公开(公告)号：US12037324B2

公开(公告)日：2024-07-16

申请号：US17861809

申请日：2022-07-11

Applicant: Université de Montréal ,  Bristol-Myers Squibb Company

Inventor： Eldon Scott Priestley ,  Samuel Kaye Reznik ,  Edward H. Ruediger ,  James R. Gillard ,  Oz Scott Halpern ,  Wen Jiang ,  Jeremy Richter ,  Rejean Ruel ,  Sasmita Tripathy ,  Wu Yang ,  Xiaojun Zhang

IPC: C07D401/14 ,  A61K31/41 ,  A61K31/4245 ,  A61K31/427 ,  A61K31/437 ,  A61K31/4439 ,  A61K31/4709 ,  A61K31/497 ,  A61K31/501 ,  A61P9/04 ,  C07D233/90 ,  C07D235/26 ,  C07D239/20 ,  C07D257/04 ,  C07D271/07 ,  C07D401/10 ,  C07D403/10 ,  C07D403/14 ,  C07D405/14 ,  C07D413/10 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D498/10

CPC classification number: C07D401/14 ,  A61K31/41 ,  A61K31/4245 ,  A61K31/427 ,  A61K31/437 ,  A61K31/4439 ,  A61K31/4709 ,  A61K31/497 ,  A61K31/501 ,  A61P9/04 ,  C07D233/90 ,  C07D235/26 ,  C07D239/20 ,  C07D257/04 ,  C07D271/07 ,  C07D401/10 ,  C07D403/10 ,  C07D403/14 ,  C07D405/14 ,  C07D413/10 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D498/10

Abstract: The present invention provides compounds of Formula (I):




wherein all variables are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are biased agonists, or β-Arrestin agonists of the angiotensin II receptor, which may be used as medicaments.

公开(公告)号：US20240216337A1

公开(公告)日：2024-07-04

申请号：US18287040

申请日：2022-03-31

Applicant: ADS THERAPEUTICS LLC

Inventor： Wenkui Ken FANG ,  Jinsong NI ,  Rong YANG ,  Van DINH

IPC: A61K31/4178 ,  A61K9/00 ,  A61P27/02 ,  C07D233/90

CPC classification number: A61K31/4178 ,  A61K9/0048 ,  A61P27/02 ,  C07D233/90

Abstract: A co-drug or a pharmaceutical salt thereof includes a muscarinic agonist moiety and an alpha2 adrenergic agonist moiety. The muscarinic agonist moiety and the alpha2 adrenergic agonist moiety are connected covalently via a linker, and the link includes an ester bond, an amide bond, a carbamate bond, or a combination thereof.

公开(公告)号：US12018000B2

公开(公告)日：2024-06-25

申请号：US16494435

申请日：2018-03-27

Applicant: HYDRO-QUÉBEC ,  MURATA MANUFACTURING CO., LTD.

Inventor： Charlotte Mallet ,  Sylviane Rochon ,  Antoine Lafleur-Lambert ,  Shinichi Uesaka ,  Karim Zaghib

IPC: C07D233/90 ,  C07C311/51 ,  C07D207/448 ,  C07D233/72 ,  C07D233/96 ,  H01M4/60 ,  H01M4/62 ,  H01M10/0525 ,  H01M10/0567 ,  H01M10/0569

CPC classification number: C07D233/90 ,  C07C311/51 ,  C07D207/448 ,  C07D233/72 ,  C07D233/96 ,  H01M4/60 ,  H01M4/62 ,  H01M10/0525 ,  H01M10/0567 ,  H01M10/0569

Abstract: Here are described compounds for use as electrode additives or as salts in electrolyte compositions, and their methods of preparation. Also described are electrochemical cells comprising the compounds as electrode additives or as salts in electrolyte compositions.

公开(公告)号：US11926612B2

公开(公告)日：2024-03-12

申请号：US16341597

申请日：2017-10-11

Applicant: Research Triangle Institute

Inventor： Scott P. Runyon ,  Rangan Maitra ,  Sanju Narayanan ,  Kenneth S. Rehder

IPC: C07D233/90 ,  C07D249/10 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D417/14

CPC classification number: C07D401/12 ,  C07D233/90 ,  C07D249/10 ,  C07D401/04 ,  C07D401/14 ,  C07D403/12 ,  C07D417/14

Abstract: This disclosure is directed to agonists of the apelin receptor (APJ) with heterocyclic cores and uses of such agonists.

公开(公告)号：US11834417B2

公开(公告)日：2023-12-05

申请号：US17315969

申请日：2021-05-10

Applicant: Vectus Biosystems Limited

Inventor： Karen Annette Duggan

IPC: C07D233/64 ,  C07D241/04 ,  A61P9/00 ,  A61P13/12 ,  A61P11/00 ,  C07D233/90 ,  C07D401/06 ,  C07D401/04 ,  C07D401/12 ,  C07D403/04 ,  C07D417/04 ,  C07D413/04 ,  C07D413/06 ,  C07D403/06 ,  C07D407/04 ,  C07D417/06 ,  C07D407/06 ,  C07D409/06 ,  C07D409/04 ,  A61P1/16 ,  A61P9/12

CPC classification number: C07D233/64 ,  A61P1/16 ,  A61P9/00 ,  A61P9/12 ,  A61P11/00 ,  A61P13/12 ,  C07D233/90 ,  C07D241/04 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D403/04 ,  C07D403/06 ,  C07D407/04 ,  C07D407/06 ,  C07D409/04 ,  C07D409/06 ,  C07D413/04 ,  C07D413/06 ,  C07D417/04 ,  C07D417/06

Abstract: The present invention relates to novel compounds and their use in the prophylactic and/or therapeutic treatment of hypertension and/or fibrosis.

公开(公告)号：US20230295368A1

公开(公告)日：2023-09-21

申请号：US18201401

申请日：2023-05-24

Applicant: KOEI CHEMICAL COMPANY, LIMITED

Inventor： Motoyoshi MIYAGI ,  Hitomi TSUBOI ,  Shingo NITTA

IPC: C08G18/20 ,  C08G18/80 ,  C08G18/18 ,  C07D233/90 ,  C08G18/48 ,  C08G18/73 ,  C08G18/32

CPC classification number: C08G18/2081 ,  C08G18/2027 ,  C08G18/80 ,  C08G18/1858 ,  C07D233/90 ,  C08G18/8074 ,  C08G18/18 ,  C08G18/4829 ,  C08G18/8077 ,  C08G18/807 ,  C08G18/73 ,  C08G18/3231 ,  B01J31/0235

Abstract: A blocking agent dissociation catalyst for blocked isocyanates comprising a nitrogen-containing compound represented by Formula (1a):




wherein D is represented by Formula (2):




wherein R1, R2, R3, R4, and a are as described in the specification.

公开(公告)号：US20230257354A1

公开(公告)日：2023-08-17

申请号：US18117966

申请日：2023-03-06

Applicant: Hoffmann-La Roche Inc.

Inventor： Zhanling CHENG ,  Christian LERNER ,  Yongqiang LIU ,  Matthias NETTEKOVEN ,  Philippe PFLIEGER ,  Bernd PUELLMANN ,  Jianhua WANG ,  Min WANG ,  Yongguang WANG ,  Song YANG ,  Chengang ZHOU

IPC: C07D233/90 ,  C07D403/12 ,  C07D401/12 ,  C07D401/14 ,  C07D403/14 ,  A61P31/04

CPC classification number: C07D233/90 ,  C07D403/12 ,  C07D401/12 ,  C07D401/14 ,  C07D403/14 ,  A61P31/04

Abstract: The invention provides novel heterocyclic compounds having the general formula (I), and pharmaceutically acceptable salts thereof, wherein R1 to R9 and p are as described herein:




Further provided are pharmaceutical compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds as medicaments, in particular methods of using the compounds as antibiotics for the treatment or prevention of bacterial infections and resulting diseases.

公开(公告)号：US11718612B2

公开(公告)日：2023-08-08

申请号：US17014184

申请日：2020-09-08

Applicant: Board of Regents, The University of Texas System

Inventor： Richard T. Lewis ,  Matthew Hamilton ,  William J. Ray ,  Fernando Alvarez ,  Naphtali Reyna ,  Jason Cross ,  Suyambu Kesava Vijayan Ramaswamy

IPC: C07D487/04 ,  C07D471/04 ,  A61K31/4035 ,  A61K31/407 ,  A61K31/415 ,  A61K31/4172 ,  A61K31/4196 ,  A61K31/4245 ,  A61K31/437 ,  A61K31/497 ,  A61K31/4985 ,  A61K31/5383 ,  A61K31/551 ,  A61K45/06 ,  C07D209/44 ,  C07D231/44 ,  C07D233/90 ,  C07D249/14 ,  C07D403/06 ,  C07D403/12 ,  C07D413/12 ,  C07D498/04

CPC classification number: C07D471/04 ,  A61K31/407 ,  A61K31/4035 ,  A61K31/415 ,  A61K31/4172 ,  A61K31/4196 ,  A61K31/4245 ,  A61K31/437 ,  A61K31/497 ,  A61K31/4985 ,  A61K31/5383 ,  A61K31/551 ,  A61K45/06 ,  C07D209/44 ,  C07D231/44 ,  C07D233/90 ,  C07D249/14 ,  C07D403/06 ,  C07D403/12 ,  C07D413/12 ,  C07D487/04 ,  C07D498/04

Abstract: Disclosed herein are compounds which inhibit RIPK1, pharmaceutical compositions, and methods of treatment of RIPK1-mediated diseases, such as neurodegenerative disorders, inflammatory disorders, and cancer.

公开(公告)号：US20230142739A1

公开(公告)日：2023-05-11

申请号：US17915706

申请日：2021-04-02

Applicant: The Regents of the University of California ,  Eindhoven University of Technology ,  Taros Chemicals GmbH & Co. KG

Inventor： Michelle R. Arkin ,  Lucas Brunsveld ,  Christian Ottmann ,  Adam R. Renslo ,  R. Jeffrey Neitz ,  Mengqi Zhong ,  Kenneth K. Hallenbeck ,  Priyadarshini Jaishankar ,  Shubhankar Dutta ,  John K. Morrow ,  Eline Sijbesma ,  Bente Aminhan Somsen ,  Galen Patrick Miley ,  Emira Josien Visser ,  Peter James Cossar ,  Madita Wolter ,  Thorsten Genski ,  Laura Mariana Levy ,  Torsten Hoffmann ,  Dimitrios Tzalis ,  Dario Valenti ,  Markella Konstantinidou

IPC: A61K31/495 ,  A61K45/06 ,  C07D295/185 ,  A61K31/4453 ,  A61K31/5375 ,  C07D265/30 ,  C07D233/58 ,  C07D233/90 ,  C07D233/64 ,  C07D401/04 ,  A61K31/4439 ,  A61K31/4164 ,  C07D235/24 ,  A61K31/4184 ,  A61K31/415 ,  C07D231/42 ,  C07C311/16 ,  A61K31/18 ,  A61K31/397 ,  A61K31/40 ,  C07D207/48 ,  C07D295/26 ,  A61K31/551 ,  C07D211/58 ,  C07D211/42 ,  C07D211/44 ,  C07D217/08 ,  C07D215/58 ,  C07D309/14 ,  A61K31/4468 ,  A61K31/4462 ,  A61K31/4465 ,  A61K31/454 ,  A61K31/472 ,  A61K31/47 ,  A61K31/404 ,  A61K31/538 ,  A61K31/498 ,  C07D209/08 ,  C07D241/50 ,  C07D265/36 ,  G01N33/68 ,  C07D241/08

CPC classification number: A61K31/495 ,  A61K45/06 ,  C07D295/185 ,  A61K31/4453 ,  A61K31/5375 ,  C07D265/30 ,  C07D233/58 ,  C07D233/90 ,  C07D233/64 ,  C07D401/04 ,  A61K31/4439 ,  A61K31/4164 ,  C07D235/24 ,  A61K31/4184 ,  A61K31/415 ,  C07D231/42 ,  C07C311/16 ,  A61K31/18 ,  A61K31/397 ,  A61K31/40 ,  C07D207/48 ,  C07D295/26 ,  A61K31/551 ,  C07D211/58 ,  C07D211/42 ,  C07D211/44 ,  C07D217/08 ,  C07D215/58 ,  C07D309/14 ,  A61K31/4468 ,  A61K31/4462 ,  A61K31/4465 ,  A61K31/454 ,  A61K31/472 ,  A61K31/47 ,  A61K31/404 ,  A61K31/538 ,  A61K31/498 ,  C07D209/08 ,  C07D241/50 ,  C07D265/36 ,  G01N33/6845 ,  C07D241/08

Abstract: Provided herein, inter alia, are stabilizers of protein-protein interactions and methods of identifying and using the same.

公开(公告)号：US20230115836A1

公开(公告)日：2023-04-13

申请号：US17817865

申请日：2022-08-05

Applicant: Insilico Medicine IP Limited

Inventor： Aleksandrs Zavoronkovs ,  Aleksandr Aliper ,  Vladimir Aladinskiy ,  Andrey Kukharenko

IPC: C07D403/04 ,  C07D233/90 ,  C07D403/14 ,  A61P13/12 ,  A61P11/00 ,  C07D487/08

Abstract: The disclosure provides TNIK and/or MAP4K4 kinases inhibitors for the treatment of disease. In one aspect, disclosed herein are kinase inhibitors having a structure of Formula (A), (A*), (I), (IIA), or (IIB). Further described herein are pharmaceutical composition comprising these compounds and methods of using these compounds. In one aspect, disclosed herein are methods of treating a disease or condition by administering the kinases inhibitors described herein.