公开(公告)号：US20240327339A1

公开(公告)日：2024-10-03

申请号：US18577631

申请日：2022-07-06

申请人： University of Georgia Research Foundation, Inc.

发明人： Ralph A. Tripp ,  Jackelyn Murray ,  Devi Kalyan Karumanchi ,  David Eugene Martin

IPC分类号： C07C311/16 ,  A23K20/111 ,  A23K50/30 ,  A23K50/75 ,  A61K31/18 ,  A61P31/14

CPC分类号： C07C311/16 ,  A23K20/111 ,  A23K50/30 ,  A23K50/75 ,  A61K31/18 ,  A61P31/14

摘要： Probenecid prodrug compounds, and formulations including one or more of probenecid, metabolites and analogs thereof, and prodrugs thereof, and pharmaceutically acceptable salt thereof are provided. Delivery vehicles and pharmaceutical compositions including any of the foregoing are also provided. Methods of using the compounds and compositions to treat viral infections are also provided. In some embodiments, the viral infection is caused by an RNA virus. Particular viruses include, but are not limited to, influenza virus A, influenza virus B, or influenza virus C, respiratory syncytial virus (RSV), coronaviruses, measles virus, mumps virus, Zika virus, and dengue virus. Dosage regimens are also provided.

公开(公告)号：US20230150924A1

公开(公告)日：2023-05-18

申请号：US17634361

申请日：2020-08-18

申请人： CELLGENTEK CO., LTD.

发明人： Kyung Keun KIM ,  Hyung Ho HA ,  Hangun KIM ,  Woo Kyun BAE ,  Jung A BAE

IPC分类号： C07C233/76 ,  C07C233/31 ,  C07D307/68 ,  C07D333/38 ,  C07C311/13 ,  C07C311/16 ,  C07D213/75 ,  C07D295/155 ,  C07D211/46 ,  C07D405/06 ,  C07D409/06 ,  C07D211/96 ,  C07D317/58 ,  C07D217/06 ,  C07D217/04 ,  C07D295/073 ,  C07D401/04 ,  C07D295/135 ,  C07D211/58 ,  C07D239/42 ,  C07D265/30 ,  C07D215/14

CPC分类号： C07C233/76 ,  C07C233/31 ,  C07D307/68 ,  C07D333/38 ,  C07C311/13 ,  C07C311/16 ,  C07D213/75 ,  C07D295/155 ,  C07D211/46 ,  C07D405/06 ,  C07D409/06 ,  C07D211/96 ,  C07D317/58 ,  C07D217/06 ,  C07D217/04 ,  C07D295/073 ,  C07D401/04 ,  C07D295/135 ,  C07D211/58 ,  C07D239/42 ,  C07D265/30 ,  C07D215/14

摘要： The present invention provides a novel compound that increases KAI1 promoter activity, a pharmaceutically acceptable salt thereof, and a composition for inhibiting cancer metastasis and invasion or treating colorectal cancer containing the same.

公开(公告)号：US20190169122A1

公开(公告)日：2019-06-06

申请号：US16146225

申请日：2018-09-28

申请人： Pellficure Pharmaceuticals, Inc.

发明人： Per Borgström ,  Adrian Chrastina ,  Veronique Therese Baron ,  Parisa Abedinpour

IPC分类号： C07C323/61 ,  C07C311/16 ,  A61K31/105 ,  A61K31/135 ,  A61K31/136 ,  A61K31/137 ,  A61K31/165 ,  A61K31/167 ,  A61K31/18 ,  A61K31/222 ,  A61K31/235 ,  A61K31/277 ,  A61K31/325 ,  A61K31/4164 ,  A61K31/4166 ,  A61K31/45 ,  A61K31/496 ,  A61K31/56 ,  A61K31/573 ,  A61K31/58 ,  A61K31/661 ,  C07C50/32 ,  C07C69/63 ,  C07C69/92 ,  C07C205/36 ,  C07C217/60 ,  C07C225/30 ,  C07C233/23 ,  C07C233/25 ,  C07C271/46 ,  C07C311/51 ,  A61K31/122 ,  A61K31/05

CPC分类号： C07C323/61 ,  A61K31/05 ,  A61K31/105 ,  A61K31/122 ,  A61K31/135 ,  A61K31/136 ,  A61K31/137 ,  A61K31/165 ,  A61K31/167 ,  A61K31/18 ,  A61K31/222 ,  A61K31/235 ,  A61K31/277 ,  A61K31/325 ,  A61K31/4164 ,  A61K31/4166 ,  A61K31/45 ,  A61K31/496 ,  A61K31/56 ,  A61K31/573 ,  A61K31/58 ,  A61K31/661 ,  C07C50/32 ,  C07C69/63 ,  C07C69/92 ,  C07C205/36 ,  C07C217/60 ,  C07C225/30 ,  C07C233/23 ,  C07C233/25 ,  C07C271/46 ,  C07C311/16 ,  C07C311/51 ,  A61K2300/00

摘要： Disclosed herein are 1,4-naphthoquinone analogs, pharmaceutical compositions that include one or more of such 1,4-naphthoquinone analogs, and methods of treating and/or ameliorating diseases and/or conditions associated with a cancer, such as prostate cancer with such 1,4-naphthoquinone analogs. Also included are combination therapies wherein a 1,4-naphthoquinone analog disclosed herein, and a hormone therapy agent are provided to a subject suffering from a condition such as cancer.

公开(公告)号：US20180222856A1

公开(公告)日：2018-08-09

申请号：US15748559

申请日：2015-09-01

申请人： VILNIUS UNIVERSITY

发明人： Daumantas MATULIS ,  Edita CAPKAUSKAITE ,  Andrius ZAKSAUSKAS ,  Vaida MORKUNAITE

IPC分类号： C07C311/16 ,  A61P3/04 ,  A61P25/08 ,  A61P25/18 ,  A61P35/00

CPC分类号： C07C311/16 ,  A61P3/04 ,  A61P25/08 ,  A61P25/18 ,  A61P35/00 ,  C07C317/40 ,  C07C321/28 ,  C07C2601/14 ,  C07C2601/18 ,  C07D209/08 ,  C07D215/08 ,  C07D233/58 ,  C07D235/08 ,  C07D265/30

摘要： Disclosed are novel compounds—benzenesulfonamides of general formulas (I) and The compounds can be used in biomedicine as active ingredients in pharmaceutical formulations, because they inhibit enzymes which participate in disease progression. Also disclosed are method of treatment using such compounds.

公开(公告)号：US20180093960A1

公开(公告)日：2018-04-05

申请号：US15285296

申请日：2016-10-04

申请人： California State University, Fresno ,  Mayo Foundation for Medical Education and Research

发明人： Santanu Maitra ,  Jungsu Kim

IPC分类号： C07D295/26 ,  C07C233/65 ,  C07D295/195 ,  C07C311/16 ,  C07D295/03 ,  C07C211/30 ,  A61K31/166 ,  A61K31/5375 ,  A61K31/40 ,  A61K31/4453 ,  A61K31/18 ,  A61K31/137 ,  A61K31/167 ,  C07C233/75 ,  C07C233/64 ,  C07C311/21 ,  C07C311/20

CPC分类号： C07D295/26 ,  A61K31/137 ,  A61K31/166 ,  A61K31/167 ,  A61K31/18 ,  A61K31/40 ,  A61K31/4453 ,  A61K31/5375 ,  C07C211/30 ,  C07C233/64 ,  C07C233/65 ,  C07C233/75 ,  C07C311/16 ,  C07C311/20 ,  C07C311/21 ,  C07C2601/14 ,  C07D295/03 ,  C07D295/195

摘要： This invention offers an effective method of decreasing expression of apolipoprotein E and increasing expression of at least one of either LDL-receptor protein or AbcA1 protein including selecting mammalian cells expressing apoE and at least one of either LDL-receptor protein or AbcA1 protein, contacting the mammalian cell with an effective amount of a compound having general formula (I) or general formula (II) in an amount sufficient to decrease expression of the apoE and increase expression of at least one of the LDL-receptor protein or the AbcA1 protein in the mammalian cell.

公开(公告)号：US20180086698A1

公开(公告)日：2018-03-29

申请号：US15725363

申请日：2017-10-05

申请人： Boehringer Ingelheim International GmbH

发明人： Mandar Deodhar ,  Alison Dorothy Findlay ,  Jonathan Stuart Foot ,  Wolfgang Jarolimek ,  Ian Alexander Mcdonald ,  Alan Duncan Robertson ,  Craig Ivan Turner

IPC分类号： C07C321/26 ,  C07C311/29 ,  C07C323/63 ,  C07C235/46 ,  C07C323/62 ,  C07C237/30 ,  C07C311/16 ,  C07C311/37

CPC分类号： C07C321/26 ,  C07C235/46 ,  C07C237/30 ,  C07C311/16 ,  C07C311/29 ,  C07C311/37 ,  C07C323/62 ,  C07C323/63

摘要： The present invention is related to the preparation and pharmaceutical use of substituted 3-haloallylamine derivatives as SSAO/VAP-1 inhibitors having the structure of Formula I, as defined in the specification: The invention also relates to methods of using compounds of Formula I, or pharmaceutically acceptable salt or derivatives thereof, for the treatment of a variety of indications, e.g., inflammatory diseases, ocular diseases, fibrotic diseases, diabetes-induced diseases and cancer.

公开(公告)号：US20180072656A1

公开(公告)日：2018-03-15

申请号：US15561674

申请日：2016-03-24

申请人： The Florey Institute of Neuroscience and Mental Health ,  The University of Melbourne

发明人： Spencer John Williams ,  Bevyn Jarrot

IPC分类号： C07C217/18 ,  C07C255/58 ,  C07C217/58 ,  C07D213/36 ,  C07C311/16 ,  C07D271/06 ,  C07D231/56 ,  C07C233/43 ,  C07D239/26 ,  C07D401/14 ,  C07D403/12

CPC分类号： C07C217/18 ,  C07C217/58 ,  C07C233/43 ,  C07C255/58 ,  C07C311/16 ,  C07C311/37 ,  C07D213/36 ,  C07D231/56 ,  C07D239/26 ,  C07D271/06 ,  C07D401/14 ,  C07D403/12

摘要： The present disclosure relates generally to compounds having activity as voltage-gated sodium channel blockers and their use in the field of therapeutic treatment, including the therapy or management of conditions associated with excessive, unwanted, inadequate or otherwise undesirable sodium ion passage through cellular membranes via voltage-gated sodium channels. In some embodiments, the disclosure relates to aryloxy-substituted amines for use as sodium channel blockers or modulators. Methods for their manufacture and compositions containing the compounds are also disclosed.

公开(公告)号：US20180036296A1

公开(公告)日：2018-02-08

申请号：US15466530

申请日：2017-03-22

申请人： Millennium Pharmaceuticals, Inc.

发明人： Bing-Yan Zhu ,  Penglie Zhang ,  Lingyan Wang ,  Wenrong Huang ,  Erick A. Goldman ,  Wenhao Li ,  Jingmei Zuckett ,  Yonghong Song ,  Robert M. Scarborough

IPC分类号： A61K31/44 ,  A61K9/20 ,  A61K9/48 ,  A61K31/616 ,  A61K45/06 ,  C07C237/42 ,  C07C311/16 ,  C07C311/46 ,  C07C317/40 ,  C07C317/44 ,  C07D213/75 ,  C07D213/81 ,  C07D213/82 ,  C07D217/22 ,  C07D231/12 ,  C07D249/08 ,  C07C255/60 ,  C07C257/18 ,  C07C259/18 ,  C07D233/56 ,  C07D233/64 ,  C07D295/125 ,  C07D333/38 ,  C07D401/12 ,  C07D409/12 ,  C07D409/14

CPC分类号： A61K31/44 ,  A61K9/20 ,  A61K9/2013 ,  A61K9/2054 ,  A61K9/48 ,  A61K9/4858 ,  A61K9/4866 ,  A61K31/616 ,  A61K45/06 ,  A61K2201/094 ,  C07C237/42 ,  C07C255/60 ,  C07C257/18 ,  C07C259/18 ,  C07C311/16 ,  C07C311/46 ,  C07C317/40 ,  C07C317/44 ,  C07D213/75 ,  C07D213/81 ,  C07D213/82 ,  C07D217/22 ,  C07D231/12 ,  C07D233/56 ,  C07D233/64 ,  C07D249/08 ,  C07D295/125 ,  C07D333/38 ,  C07D401/12 ,  C07D409/12 ,  C07D409/14

摘要： Novel benzamide compounds including their pharmaceutically acceptable isomers, salts, hydrates, solvates and prodrug derivatives having activity against mammalian factor Xa are described. Compositions containing such compounds are also described. The compounds and compositions are useful in vitro or in vivo for preventing or treating coagulation disorders.

公开(公告)号：US20170283374A1

公开(公告)日：2017-10-05

申请号：US15508391

申请日：2015-09-11

申请人： Pellficure Pharmaceuticals, Inc.

发明人： Per Borgström ,  Adrian Chrastina ,  Veronique Therese Baron ,  Parisa Abedinpour

IPC分类号： C07C323/61 ,  A61K31/122 ,  C07C233/25 ,  A61K31/167 ,  C07C217/60 ,  A61K31/137 ,  C07C205/36 ,  C07C69/92 ,  A61K31/235 ,  C07C271/46 ,  A61K31/325 ,  C07C225/30 ,  A61K31/135 ,  A61K31/136 ,  C07C311/51 ,  A61K31/18 ,  C07C311/16 ,  C07C233/23 ,  A61K31/165 ,  C07C69/63 ,  A61K31/222 ,  A61K31/573 ,  A61K31/58 ,  A61K31/56 ,  A61K31/4166 ,  A61K31/277 ,  A61K31/05 ,  A61K31/661 ,  A61K31/496 ,  A61K31/45 ,  A61K31/4164 ,  C07C50/32

CPC分类号： C07C323/61 ,  A61K31/05 ,  A61K31/105 ,  A61K31/122 ,  A61K31/135 ,  A61K31/136 ,  A61K31/137 ,  A61K31/165 ,  A61K31/167 ,  A61K31/18 ,  A61K31/222 ,  A61K31/235 ,  A61K31/277 ,  A61K31/325 ,  A61K31/4164 ,  A61K31/4166 ,  A61K31/45 ,  A61K31/496 ,  A61K31/56 ,  A61K31/573 ,  A61K31/58 ,  A61K31/661 ,  C07C50/32 ,  C07C69/63 ,  C07C69/92 ,  C07C205/36 ,  C07C217/60 ,  C07C225/30 ,  C07C233/23 ,  C07C233/25 ,  C07C271/46 ,  C07C311/16 ,  C07C311/51 ,  A61K2300/00

摘要： Disclosed herein are 1,4-naphthoquinone analogs, pharmaceutical compositions that include one or more of such 1,4-naphthoquinone analogs, and methods of treating and/or ameliorating diseases and/or conditions associated with a cancer, such as prostate cancer with such 1,4-naphthoquinone analogs. Also included are combination therapies wherein a 1,4-naphthoquinone analog disclosed herein, and a hormone therapy agent are provided to a subject suffering from a condition such as cancer.

公开(公告)号：US20170014360A1

公开(公告)日：2017-01-19

申请号：US15124283

申请日：2015-03-10

申请人： The University of Chicago

发明人： Phillip P. CONNELL ,  Douglas K. BISHOP ,  Brian BUDKE ,  Ralph WEICHSELBAUM

IPC分类号： A61K31/18 ,  A61K31/415 ,  A61K45/06 ,  C07D231/14 ,  C07C311/16 ,  C07C311/21 ,  C07D213/40 ,  A61K31/4406 ,  A61K31/4709

CPC分类号： A61K31/18 ,  A61K31/415 ,  A61K31/4406 ,  A61K31/4709 ,  A61K45/06 ,  C07C311/16 ,  C07C311/21 ,  C07D213/40 ,  C07D231/14 ,  A61K2300/00

摘要： Methods of killing or inhibiting the growth cancer cells and tumors and of treating cancer by administering compounds that stimulate the activity of RAD51. Cells overexpressing RAD51 or with other imbalances in homologous recombination machinery are particularly susceptible targets of RAD51 stimulators.

摘要翻译： 通过施用刺激RAD51活性的化合物来杀死或抑制生长癌细胞和肿瘤以及治疗癌症的方法。 过表达RAD51的细胞或同源重组机制中的其他失衡的细胞是RAD51刺激物特别敏感的靶标。