D295/26 , C07D309/14 , C07D211/96 , A61K31/196 , A61K31/341 , A61K31/40 , A61K31/4453 , A61K31/5375 , A61K31/495 , A61K31/445 , A61K31/351
摘要： The present invention relates to a compound of Formula la, lb and Ic, (Formula Ia) a pharmaceutical composition comprising the same and their use in the treatment or prevention of pathological conditions associated to depolarizing GABAergic transmission including, for example, Down syndrome and autism.
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公开(公告)号：US20220177425A1
公开(公告)日：2022-06-09
申请号：US17602924
申请日：2020-04-10
IPC分类号： C07D207/09 , A61P35/00 , C07D207/48 , C07D295/26 , C07D243/08 , C07D211/28 , C07D211/96
摘要： The present disclosure provides compounds of formula (I), as described herein, their pharmaceutically acceptable salts, and their pharmaceutical compositions, which are effective in reducing the expression level of KLF5 or EGR1 in a living cell, and for the treatment of tumors and colorectal cancer in a human patient.
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公开(公告)号：US20220073477A1
公开(公告)日：2022-03-10
申请号：US17481649
申请日：2021-09-22
IPC分类号： C07D249/06 , C07C309/30 , A61K9/00 , A61K31/496 , C07D239/26 , A61K31/506 , C07D295/192 , A61K31/495 , C07D279/12 , A61K31/54 , C07D205/04 , A61K31/397 , C07D295/26 , C07D215/54 , C07C53/18 , C07D231/12 , C07D263/32 , A61K31/541 , C07B59/00 , C07D403/12 , A61K31/4192 , C07D401/12 , A61K31/454 , C07D249/08 , A61K31/4196 , C07D211/66 , A61K31/445 , C07D239/42 , C07D491/107 , C07D413/12 , A61K31/5377 , C07D498/08 , A61K31/5383 , C07D471/10 , A61K31/435 , C07D401/04 , A61K31/41 , C07D487/04 , A61K31/4162 , C07D487/08 , A61K31/4995 , A61K31/551 , C07D237/08 , A61K31/501 , A61K9/16 , A61K9/48 , A61K45/06 , A61P29/00 , A61P35/00 , A61P35/02 , A61P43/00
摘要： Disclosed herein are new compounds and compositions and their application as pharmaceuticals for the treatment of diseases. Methods of inhibition of KDM1A, methods of increasing gamma globin gene expression, and methods to induce differentiation of cancer cells in a human or animal subject are also provided for the treatment of diseases such as acute myelogenous leukemia.
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9.发明授权公开(公告)号：US11028252B2
公开(公告)日：2021-06-08
申请号：US16621757
申请日：2018-06-05
发明人： Georgiy Teverovskiy , Chetan P. Jariwala , Ajay K. Vidyasagar , Maria A. Appeaning , Kristy A. Jost , Robert A. Polik
摘要： A melt additive compound has the general formula (I) wherein R represents a linear alkylene group having from 1 to 18 carbon atoms; n represents an integer from 1 to 4, inclusive; and Rf1 is represented by the general formula II wherein Rf represents a perfluorinated group having from 3 to 5 carbon atoms. Compositions comprising a thermoplastic polymer and the melt additive compound, methods of extruding them and extruded articles are also disclosed.
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公开(公告)号：US11008334B2
公开(公告)日：2021-05-18
申请号：US16720526
申请日：2019-12-19
发明人： Jonathan Ostrem , Ulf Peters , Kevan M. Shokat
IPC分类号： C12Q1/6886 , C12N9/14 , C07D495/04 , A61K38/17 , C07D231/40 , C07D401/04 , C07D401/06 , C07D401/12 , C07D405/12 , C07D409/04 , C07D413/12 , C07D417/12 , C07D471/10 , C07D487/10 , C07D207/14 , C07D211/62 , C07D295/185 , C07D295/26 , C07D211/58 , C07D487/04 , C07C235/20 , C07C317/08
摘要： K-Ras is the most frequently mutated oncogene in human cancer. Disclosed herein are compositions and methods for modulating K-Ras and treating cancer.
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