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公开(公告)号：US20230165830A1
公开(公告)日：2023-06-01
申请号：US18152098
申请日：2023-01-09
Applicant: UNIVERSITY OF SOUTH FLORIDA , THE UAB RESEARCH FOUNDATION
Inventor： Bill J. Baker , Lindsey N. Shaw , Andrew Jason Shilling , Alexandre Jean Bory , Jessie Allen (Adams) , Charles Dunkle Amsler, JR. , James Bruce McClintock
IPC: A61K31/343 , A61K31/352 , A61K31/192
CPC classification number: A61K31/343 , A61K31/352 , A61K31/192 , A61K2236/39
Abstract: Described herein are Dendrilla membranosa compounds and derivatives thereof. Also described herein are formulations that can contain an amount of one or more Dendrilla membranosa compounds or derivatives thereof and a carrier. Also described herein are methods of administering one or more Dendrilla membranosa compound and/or derivative thereof or a formulation thereof to a subject in need thereof.
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公开(公告)号：US11331367B1
公开(公告)日：2022-05-17
申请号：US16725182
申请日：2019-12-23
Applicant: University of South Florida
Inventor： Bill J. Baker , Nerida G. Wilson , John H. Adams , Matthew A. Knestrick , Alison Elizabeth Roth
IPC: A61K38/08 , A61P33/06 , A61K31/4706
Abstract: Described herein are compounds, formulations, and methods for blocking sporozoite invasion and subsequent liver-stage parasite development of a protozoan parasite, such as Plasmodium falciparum.
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公开(公告)号：US20220136019A1
公开(公告)日：2022-05-05
申请号：US17406025
申请日：2021-08-18
Inventor： Bill J. Baker , Dennis E. Kyle , Mario Alberto Rodriguez-Pérez , Anne-Claire D. Limon , Ala Azhari
IPC: C12P17/18 , C12N1/14 , A61K31/366 , A61P33/02
Abstract: Described herein are methods of epigenetic modification of fungi and uses thereof. Also described herein are compounds that can have antileishmanial activity and formulations thereof. Also described herein are methods of treating leishmanial infection in a subject that include the step of administering a compound or formulation thereof described herein to the subject.
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公开(公告)号：US11213507B2
公开(公告)日：2022-01-04
申请号：US16081494
申请日：2017-04-17
Applicant: University of South Florida , UAB Research Foundation
Inventor： Bill J. Baker , Lindsey N. Shaw , James Bruce McClintock , Charles D. Amsler , Jacqueline Lee Fries , Witowski G. Christopher , Renee M. Fleeman
IPC: A61K31/365 , A61P31/04 , A61K9/00
Abstract: Provided is a darwinolide compound having a previously undescribed carbon skeleton and the crystalline form thereof. Also provided are processes of isolating darwinolide, compositions comprising darwinolide, and methods of treating infection, such as a methicillin-resistant Staphylococcus aureus biofilm infection.
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公开(公告)号：US20180265442A1
公开(公告)日：2018-09-20
申请号：US15993232
申请日：2018-05-30
Applicant: UNIVERSITY OF SOUTH FLORIDA , The United States Government as represented by the Department of Veterans Affairs
Inventor： Chad Dickey , Umesh Jinwal , Laurent Calcul , Bill J. Baker , Matthew Lebar
IPC: C07C43/23 , A61K31/05 , C07C69/28 , C07C43/21 , C07C43/215 , A61K31/11 , A61K31/121 , C07C47/277
CPC classification number: C07C43/23 , A61K31/05 , A61K31/11 , A61K31/121 , C07B2200/07 , C07C43/21 , C07C43/215 , C07C47/277 , C07C69/28 , C07C2603/38 , C07C2603/40
Abstract: The subject invention pertains to myricanol derivatives, therapeutic compositions, and methods for treatment of neurodegenerative diseases, in particular, neurodegenerative dieses associated with abnormal accumulation of protein tau.
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Patent Agency Ranking
公开(公告)号：US09394270B2
公开(公告)日：2016-07-19
申请号：US14204996
申请日：2014-03-11
Applicant: UNIVERSITY OF SOUTH FLORIDA , THE UAB RESEARCH FOUNDATION
Inventor： Bill J. Baker , Thushara Diyabalanage , James B. McClintock , Charles D. Amsler
IPC: A61K31/365 , C07D313/00
CPC classification number: C07D313/00 , A61K31/365
Abstract: The present invention concerns groups of compounds derived from tunicates of the Synoicum species, as well as to pharmaceutical compositions comprising these compounds, and uses thereof. Extracts from tunicates show selective toxicity against several different cancer cell lines in the NCI 60 cell line panel. These compounds are useful in the effective treatment of cancers, particularly malignant melanomas, colon cancer, and renal cancer cell lines.
Abstract translation: 本发明涉及来源于Synoicum种的囊泡的化合物组，以及包含这些化合物的药物组合物及其用途。 提取物提取物对NCI60细胞系中几种不同的癌细胞株显示选择性毒性。 这些化合物可用于有效治疗癌症，特别是恶性黑素瘤，结肠癌和肾癌细胞系。
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公开(公告)号：US12180524B2
公开(公告)日：2024-12-31
申请号：US17406025
申请日：2021-08-18
Inventor： Bill J. Baker , Dennis E. Kyle , Mario Alberto Rodriguez-Pérez , Anne-Claire D. Limon , Ala Azhari
IPC: A61K31/366 , A61P33/02 , C12N1/14 , C12P17/18
Abstract: Described herein are methods of epigenetic modification of fungi and uses thereof. Also described herein are compounds that can have antileishmanial activity and formulations thereof. Also described herein are methods of treating leishmanial infection in a subject that include the step of administering a compound or formulation thereof described herein to the subject.
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公开(公告)号：US10358405B2
公开(公告)日：2019-07-23
申请号：US15993232
申请日：2018-05-30
Applicant: UNIVERSITY OF SOUTH FLORIDA , The United States of America as represented by the Department of Veterans Affairs , Adria Dickey
Inventor： Chad Dickey , Umesh Jinwal , Laurent Calcul , Bill J. Baker , Matthew Lebar
IPC: A61K31/05 , A61K31/11 , A61K31/121 , C07C43/21 , C07C43/215 , C07C43/23 , C07C47/277 , C07C69/28
Abstract: The subject invention pertains to myricanol derivatives, therapeutic compositions, and methods for treatment of neurodegenerative diseases, in particular, neurodegenerative diseases associated with abnormal accumulation of protein tau.
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公开(公告)号：US20190218165A1
公开(公告)日：2019-07-18
申请号：US16373956
申请日：2019-04-03
Applicant: UNIVERSITY OF SOUTH FLORIDA , The United States Government as represented by the Department of Veterans Affairs
Inventor： Chad Dickey , Umesh Jinwal , Laurent Calcul , Bill J. Baker , Matthew Lebar
IPC: C07C43/23 , C07C69/28 , C07C43/21 , A61K31/121 , A61K31/11 , A61K31/05 , C07C47/277 , C07C43/215
CPC classification number: C07C43/23 , A61K31/05 , A61K31/11 , A61K31/121 , C07B2200/07 , C07C43/21 , C07C43/215 , C07C47/277 , C07C69/28 , C07C2603/38 , C07C2603/40
Abstract: The subject invention pertains to myricanol derivatives, therapeutic compositions, and methods for treatment of neurodegenerative diseases, in particular, neurodegenerative dieses associated with abnormal accumulation of protein tau.
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公开(公告)号：US10287227B2
公开(公告)日：2019-05-14
申请号：US15414242
申请日：2017-01-24
Applicant: University of South Florida , The United States of America as represented by the Department of Veterans Affairs
Inventor： Chad Dickey , Umesh Jinwal , Laurent Calcul , Bill J. Baker , Matthew Lebar
IPC: A61K31/05 , A61K31/11 , A61K31/121 , C07C43/21 , C07C43/215 , C07C43/23 , C07C47/277 , C07C69/28
Abstract: The subject invention pertains to myricanol derivatives, therapeutic compositions, and methods for treatment of neurodegenerative diseases, in particular, neurodegenerative diseases associated with abnormal accumulation of protein tau.
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