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公开(公告)号：US12194048B2
公开(公告)日：2025-01-14
申请号：US18486783
申请日：2023-10-13
Applicant: VORONOI CO., LTD.
Inventor： Soo Chan Kim , Dae Kwon Kim , Dong Hyuk Seo , Hyun Kyung Kim , Sung Hwan Kim , Hye Min Hwang , Ji Eun Choi
Abstract: The present invention relates to a pharmaceutical composition for preventing and/or treating inflammatory disease, the composition comprising a pyrrolopyridine-derivative compound as an active ingredient; the compound represented by Chemical Formula 1 according to the present invention, enantiomers thereof or pharmaceutically acceptable salts thereof, which have excellent inhibitory activity against not only protein kinases but also inflammatory factors and inflammatory cytokines; therefore a pharmaceutical composition comprising the same as an active ingredient may be useful in prevention, treatment and/or improvement of inflammatory disease, in particular but not limited to inflammatory bowel disease, rheumatoid arthritis, or lupus.
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公开(公告)号：US12187728B2
公开(公告)日：2025-01-07
申请号：US17579443
申请日：2022-01-19
Applicant: Raze Therapeutics, Inc.
Inventor： Nello Mainolfi , Mikel P. Moyer , Eddine Saiah , Cristina Lecci , Robert David Matthew Pace , Heather Tye , Julia Vile
IPC: C07D473/30 , A61K45/06 , A61P35/00 , C07D473/18 , A61P3/04 , A61P17/06 , A61P19/02
Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.
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公开(公告)号：US12180211B2
公开(公告)日：2024-12-31
申请号：US17350581
申请日：2021-06-17
Applicant: Denali Therapeutics Inc.
Inventor： Anthony A. Estrada , Jianwen A. Feng , Brian Fox , Cheng Hu , Maksim Osipov , Zachary K. Sweeney , Javier de Vicente Fidalgo , Arun Thottumkara
IPC: C07D487/04 , A61P1/04 , A61P9/10 , A61P17/02 , A61P17/06 , A61P19/02 , A61P25/00 , A61P25/14 , A61P25/16 , A61P25/28 , A61P27/02 , A61P27/06 , A61P31/00 , A61P31/04 , G01N33/50 , G01N33/574 , G01N33/68
Abstract: The present disclosure relates generally to methods and compositions for preventing or arresting cell death and/or inflammation.
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公开(公告)号：US20240400501A1
公开(公告)日：2024-12-05
申请号：US18601679
申请日：2024-03-11
Applicant: Allergan, Inc.
Inventor： Christopher D. Hein , Tien T. Duong , Santosh Sinha , Ling Li , Jeremiah H. Nguyen , David W. Old , Robert Burk , Veena Viswanath , Sandhya Rao , John E. Donello
IPC: C07C311/39 , A61P17/06 , A61P27/02 , A61P29/00 , C07B59/00 , C07C211/52 , C07C237/44 , C07C311/43 , C07D215/42 , C07D307/36 , C07D307/79 , C07D333/54
Abstract: Described herein are compounds, or pharmaceutically acceptable salts thereof, of the following formula: The compounds are useful for treating inflammatory and autoimmune diseases.
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公开(公告)号：US20240382477A1
公开(公告)日：2024-11-21
申请号：US18557300
申请日：2022-05-04
Applicant: SHANGHAI ZHEYE BIOTECHNOLOGY CO. LTD.
Inventor： Qiang ZHANG , Fengtian DU , Xiangyu YANG
IPC: A61K31/501 , A61K31/444 , A61K31/53 , A61K31/695 , A61P17/06 , A61P37/00 , C07B59/00 , C07D401/14 , C07D403/12 , C07F7/08
Abstract: The present invention provides a nitrogen-containing heterocyclic protein inhibitor compound, and a stereoisomer, a tautomer or a pharmaceutically acceptable salt thereof. Also provided are a preparation method for the nitrogen-containing heterocyclic compound and a use thereof. A drug prepared from the compound is widely used for treating diseases, the diseases comprising multiple types of autoimmune diseases, such as multiple sclerosis, rheumatoid arthritis, inflammatory bowel disease, lupus erythematosus, neurodermatitis, dermatitis, psoriasis, psoriatic arthritis, Crohn's disease, dry syndrome, scleroderma.
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公开(公告)号：US20240335462A1
公开(公告)日：2024-10-10
申请号：US18579862
申请日：2022-07-15
Applicant: MEDSHINE DISCOVERY INC.
Inventor： WANG Jianfei , Guangwen YANG , Zhihua AO , Jikui SUN , Yang ZHANG , Shuhui CHEN
IPC: A61K31/675 , A61K31/44 , A61K31/444 , A61K31/50 , A61K31/501 , A61K31/506 , A61K31/541 , A61P17/06 , C07D213/82 , C07D401/12 , C07D401/14 , C07D403/12 , C07D417/14 , C07F9/58 , C07F9/6509 , C07F9/6558
CPC classification number: A61K31/675 , A61K31/44 , A61K31/444 , A61K31/50 , A61K31/501 , A61K31/506 , A61K31/541 , A61P17/06 , C07D213/82 , C07D401/12 , C07D401/14 , C07D403/12 , C07D417/14 , C07F9/58 , C07F9/650905 , C07F9/65583
Abstract: Provided are a sulfur/phosphorus-containing aryl compound and an application thereof, and specifically disclosed are a compound represented by formula (V) and a pharmaceutically acceptable salt thereof.
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公开(公告)号：US20240300974A1
公开(公告)日：2024-09-12
申请号：US18516014
申请日：2023-11-21
Applicant: Genentech, Inc.
Inventor： Snahel PATEL , Gregory HAMILTON , Guiling ZHAO , Huifen CHEN , Blake DANIELS , Craig STIVALA
IPC: C07D498/04 , A61P1/00 , A61P17/06 , A61P19/02 , A61P21/00 , A61P25/16 , A61P25/28 , C07D235/12 , C07D471/04 , C07D487/04
CPC classification number: C07D498/04 , A61P25/16 , A61P25/28 , C07D235/12 , C07D471/04 , C07D487/04 , A61P1/00 , A61P17/06 , A61P19/02 , A61P21/00
Abstract: The invention provides novel compounds having the general formula I:
wherein R1, the A ring and the B ring are as described herein, pharmaceutical compositions including the compounds, and methods of using the compounds.
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8.发明公开
公开(公告)号：US20240300945A1
公开(公告)日：2024-09-12
申请号：US18571578
申请日：2022-06-17
Applicant: NANJING WELLBEST PHARMACEUTICAL CO., LTD
Inventor： Min CHEN , Yongping WU
IPC: C07D471/04 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61P11/00 , A61P17/02 , A61P17/06 , A61P17/10 , A61P17/14 , A61P19/02 , A61P37/06 , C07D401/12 , C07D401/14
CPC classification number: C07D471/04 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61P11/00 , A61P17/02 , A61P17/06 , A61P17/10 , A61P17/14 , A61P19/02 , A61P37/06 , C07D401/12 , C07D401/14
Abstract: Disclosed a CLY series compound, a preparation method therefor and the use thereof in the preparation of drugs. The CLY series compound can significantly prolong the survival time of acute GVHD mice, and can reduce clinical symptoms, exhibiting a therapeutic effect on acute GVHD; in a pulmonary fibrosis mouse model, same can obviously reduce the levels of MMP-2 and MMP-9 in the lung tissue, increase the levels of TIMP-1 and VEGF, and simultaneously increase the levels of SOD and CAT enzymes in peripheral blood; and same can also improve the arthritis symptoms of rheumatoid arthritis mice by means of reducing the level of IL-17 in peripheral blood and increasing inflammatory indexes such as IL-10. The compound can be used alone or in combination with other drugs, and provides a new drug choice for the treatment of the above diseases.
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公开(公告)号：US20240299315A1
公开(公告)日：2024-09-12
申请号：US18298012
申请日：2023-04-10
Applicant: Liangdan Sun
Inventor： Qi Zhen , Weiwei Chen , Zhuo Li , Yirui Wang , Liangdan Sun
IPC: A61K31/122 , A61P17/06
CPC classification number: A61K31/122 , A61P17/06
Abstract: A use of a compound or a medicinal derivative thereof in inhibiting absent in melanoma 2 (AIM2) protein activity is provided and belongs to the field of protein inhibitory medicines. Compared with traditional broad-spectrum immunomodulators, the compound has a strong targeting effect, and is more accurate, rapid, effective, safe and stable. Moreover, the compound has a strong binding force with human AIM2 protein and mouse AIM2 protein, and binding constants are as high as KD=1.56E−6M and KD=5.12E−6M respectively. Compared with traditional biological inhibitors, the compound has advantages of easy storage, stable activity, small molecular weight, lower production cost and easy absorption.
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公开(公告)号：US12076403B2
公开(公告)日：2024-09-03
申请号：US17993799
申请日：2022-11-23
Applicant: Bausch Health Ireland Limited
Inventor： Arturo Angel , Gordon Dow
IPC: A61K47/14 , A61K9/00 , A61K9/06 , A61K9/107 , A61K9/127 , A61K9/14 , A61K31/573 , A61K31/58 , A61P17/06
CPC classification number: A61K47/14 , A61K9/0014 , A61K9/06 , A61K9/107 , A61K9/127 , A61K31/573 , A61K31/58 , A61P17/06
Abstract: Pharmaceutical compositions for topical application to skin are provided. In some embodiments, the pharmaceutical compositions comprise a corticosteroid and further comprise a liquid oil component comprising one or more dicarboxylic acid esters and/or monocarboxylic acid esters.
