公开(公告)号：US20230174562A1

公开(公告)日：2023-06-08

申请号：US17923831

申请日：2021-05-07

Applicant: TONIX PHARMACEUTICALS, INC. ,  TONIX PHARMACEUTICALS HOLDING CORP.

Inventor： Philip S. Schein ,  Darryl C. Rideout

IPC: C07F9/165 ,  A61K45/06 ,  A61P39/00 ,  A61K31/661 ,  C07D243/08 ,  A61K31/551 ,  C07D241/04 ,  A61K31/495 ,  C07D243/10 ,  C07D245/02 ,  A61K31/395 ,  C07D245/04 ,  C07D487/04 ,  A61K31/4985 ,  C07C53/18 ,  C07D241/38 ,  A61K31/498 ,  C07F9/6571 ,  A61K31/675 ,  C07C323/25 ,  A61K31/145

CPC classification number: C07F9/1651 ,  A61K45/06 ,  A61P39/00 ,  A61K31/661 ,  C07D243/08 ,  A61K31/551 ,  C07D241/04 ,  A61K31/495 ,  C07D243/10 ,  C07D245/02 ,  A61K31/5545 ,  C07D245/04 ,  C07D487/04 ,  A61K31/4985 ,  C07C53/18 ,  C07D241/38 ,  A61K31/498 ,  C07F9/657118 ,  A61K31/675 ,  C07C323/25 ,  A61K31/145 ,  C07B2200/13

Abstract: The present disclosure relates to prodrugs, double prodrugs, derivatives and analogues of 3-(methylamino)-2-((methy-lamino)methyl)propane-1-thiol. Their use as radio- and chemo-protectors is also described.

公开(公告)号：US11242317B2

公开(公告)日：2022-02-08

申请号：US16519590

申请日：2019-07-23

Applicant: THE WISTAR INSTITUTE OF ANATOMY AND BIOLOGY

Inventor： Troy E. Messick ,  Garry R. Smith ,  Allen B. Reitz ,  Paul M. Lieberman ,  Mark E. McDonnell ,  Yan Zhang ,  Venkata Velvadapu

IPC: A61K31/405 ,  A61K31/41 ,  A61K31/42 ,  A61K31/415 ,  A61K31/40 ,  C07D515/02 ,  C07D209/44 ,  C07D295/04 ,  C07D261/06 ,  C07D233/02 ,  C07D233/00 ,  C07D207/327 ,  A61K31/404 ,  A61K31/4439 ,  A61K31/496 ,  A61K31/192 ,  A61K31/44 ,  C07C229/56 ,  C07C255/54 ,  C07C255/55 ,  C07C211/27 ,  C07C217/84 ,  C07C233/11 ,  C07C233/64 ,  C07C233/65 ,  C07C235/58 ,  C07C311/08 ,  C07C311/16 ,  C07C311/17 ,  C07C317/14 ,  C07D235/06 ,  C07D403/10 ,  C07D239/26 ,  C07D409/10 ,  C07D417/10 ,  C07D471/04 ,  C07D487/04 ,  C07D209/08 ,  C07D295/155 ,  C07D213/55 ,  C07C53/18 ,  C07C63/66 ,  C07C65/19 ,  C07C65/28 ,  C07C229/64 ,  C07C317/44 ,  C07D207/08 ,  C07D207/12 ,  C07D207/14 ,  C07D207/16 ,  C07D211/70 ,  C07D213/64 ,  C07D213/74 ,  C07D215/14 ,  C07D231/12 ,  C07D249/06 ,  C07D277/30 ,  C07D307/79 ,  C07D333/54 ,  C07D401/04 ,  C07D401/10

Abstract: Pharmaceutical compositions of the invention comprise EBNA1 inhibitors useful for the treatment of diseases caused by EBNA1 activity such as cancer, infectious mononucleosis, chronic fatigue syndrome, multiple sclerosis, systemic lupus erythematosus and rheumatoid arthritis. Pharmaceutical compositions of the invention also comprise EBNA1 inhibitors useful for the treatment of diseases caused by latent Epstein-Barr Virus (EBV) infection. Pharmaceutical compositions of the invention also comprise EBNA1 inhibitors useful for the treatment of diseases caused by lytic Epstein-Barr Virus (EBV) infection.

公开(公告)号：US11230534B2

公开(公告)日：2022-01-25

申请号：US16672083

申请日：2019-11-01

Applicant: Imago Biosciences, Inc.

Inventor： Hugh Y. Rienhoff, Jr. ,  John M. McCall ,  Michael Clare ,  Cassandra Celatka ,  Amy E. Tapper

IPC: A61K31/397 ,  C07D249/06 ,  C07C309/30 ,  A61K9/00 ,  A61K31/496 ,  C07D239/26 ,  A61K31/506 ,  C07D295/192 ,  A61K31/495 ,  C07D279/12 ,  A61K31/54 ,  C07D205/04 ,  C07D295/26 ,  C07D215/54 ,  C07C53/18 ,  C07D231/12 ,  C07D263/32 ,  A61K31/541 ,  C07B59/00 ,  C07D403/12 ,  A61K31/4192 ,  C07D401/12 ,  A61K31/454 ,  C07D249/08 ,  A61K31/4196 ,  C07D211/66 ,  A61K31/445 ,  C07D239/42 ,  C07D491/107 ,  C07D413/12 ,  A61K31/5377 ,  C07D498/08 ,  A61K31/5383 ,  C07D471/10 ,  A61K31/435 ,  C07D401/04 ,  A61K31/41 ,  C07D487/04 ,  A61K31/4162 ,  C07D487/08 ,  A61K31/4995 ,  A61K31/551 ,  C07D237/08 ,  A61K31/501 ,  A61K9/16 ,  A61K9/48 ,  A61K45/06 ,  A61P29/00 ,  A61P35/00 ,  A61P35/02 ,  A61P43/00

Abstract: Disclosed herein are new compounds and compositions and their application as pharmaceuticals for the treatment of diseases. Methods of inhibition of KDM1A, methods of increasing gamma globin gene expression, and methods to induce differentiation of cancer cells in a human or animal subject are also provided for the treatment of diseases such as acute myelogenous leukemia.

公开(公告)号：US20220017459A1

公开(公告)日：2022-01-20

申请号：US17387478

申请日：2021-07-28

Applicant: Lantheus Medical Imaging, Inc.

Inventor： Ajay Purohit ,  Pedro Benites ,  Heike S. Radeke ,  Joel Lazewatsky ,  L. Veronica Lee

IPC: C07C303/30 ,  A61K51/04 ,  C07B59/00 ,  C07C53/06 ,  C07C217/58 ,  C07C255/54 ,  C07C279/10 ,  C07C279/24 ,  C07C309/65 ,  C07C309/66 ,  C07C309/73 ,  C07C277/08 ,  C07C53/10 ,  C07C53/18 ,  C07C63/08 ,  C07C213/02 ,  C07C303/28 ,  C07C309/04 ,  C07C309/30

Abstract: The present invention generally relates to novel synthetic methods, systems, kits, salts, and precursors useful in medical imaging. In some embodiments, the present invention provides compositions comprising an imaging agent precursor, which may be formed using the synthetic methods described herein. An imaging agent may be converted to an imaging agent using the methods described herein. In some cases, the imaging agent is enriched in 18F. In some cases, an imaging agent including salt forms (e.g., ascorbate salt) may be used to image an area of interest in a subject, including, but not limited to, the heart, cardiovascular system, cardiac vessels, brain, and other organs.

公开(公告)号：US11111201B2

公开(公告)日：2021-09-07

申请号：US16607846

申请日：2018-04-25

Applicant: SOLVAY SA

Inventor： Jean-Marie Blaude ,  Benoit Gosselin ,  Alain Lambert ,  Matthias Marek ,  Harald Krueger ,  Jan Schostag ,  Miriam Heyd

IPC: C07C51/42 ,  C01B17/88 ,  C01B17/90 ,  C07C51/43 ,  C07C51/56 ,  C07C51/573 ,  C07C53/00 ,  C07C53/16 ,  C07C53/18

Abstract: The present invention concerns a process for the reduction of content of carboxylic acids and derivatives thereof in oleum, disulfuric acid or concentrated sulfuric acid. The invention further concerns a process for the manufacture of carboxylic acid anhydrides comprising the process for the reduction of content of carboxylic acids and derivatives thereof from oleum, disulfuric acid or concentrated sulfuric acid.

公开(公告)号：US20200002335A1

公开(公告)日：2020-01-02

申请号：US16542792

申请日：2019-08-16

Applicant: PROXIMAGEN, LLC

Inventor： Max ESPENSEN ,  Lee PATIENT ,  David EVANS ,  Iain SIMPSON ,  Edward SAVORY

IPC: C07D471/04 ,  A61K31/40 ,  C07C53/18

Abstract: The compounds of formula (I) are inhibitors of SSAO activity wherein V, W, X, Y, Z, R1 and R2 are as defined in the claims.

公开(公告)号：US10221202B2

公开(公告)日：2019-03-05

申请号：US15654301

申请日：2017-07-19

Applicant: Boehringer Ingelheim International GmbH

Inventor： Armin Heckel ,  Dieter Hamprecht ,  Joerg Kley ,  Dieter Wiedenmayer

IPC: C07F9/6558 ,  C07D405/14 ,  A61K31/541 ,  A61K45/06 ,  C07C53/18 ,  A61K31/675 ,  C07D403/12 ,  A61K31/497 ,  C07D401/14 ,  C07C53/06

Abstract: The present invention relates to compounds of formula (I) wherein R1, R2, R3, and Z− have one of the meanings as indicated in the specification or a pharmaceutically acceptable salt thereof, to the use of compounds of formula (I) as a medicament, to pharmaceutical compositions comprising at least one compound of formula (I), as well as to medicament combinations containing one or more compounds of formula (I).

公开(公告)号：US20180312474A1

公开(公告)日：2018-11-01

申请号：US15952073

申请日：2018-04-12

Applicant: Imago Biosciences, Inc.

Inventor： Hugh Y. RIENHOFF, Jr. ,  John M. MCCALL ,  Michael CLARE ,  Cassandra CELATKA ,  Amy E. TAPPER

IPC: C07D249/06 ,  A61K31/501 ,  C07D237/08 ,  A61K31/551 ,  A61K31/4995 ,  C07D487/08 ,  A61K31/4162 ,  C07D487/04 ,  A61K31/41 ,  C07D401/04 ,  A61K31/435 ,  C07D471/10 ,  A61K31/5383 ,  C07D498/08 ,  A61K31/5377 ,  C07D413/12 ,  C07D491/107 ,  C07D239/42 ,  A61K31/445 ,  C07D211/66 ,  A61K31/4196 ,  C07D249/08 ,  A61K31/454 ,  C07D401/12 ,  A61K31/4192 ,  C07D403/12 ,  A61K31/541 ,  C07D263/32 ,  C07D231/12 ,  C07D215/54 ,  C07D295/26 ,  A61K31/397 ,  C07D205/04 ,  A61K31/54 ,  C07D279/12 ,  A61K31/495 ,  C07D295/192 ,  A61K31/506 ,  C07D239/26 ,  A61K31/496 ,  C07C309/30 ,  C07B59/00 ,  C07C53/18 ,  A61K9/00 ,  A61P43/00 ,  A61P35/02 ,  A61P35/00 ,  A61P29/00 ,  A61K45/06 ,  A61K9/48 ,  A61K9/16

CPC classification number: C07D249/06 ,  A61K9/0053 ,  A61K9/1623 ,  A61K9/4858 ,  A61K31/397 ,  A61K31/41 ,  A61K31/4162 ,  A61K31/4192 ,  A61K31/4196 ,  A61K31/435 ,  A61K31/445 ,  A61K31/454 ,  A61K31/495 ,  A61K31/496 ,  A61K31/4995 ,  A61K31/501 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/5383 ,  A61K31/54 ,  A61K31/541 ,  A61K31/551 ,  A61K45/06 ,  A61P29/00 ,  A61P35/00 ,  A61P35/02 ,  A61P43/00 ,  C07B59/002 ,  C07B2200/05 ,  C07B2200/07 ,  C07B2200/13 ,  C07C53/18 ,  C07C309/30 ,  C07D205/04 ,  C07D211/66 ,  C07D215/54 ,  C07D231/12 ,  C07D237/08 ,  C07D239/26 ,  C07D239/42 ,  C07D249/08 ,  C07D263/32 ,  C07D279/12 ,  C07D295/192 ,  C07D295/26 ,  C07D401/04 ,  C07D401/12 ,  C07D403/12 ,  C07D413/12 ,  C07D471/10 ,  C07D487/04 ,  C07D487/08 ,  C07D491/107 ,  C07D498/08 ,  A61K2300/00

Abstract: Disclosed herein are new compounds and compositions and their application as pharmaceuticals for the treatment of diseases. Methods of inhibition of KDM1A, methods of increasing gamma globin gene expression, and methods to induce differentiation of cancer cells in a human or animal subject are also provided for the treatment of diseases such as acute myelogenous leukemia.

公开(公告)号：US10017478B2

公开(公告)日：2018-07-10

申请号：US15808421

申请日：2017-11-09

Applicant: H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.

Inventor： Nupam P. Mahajan ,  Kiran N. Mahajan ,  Nicholas J. Lawrence ,  Harshani R. Lawrence

IPC: C07D405/12 ,  C07D239/49 ,  C07D239/42 ,  C07D405/14 ,  C07C53/18 ,  C07D239/48

CPC classification number: C07D239/49 ,  A61P35/00 ,  C07C53/18 ,  C07D239/42 ,  C07D239/48 ,  C07D405/12 ,  C07D405/14

Abstract: Described are cancer therapies and anti-cancer compounds. In particular, disclosed are inhibitors of Ack1 tyrosine kinase and their use in the treatment of cancer. Methods of screening for new Ack1 tyrosine kinase inhibitors are also disclosed. In specific example, compound having Formula I through IV are disclosed.

公开(公告)号：US10011547B2

公开(公告)日：2018-07-03

申请号：US15506583

申请日：2015-08-25

Applicant: The Scripps Research Institute

Inventor： Roy A. Periana ,  Michael M. Konnick ,  Brian G. Hashiguchi

IPC: C07C69/34 ,  C07C29/48 ,  C07C53/18 ,  C07C67/055 ,  C07C67/12 ,  C07C29/72

CPC classification number: C07C29/48 ,  C07C29/72 ,  C07C51/54 ,  C07C53/18 ,  C07C67/035 ,  C07C67/05 ,  C07C67/055 ,  C07C67/12 ,  C07C71/00 ,  C07C2523/08 ,  C07C2523/14 ,  C07C2523/16 ,  C07C2523/70 ,  Y02P20/582 ,  C07C69/63

Abstract: Provided are methods and materials for the functionalization of a heteroalkane or arene using an oxidizing electrophile as a stoichiometric agent or catalyst. The reaction involves the replacement of a hydrogen atom on an sp3-hybridized carbon atom of the heteroalkane or of a hydrogen atom on an sp2-hybridized carbon atom of the arene. A main group element organometallic intermediate is formed that undergoes further conversion to a functionalized heteroalkane or arene.