公开(公告)号：US20240307340A1

公开(公告)日：2024-09-19

申请号：US18263059

申请日：2022-01-19

申请人： INJE UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION

发明人： Seok Ju PARK

IPC分类号： A61K31/235 ,  A61K31/166 ,  A61P17/06 ,  A61P35/00 ,  A61P37/06

CPC分类号： A61K31/235 ,  A61K31/166 ,  A61P17/06 ,  A61P35/00 ,  A61P37/06

摘要： The present invention discloses the use of benzene derivatives as immunosuppressants. The benzene derivatives as immunosuppressants are represented by Formula 1:




wherein R is a linear alkyl group, a branched alkyl group or an alkyl group containing one or more carbon-carbon double bonds, X is an amide or ester group, and Y is a halo, methoxy, ethoxy, hydroxyl or nitro group. The benzene derivatives are used in the preparation of immunosuppressive medicaments. The benzene derivatives are effective for treating T cell-mediated immune diseases, for example, for preventing and treating rejection after organ and bone marrow transplantation and treating T cell-mediated autoimmune diseases, psoriasis, multiple sclerosis, rheumatoid arthritis, insulin-dependent diabetes mellitus, specific hemolytic anemia, ulcerative colitis, myasthenia gastrica, glomerulonephritis, Guillain-Barre syndrome, and allergic diseases such as allergic asthma and atopy due to their ability to inhibit the proliferation of T lymphocytes.

公开(公告)号：US20240299299A1

公开(公告)日：2024-09-12

申请号：US18572884

申请日：2022-06-22

申请人： The Regents of the University of Michigan

发明人： James J. MOON ,  Kai HAN ,  Deepak NAGRATH ,  Kim HUTCHINGS ,  Martin CLASBY

IPC分类号： A61K9/127 ,  A61K9/00 ,  A61K9/51 ,  A61K31/216 ,  A61K31/235 ,  A61K31/417 ,  A61K39/00 ,  A61K45/06 ,  A61P35/00 ,  C07K16/28

CPC分类号： A61K9/127 ,  A61K9/0053 ,  A61K9/5123 ,  A61K31/216 ,  A61K31/235 ,  A61K31/417 ,  A61K39/0011 ,  A61K45/06 ,  A61P35/00 ,  C07K16/2818 ,  A61K2039/505

摘要： This invention relates generally to compositions and methods for increasing the efficacy of immunotherapies and vaccines. In particular, the present invention relates to compositions comprising one or more metabolites (derivatives, prodrugs, or pharmaceutical salts thereof), and related methods of increasing the efficacy of immunotherapies and vaccines through administration of such compositions.

公开(公告)号：US20240285666A1

公开(公告)日：2024-08-29

申请号：US18651293

申请日：2024-04-30

申请人： Bonafide Health, LLC

发明人： James R. Komorowski ,  Sarah Sylla ,  Devon Bernsley

IPC分类号： A61K31/7076 ,  A61K31/235 ,  A61K36/185 ,  A61K36/31 ,  A61K36/42 ,  A61K36/54 ,  A61K38/16 ,  A61P13/06

CPC分类号： A61K31/7076 ,  A61K31/235 ,  A61K36/185 ,  A61K36/31 ,  A61K36/42 ,  A61K36/54 ,  A61K38/168 ,  A61P13/06

摘要： Disclosed herein are compositions for supporting bladder health and/or treating, ameliorating, preventing, or reducing overactive bladder or the symptoms associated therewith. The compositions disclosed herein comprise a beta-adrenergic receptor agonist and at least one muscarinic receptor antagonist. Also described herein are methods utilizing the aforementioned compositions.

公开(公告)号：US20240199620A1

公开(公告)日：2024-06-20

申请号：US18389182

申请日：2023-11-13

申请人： RAPT THERAPEUTICS, INC.

发明人： Hilary Plake Beck ,  Berenger Biannic ,  Minna Hue Thanh Bui ,  Dennis X. Hu ,  John Michael Ketcham ,  Jay Patrick Powers ,  Maureen Kay Reilly ,  Omar Robles-Resendiz ,  Hunter Paul Shunatona ,  James Ross Walker ,  David Juergen Wustrow ,  Ashkaan Younai ,  Mikhail Zibinsky ,  Jeffrey J. Jackson

IPC分类号： C07D487/04 ,  A61K31/122 ,  A61K31/198 ,  A61K31/235 ,  A61K31/42 ,  A61K31/454 ,  A61K31/4706 ,  A61K31/4985 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/593 ,  A61K31/7135 ,  A61K31/728 ,  A61K45/06

CPC分类号： C07D487/04 ,  A61K31/122 ,  A61K31/198 ,  A61K31/235 ,  A61K31/42 ,  A61K31/454 ,  A61K31/4706 ,  A61K31/4985 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/593 ,  A61K31/7135 ,  A61K31/728 ,  A61K45/06

摘要： Disclosed herein, inter alia, are compounds and methods of use thereof for the modulation of CCR4 activity.

公开(公告)号：US12005093B2

公开(公告)日：2024-06-11

申请号：US17885579

申请日：2022-08-11

申请人： HONG KONG CHINESE MEDICINE OPHTHALMOLOGY INSTITUTE LIMITED

发明人： See Tung Kwan

IPC分类号： A61K36/28 ,  A61K9/00 ,  A61K31/235 ,  A61K35/413 ,  A61K36/25 ,  A61K36/286 ,  A61K36/533 ,  A61K36/59 ,  A61K36/808 ,  A61K47/02

CPC分类号： A61K36/28 ,  A61K9/0048 ,  A61K31/235 ,  A61K35/413 ,  A61K36/25 ,  A61K36/286 ,  A61K36/533 ,  A61K36/59 ,  A61K36/808 ,  A61K47/02 ,  A61K2236/331 ,  A61K2236/39 ,  A61K2236/53

摘要： The present invention relates to the preparation technical field of traditional Chinese medicine and more particularly, to a traditional Chinese medicine eye drops and the preparation method thereof. The traditional Chinese medicine components of the traditional Chinese medicine eye drops provided by the embodiments of the invention comprise: ginseng Radix et rhizoma of 5-10 wt %, scrophulariae Radix of 15-20 wt %, xanthii Fructus of 5-10 wt %, bovis Calculus sativus of 5-10 wt %, Carthami flos of 5-10 wt %, borneolum of 5-10 wt %, senecionis scandentis herba of 25-35 wt %, fibraureae caulis of 5-15 wt % and motherwort fruit of 5-10 wt %.

公开(公告)号：US11986459B2

公开(公告)日：2024-05-21

申请号：US17713576

申请日：2022-04-05

申请人： University of South Florida

发明人： Bill J. Baker ,  Kyle Rohde ,  Bingjie Yang ,  Marisa Fuse

IPC分类号： A61K31/12 ,  A61K31/133 ,  A61K31/145 ,  A61K31/192 ,  A61K31/235 ,  A61K31/343 ,  A61K31/352 ,  A61K31/365 ,  A61K31/366 ,  A61K31/4015 ,  A61K31/4045 ,  A61K31/44 ,  A61K31/4409 ,  A61K31/454 ,  A61K31/472 ,  A61K31/496 ,  A61K31/498 ,  A61K31/505 ,  A61K31/7036 ,  A61P31/06

CPC分类号： A61K31/366 ,  A61K31/12 ,  A61K31/133 ,  A61K31/145 ,  A61K31/192 ,  A61K31/235 ,  A61K31/343 ,  A61K31/352 ,  A61K31/365 ,  A61K31/4015 ,  A61K31/4045 ,  A61K31/44 ,  A61K31/4409 ,  A61K31/454 ,  A61K31/472 ,  A61K31/496 ,  A61K31/498 ,  A61K31/505 ,  A61K31/7036 ,  A61P31/06

摘要： The present disclosure provides methods for the treatment of infections with Mycobacterium such as tuberculosis or leprosy.

公开(公告)号：US20240100008A1

公开(公告)日：2024-03-28

申请号：US18257817

申请日：2021-12-15

申请人： Rush University Medical Center

发明人： Kalipada Pahan

IPC分类号： A61K31/235 ,  A61P3/00 ,  A61P25/28

CPC分类号： A61K31/235 ,  A61P3/00 ,  A61P25/28

摘要： The present disclosure generally relates to This disclosure relates to pharmaceutical compositions useful for inhibiting the progression of urea cycle disorders and neurodegenerative disorders, such as Huntington's disease, Parkinson's disease, dementia with Lewy bodies, multiple system atrophy, Alzheimer's disease, multiple sclerosis, and amyotrophic lateral sclerosis. The pharmaceutical compositions may include glycerol tribenzoate and glycerol phenylbutyrate. The pharmaceutical compositions may be administered to the patient in any suitable manner, such as intranasally or orally.

公开(公告)号：US20240091190A1

公开(公告)日：2024-03-21

申请号：US17946067

申请日：2022-09-16

申请人： Elsia Kelly

发明人： Elsia Kelly

IPC分类号： A61K31/235 ,  A61K9/00 ,  A61K9/107 ,  A61K31/355 ,  A61K33/30 ,  A61K47/06 ,  A61K47/10 ,  A61K47/26 ,  A61K47/32 ,  A61K47/44

CPC分类号： A61K31/235 ,  A61K9/0014 ,  A61K9/107 ,  A61K31/355 ,  A61K33/30 ,  A61K47/06 ,  A61K47/10 ,  A61K47/26 ,  A61K47/32 ,  A61K47/44

摘要： A composition for external use that is used to heal and prevent wounds is described. The composition is used to prevent bedsores. The composition includes a thickening agent, an anti-fungal agent, an emulsifier, a glycerol, a skin protectant, a petroleum jelly, an oil, and at least one vitamin.

公开(公告)号：US20240082203A1

公开(公告)日：2024-03-14

申请号：US18259964

申请日：2021-12-29

申请人： SHANGHAI HUILUN BIOLOGICAL TECHNOLOGY CO., LTD. ,  SHANGHAI HUILUN JIANGSU PHARMACEUTICAL CO., LTD.

发明人： Changjun LI ,  Wenhua LI ,  Jihong QIN ,  Huali LIU ,  Jinfeng LI ,  Xiangjiang NIE

IPC分类号： A61K31/235 ,  A61K9/00 ,  A61K47/02 ,  A61K47/26

CPC分类号： A61K31/235 ,  A61K9/0078 ,  A61K47/02 ,  A61K47/26

摘要： The present invention relates to a pharmaceutical composition for inhalation, comprising N-[2-[[[4-(2,2-dimethyl-1-oxopropoxy)phenyl]sulfonyl]amino]benzoyl]-(S)-glycinate sodium or a hydrate thereof, a pH adjuster, an osmotic pressure adjuster, and optionally a surfactant. The pharmaceutical composition for inhalation of the present invention can improve drug stability. After being atomized by an inhalation atomizing device, inhalation droplets can maintain good uniformity.

公开(公告)号：US20230390224A1

公开(公告)日：2023-12-07

申请号：US18205308

申请日：2023-06-02

申请人： ATOMIC PHARMACEUTICS INC.

发明人： Julián SECO CALVO ,  Ignacio MURUA DAZA

IPC分类号： A61K31/167 ,  A61K9/00 ,  A61K9/16 ,  A61K31/192 ,  A61K31/196 ,  A61K31/4402 ,  A61K31/165 ,  A61K31/235 ,  A61K31/00

CPC分类号： A61K31/167 ,  A61K9/0095 ,  A61K9/1652 ,  A61K9/1611 ,  A61K9/1664 ,  A61K9/1617 ,  A61K31/192 ,  A61K31/196 ,  A61K31/4402 ,  A61K31/165 ,  A61K31/235 ,  A61K31/658

摘要： Described herein are therapeutic beverages that include a beverage type liquid medium and a plurality of spherical- and/or spheroidal-shaped particles dispersed within the liquid medium, wherein the plurality of the spherical- and/or spheroidal-shaped particles comprise at least one active pharmaceutical ingredient (API) disposed within the plurality of the spherical- and/or spheroidal-shaped particles. Also, described herein are methods of producing the described therapeutic beverages.