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公开(公告)号：US20200095214A1
公开(公告)日：2020-03-26
申请号：US16445768
申请日：2019-06-19
IPC分类号： C07D295/192 , C07C237/22 , C07D213/81 , C07D233/90 , C07D295/185 , C07D295/26 , A61K31/166 , A61K31/40 , A61K31/4453 , A61K31/454 , A61K31/4545 , A61K31/47 , A61K31/495 , A61K31/5375 , A61K31/54 , C07D215/14
摘要： Disclosed herein are new compounds and compositions and their application as pharmaceuticals for the treatment of diseases. Methods of inhibition of KDM1A, methods of increasing gamma globin gene expression, and methods to induce differentiation of cancer cells in a human or animal subject are also provided for the treatment of diseases such as acute myelogenous leukemia.
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公开(公告)号：US20230250090A1
公开(公告)日：2023-08-10
申请号：US18066667
申请日：2022-12-15
IPC分类号： C07D403/14 , A61K9/00 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/5377 , A61K31/541 , A61K45/06 , C07D241/08 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/10 , C07D491/107
CPC分类号： C07D403/14 , A61K9/0053 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/5377 , A61K31/541 , A61K45/06 , C07D241/08 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/10 , C07D491/107
摘要： The present disclosure relates to compounds and methods which may be useful as inhibitors of KDM1A for the treatment or prevention of diseases. Methods of inhibition of KDM1A, methods of increasing gamma globin gene expression, and methods to induce differentiation in cancer cells in a human or animal subject are also provided for treatment of disease such as acute myelogenous leukemia.
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公开(公告)号：US20210115023A1
公开(公告)日：2021-04-22
申请号：US17054126
申请日：2019-05-13
IPC分类号： C07D403/14 , A61K45/06 , A61K9/00 , C07D241/08 , A61K31/497 , A61K31/5377 , C07D491/107 , A61K31/541 , C07D401/04 , A61K31/506 , C07D403/10 , A61K31/501 , C07D401/14 , C07D403/04
摘要： The present disclosure relates to compounds and methods which may be useful as inhibitors of KDM1 A for the treatment or prevention of diseases. Methods of inhibition of KDM1 A, methods of increasing gamma globin gene expression, and methods to induce differentiation in cancer cells in a human or animal subject are also provided for treatment of disease such as acute myelogenous leukemia.
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公开(公告)号：US20180312474A1
公开(公告)日：2018-11-01
申请号：US15952073
申请日：2018-04-12
IPC分类号： C07D249/06 , A61K31/501 , C07D237/08 , A61K31/551 , A61K31/4995 , C07D487/08 , A61K31/4162 , C07D487/04 , A61K31/41 , C07D401/04 , A61K31/435 , C07D471/10 , A61K31/5383 , C07D498/08 , A61K31/5377 , C07D413/12 , C07D491/107 , C07D239/42 , A61K31/445 , C07D211/66 , A61K31/4196 , C07D249/08 , A61K31/454 , C07D401/12 , A61K31/4192 , C07D403/12 , A61K31/541 , C07D263/32 , C07D231/12 , C07D215/54 , C07D295/26 , A61K31/397 , C07D205/04 , A61K31/54 , C07D279/12 , A61K31/495 , C07D295/192 , A61K31/506 , C07D239/26 , A61K31/496 , C07C309/30 , C07B59/00 , C07C53/18 , A61K9/00 , A61P43/00 , A61P35/02 , A61P35/00 , A61P29/00 , A61K45/06 , A61K9/48 , A61K9/16
CPC分类号： C07D249/06 , A61K9/0053 , A61K9/1623 , A61K9/4858 , A61K31/397 , A61K31/41 , A61K31/4162 , A61K31/4192 , A61K31/4196 , A61K31/435 , A61K31/445 , A61K31/454 , A61K31/495 , A61K31/496 , A61K31/4995 , A61K31/501 , A61K31/506 , A61K31/5377 , A61K31/5383 , A61K31/54 , A61K31/541 , A61K31/551 , A61K45/06 , A61P29/00 , A61P35/00 , A61P35/02 , A61P43/00 , C07B59/002 , C07B2200/05 , C07B2200/07 , C07B2200/13 , C07C53/18 , C07C309/30 , C07D205/04 , C07D211/66 , C07D215/54 , C07D231/12 , C07D237/08 , C07D239/26 , C07D239/42 , C07D249/08 , C07D263/32 , C07D279/12 , C07D295/192 , C07D295/26 , C07D401/04 , C07D401/12 , C07D403/12 , C07D413/12 , C07D471/10 , C07D487/04 , C07D487/08 , C07D491/107 , C07D498/08 , A61K2300/00
摘要： Disclosed herein are new compounds and compositions and their application as pharmaceuticals for the treatment of diseases. Methods of inhibition of KDM1A, methods of increasing gamma globin gene expression, and methods to induce differentiation of cancer cells in a human or animal subject are also provided for the treatment of diseases such as acute myelogenous leukemia.
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公开(公告)号：US20170334873A1
公开(公告)日：2017-11-23
申请号：US15667166
申请日：2017-08-02
IPC分类号： C07D295/192 , C07D295/185 , C07D233/90 , C07D215/14 , C07D213/81 , C07C237/22 , A61K31/54 , A61K31/5375 , A61K31/495 , A61K31/47 , A61K31/4545 , A61K31/454 , A61K31/4453 , A61K31/40 , A61K31/166 , C07D295/26 , C07C2601/02
CPC分类号： C07D295/192 , A61K31/166 , A61K31/40 , A61K31/4453 , A61K31/454 , A61K31/4545 , A61K31/47 , A61K31/495 , A61K31/5375 , A61K31/54 , C07C237/22 , C07C2601/02 , C07D213/81 , C07D215/14 , C07D233/90 , C07D295/185 , C07D295/26
摘要： Disclosed herein are new compounds and compositions and their application as pharmaceuticals for the treatment of diseases. Methods of inhibition of KDM1A, methods of increasing gamma globin gene expression, and methods to induce differentiation of cancer cells in a human or animal subject are also provided for the treatment of diseases such as acute myelogenous leukemia.
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公开(公告)号：US20220073477A1
公开(公告)日：2022-03-10
申请号：US17481649
申请日：2021-09-22
IPC分类号： C07D249/06 , C07C309/30 , A61K9/00 , A61K31/496 , C07D239/26 , A61K31/506 , C07D295/192 , A61K31/495 , C07D279/12 , A61K31/54 , C07D205/04 , A61K31/397 , C07D295/26 , C07D215/54 , C07C53/18 , C07D231/12 , C07D263/32 , A61K31/541 , C07B59/00 , C07D403/12 , A61K31/4192 , C07D401/12 , A61K31/454 , C07D249/08 , A61K31/4196 , C07D211/66 , A61K31/445 , C07D239/42 , C07D491/107 , C07D413/12 , A61K31/5377 , C07D498/08 , A61K31/5383 , C07D471/10 , A61K31/435 , C07D401/04 , A61K31/41 , C07D487/04 , A61K31/4162 , C07D487/08 , A61K31/4995 , A61K31/551 , C07D237/08 , A61K31/501 , A61K9/16 , A61K9/48 , A61K45/06 , A61P29/00 , A61P35/00 , A61P35/02 , A61P43/00
摘要： Disclosed herein are new compounds and compositions and their application as pharmaceuticals for the treatment of diseases. Methods of inhibition of KDM1A, methods of increasing gamma globin gene expression, and methods to induce differentiation of cancer cells in a human or animal subject are also provided for the treatment of diseases such as acute myelogenous leukemia.
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公开(公告)号：US20210147373A1
公开(公告)日：2021-05-20
申请号：US17108663
申请日：2020-12-01
IPC分类号： C07D295/192 , C07C237/22 , C07D213/81 , C07D233/90 , C07D295/185 , C07D295/26 , A61K31/166 , A61K31/40 , A61K31/4453 , A61K31/454 , A61K31/4545 , A61K31/47 , A61K31/495 , A61K31/5375 , A61K31/54 , C07D215/14
摘要： Disclosed herein are new compounds and compositions and their application as pharmaceuticals for the treatment of diseases. Methods of inhibition of KDM1A, methods of increasing gamma globin gene expression, and methods to induce differentiation of cancer cells in a human or animal subject are also provided for the treatment of diseases such as acute myelogenous leukemia.
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公开(公告)号：US20200283397A1
公开(公告)日：2020-09-10
申请号：US16672083
申请日：2019-11-01
IPC分类号： C07D249/06 , C07C309/30 , A61K9/00 , A61K31/496 , C07D239/26 , A61K31/506 , C07D295/192 , A61K31/495 , C07D279/12 , A61K31/54 , C07D205/04 , A61K31/397 , C07D295/26 , C07D215/54 , C07C53/18 , C07D231/12 , C07D263/32 , A61K31/541 , C07B59/00 , C07D403/12 , A61K31/4192 , C07D401/12 , A61K31/454 , C07D249/08 , A61K31/4196 , C07D211/66 , A61K31/445 , C07D239/42 , C07D491/107 , C07D413/12 , A61K31/5377 , C07D498/08 , A61K31/5383 , C07D471/10 , A61K31/435 , C07D401/04 , A61K31/41 , C07D487/04 , A61K31/4162 , C07D487/08 , A61K31/4995 , A61K31/551 , C07D237/08 , A61K31/501 , A61K9/16 , A61K9/48 , A61K45/06 , A61P29/00 , A61P35/00 , A61P35/02 , A61P43/00
摘要： Disclosed herein are new compounds and compositions and their application as pharmaceuticals for the treatment of diseases. Methods of inhibition of KDM1A, methods of increasing gamma globin gene expression, and methods to induce differentiation of cancer cells in a human or animal subject are also provided for the treatment of diseases such as acute myelogenous leukemia.
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